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Medula
Published by Universitas Halu Oleo
ISSN : 23391006     EISSN : 24430218     DOI : http://dx.doi.org/10.33772/medula
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health
MEDULA mengundang kontribusi bagi penelitian original dan fundamental pada bidang kesehatan sebagai sebuah artikel yang melewati proses review.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 9 Documents
 1 
Search results for , issue "Vol 10, No 1 (2022)" : 9 Documents clear
Aktivitas Antibakteri dan Skrining Fitokimia Ekstrak Etanol Daun Jambu Mete Anacardium occidentale L. Terhadap Pertumbuhan Escherichia coli Antibacterial Activity and Phytochemical Screening of Ethanol Extract of Cashew Leaves Anacardium occidentale L. Against Escherichia coli Eka Astuty
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.26112

Abstract

ABSTRACTBackground: All parts of the cashew tree Anacardium occidentale L. (especially the leaves and bark) have been widely used as traditional herbal medicines, and are used throughout the world. Thus, in recent decades, the traditional medicinal properties of the Anacardium plant, and its various biological effects are being studied extensively. Purpose(s): This study aims to conduct a preliminary study of the antibacterial properties and phytochemical screening of the ethanol extract of cashew leaves. Methods: The antibacterial test of was determined by the Kirby baeur disc paper diffusion method. Qualitative test of phytochemical content was carried out using chemical reagents. Results: The results indicated that the ethanol extract of cashew leaves has an inhibitory effect on the growth of Escherichia coli. The smallest inhibition zone was found in the extract with a concentration of 10% of 5.75 mm and the largest was found at a concentration of 100% with a diameter of 14 mm. The phytochemical screening revealed that extracts contained; alkaloids, flavonoids, steroids, terpenoids, phenolics, saponins, and tanins Conclusion: The ethanol extract of cashew leaves was able to inhibit the growth of Escherichia coli test bacteria at all concentration variations. Phytochemical screening also found that the ethanol extract of cashew leaves contains alkaloids, flavonoids, steroid terpenoids, phenolics, saponins, and tannins which are known to have antibacterial properties.Keywords: cashew, ethanol extract, antibacteria ABSTRAKLatar Belakang: Semua bagian pohon jambu mete Anacardium occidentale L. (terutama daun dan kulit batang) telah banyak digunakan sebagai obat herbal tradisional, dan digunakan di seluruh dunia. Dengan demikian, dalam beberapa dekade terakhir, sifat obat tradisional tanaman Anacardium, dan berbagai efek biologis sedang dipelajari secara ekstensif Tujuan: Penelitian ini bertujuan untuk melakukan studi pendahuluan sifat antibakteri dan skrining fitokimia dari ekstrak etanol daun jambu mete. Metode: Uji antibakteri ekstrak ditentukan dengan metode difusi kertas cakram Kirby baeur. Uji kualitatif kandungan fitokimia dalam ekstrak dilakukan dengan pereaksi kimia. Hasil: Ekstrak etanol daun jambu mete memiliki daya hambat terhadap pertumbuhan Escherichia coli. Zona hambat terkecil terdapat pada ekstrak dengan konsentrasi 10% sebesar 5,75 mm dan terbesar terdapat pada konsentrasi 100% dengan diameter 14 mm. Hasil skrining fitokimia menunjukkan bahwa ekstrak etanol daun jambu mete mengandung senyawa golongan alkaloid, flavonoid, steroid, terpenoid, fenolik, saponin, dan tanin Simpulan: Ekstrak etanol daun jambu mete mampu menghambat pertumbuhan bakteri uji Escherichia coli pada semua variasi konsentrasi. Skrining fitokimia juga menemukan bahwa dalam ekstrak etanol daun jambu mete mengandung alkaloid, flavonoid, steroid terpenoid, fenolik, saponin, dan tannin yang diketahui memiki kemampuan sebagai antibakteriKata Kunci: jambu mete, ekstrak etanol, antibakteri
Analisis Penggunaan Kondom Pada Wanita Pekerja Seks Sebagai Upaya Pencegahan HIV/AIDS di Kota Kendari: Cross Sectional Study Adius Kusnan; Nur Indah Purnamasari; Nisa Melynia Arman; La Ode Alifariki
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.26733

Abstract

Latar Belakang: Salah satu populasi yang berisiko tinggi HIV/AIDS adalah Wanita Pekerja Seks (WPS) dikarenakan perilaku seks yang tidak aman yakni berganti-ganti pasangan. Penggunaan kondom merupakan salah satu inisiatif untuk mencegah penularan HIV/AIDS, dan penggunaannya dapat dipengaruhi oleh berbagai variabel. Tujuan: Menganalisis berbagai faktor yang berhubungan dengan penggunaan kondom pada WPS sebagai upaya pencegahan HIV/AIDS. Metode: Penelitian cross sectional ini merupakan penelitian observasional analitik yang dilakukan di Kota Kendari dengan jumlah sampel 65 orang sesuai kriteria inklusi dan eksklusi yang dipilih menggunakan purposive sampling, analisis data menggunakan uji chi-square Pearson dengan nilai p-value ≤ 0.05 dinyatakan bermakna. Hasil: Pengetahuan baik tentang HIV/AIDS dan kondom (58,5%),  memiliki sikap tentang penggunaan kondom positif (66,2%), ada paparan informasi tentang kondom untuk mencegah HIV/AIDS (95,4%) serta selalu menggunakan kondom (55,4%). Terdapat hubungan antara pengetahuan (p-value=0,012) dan sikap (p-value=0,027) penggunaan kondom pada WPS. Tidak terdapat hubungan keterpaparan informasi (p-value=0,084) dengan penggunaan kondom pada WPS. Simpulan: WSP yang memiliki pengetahuan kurang dan sikap negative cenderung berimplikasi pada menurunnya penggunaan kondom
The Activity of Notika Leaves (Archboldiodendron calosericeum KOBUSKI) Against Tumors Necrosis Factor Alpha (TNF-) Levels in Rats Nuralifah Nuralifah; Parawansah Parawansah; Fadhliyah Malik; Nining Yulianti
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.23816

Abstract

Inflammation is a response process to tissue injury and infection. The inflammatory response causes the release of pro-inflammatory mediators such as IL-1, IL-6 and TNF-α which are the main cytokines in the acute inflammatory response. Plants that have the potential to be anti-inflammatory are notika leaves (Archboldiodendron calosericeum KOBUSKI). This research was conducted to determine the anti-inflammatory activity of the ethanol extract of notika leaves against the levels of Tumor Necrosis Factor Alpha (TNF-a) in wistar mice. This study used a post test only control group design. Using 5 treatment groups, namely positive control (diclofenac sodium), negative control (NaCMC 0.5%), 100 mg/kgBW extract test group, 200 mg/kgBW extract group and 300 mg/kgBW extract group. In vivo tests were carried out by induction of inflammatory substances, administering preparations and measuring TNF-α levels using the ELISA method. Data were analyzed using the One Way ANOVA test. The results showed that the mean levels of TNF-α in the positive control group (0.475 ng/L), negative control (0.816 ng/L), extract dose 100 mg/kgBW (0.67 ng/L), extract dose 200 mg/kgBW (0.7285 ng/L) and extract dosage of 300 mg/kgBW (0.7785 ng/L). The conclusion obtained is that the ethanol extract of notika leaves has anti-inflammatory activity against the levels of Tumor Necrosis Factor Alpha (TNF-a) in Wistar rats based on the reduction in levels with negative control and the best dose was 100 mg/kgBW.
Hubungan Faktor Risiko dengan Kejadian Sindrom Dispepsia Fungsional pada Mahasiswa Fakultas Kedokteran Universitas Khairun Muhammad Sultan Firman Syah; Abdul A Manaf; Fera The
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.25877

Abstract

Dispepsia merupakan kumpulan rasa tidak nyaman, nyeri epigastrium, kembung, mual muntah, sendawa dan rasa penuh. Stres, pola makan, makanan/minuman iritatif, obat anti inflamasi non-steroid (OAINS), Helicobacter pylori, alkohol dan merokok merupakan faktor risiko dispepsia. Meski berada di urutan ke-8 dari 10 penyakit spesifik di Maluku Utara, belum ada penelitian terkait hubungan faktor risiko dengan kejadian pada kelompok ini, khususnya pada kaum muda di Universitas Khairun. Tujuan: Mengetahui hubungan faktor risiko dengan kejadian sindrom dispepsia fungsional pada mahasiswa Fakultas Kedokteran Universitas Khairun. Metode: Penelitian observasional analitik cross sectional ini dilaksanakan mengunakan metode random sampling dari populasi mahasiswa Fakultas Kedokteran Universitas Khairun pada Januari 2022. Data diperoleh melalui kuesioner. Hasil: Dari 136 sampel, sebagian besar berusia 20-24 tahun (54,4%), 71,3% perempuan, 52,5% memiliki tingkat stres normal, 64,7% memiliki pola makan teratur, 56,6% mengonsumsi makanan/minuman iritatif, 23,5% mengonsumsi OAINS, 2,2% perokok, dan 6,6% mengonsumsi alkohol. Dispepsia fungsional dialami 55,9% mahasiswa. Dari seluruh variabel independen, jenis kelamin, tingkat stres, diet iritatif, OAINS, dan status perokok ditemukan berhubungan bermakna secara statistis dengan kejadian dispepsia fungsional (p<0,05). Simpulan: Pada mahasiswa Fakultas Kedokteran Universitas Khairun, jenis kelamin, tingkat stres, diet iritatif, OAINS, dan status perokok ditemukan berhubungan bermakna secara statistis dengan kejadian dispepsia fungsional.Kata Kunci: Dispepsia, faktor risiko, mahasiswa fakultas kedokteran
Risk Factors for Acute Respiratory Infection in Toddlers : A Case Control Study Elpira Asmin; Mira Juanita; Vebiyanti Tentua
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.26409

Abstract

Background: Acute Respiratory Infection (ARI) is a disease that attacks the upper and lower respiratory tract caused by bacteria and viruses. ARI is one of the causes of high morbidity and mortality in under-fives. Purpose(s): This study aims to determine the relationship between toddler age, immunization status, smoking habits of family members, mother's knowledge, and residential density to the incidence of ARI in the working area of the Namlea Health Center in 2021 Methods: This study is a research study quantitative analysis using a case control research design. The sample in the case group was taken using the simple random sampling method and the control group was taken using the accidental sampling method. Results: the age of toddlers who were 36 months (55.2%), incomplete immunization status (46.9%), smoking habits of family members (68.8%), low maternal knowledge (30.2%), and density of bedroom occupancy (60.4%). The results of the chi-square test showed that the p-values for each variable were age (p = 0.035), immunization status (p = 0.017), room occupancy density (p = 0.022), mother's knowledge (p = 0.046), and smoking habits. family members (p = 0.036). Conclusion: There is a significant relationship between age, immunization status, room occupancy density, mother's knowledge, and smoking habits of family members with the incidence of ARI in children under five in the working area of the Namlea Health Center in 2021.
Correlation between Chest Radiograph and Lung Ultrasound with Clinical Appearance in Hyaline Membrane Disease Patients Wa Ode Zerbarani; Sri Asriani; Mirna Muis; Ema Alasir
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.28495

Abstract

ABSTRACT Background: Hyaline membrane disease (HMD) is a respiratory distress disease in premature infants due to surfactant deficiency. The combination of clinical, laboratory and radiological features makes it easy to quickly, precisely & accurately establish HMD which is important for early therapy in preventing death. Purpose: Knowing the suitability between chest X-ray & Thorax ultrasound with the clinical picture in HMD patients. Methods: This study is an observational study with a cross sectional method conducted in the radiology & NICU section of Dr. Wahidin Sudirohusodo Makassar from August 2021 to January  2022.  Sampling  was  done  by  consecutive  sampling.  The  researcher  performed  a  thorax ultrasound & assessed the chest x-ray. The results were verified by two pediatric radiology consultants. Results: The largest sample was in neonates at 34 weeks of gestation, 8 samples (21.1%), sex with 25 samples (65.8%), the highest birth weight between 1000-2000 grams 32 samples (84.2%) , the most preterm etiology was due to severe preeclampsia in 13 samples (34.2%), the most deliveries were by cesarean section 34 samples (89.4%), the highest APGAR Score was in moderate degree 25 samples (65.8%), the highest O2 saturation was between 90 -94%, namely 24 samples (63.2%), the most down scores were moderate degrees 15 samples (39.5%), HMD degrees based on chest radiographs were mostly grade II 25 samples (65.8%), HMD degrees based on thorax ultrasound the most in the moderate degree 19 samples (50%).Conclusion: Ultrasound is considered as the radiological modality of choice because it is safe, inexpensive, easy & sensitive to assess respiratory distress in neonates but is influenced by the operator's ability to apply it.Keywords: hyaline membrane disease, down score, chest radiograph, lung ultrasound
Relationship between Waist Circumference (Abdomen) and Triglyceride and Low Density Lipoprotein-Cholesterol (LDL-C) Levels in Premenopausal Women Mutmainnah Abbas; Rosdiana Mus
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.26412

Abstract

 Background: Premenopausal is a period that women will experience before heading to the menopause phase in the age range of 4 5-55 years. In the premenopausal period it is characterized by the instability of the hormone estrogen which will affect lipid metabolism which is closely related to the increase in abdominal fat known as abdominal or central obesity . The instability of the hormone estrogen results in hormonal changes that affect the levels of lipids in the body such as TG and LDL-Chol levels in the blood. Purpose(s): This study aims to determine whether there is a relationship between Waist Circumference (Abdomen) and Triglyceride and Low Density Lipoprotein-Cholesterol (LDL-C) Levels in Premenopausal Women. Methods: This study used an analytical correlative method with a cross-sectional study approach. This study involved 40 research subjects who met the criteria. Results: In the results of the pearson correlation test analysis to determine the relationship between the abdominal waist circle and TG levels in premenopausal women, the results of the p value = 0.351 and the pearson correlation test value = 0.15 were obtained. In the correlation test between waist circumference (abdomen) and LDL- Chol levels in premenopausal women, a value of p = 0.164 with a pearson correlation value of 0.224 was obtained. Conclusion: There is no relationship between Waist Circumference (Abdomen) and Triglyceride and Low Density Lipoprotein-Cholesterol (LDL-C) Levels in Premenopausal Women.Keywords: Premenopause, Waist Circumference, Lipid, Triglycerides, Low Density Lipoprotein
Factors Related to Nutritional Status of Toddlers in the Working Area of Soropia Health Center, Konawe Regency in 2021 Lisnawaty Lisnawaty; Jafriati Jafriati; Nurfajriyanti Hamka; Febriana Muchtar
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.28496

Abstract

ABSTRACTBackground: Nutritional status is a state of health related to the use of food by the body. As a result of poor nutritional status during infancy, it can cause stunted growth, cause toddlers to be lazy to carry out activities related to energy production, disruption of the toddler's immune system so that they  are  susceptible  to  infectious  diseases,  inhibition  of  optimal  brain  growth,  and  changes  in behavior such as apathy. Purposes: This study aimed to determine the relationship between parental income, and eating patterns in children under five with the occurrence of malnutrition in children under five in the working area of Soropia Health Center. Methods: This research was a quantitative research  that  is  observational  analytic  with  a  Cross  Sectional  Study  approach.  The  number  of samples were 50 toddler with a sampling technique using total sampling and for analysis using the Chi-Square test. Results: The results showed that there was a relationship between parental income (p=0.048) and eating patterns (p=0.000) with the nutritional status of children under five in the Soropia Health Center area in 2021. Conclusion:it was found that there was a relationship between parents' income and diet. on the nutritional status of children.Keywords: Toddler, nutritional status, parents' income, diet
PENGEMBANGAN SEDIAAN SPRAY GEL DARI EKSTRAK ETANOL BATANG TUMBUHAN BAMBU-BAMBU (Polygonum pulchrum Blume) MENGGUNAKAN BASIS KOMBINASI GEL VISKOLAM® DAN Hydroxypropyl Methyl Cellulose (HPMC) Wa Ode Sitti Zubaydah
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.26555

Abstract

Background: Bamboo plants are one of the traditional medicinal plants that are often used by the community. The stem of Polygonum pulchrum Blume contains a triterpenoid steroid compound that acts as an active antioxidant. Objectives: This study aims to determine the optimal formula for spray gel preparation of Polygonum pulchrum Blume ethanol extract using Design Expert®. Methods: The stems of Polygonum pulchrum Blume were extracted by maceration using 96% ethanol to obtain a thick extract through . The extract obtained was formulated with spray gel preparations with variations in the concentration of viscolam® and HPMC F1(0,1%:0,1%), F2(0,4%:0,1%), F3(0,4%:0, 4%), and F4(0,1%:0,4%). The test was carried out by looking at the characteristics consisting of organoleptic test, pH test, viscosity test, spray pattern test, dry time test and homogeneity test, as well as looking at the stability of the preparation before and after the cycling test. Optimization of the spray gel formula using a factorial design of 23 with a viscolam® factor and HPMC using dry time response, viscosity, and spraying pattern. After obtaining the optimum formula, hedonic testing was carried out by looking at the parameters of color, aroma, texture, and overall appearance. Results and conclusions: The results showed that the optimum formula for the F2 formula was the concentration of viscolam® and HPMC 0.4%: 0.1%, as well as spray gel preparations that had been tested for stability and had met the stability test requirements based on the test parameters.

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