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INDONESIA
Journal of Agromedicine and Medical Sciences
Published by Universitas Jember
ISSN : 24609048     EISSN : 27145654     DOI : -
Core Subject : Health,
Health Professions
Jurnal Agromedicine and Medical Sciences (AMS) adalah jurnal berkala empat bulan (Februari, Juni dan Oktober) yang berisi berbagai artikel dalam bentuk penelitian, tinjauan sistematis dan laporan kasus dalam bidang kedokteran dengan fokus pada ilmu-ilmu kedokteran dasar, kedokteran klinis dan agromedis.
Arjuna Subject : -
Articles 305 Documents
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Hydroquinone Identification in Whitening Creams Sold at Minimarkets in Minomartini, Yogyakarta Astuti, Dian Wuri; Prasetya, Hieronimus Rayi; Irsalina, Dina
Journal of Agromedicine and Medical Sciences Vol 2, No 1 (2016)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

Whitening cream is a cosmetic which is contains chemicals and other materials that can etiolate black (brown) stain on the skin. Hydroquinone is a supplemental ingredient in whitening cream. Hydroquinone is the active ingredient that can control the production of uneven pigment, rather serves to reduce or inhibit the formation of melanin. The use of hydroquinone in cosmetics should not be more than 2%.The excessive use of hydroquinone can cause oochronosis,a rough, speckled bluish skin. The purpose of this study is to determine whether or not there are any hydroquinone in whitening cream sold at Minimarket in Minomartani, Yogyakarta. If found, further testing is done to determine the level of hydroquinone in it. This research describes the presence or absence of hydroquinone in the whitening creams and find out how much the percentage is. The method used is Thin Layer Chromatography (TLC) and serimetri titration. The qualitative study test results that 64% of the samples positively contain hydroquinone, whereas from the quantitative assay it is obtained that 89% of the samples are not suitably qualified according to Permenkes No.445/MENKES/PER/V/1998. There are 9 out of 14 whitening cream brands that contain hydroquinone and 8 of them contain levels of hydroquinone more than normal (> 2 %).Keywords: face whitening cream, hydroquinone, Thin Layer Chromatography, serimetri titration.
The Correlation between Service Quality of Maternal and Child Healthcare/Family Planning Clinic and Degree of Maternal and Child Health at Two Primary Health Care Centers in Jember Makayasa Putri, Kunthi Kencana; Wiji Astuti, Ida Srisurani; Sugiyanta, Sugiyanta
Journal of Agromedicine and Medical Sciences Vol 2, No 1 (2016)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

The high Maternal Mortality Rate (MMR) and Infant Mortality Rate (IMR) is still a major health problem in Indonesia. As an one of indicator to assess the quality of maternal and child healthcare is MMR and IMR. Service quality consists of five dimensions i.e., tangible, responsiveness, reliability, assurance, and empathy. The aim of this research was to determine the correlation between service quality of maternal and child healthcare/family planning polyclinic and degree of maternal and child health at Two Primary Health Care Centers in Jember. This research used cross-sectional design with 144 respondents. Service quality was measured using ServQual questionnaire and degree of maternal and children health were measured using MMR and IMR. The results of statistical test with Spearman correlation test showed that the significance (p) = 0.000 and correlation coefficients (r) = 0.690. Thus, it can be concluded that there were a strong correlation between service quality of maternal and child healthcare/family planning clinic and degree of maternal and child health at Two Primary Health Care Centers in Jember. Keywords: Maternal Mortality Rate, Infant Mortality Rate, ServQual. 
The Selectivity of Ethanolic Extract of Buah Makassar (Brucea javanica) on Metastatic Breast Cancer Cells Sutejo, Ika Rahmawati; Putri, Herwandhani; Meiyanto, Edy
Journal of Agromedicine and Medical Sciences Vol 2, No 1 (2016)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

Treatment of cancer such as surgery, radiotherapy and chemotherapy has many side effects. Chemopreventive agent is needed to reduce the side effect and increase the effectivity of therapy. The discovery of  cochemopreventive agent should consider on its selectivity to reduce side effects. The selective cochemopreventive agents work effectively in cancer cells and safe for normal cells. Buah Makassar (Brucea javanica) is a natural product that is empirically used for anti-inflammatory and antitumor. The purpose of this study is to determine the cytotoxic effect of ethanolic extract of buah Makassar against 4T1, MCF7, HeLa, and Vero cell lines. The cytotoxic test is performed by MTT assay. The parameter obtained from the cytotoxic test was IC50. Selectivity index is determined from IC50 ratio of cancer cells to normal cells. The results showed that ethanolic extract of buah Makassar has a cytotoxic activity on 4T1, MCF7, HeLa, and Vero cells with IC50 were 49,9±0,83 μg/mL; 107,6±8,14 μg/mL; 228,9±4,16 μg/mL and 395,5± 4,21 μg/mL respectively. It also has high selectivity on 4T1 metastatic breast cancer cell with selectivity index of 7,93. It can be concluded that the ethanolic extract of buah Makassar has potential to be delevoped as cochemopreventive agent especially on metastatic breast cancer. Keywords: Brucea javanica, MTT assay, selectivity index, 4T1, MCF7, HeLa, Vero
The Effect Of Mefenamic Acid On Longitudinal Development Of Growth Plate In Young Male White Rats Hasan, Muhamad
Journal of Agromedicine and Medical Sciences Vol 2, No 1 (2016)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

The past epidemiologic studies did not have definite explanation about the effect of consuming Mefenamic Acid on Longitudinal Bone Development. The aim of this study is to explain the effect of Mefenamic Acid on Longitudinal Bone Development. The design of this study was the Separate pretest, Posttest Only Control Group Design using 40 male wistar strain rats and divided into four groups. They  consists of one pretest group, one control group and two treatment groups. The treatment groups were given mefenamic acid orally in the dose of 27 mg/200 g BW/day, and 54 mg/200 g BW/day which were dissolved in 2 ml of distilled water. After 4 weeks, the length of femur, length of growth plate  and number of longitudinal cell of growth plate are noticed. The result was showed in all of experimental animals had a significant difference to control groups (p<0.05). Pair wise comparisons showed  that significant difference (p<0.05) occurred in all of groups except between mefenamic acid 27 mg and mefenamic acid 54 mg that not significant difference. This study show that mefenamic acid treatment cause decrease of femur length, decrease of growth plate length and decrease number of growth plate cell. Keywords: mefenamic acid, chondrocyte, growth plate
The Effect of Mirabilis jalapa Leaf Ethanolic Extract against Streptococcus pyogenes Pambudi, Bagus Satrio; Suswati, Enny; Firdaus, Jauhar
Journal of Agromedicine and Medical Sciences Vol 2, No 1 (2016)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

Streptococcus pyogenes is a Gram positive bacteria that commonly cause disease in human. If not treated immediately, this bacteria can cause serious complication such as reumatic fever that causing heart valve tissue damage. Penicilin, drug of choice to eradicate S. pyogenes, oftenly cause various side effects such as anaphylaxis. This study aimed to investigate the effect of Mirabilis jalapa leaf ethanolic extract against S. pyogenes growth using in vitro techniques. The study design was a quasi experimental design. S. pyogenes culture as the study subject were divided into positive control group (penicilin V 100 IU), negative control group (NaCMC 0,5%), and eight treatment groups that were given with M. jalapa leaf ethanolic extract as much as 0,1 mg/ml, 1 mg/ml, 5 mg/ml, 10 mg/ml, 20 mg/ml, 30 mg/ml, 40mg/ml, and 50 mg/ml. After 24 hours incubation periods, the inhibition zone were found in all treatment group except in concentration 0,1 mg/ml. This study showed that M. jalapa leaf ethanolic extract could inhibit the growth of S. pyogenes. There was significant correlation between the concentration of M. jalapa leaf ethanolic extract and the diameter of inhibition zone (p=0,00), the higher concentration of M. jalapa leaf extract, the larger diameter of inhibition zone of S. pyogenes. Keywords: Mirabilis jalapa, leaf extract, antimicrobial activity
The Difference of the Knowledge, Stigma and Attitude between The First Year and Final Year Student of Medical Faculty of Jember University toward Mental Disorders Dinda Ayu Teresha; Justina Evy Tyaswati; Kadek Dharma Widhiarta
Journal of Agromedicine and Medical Sciences Vol 1 No 2 (2015)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Mental disorders is one of the health problems in developing countries and developed countries. One of the biggest problems faced by those with mental disorders is the presence of that and negative attitudes due to lack of public knowledge. Several previous studies have found that education increase knowledge and change the stigma and negative attitudes on medical students. The purpose of this study was to analyze the differences of knowledge, stigma and attitude between first year and final year student of the Medical Faculty of Jember University toward mental disorders. This research was a quantitative research with cross sectional approach. The samples were the students class of 2012 and 2014. The independent variable was the class of the students, while the dependent variable was knowledge, stigma, authoritarianism, benevolence, social restrictions, and istatistik of health community. The data was analyzed using chi-square test. Based on the test result, it was found that the variables with a significant difference is stigma (p= 0.001) and authoritarianism (p = 0.025). In conclusion there were significant differences on stigma and attitudes of authoritarianism between the first year and final year students to the mental disorders. Keywords: Stigma, Authoritarianism, Benevolence, Social Restrictiveness, Community Mental Health Istatistik
Monitoring Of Side Effects Of Anti-Tuberculosis Drugs (ATD) On The Intensive Phase Treatment Of Pulmonary TB Patients In Makassar Akhmadi Abbas
Journal of Agromedicine and Medical Sciences Vol 3 No 1 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i1.4093

Abstract

Side effects of Anti-Tuberculosis Drugs (ATD) is a problem in the treatment of TB patients. The severity of the side effects experienced by patients will have an impact on treatment compliance and loss to follow-up rate. This study aimed to obtain information about ATD side effects experienced by pulmonary TB patients during the intensive phase treatment in Makassar. This type of research was observational descriptive with the time series design. The number of samples in this study were 58 people. The results showed that the percentage of patients who experienced ATD side effects during the intensive phase of treatment is the first week of 96.6%, 91.4% the second week, third week of 86.2%, 74.1% fourth week, the fifth week 74.1% , the sixth week 81%, the seventh week of 75.9% and 67.2% eighth week. The percentage of patients based on the type of side effects experienced is 81% joint pain, nausea 79.3%, 77.6% itching, loss of appetite 75.9%, 67.2% dizziness, tingling 50%, vomiting 41.4%, 34.5% abdominal pain, visual disturbances 27.6%, headache 24.1% and 6.9% hearing loss. This study showed that patients experienced ATD side effects every week during the intensive phase treatment. More side effects experienced during the first and the second weeks and tend to decrease until the end of the intensive phase. The main type of side effects experienced by TB patients are joint pain. Health workers should always conduct routine monitoring of ATD side effects experienced by TB patients in order to improve patient treatment compliance and prevent them from loss to follow-up of treatment. Keywords: Monitoring, Side effects, ATD, TB, Intensive phase
The Activity of Ethanolic Extract of Cyclea barbata Miers as Inhibitor of Bacterial Biofilm Formation of Salmonella typhi Dimes Atika Permanasari; Elly Nurus Sakinah; Ali Santosa
Journal of Agromedicine and Medical Sciences Vol 2 No 2 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Biofilm is a matrix consist of extracelullar polysaccharides from the replication of microbial cells that are irreversibly attached on the cell surface. Biofilm in bacteria S.typhi strain DT104 contains food substance for protection. Biofilm can be attached to the clutery, causing food contaminaton. Cyclea barbata Miers is a plant has flavonoid that can inhibited bacteria biofilm formation. Flavonoid is phenolic compounds that has function as antibacterial by forming complex compounds disturbing the integrity of cell membranes and inhibiting biofilm. This study aims to determine the activity of the Cyclea barbata Miers as inhibitor of S.typhi DT 104 biofilm formation. This study used Quasy Experimental design with completely randomized design This study used 28 samples consist of 5 doses groups (0.29 mg/ ml, 0.33 mg / ml, 0.40 mg / ml, 0.50 mg / ml, 0.67 mg / ml), positive group (a bacterial suspension with H2O2) and negative group (a bacterial suspension with H2O) The result showed that the increasing doseof extract will decrease the biofilm formation revealed by decreasing of Optical Density and showed One Way Anova test resulted p = 0.004. In conclusion, the ethanolic extract of Cyclea barbata Miers was able to inhibit S.typhi DT 104 biofilm formation and there was a correlation between the concentration of ethanoic extract of Cyclea barbata Miers and inhibition of S.typhi biofilm formation. Key words: biofilm, Cyclea barbata Miers, S.typhi
Slow Release Metformin Effect in Weight Loss and Total Calorie Intake in Obese Volunteers Cholis Abrori; Lucky Tiya; Deti Rosalina
Journal of Agromedicine and Medical Sciences Vol 3 No 1 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i1.4098

Abstract

Obesity can cause serious problems that will lead to poor quality of life, increased morbidity and mortality rate. Slow-release metformin will work longer in the body with a single dose everyday be an alternative drug for weight loss. The purpose of this study was to compare the effectiveness of slow-release metformin compared to metformin regular to body weight and calorie intake in volunteers with obesity. The study was conducted on 16 volunteers who were divided into two groups in pairs. Volunteers will be measured weight and calorie intake with a 24-hour food recall method, data was taken at the time before the intervention, the end of week 1st, 2nd, 3rd, and 4th. The result obtained weight loss better in the group receiving slow-release metformin by 5.08% compared to the group receiving regular metformin by 2,60%, but there was no significant difference between the groups in terms of calorie intake during the study. The conclusion of this study is a slow-release metformin is greater in weight loss than regular metformin, but does not affect the amount of calorie intake.Keywords: Metformin, slow-release, weight loss, calorie intake, obesity
Antiinflamatory Activity Test N-Hexane Extract of Breadfruit Leaf (Artocarpus altilis) for Erythema on Skin White Rat (Rattus novergiccus) Desi Suryani Dewi; Intan Zhofir Asyur Lazuardi; Nurlaila Ayu Purwaningsih
Journal of Agromedicine and Medical Sciences Vol 2 No 3 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Ultraviolet radiation (UV) is part of a spectrum of electromagnetic radiation emitted by the sun. UV-C has the shortest wavelength than the wavelength of UV-A and UV-B. UV-C is able to penetrate the earth due to the reduction of ozone in the stratosphere and is capable of causing skin cancer. The initial symptoms of cancer of skin erythema. Researchers used the N-Heksane extract of leaves of breadfruit for the treatment of erythema skin white rat (Rattus novergiccus) were exposed to UV-C radiation for 168 hours. Rats were divided into two groups of control and three experimental groups. The control group was not given the therapy and were treated dexamethasone 1 mg / kg / day while the experimental group was given the extract N-Heksane leaves of breadfruit (Artocarpus altilis) at a dose of 50 mg / kg / day, 100 mg / kg / day and 200 mg / kg /day. The method used is pure experimental (true experimental design) in vivo by design pretest-posttest control group design. Results are extensive changes erythema and ultrastructural changes in the epidermis and dermis rats were observed microscopically before and after therapy in rats irradiated skin UV-C light.Keywords: N-Hexane Extract Leaves Breadfruit (Artocarpus altilis), rat (Rattus novergiccus), UV-C radiation

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