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Global Medical and Health Communication
Published by Universitas Islam Bandung
ISSN : 23019123     EISSN : 24605441     DOI : https://doi.org/10.29313/gmhc
Core Subject : Health, Science,
Dentistry Health Professions Immunology & microbiology Nursing Public Health
Global Medical and Health Communication is a journal that publishes research articles on medical and health published every 4 (four) months (April, August, and December). Articles are original research that needs to be disseminated and written in English. Subjects suitable for publication include but are not limited to the following fields of anesthesiology and intensive care, biochemistry, biomolecular, cardiovascular, child health, dentistry, dermatology and venerology, endocrinology, environmental health, epidemiology, geriatric, hematology, histology, histopathology, immunology, internal medicine, nursing sciences, midwifery, nutrition, nutrition and metabolism, obstetrics and gynecology, occupational health, oncology, ophthalmology, oral biology, orthopedics and traumatology, otorhinolaryngology, pharmacology, pharmacy, preventive medicine, public health, pulmonology, radiology, and reproductive health.
Arjuna Subject : Kedokteran - Epidemilogi
Articles 422 Documents
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Identification of Mitochondrial DNA Polymorphism on Linezolid-induced Toxic Optic Neuropathy Patients Setyorini, Dwi Indira; Ahmad, Zen; Amalia, Ella; Subandrate, Subandrate; Hutabarat, Yosafat Beltsazar
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14142

Abstract

Drug-resistant tuberculosis (DR-TB) is difficult to eradicate due to several factors, including insufficient treatment and medication side effects. Linezolid is among the medications with serious adverse effects. Linezolid toxicity is suspected to be related to the drug's binding to mitochondrial 16s rRNA. Some studies indicate that polymorphisms in patients' mtDNA may increase vulnerability to the development of toxic optic neuropathy. This study aims to identify a genetic influence on the vulnerability to the occurrence of toxic optic neuropathy side effects in drug-resistant tuberculosis patients receiving linezolid treatment. This research was conducted at the Faculty of Medicine, Universitas Sriwijaya, Palembang, from September to October 2023. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was undertaken to detect mutations in the G3010A mtDNA of the patients. Two patients experiencing toxic optic neuropathy side effects during drug-resistant tuberculosis treatment underwent blood sample collection. Blood samples were examined for mutations in the G3010A and A2706G genes using the PCR-RFLP method. The PCR-RFLP examination results indicated the presence of mutations in G3010A. In conclusion, polymorphism of G3010A mtDNA may contribute to the vulnerability to toxic optic neuropathy side effects in drug-resistant tuberculosis patients receiving linezolid. Further research with a larger population is needed to prove the involvement of mtDNA polymorphisms in the vulnerability to toxic optic neuropathy.
Autism Spectrum Disorder: a Two-center Evaluation of Pharmacological Intervention and Behavioral Therapies on Core Symptoms Solek, Purboyo; Gamayani, Uni; Rusmil, Kusnandi; Afriandi, Irvan; Prasetya, Taufan; Rizqiamuti, Anggia Farrah; Nurfitri, Eka; Burhan, Burhan; Sahril, Indra; Gunawan, Kevin
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by chronic deficits in social communication and interaction, with sensory processing abnormalities affecting over 90% of individuals across different sensory areas. This study investigated the combined effects of aripiprazole and behavioral therapy (BT) on core symptoms of ASD in children aged 6–10. Utilizing the considerable neuroplasticity still present at this age, we hypothesized that this combined approach might yield superior outcomes compared to BT alone. The 12-week randomized, double-blind, placebo-controlled trial was conducted from February 2023 to January 2024 at two sites of Child Development Centers in Bandung city, involving 51 participants (22 intervention, 29 placebo). The intervention group received aripiprazole and BT, while the placebo group received saccharum lactis and BT. Both groups underwent BT comprising applied behavioral analysis (ABA) and discrete trial training (DTT). The Childhood Autism Rating Scale (CARS) assessed treatment effects. The independent 2-sample t-tests and Mann-Whitney tests showed no significant differences in overall CARS scores between groups. However, the analysis revealed significant improvements in three subcategories: VII (visual response, p=0.021), IX (taste-smell-touch response, p=0.035), and X (fear or nervousness, p=0.043). These findings suggest that the combined approach may enhance sensory processing and emotional regulation in children with ASD. The study highlights the potential benefits of a multimodal approach to ASD treatment, combining targeted pharmacological intervention with behavioral therapies. However, limitations such as study duration and sample size warrant further research to optimize treatment strategies for individuals across the autism spectrum. DOI: https://doi.org/10.29313/gmhc.v12i3.14460

Page 43 of 43 | Total Record : 422

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