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INDONESIA
Journal of Agromedicine and Medical Sciences
Published by Universitas Jember
ISSN : 24609048     EISSN : 27145654     DOI : -
Core Subject : Health,
Health Professions
Jurnal Agromedicine and Medical Sciences (AMS) adalah jurnal berkala empat bulan (Februari, Juni dan Oktober) yang berisi berbagai artikel dalam bentuk penelitian, tinjauan sistematis dan laporan kasus dalam bidang kedokteran dengan fokus pada ilmu-ilmu kedokteran dasar, kedokteran klinis dan agromedis.
Arjuna Subject : -
Articles 10 Documents
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Search results for , issue "Vol 10 No 2 (2024)" : 10 Documents clear
In Silico Test Potential of Bromelain and Actinidin Enzymes as Proteolytic againts Cataract-forming Proteins Elok Tiara Pratmawati; Nugraha Wahyu Cahyana; Zahrah Febianti
Journal of Agromedicine and Medical Sciences Vol 10 No 2 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i2.25496

Abstract

A cataract is the development of an opacity within the lens that can cause blindness. Cataracts are caused by the aggregation of crystallin proteins, which are water-soluble proteins that make up 80% of all lens proteins. Crystallin protein aggregation can occur due to several mechanisms such as the formation of amyloid fibrils (associated with senile cataract) and P23T mutations (associated with congenital cataracts). Currently, surgery is the only cataract treatment available. Although it is the best treatment, surgery requires high cost and is not free from complications. Therefore, alternative treatments for cataracts are needed, such as the use of natural ingredients that have proteolytic properties. Pineapple contains bromelain and kiwi contains actinidin. Both enzymes are protease which destabilize and inhibit the formation of aggregates. So that those enzymes can potentially lyse the protein causes cataracts. To prove the potency of the enzymes, we consucted an insilico study using Cluspro docking online program. We investigate the binding energy of each enzymes with the amyloid fibril and P23T mutation. The results of Cluspro docking between Bromelain Enzyme and Actinidin Enzyme with P23T mutation protein respectively are -696.2 Kcal/mol and -750.8 Kcal/mol. The results of Cluspro docking between Bromelain Enzyme and Actinidin Enzyme with amyloid protein are -696.2 Kcal/mol and -750.8 Kcal/mol respectively. Therefore, bromelain enzyme had a better ability to bind to amyloid protein, while the actinidin enzyme had a better ability to bind to the P23T D-crystallin mutation protein. Keywords: ClusPro, Molecular Docking, Bromelain, Actinidin, Cataract, SwissModel
Fibroma of the Vastus Lateralis Tendon Sheath in the Thigh of the 58-year-old Female: A Rare Case Report Heni Fatmawati; Hantonius Hantonius; Antonius Dwi Saputra; Candra Bumi
Journal of Agromedicine and Medical Sciences Vol 10 No 2 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i2.45329

Abstract

Background: Fibroma of the tendon sheath (FTS) is a rare slow-growing noncancerous fibrous tumor that is usually small, painless and involves the upper extremity tendons in young adult males. FTS of the lower extremity is an unusual and underreported variety that poses a diagnostic preoperative challenge. Case description: We report an atypical case of a large fibroma of the vastus lateralis tendon in a 58-year-old female presented with a painful lump in her right thigh within the past six months. Physical examination showed a hard firm mass approximately 6 cm in diameter palpated in the anterior of the lower thigh. The mass was smooth, mobile, solid, and had well-defined borders. There was no adhesion to the skin, redness, or tenderness. MRI showed a 4,2 x 5,8 x 6,2 cm tumor with isointense signals on T1-weighted images (T1WI), heterogeneous hypointense signals on T2-weighted images (T2WI), and hyperintense signals on FatSat images. Biopsy revealed no malignant findings and the tumor had been surgically resected. Imaging studies for FTS have rarely been described, T1WI often show a low signal mass, with slight isointense to hypointense to the muscle. The T2WI’s appearance of FTS is more variable. Conclusion: In spite of rarity, FTS must still be included as a differential diagnosis of a thigh mass especially if the mass is painful and benign-appearing on physical exam and radiology.
Enhanced Recovery After Cesarean Surgery (ERACS) Method Accelerates Mobilization and Duration of Hospitalization After Cesarean Section Alfina Galuh Hannie Sisdayani; Erfan Efendi; Muhamad Hasan
Journal of Agromedicine and Medical Sciences Vol 10 No 2 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i2.45478

Abstract

ERACS is a caesarean section method that supports recovery more quickly. The principle of ERACS is the use of multidrug anesthesia, namely bupivacaine at a reduced dose (<10 mg) and combined with fentanyl and morphine to maintain the quality of anesthesia so that patients can mobilize more quickly with minimal pain and reduce the duration of hospitalization. This research used an observational analytical design with a cross sectional approach in September – November 2023 at the Bina Sehat Jember Hospital. This study used 100 samples medical records with sampling using a purposive sampling technique and calculating using Slovin formula. The data was analyzed using Mann-Whitney test with a confidence level of 95%. The research results showed that the average walking mobility ability after ERACS was 10,10 hours, while conventional was 14.76 hours and the duration of hospitalization after ERACS was 2.22 days, while after conventional was 2.98 days. This is supported by the results of statistical tests which show that the significance value (p) for both variables is 0.000 (p < 0.05), which means there is a significant difference between the speed of walking mobilization and the duration of hospitalization with the SC method used. The conclusion of this study was that ERACS can speed up the ability to mobilize after surgery by up to 4.66 hours and the duration of hospitalization is 0.76 days shorter than conventional. Keywords: ERACS, mobilization, duration of hospitalization
Comparison of Cyclosporine and Steroids in Treating Severe Allergic Conjunctivitis in Children: an Evidence-based Case Report Muhammad Ilham Dhiya Rakasiwi; Julie Dewi Barliana; Afid Brilliana Putra; Muhammad Imran Khan Ismail; Awliya Awliya; Gusti Candra Pamungkas; Nida Ghitha Aulia
Journal of Agromedicine and Medical Sciences Vol 10 No 2 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i2.46062

Abstract

The efficacy of cyclosporine compared with corticosteroid in reducing symptoms and signs in children with severe allergic conjunctivitis, either in vernal keratoconjunctivitis or atopic keratoconjunctivitis, is still unknown. Here we present the case of an 8-year-old boy with a case of allergic keratoconjunctivitis. The patient had been given steroid eye drops (Dexamethasone 1 mg) for 2 weeks and only slight improvement was found. Considering the steroid’s long-term effects, the doctor prescribed cyclosporine eye drops. Therefore, this case study is conducted to compare the better efficacy between cyclosporine eye drops and steroid eye drops as a treatment for severe allergic conjunctivitis. After conducting a systematic literature analysis following the PRISMA guidelines, full-text analysis was carried out on two RCTs by assessing their validity, clinical importance, and applicability according to the Oxford CEBM criteria. One of the studies did not meet the validity criteria, while another study showed that cyclosporine eye drops that were given to patients with severe vernal keratoconjunctivitis could reduce signs and symptoms. There was no significant difference between cyclosporine eye drops and dexamethasone eye drops. Cyclosporine's function to reduce signs and symptoms of severe allergic conjunctivitis in children is equivalent to that of corticosteroids. Keywords: Cyclosporine, corticosteroid, severe allergic conjunctivitis, therapy
Gestational Weeks Related with Maternal Anemia in Pregnancy at Sooko Public Health Center Mojokerto District Rifqi Rahadian
Journal of Agromedicine and Medical Sciences Vol 10 No 2 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i2.44696

Abstract

The prevalence of anemia in pregnant women in Indonesia is still high. Anemia in pregnancy has an impact on maternal and fetuses. We conducted a study on factors related to the incidence of anemia in pregnancy in pregnant women who had their first antenatal visit. The study was conducted on 218 pregnant women who had their first antenatal visit at the Maternal and Child Health Polyclinic at the Sooko Public Health Center, Mojokerto District in January – March 2021. We collected data on risk factors related to the incidence of anemia in pregnancy, namely maternal age during pregnancy, gestational week, distance between current and previous pregnancies, history of parity and body mass index. Chi-square analysis was performed to assess the relationship between variables with a significant value of p<0.05. It was found that 54 (24.8%) of pregnant women had anemia. Gestational age at risk (p=0.970), distance from previous pregnancies (p=0.135), history of parity (p=0.420) and body mass index (p=0.577) had no significant relationship with the incidence of anemia in pregnancy. Gestational age had a significant relationship (p=0.000) to the incidence of anemia in pregnancy. Gestational age has a relationship with the incidence of anemia in pregnant women who make their first antenatal visit. Anemia in pregnancy has a high prevalence. Further treatment is needed, such as giving Fe tablets and educating pregnant women during antenatal care to prevent and treat anemia in pregnancy. Keywords: anemia in pregnancy, gestational week, antenatal care
Correlation Analysis of Body Weight with Insulin Resistance and Leptin Levels in Farm Workers Naurah Nazihah Azzalina; Sugiyanta Sugiyanta; Kristianningrum Dian Sofiana
Journal of Agromedicine and Medical Sciences Vol 10 No 2 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i2.44231

Abstract

Insulin resistance is a pathological condition resulting from impaired insulin response which causes increased insulin production as a form of compensation from pancreatic beta cells. A stable body weight can prevent insulin resistance and excessive body weight can be a predisposing factor insulin resistance. Individuals with insulin resistance will experience an increase leptin levels 2.3 times more than normal individuals. The aim of this study was to analyze the correlation between body weight and insulin resistance and leptin levels in farm workers. This research method is a cross-sectional analytical observational study conducted from April to September 2023. This research has taken primary data in the form of body weight, fasting blood glucose levels, and insulin and leptin levels from 46 farm worker respondents in Wringin Agung Village, Jombang District, Jember Regency. The results of the Pearson Correlation analysis showed that there was no correlation between body weight and insulin resistance and leptin levels in farm workers. The results of the analysis between body weight and insulin resistance were p = 0.265 with a correlation coefficient of 0.168, which means the degree of correlation is very low. The results of the analysis between body weight and leptin levels were p = 0.870 with a correlation coefficient of 0.025, which means the degree of correlation is very low. The conclusion of this study is that there is no significant correlation between body weight and insulin resistance and leptin levels in farm workers. Keywords: Body weight, insulin resistance, leptin levels
Anticholinergic Syndrome Due to Cetirizine Overdose: Case Report Irawan Fajar Kusuma; Mukhammad Arif Hadi Khoiruddin; Yusi Windya Febriyanti
Journal of Agromedicine and Medical Sciences Vol 10 No 2 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i2.44078

Abstract

Anticholinergic toxicity can be the result of antihistamines use. Anticholinergic toxicity is pretty rare in second-generation antihistamines such as cetirizine. Using cetirizine in unreasonable doses will cause side effects. We report cetirizine intoxication due to overdose. A girl, 16 years-old came in with chief complaint syncope at school after consuming 5-6 tablets of cetirizine. The patient was being sent to the primary health center and experienced vomiting. Other symptoms experienced when the patient is conscious, such as nausea, dizziness, and dry mouth. On physical examination, it was found that both of the patient's eyes were dry, with a heart rate of 105 beats per minute. We examined liver function and kidney function tests, which showed that BUN, serum creatinine, SGOT, and SGPT levels were within normal limits. Symptoms that arise due to antihistamine toxicity include vasodilation and redness of the skin, anhidrosis, lack of sweat production, hyperthermia, mydriasis, hallucinations, delirium, and urinary retention. Antihistamines are anticholinergics that work as antimuscarinics. The action of cetirizine on M1, M2, and M3 receptors affects clinical manifestations of the patients. Cetirizine can also induce hepatic and renal toxicity. Understanding the dosage and use of cetirizine is necessary to prevent unwanted events and side effects. Keyword: cetirizine overdose, anticholinergic syndrome
Association between Physical Activity with Burnout Syndrome After the Second Wave of the COVID-19 Pandemic in Health Workers at RSD dr. Soebandi Jember Dilar Bambang Sudito; Ancah C N Marchianti; Adelia Handoko
Journal of Agromedicine and Medical Sciences Vol 10 No 2 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i2.30975

Abstract

Health workers have a key role in handling the COVID-19 pandemic. Working in a stressful environment can affect the emotional stability of health workers and can trigger burnout syndrome. Physical activity is one of the factors that can trigger burnout syndrome. Therefore, this study was conducted to analyze the relationship between physical activity and the incidence of burnout syndrome after the peak of the second wave of the COVID-19 pandemic among health workers at RSD dr. Soebandi Jember. This cross-sectional analytic observational study conducted from November to December 2021 was attended by 84 doctors and nurses working at RSD dr. Soebandi. The data were obtained using the Global Physical Activity Questionnaire and the Maslach Burnout Inventory. Ordinal logistic regression analysis showed a significant relationship between work activities and the level of burnout syndrome (p = 0.04). The effect of physical activity on burnout syndrome in this study was 32%. Our recommend is that further research is needed on the factors that can affect burnout syndrome with more objective research methods so that more valid results are obtained.
Diet Reduce Apnea Hypopnea Index (Ahi) Score in Obstructive Sleep Apnea Patient: Systematic Review and Meta-analysis Adella Bintang Saputri; Nindya Shinta Rumastika; Muhammad Afiful Jauhani; Wiwien Sugih Utami; Jauhar Firdaus
Journal of Agromedicine and Medical Sciences Vol 10 No 2 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i2.38538

Abstract

Obstructive sleep apnea (OSA) is a breathing disorder during sleep that can cause obstruction to the flow of breathing with characteristics such as collapse of the upper airway which can cause breathing to stop, either completely (apnea) or partial (hypopnea). Based on a study of taxi drivers in Jakarta, it was found that 52,5% of the sample had OSA. One of the main factors for OSA is obesity. Based on The American Academy of Sleep Medicine (AASM) recommends weight loss through lifestyle modifications (eg applying diet) as a treatment option for AHI improvement in OSA. The purpose of writing this article is to prove that adopting a diet can reduce the apnea hypopnea index (AHI) of OSA. The method in this study is a systematic review and meta-analysis using secondary data derived from PubMed, Science Direct, and Springer databases published from 2019 to 2022.. A total of six randomized controlled trial (RCT) articles were investigated by meta-analysis The weighted mean difference in AHI (-6,77 event/d with 95% CI: -13,42 to -0,1) significantly favoured diet over control arms. Based on the results of a systematic review and meta-analysis of six articles, the application of a diet is proven to reduce AHI scores in OSA patients. Keywords: Obstructive sleep apnea, Apnea hypopnea index, Diet
Successful Treatment of Severe Generalized Tetanus with Refractory Spasm and Pneumonia Co-Infection: a Case Report Komang Yunita Wiryaning Putri; Ichlasul Mahdi Fardhani; Muhammad Isra Rafidin Rayyan
Journal of Agromedicine and Medical Sciences Vol 10 No 2 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i2.47191

Abstract

Background: Tetanus is a high mortality rate infectious disease caused by Clostridium tetani. Although it can be prevented through vaccination, tetanus remains a significant problem, especially in developing countries, so comprehensive management is needed to prevent more fatal complications. Case report: A 52-year-old patient was diagnosed with tetanus due to exposure to tree thorns and experienced muscle spasms and jaw stiffness that could not be controlled with benzodiazepine agents alone. The patient was treated for more than 30 days in the intensive care unit with mechanical ventilation, immunoglobulin, antibiotics, antispasms, and sedatives. Patients experience autonomic dysfunction, causing bradycardia, tachycardia, and fluctuating blood pressure. In addition, the patient was also infected with Pseudomonas aeruginosa pneumonia during the treatment period. Finally, the patient was successfully treated and removed. Conclusion: This case report highlights the importance of multidisciplinary ICU care in diagnosis and therapy, which is expected to provide the best patient outcomes. Keywords: Generalized tetanus; refractory spasms; pneumonia; neuroinfectious disease

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