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Journal of Agromedicine and Medical Sciences
Published by Universitas Jember
ISSN : 24609048     EISSN : 27145654     DOI : -
Core Subject : Health,
Health Professions
Jurnal Agromedicine and Medical Sciences (AMS) adalah jurnal berkala empat bulan (Februari, Juni dan Oktober) yang berisi berbagai artikel dalam bentuk penelitian, tinjauan sistematis dan laporan kasus dalam bidang kedokteran dengan fokus pada ilmu-ilmu kedokteran dasar, kedokteran klinis dan agromedis.
Arjuna Subject : -
Articles 305 Documents
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Effect of Soyflour (Glycine max L.) Hepatoprotector Activity on Liver MDA Level in Male Wistar Rat Induced by Diazinon Sofi Aliyatul Himah; Desie Dwi Wisudanti; Heni Fatmawati
Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i1.6857

Abstract

Diazinon is metabolized in liver becomes diazoxon, an active metabolite form that can cause free radical raisingthat leads to lipid peroxidation. The result of lipid peroxidation is MDA. Soyflour has higher isoflavones than theother processed food of Glycine max L.This isoflavones donate its electron and hydrogen atom in lipidperoxidation so it can block the lipid peroxidation. The aim of this experiment is to investigate the effect of soyflour on MDA hepar level increase of male wistar rat induced by diazinon. The sample are divided into 5 groupswhich are Kn, K(-) group induced by diazinon 40mg/kgBW, K1, K2, K3 group given with soy flour 10%, 15%, and20% orally, then induced by diazinon 40 mg/kgBW. MDA liver measured on the day 34th with MDA-TBAmethode which has pink colour and measured by spectrofotometer. Average of liver MDA levels is Kn 6,35μg/mL; K(-) 9,23 μg/mL; K1 8,85 μg/mL; K2 7,88 μg/mL; K3 7,04 μg/mL. One way ANOVA and Post hoc LSDshowed significantly different (p<0,05). Pearson correlation showed strong negative correlation. Keywords: Diazinon, Diazoxon, MDA, Soyflour, Glycine max L., antioxidant
Acute Toxicity Tests of Basil Leaves (Ocimumsanctum) Ethanolic Extract Determined By LD50 and Renal Histopathology Cholis Abrori; Khana Nurfadhila; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 5 No 1 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i1.6501

Abstract

Basil leaves are widely used as herbal remedies and have proven many benefits because the content of phytonutrients includes antioxidants, but at certain doses a compound retains a probability of causing toxicity in the body. This study aims to determine the acute toxicity of ethanolic extract of basil leaves seen from the value of LD50 range and renal histopathology which is the vital organ of the target of toxicity in the body. The method of acute oral toxicity test was OECD 420 fix dose procedure method with a group of 5 Balb/c female mice given a multilevel dosage. The initial dose is 2000 mg/Kg.b.w selected on a sighting study as a dose that may cause mild toxicity symptoms but does not cause death. There are 2 groups consist of treatment with dose at LD50 value and control. The result of this research showed that LD50 value of ethanol extract of Ocimum sanctum > 2000 mg/Kg.b.w. The mean renal histopathologyc scores between the control and the treatment were significantly different by The Mann-Whitney test with significance value of p=0.018. Ocimum sanctum ethanolic extract is classified as non-toxic compounds but there was a change in renal histopathology of mice in the form of focal lesions after acute exposure at highest dose of OECD 420 method. Keywords: acute toxicity test, renal histopathology, basil leaves
Difference of Right Ventricular Systolic Function Before and After Hemodialysis in Chronic Kidney Disease Stage V In RSD dr. Soebandi Jember Saskia Mediawati; Suryono Suryono; Enny Suswati
Journal of Agromedicine and Medical Sciences Vol 4 No 2 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i2.7873

Abstract

End stage renal disease is a clinical state with an irreversible chronic decreasing function of renal that need a hemodialysis or renal transplant as theraphy. One of the complication of End stage renal disease is cardiovascular. Cardiovascular complication is a major cause of mortality and mobility in End stage renal disease by 44% in Indonesia. Systolic function of right ventricle can be used to assess the heart function. The purpose of this study is to differentiate the systolic function of right ventricle in patient with end stage renal disease in RSD dr. Soebandi Jember. We used analytical observational approach with cross sectional method held at Dialysis and Echocardiography Unit of RSD dr. Soebandi Jember from September to November 2017. Thirty patients with end stage renal disease who routinely undergoes dialysis were observed. Shapiro-Wilk test results 0,000 significance shows that the data is not normally distribute. Wilcoxon test results significance level 0,005 which shows there is a differentiation between before and after hemodialysis of systolic function in end stage renal disease patients of RSD dr. Soebandi Jember. Keywords : End stage renal disease, systolic function on right ventricle, hemodialysis
Antibiotic Sensitivity Test on Staphylococcus Aureus Detected in Sputum of Patients with Pneumonia Treated in Hospitals Dini Agustina; Diana Chusna Mufida; Hanifa Rizki A.S.; Dion Krismashogi Dharmawan
Journal of Agromedicine and Medical Sciences Vol 5 No 1 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i1.9267

Abstract

Pneumonia is a respiratory tract infection that attacks the pulmonary parenchyma. This disease can be caused by bacteria, one of which is Staphylococcus aureus. Antibiotics have an important role to play in reducing the morbidity and mortality incidence of pneumonia, but currently, the incidence of resistance antibiotics is increased. The purpose of this study was to determine the sensitivity of antibiotics Staphylococcus aureus in pneumatic sputum patients. The design of this study was observational descriptive, using sputum samples from pneumonia patients in Subandi and Paru Jember hospitals in November to December 2018. The identification of bacteria in sputum was continued by testing the sensitivity of bacteria to antibiotics. The antibiotics used in this study were chloramphenicol, gentamicin, amikacin, levofloxacin, ampicillin-sulbactam, cotrimoxazole, and ciprofloxacin — data obtained in the frequency distribution table. Of the ten sputum that was successfully cultured, four Gram-negative bacilli bacteria and six Gram-positive coccus bacteria were obtained. The results approved the six Gram-positive coccus bacteria, detected as Staphylococcus aureus. The antibiotic resistance of Staphylococcus aureus to ampicillin-sulbactam was high. Keywords: antibiotic sensitivity, bacteria, pneumonia
The Larvacidal Activity of Ethanol Extracts of Phyllanthus acidus Leaves on The Culex quinquefasciatus Instar III/IV Larvae Afifatun Hasanah; Bagus Hermansyah; Cholis Abrori
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.6842

Abstract

Culex quinquefasciatus was one of a vector of filariasis disease caused by filarial worm infection. Mode of transmission was through mosquito bites that contain filaria worm. To overcome the problem in terms of eradicating the mosquito larvae was by searching for safe biological materials for humans and the environment, one of them was Phyllanthus acidus leaves. The purposes of this research were to know whether the ethanol extract of Phyllanthus acidus leaves have larvicidal activity on Culex quinquefasciatus instar III / IV larvae and to know the lethal concentration 50 (LC50) ethanol extract of Phyllanthus acidus leaves on Culex quinquefasciatus instar III / IV larvae within 24 hours. This study used true experimental method with post test only controlled group design with 1 positive control group (Temephos), 1 negative control group (Aquades and DMSO), and 5 treatment groups (0.0625%; 0.125%; 0.25%, 0.5% and 1% extract) respectively 20 Culex quinquefasciatus instar III/IV larvae. The result of regression test of inverse to know the effect of leaf extract of ceremai to the death of Culex quinquefasciatus larvae obtained R2=0909 which was mean the effect of ethanol extract of Phyllanthus acidus leaves to the number of the death of Culex quinquefasciatus larvae equal to 90.9%. The result of probit test obtained LC50 result of 0.189% with 95% confidence interval (0.142% -0.233%).
Potential of Cocoa Ethanol Extract Toward Nematocyst Tubul Firing Inhibition of Physalia Utriculus Toxin In Vitro Sarwendah Siswi Winasis; Al Munawir; Adelia Handoko
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.9623

Abstract

There was estimated 150 million envenomation cases due to jellyfish stings occur globally every year. 100 from 10,000 jellyfish species in the world known to be dangerous, one them is Physalia utriculus. The aim of this study was to determine the potential of cocoa (Theobroma cacao L.) ethanol extract toward nematocyst tubul firing inhibition of jellyfish (Physalia utriculus) toxin in vitro. The method was true experimental design with post test only control group design. The study divided into 8 groups: 1 normal control, 1 positive control, 1 negative control, and 5 treatments grups by giving cocoa ethanol extract with concentration 20%, 2%, 0.2%, 0.02%, 0.002%. The observation was made by calculating the percentage number of firing nematocysts. The result showed average percentage of firing nematocyst in the normal control group was 42.50 ± 3.18, positive control group was 37.97 ± 5.57, negative control group was 52.44 ± 2.98, and treatment group which given with cocoa ethanol extract 20%, 2%, 0.2%, 0.02%, 0.002% were 48.24 ± 5.37; 40.62 ± 7.10; 29.45 ± 5.39; 37.60 ± 9.78; 41.11 ± 3.92, respectively. The One Way Annova statistical results test show significance value 0.001 (p≤0.05). The conclusion of this study was the cocoa ethanol extract with concentration 0.2% has most potential to inhibit the jellyfish (P. utriculus) nematocyst tubule firing in vitro. Keywords: Physalia utriculus, cocoa, toxin, jellyfish
Correlation of Cholinesterase Levels to Lung Function in Farmer Exposed by Organophosphate Pesticides in Sukorambi Village, Jember Regency Puput Sagita Mey Sandra; Kristianingrum Dian Sofiana; Ika Rahmawati Sutejo
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.9651

Abstract

Abstract Most of the Indonesia population work as a farmer. Pesticides are used in agriculture sector for pest and plant diseases. Pesticides can cause intoxication. The World Health Organization (WHO) estimates that 1-5 million cases of pesticides poisoning among agricultural workers occur in developing countries. Indonesia pesticide poisoning cases reach 771 cases. Organophosphate enter the body through inhalation. Organophosphate pesticides work systemic to inhibit the cholinesterase enzyme causing lung function disorders. The purpose of this study was to analyze the correlation of cholinesterase levels to lung function in farmers exposed to organophosphate pesticides in Sukorambi Village, Jember Regency. This is an observational analytic study using a cross sectional design. Cholinesterase levels test using the DGKC method to determine the presence of poisoning, while for lung function test using spirometry with FVC, FEV1 and FEV1 / FVC ratios as parameters. The results of the test in 30 samples showed 14.33% (4/30) abnormal cholinesterase levels or decreased. Lung function test showed 20% (6/30) had obstructive disorders, 43.33% (13/30) restrictive disorders and 36.67% (11/30) were normal. Data analysis using chi square showed a significant relationship (p = 0.049) between cholinesterase levels and lung function. Conclusion: There is a significant relationship between the level of cholinesterase to decrease in pulmonary physiology of farmers exposed to organophosphate pesticides in Sukorambi Village, Jember Regency. Keyword :Organophosphate, cholinesterase level, lung function
Risk Factors Affecting Carpal Tunnel Syndrome in Women Laborer of Tobacco Warehouse Ajung District, Jember Dasarina Rizqi Amalia; Ida Srisurani Wiji Astuti; Yudha Nurdian
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.6489

Abstract

Carpal Tunnel Syndrome frequently experienced by workers whose daily activities always use repetitive movements on the wrist. Carpal Tunnel Syndrome is a syndrome that can actually be prevented because there is no risk factor that can’t be changed except the age factor. Previous research has shown a fairly high prevalence about 42%-93% in factory workers. This study aims to determine the factors that affect the occurence of Carpal Tunnel Syndrome in women workers warehouse tobacco. This is an analytical observational study with cross sectional study design which using 50 samples who met inclusion and exclusion criteria. Instrument in this research is clinical questionnaire to diagnose CTS and Phalen test. Spearman correlation test result obtained long working p=0,036, r=0,298 and pain intensity p= <0,01, r=0,635 which means there is significant correlation with moderate strength between length of work with CTS and strong correlation between the intensity of pain with CTS. Keywords: Carpal Tunnel Syndrome, risk factor, women laborer
Diazinon Toxicity to Kidney and Liver of Wistar Male Rats in terms of Biochemical and Histopathological Parameters Desie Dwi Wisudanti; Firman Herdiana; Tegar Syaiful Qodar
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.11575

Abstract

Diazinon is an organophosphate type pesticide that is still often used by farmers in Indonesia, with the effect of inhibiting the acetylcholinesterase enzyme, giving rise to the accumulation of acetylcholine in the synapse gap which will lead to incoordination, convulsions and death in insect pests. Apart from having the neurotoxic effects of diazinone it can also damage cells through the mechanism of oxidative stress. Diazinone poisoning has a high potential to cause damage to the kidney organs, because the diazinone excretion pathway and its active metabolites are through the urinary system. The purpose of this study was to determine the effect of diazinone on the liver and renal wistar male kidney. Diazinone dosage of 40 mg / kgBW, given to mice twice a day for 5 days, with each given as much as 5 ml using the gastric sonde. The research sample was in the form of rat blood taken intracardiac to examine BUN levels, serum creatinine, SGOT, SGPT, and GSH, then kidney and liver rats were taken to make histopathological preparations and MDA examinations. Analysis of this research data using the T-test for all variables. There were significant differences between groups of rats given diazinone and groups of rats not given diazinone based on levels of BUN, creatinine, SGOT, SGPT, GSH and MDA. In the group of mice not given diazinone, kidney histopathology was better than those given diazinon. Keywords: diazinon, pesticides, organophosphates
Antioxidant Effect of Kenitu leaf Etanol Extract (Chrysophyllum Cainito L.) on Wistar Rat Induced Cyclophosphamid Ekvan Danang Setya Pramudito; Erfan Efendi; Muhammad Ali Shodikin
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.6837

Abstract

Recently, cancer is globally the second highest cause of death with a total death about 8.8 million in 2015. There are some therapy of cancer, one of them by using cyclophosphamid chemotherapy, but this regimen has side effects of bone marrow depression through its active metabolite of 4 hydroxy cyclophpsphamid and increase ROS which will effect on serum MDA elevation. Increased MDA serum can be prevented by giving an antioxidant or plants that have various antioxidants, such as kenitu leaves. The aim of this study was to determine the effect of antioxidants in kenitu leaves (Chrysophyllum cainito L.)) extract to MDA serum leves of cyclophosphamid-induced mice. This study used quasi experimental method with post test only controlled group design by using 1 normal control group, 1 negative control group (cyclophosphamid), and 5 treatment groups (dose of extract 50mg/kgBW; 100mg/kgBW; 200mg/kgBW; 400mg/kgBB; and 800mg / kgBW). The results of the treatment group dose 100mg/kgBB showed the average of MDA serum levels was 1.94 μg/mL which is the highest decrease in this study. The result of Kendall Tau correlation test showed the effect of kenitu leaves extract to MDA serum level had p = 0.013 and correlation coefficient = 0.431. Keywords: kenitu leaf etanol extract, cyclophosphamid, MDA serum

Page 7 of 31 | Total Record : 305

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