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Global Medical and Health Communication
Published by Universitas Islam Bandung
ISSN : 23019123     EISSN : 24605441     DOI : https://doi.org/10.29313/gmhc
Core Subject : Health, Science,
Dentistry Health Professions Immunology & microbiology Nursing Public Health
Global Medical and Health Communication is a journal that publishes research articles on medical and health published every 4 (four) months (April, August, and December). Articles are original research that needs to be disseminated and written in English. Subjects suitable for publication include but are not limited to the following fields of anesthesiology and intensive care, biochemistry, biomolecular, cardiovascular, child health, dentistry, dermatology and venerology, endocrinology, environmental health, epidemiology, geriatric, hematology, histology, histopathology, immunology, internal medicine, nursing sciences, midwifery, nutrition, nutrition and metabolism, obstetrics and gynecology, occupational health, oncology, ophthalmology, oral biology, orthopedics and traumatology, otorhinolaryngology, pharmacology, pharmacy, preventive medicine, public health, pulmonology, radiology, and reproductive health.
Arjuna Subject : Kedokteran - Epidemilogi
Articles 14 Documents
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Search results for , issue "Vol 3, No 2 (2015)" : 14 Documents clear
Hubungan Antara Reactive Oxygen Species (ROS), Superoxide Dismutase (SOD) dengan Protein α-Sinuklein-larut Air pada Batang Otak Tikus yang Diinduksi Rotenon Yulianti, Arief Budi; Sumarsono, Sony Heru; Ridwan, Ahmad; Yusuf, Ayda T
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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Abstrak Parkinson adalah salah satu penyakit neurodegeneratif dengan ganggunan gerak bila kematian neuron dopaminergik lebih dari 70 %. Paparan neurotoksin diduga menjadi penyebab terjadinya Parkinson sporadik. Tujuan penelitian ini adalah menentukan kondisi stres oksidatif pada batang otak tikus Wistar yang diinduksi rotenon. Metode: Penelitian eksperimental dengan menggunakan tikus Wistar jantan. Variabel bebas: kelompok tikus, lama perlakuan, waktu pengamatan, dan lokasi di batang otak. Variabel terikat: konsentari SOD, konsentrasi protein α-sinuklein-larut air, dan densitas ROS. Densitas ROS berbeda secara signifikan antara kelompok perlakuan (sig: 0,029), waktu pengamatan (sig: 0,0001), dan lokasi di batang otak (sig: 0,001). Konsentrasi SOD tidak berbeda secara signifikan antar kelompok perlakuan (sig:0,566), waktu pengamatan (sig:0,441) dan lokasi di batang otak (sig: 0,091). Konsentrasi protein α-sinuklein-larut air berbeda secara signifikan antar kelompok perlakuan (sig: 0,001), waktu pengamatan (sig: 0,001) tetapi tidak berbeda secara signifikan pada lokasi di batang otak (0,625). Densitas ROS relatif tertinggi pada hari ke-10 dan 40. Sementara itu konsentrasi SOD pada hari ke-10 dan 40 relatif rendah sedangkan konsentrasi protein α-sinuklein-larut air pada hari ke-10 relatif tinggi dibandingkan dengan hari ke-40. Dengan demikian dapat disimpulkan bahwa stres oksidatif pada batang otak tikus Wistar yang diinduksi rotenon berpengaruh pada struktur protein α-sinuklein.   Kata kunci: Batang otak, protein α-sinuklein, ROS, rotenon, SOD, stres oksidatif   Abstract Parkinson is the neurodegenerative disease with movement disordered, if the dopaminergic neurons dead more than 70%. Neurotoxins exposure is predicted cause sporadic Parkinson. The research aim is to determine oxidative stress stage in the brainstems Wistar rat’s treated-rotenone. Methods: An experimental study using male Wistar rats. The independent variable: groups of rats, long treatment, observation time, and location in the brainstem. The dependent variable: SOD concentration, concentration of protein α-synuclein-water soluble, and ROS density. ROS density significantly different among treatment groups (sig: 0,029), observation time (sig: 0.0001), and the location in the brainstem (sig: 0,001). SOD concentrations not significantly different among treatment groups (sig: 0.566), observation time (sig: 0.441) and the location in the brainstem (sig: 0.091). The concentration of protein α-synuclein-water soluble significantly different among treatment groups (sig: 0,001), observation time (sig: 0,001), but not significantly different at the location in the brainstem (0,625). ROS density relatively high at day 10 and 40. Meanwhile SOD concentration on day 10 and 40 are relatively low. And the concentration of α-synuclein protein-water soluble on day 10 is relatively higher than on day 40. The conclution is oxidative stress in the brainstem Wistar rat’s treated-rotenone effected on the protein α-synuclein structure Key word: α-synuclein protein, brainstem, oxidative stress, ROS, rotenone, SOD
Hubungan Preeklamsi Berat dengan Hasil Luaran Janin (FetalOutcome) di RSUD Al-Ihsan Kabupaten Bandung Gumay, Dave Orlando; Wijayanegara, Hidayat; , Zulmansyah
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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Absak   Preeklamsi merupakan salah satu penyebab morbiditas dan mortalitas pada ibu dan neonatus. Beberapa keadaan hasil luaran janin pada ibu preeklamsi di antaranya small for gestasional age (SGA), asifiksia, prematuritas, dan stillbirth. Penelitian ini bertujuan menganalisis hubungan preeklamsi berat dengan hasil luaran janin (fetal outcome) di RSUD Al-Ihsan Kabupaten Bandung periode 1 Januari 2012–31 Maret 2014. Penelitian menggunakan metode rancangan deskriptif analitik dengan pendekatan cross-sectional. Penentuan jumlah subjek penelitian didapatkan dari jumlah populasi sebanyak 137 orang. Analisis statistik dilakukan secara bivariat dengan menggunakan metode chi-kuadrat derajat kepercayaan 95%. Hasil penelitian ini didapatkan hasil luaran janin dari ibu preeklamsi berat sebesar 33 kasus (24,1%) SGA, 73 kasus (53,3%) asfiksia ringan-sedang dan 13 kasus (9,5%) asfiksia berat pada APGAR menit pertama, 18 kasus (13,1%) lahir prematur, serta 1 kasus (0,7%) stillbirth. Terdapat hubungan preeklamsi berat dengan SGA (p=0,001; PR=6,928; 95% IK=2,797–17,162), asfiksia ringan-sedang APGAR 1 menit (p=0,001; PR=2,483; 95% IK=1,504–4,100), asfiksia berat APGAR 1 menit (p=0,001; PR=7,222; 95% IK=1,963– 26,567), prematuritas (p=0,010; PR=3,303; 95% IK=1,269–8,597). Simpulan, terdapat hubungan preeklamsi berat dengan variabel hasil luaran janin yakni SGA, asfiksia ringan-sedang dan berat APGAR 1 menit, serta prematuritas.   Kata kunci: Hasil luaran janin, preeklamsi berat   The Correlation between Severe Preeclampsia and Fetal Outcomes in RSUD Al-Ihsan Bandung   Abstct   Preeclampsia is   one of the causes of maternal-neonates morbidity and mortality. Several conditions of fetal outcomes in women with preeclampsia including small for gestasional age (SGA), asphyxia, prematurity and stillbirth. This study aims was to analyze the relationship between severe preeclampsia with fetal outcome in Al-Ihsan Hospital Bandung District period 1 January 2012−31 March 2014. The study used descriptive analytic design and cross-sectional method. Research subjects’ number obtained from a total population of 137 patients. Statistical analysis was performed with bivariat uses chi-square method with  95% confident interval. The result of this study showed that fetal outcomes of woman with severe preeclampsia were 33 cases (24.1%) SGA, 73 cases (53.3%) mild-moderate asphyxia and 13 cases (9.5%) severe asphyxia on APGAR 1 minute, 18 cases (13.1%) were born prematurely, and 1 case (0.7%) stillbirth. There were relation between severe preeclampsia and SGA (p=0.001, PR=6.928, 95% CI=2.797 to 17.162), mild-moderate asphyxia APGAR 1 minute (p=0.001, PR=2.483, 95% CI=1.504 to 4.100), severe asphyxia APGAR 1 minute (p=0.001, PR=7.222 95% CI=1.963 to 26.567) and prematurity (p=0.010, PR=3.303, 95% CI=1.269 to 8.597). In conclusions, there are a relationship between severe preeclampsia and fetal outcomes in terms of SGA, mild-moderate and severe asphyxia APGAR 1 minute and prematurity.   Key words: Fetal outcomes, severe preeclampsia
Korelasi Disfungsi Seksual dengan Usia dan Terapi padaBenign Prostatic Hyperplasia Kemalasari, Dewita Wahyu; Nilapsari, Rika; Rusmartini, Tinni
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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Abstrak Benign prostatic hyperplasia (BPH) ialah tumor jinak yang sangat sering terjadi pada pria. BPH dikarakteristikkan dengan pembesaran kelenjar prostat akibat hiperplasia pada stroma dan epitel prostat. Kejadian BPH meningkat seiring dengan pertambahan usia dan mencapai puncak pada usia di atas 80 tahun. Pengobatan yang diberikan pada pasien BPH yaitu alpha blocker, 5 alpha reductase inhibitor, ataupun kombinasi kedua obat tersebut dapat menimbulkan efek samping yaitu disfungsi ereksi, disfungsi ejakulasi, ataupun penurunan libido. Tujuan penelitian ini adalah mengetahui korelasi kejadian disfungsi seksual dengan usia dan jenis terapi pada penderita BPH. Penelitian ini bersifat analitik observational dengan metode cross sectional mempergunakan data rekam medis pasien BPH di Bagian Urologi RSUD Al-Ihsan Bandung pada bulan Januari sampai Mei 2014. Jumlah sampel yang diteliti sebanyak 42 orang yang dipilih dari 106 pasien BPH dengan menggunakan teknik consecutive sampling. Analisis statistik menggunakan Uji Kolmogorov Smirnov dan Uji Eksak Fisher. Hasil penelitian ini didapatkan angka kejadian BPH di Bagian Urologi adalah 106 dari 211 pasien yang berobat (50,2%). Puncak kejadian BPH pada rentang usia 61–70 tahun dan hanya 12% yang mengalami disfungsi seksual. Distribusi BPH berdasarkan jenis terapi didapatkan hanya 10% yang menggunakan obat. Hasil analisis statistik menunjukkan tidak terdapat korelasi kejadian disfungsi seksual dengan usia, namun terdapat korelasi antara kejadian disfungsi seksual dan terapi pada pasien BPH (p=0,001). Simpulan, tidak terdapat korelasi kejadian disfungsi seksual dengan usia tetapi terdapat korelasi antara kejadian disfungsi seksual dan penggunaan obat. Kata kunci: Benign prostatic hyperplasia, disfungsi seksual   The Correlation of Sexual Disfunction with Age and Therapy of Benign Prostatic Hyperplasia     Abstract Benign prostatic hyperplasia is a neoplasma that commonly happened to men. BPH is characterized by the enlargement of prostatic gland, caused by hyperplasia of prostatic stromal and epithelial cells of prostate gland. BPH incidence has increased with age and has reached the highest incidence at above 80 years old. The treatment of BPH are alpha blocker, 5 alpha reductase inhibitor, or the combination of those two drugs. These treatments can cause side effects which are erectile dysfunction, ejaculation dysfunction, or libido decretion. The object of this research was to find the correlation between sexual disfunction and age and also with type of therapies of BPH patients. The research is an observational analytic by using cross sectional method. It has been performed by observing at the medical records of BPH patients. All observations were performed in Urology Department RSUD Al-Ihsan Bandung during January to May 2014. The number of the samples of the research were 42 people and it was chosen from 106 BPH patients by consecutive sampling technic. Statistic analysis of this research used Kolmogorov Smirnov and Fisher’s Exact test. The result of this research showed that the incidence of BPH in Urology Department of all patients was 106 from 211 patients (50.2%). The distribution of BPH based on age showed that it reached the highest incidence at 61–70 years old and there were 12% patients suffered from sexual disfunction. Meanwhile the distribution of BPH based on drugs therapy showed that only 10% who used drugs. The result of statistic analysis showed there was no correlation between sexual disfunction and age, but there was a correlation between sexual disfunction and drugs therapy in BPH patients (p=0.001). In conclusions, there is no correlation between sexual disfunction and age but has correlation with using drugs.   Key words: Benign prostatic hyperplasia, sexual disfunction
Insidensi dan Karakteristik Hepatotoksisitas Obat Antituberkulosis pada Penderita Tuberkulosis dengan dan tanpa Infeksi HIV Sumantri, Agung Firmansyah; Djumhana, Ali; Wisaksana, Rudi; Sumantri, Rachmat
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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Abstrak   Salah satu penyulit dalam pengobatan tuberkulosis (Tb) adalah hepatotoksisitas obat antituberkulosis (OAT). Pasien Tb dengan infeksi human immunodeficiency virus (HIV) meningkatkan risiko kejadian hepatotoksisitas OAT. Hal ini menjadi tantangan dalam menghadapi pasien Tb-HIV. Penelitian ini bertujuan mengetahui insidensi dan karakteristik penderita hepatotoksisitas OAT pada Tb dengan dan tanpa infeksi HIV. Penelitian ini adalah penelitian  epidemiologi  klinik  yang  bersifat  deskriptif  observasional.  Penelitian dilaksanakan di  ruang  rawat jalan dan rawat inap RSUP Dr. Hasan Sadikin (RSHS) Bandung serta ruang rawat jalan RS Bungsu periode Juni– Oktober 2012. Terdapat 120 subjek terdiri atas 18 penderita dengan infeksi HIV dan 102 penderita tanpa infeksi HIV. Mayoritas usia penderita Tb dengan infeksi HIV yaitu ≤35 tahun (17/18 penderita), laki-laki (12/18 penderita), indeks massa tubuh <18,5 kg/m2 (10/18 penderita), dan Tb paru (16/18 penderita). Penderita Tb dengan infeksi HIV yang mengalami hepatotoksisitas terhadap OAT lebih banyak daripada penderita Tb tanpa infeksi HIV (9/18 vs 19/102 penderita). Insidensi hepatotoksisitas OAT sebesar 23,3%. Hepatotoksisitas OAT pada penderita Tb dengan dan tanpa infeksi HIV terjadi pada 2 minggu pengobatan OAT dengan derajat ringan. Simpulan, insidensi hepatotoksisitas OAT pada penderita Tb dengan infeksi HIV lebih tinggi daripada tanpa infeksi HIV. Kata kunci: Hepatotoksisitas OAT, HIV, tuberkulosis   Incidence and Characteristics of Hepatotoxicity Anti-tuberculosis Drugs in Tuberculosis Patients with and without HIV Infection   Abstract Hepatotoxicity is one of the complications in the treatment of tuberculosis (Tb). Tuberculosis patient with HIV infection has higher risk in hepatotoxicity, and this is a clinical obstacle in dealing with Tb-HIV treatment. The aims of this study were to find the incidence and characateristic of anti-tuberculosis hepatotoxicity in tuberculosis patients with and without HIV infection. A descriptive observational study was conducted in outpatient/inpatient RSUP Dr. Hasan Sadikin (RSHS) Bandung, and outpatient RS Bungsu period June–October 2012. There were 120 Tb patients consisted of 18 patients with HIV and 102 patients without HIV. Most of Tb patients with HIV occured in age ≤35 years (17/18 patients), male (12/18 patients), body mass index <18.5 kg/m2 (10/18 patients), and pulmonal Tb (16/18 patients). Tb patients with HIV had hepatotoxicity more than without HIV (9/18 vs 19/102 patients). The incidence of hepatotoxicity was 23.3%. Hepatotoxicity anti-tuberculosis drugs in Tb patients with and without HIV infection mostly occured in second week therapy with mild degree. In conclusion, anti-tuberculosis hepatotoxicity is higher in TB patients co-infected with HIV than non-HIV infections. Key words: Anti-tuberculosis hepatotoxicity, HIV, tuberculosis
Karakteristik Pasien dan Spesies Dermatofita Penyebab Tinea Kruris di Rumah Sakit Umum Daerah Gunung Jati Cirebon Jawa Barat Wahdini, Maya; Ramli, Lies Marlysa; N.H, Risa Miliawati
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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Abstrak   Tinea kruris merupakan salah satu dermatofitosis tersering di dunia, terutama di negara berkembang dan beriklim tropis. Prevalensi dermatofitosis dan spesies penyebabnya bervariasi bergantung pada letak geografis dan berubah dari waktu ke waktu. Penelitian aspek epidemiologis dan spesies penyebab penyakit diperlukan untuk menentukan masalah kesehatan yang dihadapi, termasuk karakteristik umum, durasi penyakit, sumber penularan, lokasi penyakit pada tubuh, efloresensi, dan kultur spesies Dermatofita. Prevalensi tinea kruris di Provinsi Jawa Barat belum banyak diketahui. Tujuan penelitian ini adalah mengetahui karakteristik pasien dan spesies Dermatofita di RSUD Gunung Jati Cirebon sehingga dapat melengkapi data pola tinea kruris di Jawa Barat. Penelitian dilaksanakan di Poliklinik Kulit dan Kelamin RSUD Gunung Jati Cirebon periode Februari–April 2014. Rancangan penelitian adalah deskriptif potong lintang dengan pengambilan sampel sesuai urutan kedatangan pasien. Subjek penelitian adalah pasien tinea kruris di Poliklinik tersebut. Terhadap seluruh subjek dilakukan anamnesis, pemeriksaan fisis, dan pengambilan sampel kerokan kulit lesi untuk pemeriksaan mikroskopis langsung dan kultur jamur sehingga didapatkan 37 pasien koloni jamur positif. Pasien tinea kruris mayoritas pada wanita (24/37 pasien), usia tersering 15–44 tahun (22/37 pasien), pendidikan SD/SMP (22/37 pasien), ibu rumah tangga (9/37 pasien), gizi cukup (23/37 pasien), durasi penyakit 2 minggu–6 bulan, pertama kali terkena (30/37 pasien), disertai gatal dan berkeringat. Sumber penularan tidak diketahui (25/37 pasien), kebanyakan central clearing (19/37 pasien) dan pada lipat paha/bokong berupa makula, papula, skuama, dan hiperpigmentasi (11/37 pasien). Spesies Dermatofita penyebab tinea kruris yang paling banyak ditemukan adalah Trichophyton rubrum (28/37 pasien), diikuti dengan Trichophyton mentagrophytes (9/37 pasien). . Kata kunci: Dermatofita, RSUD Gunung Jati Cirebon Jawa Barat, tinea kruris         Patients Characteristic and Dermatophytes Species Causing Tinea Cruris at Gunung Jati General Hospital Cirebon West Java   Abstract   Tinea cruris is one of the most common dermatophytosis in the world, especially in developing countries and area with warm climates. The prevalence of dermatophytosis and their etiological agents vary with geographical location and change from time to time. Study epidemiological aspects of diseases and causative agents are useful for determining the magnitude of the health problem, including general characteristics, duration of disease, source of infection, location at the body, efflorescence, and culture of Dermatophytes species. The prevalence of dermatophytosis, especially tinea cruris in West Java is unknown. The objective of this study was to know the patients characteristic and to determine the species causing dermatophytes in Gunung Jati General Hospital Cirebon, to complete the data patterns of dermatophyte species causing tinea cruris in West Java. The study was conducted at the Dermatovenereology Clinic Gunung Jati General Hospital, Cirebon during February–April 2014. This was a descriptive cross-sectional study with consecutive sampling methods. The subjects of this study were tinea cruris patients who visited the clinic. History taking, physical examination, sampling of skin scrapings from lesion were performed in all patients. Skin scrapings was taken for direct microscopic examination and fungal cultures until 37 patients with positive fungal colonies was achieved. There were most commonly found in female (24/37 patients), age 15–44 years (22/37 patients), elementary school graduated (22/37 patients), housewives (9/37 patients), normal nutritional status (23/37 patients), duration of illness 2 weeks–6 months, first time exposured (30/37 patients), with complaints of itching and sweating. The source of the infection was unknown (25/37 patients), the most common locations was central clearing (19/37 patients) and also groin and buttocks with the most common efflorescence were macula, papules, squamma, and hyperpigmented scaly patches (11/37 patients). The most commonly isolated dermatophytes were Trichophyton rubrum (28/37 patients), followed by Trichophyton mentagrophytes (9/37 patients).   Key words: Dermatophytes, Gunung Jati General Hospital Cirebon West Java, tinea cruris
Efek Pemberian Seduhan Teh Hijau terhadap Gelombang Alfa Otak pada Mahasiswa Tingkat Akhir Fakultas Kedokteran Universitas Islam Bandung Afifah, Helga Marwa; Rahimah, Santun Bhekti; Dewi, Miranti Kania
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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Abstrak   Teh merupakan bahan alam yang sudah dikenal memiliki banyak manfaat salah satunya sebagai zat relaksan. Sifat relaksan diperoleh dari kandungan senyawa pada teh terutama teh hijau yaitu L-teanin yang memicu peningkatan aktivitas gamma-aminobutyric acid (GABA), produksi serotonin dan dopamin, serta menghambat kerja glutamat. Efek keseluruhan L-teanin pada otak memicu seseorang menjadi rileks, kondisi rileks dapat dinilai dari aktivitas gelombang alfa otak. Tujuan penelitian ini menilai efek pemberian seduhan teh hijau terhadap gelombang alfa otak pada mahasiswa tingkat akhir Fakultas Kedokteran Unisba. Penelitian menggunakan metode eksperimental, melalui dua kali   perekaman gelombang alfa otak sebelum dan setelah pemberian seduhan teh hijau yang mengandung 50 mg L-teanin dengan menggunakan brain wave sensors. Hasil penelitian dianalisis melalui Uji Wilcoxon. Penelitian dilakukan di Fakultas Kedokteran Unisba pada bulan April–Mei 2014. Sampel yang digunakan adalah mahasiswa tingkat akhir Fakultas Kedokteran Unisba yaitu sebanyak 30 orang, terdiri atas 13 laki- laki dan 17 perempuan. Hasil penelitian menunjukkan bahwa pada 28 dari 30 orang memperlihatkan peningkatan gelombang alfa otak setelah pemberian seduhan teh hijau dan hanya 2 orang yang memperlihatkan gelombang alfa otak yang lebih rendah. Hasil Uji Wilcoxon menunjukkan nilai signifikansi <0,001. Berdasarkan hasil penelitian, dapat disimpulkan bahwa pemberian seduhan teh hijau memiliki efek meningkatkan gelombang alfa otak pada mahasiswa tingkat akhir Fakultas Kedokteran Unisba. Hal ini dapat disebabkan karena aktivitas L-teanin dalam teh hijau yang dapat memicu aktivitas GABA, serotonin, dan dopamin serta menghambat kerja glutamat sehingga memicu kondisi relaksasi yang dinilai dalam gelombang alfa otak.   Kata kunci: Gelombang alfa otak, L-teanin, teh, teh hijau       The Effect of Green Tea to Alpha Brain Waves of Final Students of Faculty of Medicine Universitas Islam Bandung   Abstract Tea is one of the natural materials that commonly known  that brings a lot of benefits to human beings. One of its benefits has been recognized as a relaxant substance, which is derived from L-theanine in green tea. It triggers not only an increase activity of gamma-aminobutyric acid (GABA), serotonin and dopamine production, but also inhibits the action of glutamate. The overall effect of L-theanine lies on brain activity, especially to alpha brain waves which stimulus a relax condition. The purpose of this study was to assess the effect of L-theanine in green tea against alpha brain waves to final students of Faculty of Medicine Universitas Islam Bandung. This research was conducted using experimental method, by recording alpha brain waves with brain wave sensors in two conditions, before and after the oral administration of green tea containing 50 mg L-theanine. The results were analyzed by the Wilcoxon test and targeted a study to final students of the Faculty of Medicine Unisba. Samples studied were 30 people, with 13 male and 17 female, from April to May 2014. The results showed that 28 of 30 people had a positive impact as it increasing the alpha brain waves after oral administration of green tea. Only two people showed a different impact as it decreasing the alpha brain waves. The results of Wilcoxon test showed a significance value of <0.001. It can be concluded that the distribution of green tea has the effect of increasing alpha brain waves to final students of Faculty of Medicine Unisba. This is mainly caused by the activity of L-theanine in green tea that can trigger the activity of GABA, serotonin and dopamine production, but inhibits the action of glutamate, therefore it stimulus the relax condition to people.   Key words: Alpha brain waves, green tea, L-theanine, tea
Perbandingan Tingkat Kecemasan Primigravida dengan Multigravida di RSUD Majalaya Iqbal, Iqbal Muhammad; Wati, Yuliana Ratna; Yulianti, Arief Budi
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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Abstrak   Kecemasan adalah respons terhadap situasi mengancam tertentu yang dapat menyebabkan perubahan perilaku, karena terdapat ketidakpastian di masa mendatang serta ketakutan bahwa sesuatu yang buruk akan terjadi. Kecemasan pada ibu hamil apabila tidak ditanggulangi akan membawa dampak terhadap fisik dan psikis, seperti persalinan lama, preeklamsi dan depresi pascamelahirkan. Tujuan penelitian ini adalah menganalisis perbandingan tingkat kecemasan antara ibu primigravida dan multigravida di Poli Obstetri dan Ginekologi RSUD Majalaya. Penelitian ini menggunakan rancangan observational analitik dengan pendekatan metode cross sectional periode April–Juni 2014 dengan jumlah sampel sebanyak 42 orang yang telah memenuhi kriteria inklusi. Alat ukur yang digunakan berupa kuesioner Zung Self-rating Anxiety Scale (ZSAS). Data penelitian dianalisis secara analitik dan diuji menggunakan uji t tidak berpasangan. Dari hasil penelitian didapatkan tingkat kecemasan rata-rata pada primigravida adalah 36,76±5,75, sedangkan pada multigravida 37,43±7,07. Berdasarkan hasil uji statistik tidak terdapat perbedaan tingkat kecemasan antara primigravida dan multigravida (p=0,739). Hal ini diduga karena faktor biologis seperti perubahan hormonal dan faktor dukungan sosial dari keluarga ibu primigravida maupun multigravida sehingga cukup efektif untuk menurunkan tingkat kecemasan. Simpulan, tidak terdapat perbedaan tingkat kecemasan ibu primigravida dengan multigravida di Poli Obstetri dan Ginekologi RSUD Majalaya.   Kata kunci: Kecemasan, kehamilan, multigravida, primigravida, ZSAS         Comparative Level of Anxiety between Primigravida and Multigravida in RSUD Majalaya   Abstract   Anxiety is a response to treated due to threatens the uncertainty of the future and fear that something bad will happen. Pregnancy is growth and development of fetoes intrauterin since conception until the beginning of labour. If anxiety not resolved, it will have an impact on physical and psychological, such as prolonged labour, preeclampsia and postpartum depression. The aim of this study was to assess the anxiety level comparison between primigravida and multigravida in Obstetrics and Gynecology clinic at the General Hospital Majalaya.The method was a cross sectional with number of respondent 42 people who appropriate with inclusion criteria in period April–June 2014. The questionnaires Zung Self-rating Anxiety Scale (ZSAS) used to measure level of anxiety in primigravida and multigravida. The data were analyzed and tested using independent t-test. The results showed the average level of anxiety in primigravida was 36.76±5.75, while the multigravida was 37.4 ±7.07 (p=0.74). Thus, no differences in anxiety levels between primigravida and multigravida. This is presumably due to biological factors such as hormonal changes and factors of social support from family were given the primigravida and multigravida, so it is quite effective to reduce the level of anxiety. In conclusion, there is no differences occured between primigravida and multigravida in Obstetrics and Gynecology clinic at the General Hospital Majalaya.   Key words: Anxiety, multigravida, pregnancy, primigravida, ZSAS
Insidensi dan Karakteristik Hepatotoksisitas Obat Antituberkulosis pada Penderita Tuberkulosis dengan dan tanpa Infeksi HIV Agung Firmansyah Sumantri; Ali Djumhana; Rudi Wisaksana; Rachmat Sumantri
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1574.585 KB) | DOI: 10.29313/gmhc.v3i2.1548

Abstract

Salah satu penyulit dalam pengobatan tuberkulosis (TB) adalah hepatotoksisitas obat antituberkulosis (OAT). Pasien TB dengan infeksi human immunodeficiency virus (HIV) meningkatkan risiko kejadian hepatotoksisitas OAT. Hal ini menjadi tantangan dalam menghadapi pasien TB-HIV. Penelitian ini bertujuan mengetahui insidensi dan karakteristik penderita hepatotoksisitas OAT pada TB dengan dan tanpa infeksi HIV. Penelitian ini adalah penelitian epidemiologi klinik yang bersifat deskriptif observasional. Penelitian dilaksanakan di ruang rawat jalan dan rawat inap RSUP Dr. Hasan Sadikin (RSHS) Bandung serta ruang rawat jalan RS Bungsu periode Juni–Oktober 2012. Terdapat 120 subjek terdiri atas 18 penderita dengan infeksi HIV dan 102 penderita tanpa infeksi HIV. Mayoritas usia penderita TB dengan infeksi HIV yaitu ≤35 tahun (17/18 penderita), laki-laki (12/18 penderita), indeks massa tubuh <18,5 kg/m2 (10/18 penderita), dan TB paru (16/18 penderita). Penderita TB dengan infeksi HIV yang mengalami hepatotoksisitas terhadap OAT lebih banyak daripada penderita TB tanpa infeksi HIV (9/18 vs 19/102 penderita). Insidensi hepatotoksisitas OAT sebesar 23,3%. Hepatotoksisitas OAT pada penderita TB dengan dan tanpa infeksi HIV terjadi pada 2 minggu pengobatan OAT dengan derajat ringan. Simpulan, insidensi hepatotoksisitas OAT pada penderita TB dengan infeksi HIV lebih tinggi daripada tanpa infeksi HIV. INCIDENCE AND CHARACTERISTICS OF HEPATOTOXICITY ANTI-TUBERCULOSIS DRUGS IN TUBERCULOSIS PATIENTS WITH AND WITHOUT HIV INFECTIONHepatotoxicity is one of the complications in the treatment of tuberculosis (TB). Tuberculosis patient with HIV infection has higher risk in hepatotoxicity, and this is a clinical obstacle in dealing with TB-HIV treatment. The aims of this study were to find the incidence and characateristic of anti-tuberculosis hepatotoxicity in tuberculosis patients with and without HIV infection. A descriptive observational study was conducted in outpatient/inpatient RSUP Dr. Hasan Sadikin (RSHS) Bandung, and outpatient RS Bungsu period June–October 2012. There were 120 TB patients consisted of 18 patients with HIV and 102 patients without HIV. Most of TB patients with HIV occured in age ≤35 years (17/18 patients), male (12/18 patients), body mass index <18.5 kg/m2 (10/18 patients), and pulmonal TB (16/18 patients). TB patients with HIV had hepatotoxicity more than without HIV (9/18 vs 19/102 patients). The incidence of hepatotoxicity was 23.3%. Hepatotoxicity anti-tuberculosis drugs in TB patients with and without HIV infection mostly occured in second week therapy with mild degree. In conclusion, anti-tuberculosis hepatotoxicity is higher in TB patients co-infected with HIV than non-HIV infections.
Hubungan Reactive Oxygen Species (ROS), Superoxide Dismutase (SOD) dengan Protein α-Sinuklein-Larut Air pada Batang Otak Tikus yang Diinduksi Rotenon Arief Budi Yulianti; Sony Heru Sumarsono; Ahmad Ridwan; Ayda T. Yusuf
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3179.146 KB) | DOI: 10.29313/gmhc.v3i2.1508

Abstract

Parkinson adalah salah satu penyakit neurodegeneratif dengan ganggunan gerak bila kematian neuron dopaminergik lebih dari 70%. Paparan neurotoksin diduga menjadi penyebab terjadinya Parkinson sporadik. Tujuan penelitian ini adalah menentukan kondisi stres oksidatif pada batang otak tikus Wistar yang diinduksi rotenon. Metode penelitian eksperimental dengan menggunakan tikus Wistar jantan. Penelitian dilakukan di Sekolah Ilmu dan Teknologi Hayati (SITH) periode Januari 2011–November 2013. Variabel bebas yaitu kelompok tikus, lama perlakuan, waktu pengamatan, dan lokasi di batang otak. Variabel terikat yaitu konsentrasi superoxide dismutase (SOD), konsentrasi protein α-sinuklein-larut air, dan densitas reactive oxygen species (ROS). Densitas ROS berbeda secara signifikan antara kelompok perlakuan (p=0,029), waktu pengamatan (p=0,0001), dan lokasi di batang otak (p=0,001). Konsentrasi SOD tidak berbeda secara signifikan antarkelompok perlakuan (p=0,566), waktu pengamatan (p=0,441), dan lokasi di batang otak (p=0,091). Konsentrasi protein α-sinuklein-larut air berbeda secara signifikan antarkelompok perlakuan (p=0,001) dan waktu pengamatan (p=0,001), tetapi tidak berbeda secara signifikan pada lokasi di batang otak (p=0,625). Densitas ROS relatif tertinggi pada hari ke-10 dan ke-40. Sementara itu, konsentrasi SOD pada hari ke-10 dan ke-40 relatif rendah, sedangkan konsentrasi protein α-sinuklein-larut air pada hari ke-10 relatif tinggi dibanding dengan hari ke-40. Dengan demikian, dapat disimpulkan bahwa stres oksidatif pada batang otak tikus Wistar yang diinduksi rotenon berpengaruh pada struktur protein α-sinuklein. THE RELATIONSHIP AMONG REACTIVE OXYGEN SPECIES (ROS), SUPEROXIDE DISMUTASE (SOD), AND α-SYNUCLEIN PROTEIN-WATER SOLUBLE IN WISTAR RAT'S BRAINSTEM TREATED WITH ROTENONEParkinson is the neurodegenerative disease with movement disordered, if the dopaminergic neurons dead more than 70%. Neurotoxins exposure is predicted cause sporadic Parkinson. The research aim was to determine oxidative stress stage in the brainstems Wistar rat’s treated-rotenone. An experimental study using male Wistar rats. The study was held in School of Life Sciences and Technology during January 2011–November 2013. The independent variables: groups of rats, long treatment, observation time, and location in the brainstem. The dependent variables: superoxide dismutase (SOD) concentration, concentration of protein α-synuclein-water soluble, and reactive oxygen species (ROS) density. Reactive oxygen species (ROS) density significantly different among treatment groups (p=0.029), observation time (p=0.0001), and the location in the brainstem (p=0.001). Superoxide dismutase (SOD) concentrations were not significantly different among treatment groups (p=0.566), observation time (p=0.441), and the location in the brainstem (p=0.091). The concentration of protein α-synuclein-water soluble was significantly different among treatment groups (p=0,001) and observation time (p=0.001), but not significantly different at the location in the brainstem (p=0.625). Reactive oxygen species (ROS) density were relatively high at day 10 and 40. Meanwhile SOD concentration on day 10 and 40 are relatively low. The concentration of α-synuclein protein-water soluble on day 10 was relatively higher than on day 40. The conclution is oxidative stress in the brainstem Wistar rat’s treated-rotenone effected on the protein α-synuclein structure changes.
Hubungan Preeklamsi Berat dengan Hasil Luaran Janin (Fetal Outcome) di RSUD Al-Ihsan Kabupaten Bandung Dave Orlando Gumay; Hidayat Wijayanegara; Zulmansyah Zulmansyah
Global Medical & Health Communication (GMHC) Vol 3, No 2 (2015)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2353.701 KB) | DOI: 10.29313/gmhc.v3i2.1546

Abstract

Preeklamsi merupakan salah satu penyebab morbiditas dan mortalitas pada ibu dan neonatus. Beberapa keadaan hasil luaran janin pada ibu preeklamsi di antaranya small for gestasional age (SGA), asifiksia, prematuritas, dan stillbirth. Penelitian ini bertujuan menganalisis hubungan preeklamsi berat dengan hasil luaran janin (fetal outcome) di RSUD Al-Ihsan Kabupaten Bandung periode 1 Januari 2012–31 Maret 2014. Penelitian menggunakan metode rancangan deskriptif analitik dengan pendekatan cross-sectional. Penentuan jumlah subjek penelitian didapatkan dari jumlah populasi sebanyak 137 orang. Analisis statistik dilakukan secara bivariat dengan menggunakan metode chi-kuadrat derajat kepercayaan 95%. Hasil penelitian ini didapatkan hasil luaran janin dari ibu preeklamsi berat sebesar 33 kasus (24,1%) SGA, 73 kasus (53,3%) asfiksia ringan-sedang dan 13 kasus (9,5%) asfiksia berat pada APGAR menit pertama, 18 kasus (13,1%) lahir prematur, serta 1 kasus (0,7%) stillbirth. Terdapat hubungan preeklamsi berat dengan SGA (p=0,001; PR=6,928; 95% IK=2,797–17,162), asfiksia ringan-sedang APGAR 1 menit (p=0,001; PR=2,483; 95% IK=1,504–4,100), asfiksia berat APGAR 1 menit (p=0,001; PR=7,222; 95% IK=1,963–26,567), prematuritas (p=0,010; PR=3,303; 95% IK=1,269–8,597). Simpulan, terdapat hubungan preeklamsi berat dengan variabel hasil luaran janin yakni SGA, asfiksia ringan-sedang dan berat APGAR 1 menit, serta prematuritas. THE CORRELATION BETWEEN SEVERE PREECLAMPSIA AND FETAL OUTCOMES IN RSUD AL-IHSAN BANDUNGPreeclampsia is one of the causes of maternal-neonates morbidity and mortality. Several conditions of fetal outcomes in women with preeclampsia including small for gestasional age (SGA), asphyxia, prematurity and stillbirth. This study aims was to analyze the relationship between severe preeclampsia with fetal outcome in Al-Ihsan Hospital Bandung District period 1 January 2012−31 March 2014. The study used descriptive analytic design and cross-sectional method. Research subjects’ number obtained from a total population of 137 patients. Statistical analysis was performed with bivariat uses chi-square method with  95% confident interval. The result of this study showed that fetal outcomes of woman with severe preeclampsia were 33 cases (24.1%) SGA, 73 cases (53.3%) mild-moderate asphyxia and 13 cases (9.5%) severe asphyxia on APGAR 1 minute, 18 cases (13.1%) were born prematurely, and 1 case (0.7%) stillbirth. There were relation between severe preeclampsia and SGA (p=0.001, PR=6.928, 95% CI=2.797 to 17.162), mild-moderate asphyxia APGAR 1 minute (p=0.001, PR=2.483, 95% CI=1.504 to 4.100), severe asphyxia APGAR 1 minute (p=0.001, PR=7.222 95% CI=1.963 to 26.567) and prematurity (p=0.010, PR=3.303, 95% CI=1.269 to 8.597). In conclusions, there are a relationship between severe preeclampsia and fetal outcomes in terms of SGA, mild-moderate and severe asphyxia APGAR 1 minute and prematurity.

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