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All Journal Medula Jurnal Pengabdian Nusantara (JPN)
Parawansah Parawansah
Universitas Halu Oleo
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PEMBUATAN DAN PEMANFAATAN ANTISEPTIK DAN DESINFEKTAN DALAM PENCEGAHAN COVID-19 Parawansah Parawansah; Saida Saida; Amiruddin Eso; Nurul Afifah Yusran; Wa Ode Chesaria F.A; Indriyati Indriyati; Nuzul Aulia Fajarwati B; Puteri Febriyanthi Rachman
Jurnal Pengabdian NUSANTARA Vol 1, No 1 (2021): Januari-Juni
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.762 KB) | DOI: 10.33772/jpnus.v1i1.15610

Abstract

Antiseptic is a chemical substance whose mechanism of action is to destroy microorganisms or inhibit its work so that it can prevent infection. One of the antiseptics is chlorhexidine and alcohol. The method used in this service is the comparative method of several journal sources. A literature study is conducted online by searching for journals. The results of this dedication show that the use of antiseptics and disinfectants to prevent Covid-19 transmission is effective if the selection is right and used according to their purpose. There needs to be further education by health workers to the public to be a preventive measure against the further spread of Covid-19.
The Activity of Notika Leaves (Archboldiodendron calosericeum KOBUSKI) Against Tumors Necrosis Factor Alpha (TNF-) Levels in Rats Nuralifah Nuralifah; Parawansah Parawansah; Fadhliyah Malik; Nining Yulianti
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.23816

Abstract

Inflammation is a response process to tissue injury and infection. The inflammatory response causes the release of pro-inflammatory mediators such as IL-1, IL-6 and TNF-α which are the main cytokines in the acute inflammatory response. Plants that have the potential to be anti-inflammatory are notika leaves (Archboldiodendron calosericeum KOBUSKI). This research was conducted to determine the anti-inflammatory activity of the ethanol extract of notika leaves against the levels of Tumor Necrosis Factor Alpha (TNF-a) in wistar mice. This study used a post test only control group design. Using 5 treatment groups, namely positive control (diclofenac sodium), negative control (NaCMC 0.5%), 100 mg/kgBW extract test group, 200 mg/kgBW extract group and 300 mg/kgBW extract group. In vivo tests were carried out by induction of inflammatory substances, administering preparations and measuring TNF-α levels using the ELISA method. Data were analyzed using the One Way ANOVA test. The results showed that the mean levels of TNF-α in the positive control group (0.475 ng/L), negative control (0.816 ng/L), extract dose 100 mg/kgBW (0.67 ng/L), extract dose 200 mg/kgBW (0.7285 ng/L) and extract dosage of 300 mg/kgBW (0.7785 ng/L). The conclusion obtained is that the ethanol extract of notika leaves has anti-inflammatory activity against the levels of Tumor Necrosis Factor Alpha (TNF-a) in Wistar rats based on the reduction in levels with negative control and the best dose was 100 mg/kgBW.
Co-Authors Alifariki, La Ode Amirudin Esso Arimaswti Arimaswati Asriullah Jabbar Elvantri Yani Eso, Amiruddin Fadhliyah Malik Fadilah Fadilah I Putu Sudayasa Indriyati Indriyati Irmawati Irmawati Jamaluddin jamaluddin Mubarak Mubarak Muhammad Fathur Rahman Nining Yulianti Nur Illiyyin Akib Nuralifah Nuralifah, Nuralifah Nurul Afifah Yusran Nuzul Aulia Fajarwati B Puteri Febriyanthi Rachman Ritha Hastria Saida Saida Syarifin, Andi Noor Kholidha Wa Ode Chesaria F.A Wa Ode Yentri Putia Ningtiyas Darmin