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Global Medical and Health Communication
Published by Universitas Islam Bandung
ISSN : 23019123     EISSN : 24605441     DOI : https://doi.org/10.29313/gmhc
Core Subject : Health, Science,
Dentistry Health Professions Immunology & microbiology Nursing Public Health
Global Medical and Health Communication is a journal that publishes research articles on medical and health published every 4 (four) months (April, August, and December). Articles are original research that needs to be disseminated and written in English. Subjects suitable for publication include but are not limited to the following fields of anesthesiology and intensive care, biochemistry, biomolecular, cardiovascular, child health, dentistry, dermatology and venerology, endocrinology, environmental health, epidemiology, geriatric, hematology, histology, histopathology, immunology, internal medicine, nursing sciences, midwifery, nutrition, nutrition and metabolism, obstetrics and gynecology, occupational health, oncology, ophthalmology, oral biology, orthopedics and traumatology, otorhinolaryngology, pharmacology, pharmacy, preventive medicine, public health, pulmonology, radiology, and reproductive health.
Arjuna Subject : Kedokteran - Epidemilogi
Articles 422 Documents
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Epidemiologic Spatial Analysis of a Tuberculosis Incidence in Bandung City in 2021 Rosady, Dony Septriana; Zulfa, Nysa Ro Aina; Pratama, Sony Bagja
Global Medical & Health Communication (GMHC) Vol 12, No 1 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i1.12410

Abstract

Tuberculosis (TB) is a communicable disease that is a significant cause of ill health and one of the leading causes of death worldwide. Tuberculosis remains a major global health problem. Tuberculosis infection remains one of the biggest health problems in Indonesia, which ranked second in the world on the list of countries with a high burden of TB. This is a cross-sectional study where the research displays population data, population density, and the incidence of TB in Bandung city, which is visualized in the mapping. This research analyzed the relationship between population density and the incidence of TB. The area with the highest TB incidence was the Babakan Ciparay subdistrict, with a total of 469 people and a population density of 205 people/hectare. The study has shown a strong relationship and a positive correlation between population density and the incidence of TB in Bandung city (p<0.001, r=0.603). Tuberculosis cases tend to be higher in areas with high population densities. Besides population density, other factors influence the incidence of TB in an area. House technical factors such as adequacy of windows, air ventilation, and lighting influence TB transmission. Besides that, household sanitation factors and occupancy density also impact the incidence of TB. In conclusion, subdistricts with a high population density show a high incidence of TB. There is a strong and unidirectional relationship between population density and the incidence of TB. 
Cytotoxicity Effect of Aqueous Propolis Extract of Geniotrigona thoracica Sumatrans on Colo-201 Colon Cancer Cell Line and Senescence Colo-201 Colon Cancer Cell Line Induced by Low-dose Doxorubicin Latama, Zahra Nabila; Achadiyani, Achadiyani; Kamilah, Mutiara Mila; Putra, Ramadhani Eka; Kinasih, Ida; Faridah, Lia; Ekawardhani, Savira
Global Medical & Health Communication (GMHC) Vol 12, No 2 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i2.13760

Abstract

Propolis, a resinous compound honeybees produce, demonstrates an extensive spectrum of powerful biological properties. However, the anti-cancer activity of propolis derived from Geniotrigona thoracica Sumatrans has yet to be reported. Thus, we sought to investigate the cytotoxicity of aqueous propolis extracts from Geniotrigona thoracica Sumatrans against Colo-201 colon cancer cell line and senescence Colo-201 colon cancer cell line induced by low-dose doxorubicin. This study was conducted at the Parasitology Laboratory of Human, Safety, and Environment, Universitas Padjadjaran Bandung from January to May 2024. This study assessed cell viability using the WST-1 test. Non-induced Colo-201 cells were treated with an aqueous extract of propolis (AEP) 100 ppm, or 5-fluorouracil (5-FU) 5 mg/ml as the positive control or water as a vehicle on untreated control. Colo-201 senescence was induced by doxorubicin 0.1 µM for three days. Doxorubicin-induced Colo-201 senescence was then treated with AEP 100 ppm, with 5-FU 5 mg/ml as the positive control, or with the combination of AEP 100 ppm and 5-FU 5 mg/ml, or water as a vehicle on untreated control. The data were analyzed using SPSS version 25.0, a one-way ANOVA, and Tukey’s post hoc test. The results showed that AEP has cancer-killing effects on Colo-201 cells and Colo-201 senescent cells induced by low-dose doxorubicin. AEP-treated Colo-201 cells and Colo-201 senescent cells induced by low-dose doxorubicin viability were significantly reduced to 37.15% and 13.72%, respectively, although slightly higher than those of the 5-FU-treated one at this concentration. There was also a decrease in the cancer-killing effect of 5-FU from 88.55% in non-induced Colo-201 cells to 41.5% in the doxorubicin-induced Colo-201 senescence model. In conclusion, aqueous extract of propolis from Geniotrigona thoracica Sumatrans showed cancer-killing-effects both on the Colo-201 colon cancer cell line and senescence Colo-201 colon cancer cell line induced by low-dose doxorubicin.
Ruang Sehati: Innovating Portable Lactation Pods for Wellness Tourism Using Design Thinking Method in Yogyakarta Okinarum, Giyawati Yulilania; Vidayanti, Venny; Mulyani, Sri Hasta
Global Medical & Health Communication (GMHC) Vol 12, No 1 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i1.12691

Abstract

Yogyakarta, a renowned tourist city in Indonesia, currently needs more lactation rooms and public facilities within tourist areas. To address this, inventors propose a portable lactation pod. This study utilized the design thinking method, emphasizing user needs. Interviews were conducted with thirty breastfeeding mothers on Malioboro Street in Yogyakarta to assess the necessity of lactation rooms in this popular tourist spot. From February to June 2022, the stages of "empathize," "define," "ideate," "prototype," and "test" were completed. The findings indicate that the "SEHATI" portable lactation room innovation meets user requirements, with feature satisfaction scores ranging from 4.2 to 4.9 out of 5.0. However, improvements are needed in the ventilation, exhaust fan, and fan sections, which received lower satisfaction scores during the "testing" stage. This innovation could serve as a pilot project, showcasing wellness tourism in Yogyakarta nationally.
Autism Spectrum Disorder: a Two-center Evaluation of Pharmacological Intervention and Behavioral Therapies on Core Symptoms Solek, Purboyo; Gamayani, Uni; Rusmil, Kusnandi; Afriandi, Irvan; Prasetya, Taufan; Rizqiamuti, Anggia Farrah; Nurfitri, Eka; Burhan, Burhan; Sahril, Indra; Gunawan, Kevin
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i3.14460

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by chronic deficits in social communication and interaction, with sensory processing abnormalities affecting over 90% of individuals across different sensory areas. This study investigated the combined effects of aripiprazole and behavioral therapy (BT) on core symptoms of ASD in children aged 6–10. Utilizing the considerable neuroplasticity still present at this age, we hypothesized that this combined approach might yield superior outcomes compared to BT alone. The 12-week randomized, double-blind, placebo-controlled trial was conducted from February 2023 to January 2024 at two sites of Child Development Centers in Bandung city, involving 51 participants (22 intervention, 29 placebo). The intervention group received aripiprazole and BT, while the placebo group received saccharum lactis and BT. Both groups underwent BT comprising applied behavioral analysis (ABA) and discrete trial training (DTT). The Childhood Autism Rating Scale (CARS) assessed treatment effects. The independent 2-sample t-tests and Mann-Whitney tests showed no significant differences in overall CARS scores between groups. However, the analysis revealed significant improvements in three subcategories: VII (visual response, p=0.021), IX (taste-smell-touch response, p=0.035), and X (fear or nervousness, p=0.043). These findings suggest that the combined approach may enhance sensory processing and emotional regulation in children with ASD. The study highlights the potential benefits of a multimodal approach to ASD treatment, combining targeted pharmacological intervention with behavioral therapies. However, limitations such as study duration and sample size warrant further research to optimize treatment strategies for individuals across the autism spectrum.
Polymorphisms of RS7055763 and RS41307258 in TBX22 Gene Haplotype as Risk Factors for Non-syndromic Cleft Palate Indonesian Deutero-Malay Population Susanti, Nita; Ullah, Irfan; Sulaksono, Haura Labibah Salsabil; Nasroen, Saskia Lenggogeni; Maskoen, Ani Melani
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i3.13677

Abstract

Non-syndromic cleft palate (NS-CP) is a multifactorial congenital malformation affected by genetic and environmental factors. The incidence of non-syndromic cleft lip with or without cleft palate (NS-CLP) varies considerably between ethnic groups and geographical regions. TBX22 is a crucial determinant for the formation of intramembranous bone in the posterior hard palate. Therefore, TBX22 is fundamental to palatogenesis and supports normal palate progress. The rs7055763 and rs41307258 polymorphisms in the TBX22 gene are associated with risk factors for NS-CP in the Indonesian Deutero-Malay population. In the previous study, NS-CP still needed to be investigated in the Deutero-Malay population. However, there are different races, mainly for the Deutero-Malay population. This study aims to determine whether rs7055763 and rs41307258 polymorphisms in the TBX22 gene are risk factors for NS-CP in the Deutero-Malay population. This study was conducted in Terpadu Laboratory, Faculty of Dentistry, Universitas Padjadjaran, from February until June 2023. The design of this study was a case-control study. The DNA patient samples were obtained from saliva and whole blood. Moreover, DNA is extracted, and the rs7055763 and rs41307258 segments are analyzed using PCR and Sanger sequencing. PCR data was analyzed by chi-square testing. In this study analysis, polymorphisms of rs7055763 (G>A) and rs41307258 (T>A) in the TBX22 gene show no significant differences between case and control groups, namely 0.911 and 0.645, respectively. However, the genotype in the rs41307258 shows the p-value as 0.027, indicating substantial differences and the OR is 1.390. In conclusion, the rs7055763 and rs41307258 polymorphisms in the TBX22 gene do not appear to be risk factors for developing NS-CP in the Indonesian Deutero-Malay population.
COVID-19 Treatment Patterns in Patients with Acute Respiratory Failure at Dr. Hasan Sadikin General Hospital Bandung in 2021–2022 Rohmawaty, Enny; Sumardi, Aklila Qurrota Aini; Kulsum, Iceu Dimas
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i3.14073

Abstract

Acute respiratory failure is the most common complication and cause of death in COVID-19 patients. The COVID-19 medication has yet to be discovered. COVID-19 treatment guidelines are constantly being updated. This study aims to determine the COVID-19 treatment patterns in patients with acute respiratory failure at Dr. Hasan Sadikin General Hospital Bandung in 2021–2022. This retrospective, descriptive study used systematic random sampling to examine medical records of COVID-19 patients with acute respiratory failure at Dr. Hasan Sadikin Central General Hospital between June 2021 and June 2022. Gender, age, length of stay, outcome, comorbidities, and pharmacological and non-pharmacological treatment data were analyzed by SPSS software. This study included 120 COVID-19 patients with acute respiratory failure, with the majority of patients are male (55.83%), 30–60 years old (55.83%), length of stay of 1–3 days (52.5%), and have disease severity at severe condition (43.33%) and one comorbidity (37.5%). Patients mostly received non-rebreathing oxygen mask (54.2%), antiviral remdesivir (83.3%), corticosteroid dexamethasone (76.7%), enoxaparin anticoagulants (61.7%), a combination of vitamin C, vitamin D, and multivitamins (45.8%), and two antibiotics (33.3%). Additional treatments include tocilizumab (0.8%), intravenous immunoglobulin (2.5%), and convalescent plasma (0.8%). Statistical analysis shows that patients who stay at the hospital longer, have less or no comorbidities, and are given oxygen therapy have a significant possibility of recovering. Treatments commonly prescribed to COVID-19 patients with acute respiratory failure are antivirals, corticosteroids, anticoagulants, vitamins, and antibiotics, while the administration of oxygen therapy has a significant probability of recovery.
Correlation between Length-to-width Ratio of Gallbladder and Gamma-glutamyl Transferase Value in Biliary Atresia Elmanar, Ryan; Violetta, Lenny; Setiawati, Rosy
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i3.14170

Abstract

Biliary atresia represents one of the most prevalent etiologies for neonatal cholestasis. Unmanaged biliary atresia can be fatal. Ultrasonography is the primary diagnostic test because it's accurate, cost-effective, and available. Various ultrasound findings can assist in diagnosing biliary atresia; the length-to-width ratio of the gallbladder is a particularly advantageous method, offering a short examination time, objectivity, and ease of use, with an accuracy rate of 78.9%. In cases with unconventional ultrasound findings, gamma-glutamyl transferase is believed to be able to complete the diagnostic process with an accuracy rate of up to 80%. The optimal cut-off value differs between studies, making it challenging to use as a benchmark for biliary atresia detection. In this study, researchers aim to further investigate the relationship between length-to-width ratio and gamma-glutamyl transferase in cases of biliary atresia, compared to the liver biopsy results in these patients and the optimal cut-off. This study employed an observational analytic approach with a retrospective design. The sample population consisted of all patients with neonatal cholestasis who underwent laboratory and ultrasonographic examinations at Dr. Soetomo Academic General Hospital Surabaya between 2019 and 2023. The study population comprised 82 patients. A significant relationship (p-value<0.001) was observed between the length-to-width ratio of the gallbladder and biliary atresia, as well as between gamma-glutamyl transferase and biliary atresia (area under the curve: 0.7–0.8). However, the analysis between the length-to-width ratio of the gallbladder and the value of gamma-glutamyl transferase showed p-value=0.066, which means no significant relationship was observed between the length-to-width ratio and gamma-glutamyl transferase.
Association between Clinical Characteristics of Pregnant Women in the Third Trimester and Low Back Pain Dewi, Mira Dyani; Rachmawati, Meike
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i3.13889

Abstract

Pregnancy is a physiological condition characterized by growth in both the fetus and the mother. Various biomechanical, physiological, and structural changes in pregnant women cause body posture changes, impacting low back pain (LBP). In the third trimester, LBP pain felt by pregnant women is usually accompanied by activity limitations and a decreased quality of life. This study aimed to determine the association between the clinical characteristics of pregnant women in the third trimester and low back pain. This research was conducted at the Department of Obstetrics and Gynecology and Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung from June to December 2017. The method is observational analysis with a cross-sectional approach with a sample of pregnant women in their third trimester who complained of lower back pain and lived in Bandung. According to the findings, the majority of pregnant women with LBP in the third trimester were under the age of 35 (33 of 38), had multiparous parity (25 of 38), had normal pre-pregnancy weight (21 of 38), gained an average of 11.28 kg during pregnancy, and had a median pain intensity of 5. Age was the only factor significantly correlated with LBP pain intensity; parity and weight gain during pregnancy did not. The study concludes a significant association between age in the third trimester of pregnancy and the intensity of LBP pain. Still, no significant association was found between parity and weight gain during pregnancy with the intensity of LBP pain.
Early Detection of the Heavy Metals Pollution Effect on Citarum River Using Zebrafish Muscle Mitochondria Biomarkers Gene Expression Oktorina, Lenny; Goenawan, Hanna; Sylviana, Nova; Kirana, Kartika Hajar; Feriandi, Yudi; Lesmana, Ronny
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14110

Abstract

Citarum is the longest river in West Java and one of the most polluted rivers in Indonesia and the world. Heavy metals from agriculture, industry, and household waste pollute the Citarum river. Heavy metals enter humans and animals by consuming contaminated food and beverages. Several studies have identified mitochondria as a primary target for heavy metal poisoning, resulting in impaired mitochondrial energy production, induction of oxidative stress, apoptosis, and mitophagy. This study aims to investigate the impact of heavy metals from the upstream and downstream areas of the Citarum river on mitochondrial gene expression of cox4i1, sod2, baxa, mfn1b, and ppargc1a in the skeletal muscle of zebrafish (Danio rerio) using in vivo models for biological monitoring of early detection of environmental heavy metal pollution. This experimental study was conducted from December 2019 to March 2020. The study involved four treatment groups and one control group of zebrafish, which were exposed to river water and sediments collected from two sites in the Citarum river area in December 2019. The biomarker levels were analyzed using multivariate analysis. Although all heavy metal levels except mercury were below the WHO threshold in all samples, this study's results showed that the RT-PCR results indicated that the levels of cox4i1, baxa, and ppargc1a in all samples were generally higher than those in the control. There were significant differences (p<0.05) using multivariate analysis in sod2 in Cibeureum water compared to Cibeureum sediment and ppgarc1a compared to control and Balekambang sediment. In conclusion, heavy metals from the upstream and downstream areas of the Citarum river had an impact on mitochondrial gene expression of cox4i1, sod2, baxa, mfn1b, and ppargc1a in the skeletal muscle of zebrafish. Biomarkers pparc1gc and sod2 could be further studied to identify the most valid and reliable parameters for biological monitoring, which may aid in the early detection of environmental damage to humans and animals.
Relationship of Physical Activity and Vitamin D Levels in Elderly Women Lorensia, Amelia; Jalmav, Marthy Meliana Ariyanti; Suryadinata, Rivan Virlando; Akbar, Muhammad Reza Aprililo
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i3.13499

Abstract

Older adults are at risk of vitamin D deficiency, especially in older women, due to a decrease in the hormone estrogen, which causes decreased bone density and increased risk of fractures. There is a relationship between vitamin D deficiency and lack of physical activity due to the storage of vitamin D in adipose tissue. Physical activity was measured using the International Physical Activity Questionnaire (IPAQ). The aim was to determine the relationship between physical activity and vitamin D in elderly women. This cross-sectional analytic observational study was conducted at Nursing Home X in Surabaya city from May to August 2023. The variables were physical activity (measured by IPAQ to estimate physical activity levels) and vitamin D level (measured by VIDAS® instrument to determine 25(OH) levels). The subjects were all women aged ≥60 years. The sampling technique uses the purposive sampling method. For an analysis of the relationship between physical activity levels and vitamin D levels, the Pearson correlation test was used with a ratio data scale. This research received 49 respondents. The average physical activity level was 1316.82±720.90, and most respondents had a moderate physical activity level of 44.90%. Vitamin D levels were ≤30 ng/ml for 46 respondents (93.87%). The results of the Pearson correlation test were obtained with a rvalue=0.089 and a significance value (Sig.) of 0.542. There was no significant correlation between physical activity and vitamin D levels. Other factors such as age, health conditions, and vitamin D intake can affect the results. Further research can be developed into measurements to examine physical activity in old age.

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