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Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
Arjuna Subject : -
Articles 404 Documents
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Cover, Editorial Board, Guidance for Authors Riyanto Riyanto
Biology, Medicine, & Natural Product Chemistry Vol 7, No 2 (2018)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5466.113 KB) | DOI: 10.14421/biomedich.2018.72.%p

Abstract

Anatomical and Histological Study of Shark (Carcharhinus sorrah) Kidney Hikmah Supriyati; Rakhmiyati Rakhmiyati; Muhammad Ja’far Luthfi
Biology, Medicine, & Natural Product Chemistry Vol 8, No 2 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.82.37-40

Abstract

Sharks are sea water fishes belong to the class Chondrichthyes, Subclass Elasmobranchii. Sharks are cartilaginous fish that have a different osmoregulation process than any other sea water fish. Cartilaginous fish is the only vertebrate that can maintain urea. This study aims to determine the anatomical and histological structure of the kidney in the anterior, medial and posterior parts of kidney. The study was conducted by observing anatomy of the kidney. Histological preparations were made using the paraffin method. Qualitative descriptive data analysis was done. Research results show that shark kidneys consist of three parts, namely the head kidney, the body kidney, and the tail kidney. Kidney sharks are brownish red with a size of 18 cm long. Histological observations of shark kidney in the head kidney reveals many glomerulus, body kidney reveals many distal and tubule proximal contractile tubules whereas tail kidney reveals stroma that is rarely found in vertebrate kidney.
Statistical Analysis of Habbatussauda’s Benefits for Health (Blood Pressure, Glucose and Uric Acid) Sugiyanto Sugiyanto; Luqyana Khalda; Meksianis Zadrak Ndii
Biology, Medicine, & Natural Product Chemistry Vol 8, No 1 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.81.7-10

Abstract

Habbatussauda is one of the traditional medicine existed since a long time ago and this is one of the drugs that recommended by the Prophet Muhammad. Habbatussauda’s benefits have been studied extensively in the healthcare. Habbatussauda has also been widely used to cure various diseases. This study revealed the benefits of Habbatussauda in lowering blood pressure, glucose and uric acid levels in 20 respondents that given Habbatussauda for 2 weeks. The blood pressure, glucose and uric acid levels were measured before and after consuming Habbatussauda. Blood pressure, glucose, and uric acid levels in the body will decrease after consuming Habbatussauda that shown in the statistical analysis of the obtained data.
Digital Anthropometer Development for Improving the Measurement Quality of Human Body Dimensions Trio Yonathan Teja Kusuma; Arya Wirabhuana; Faurosi Syafa’atul Yusuf
Biology, Medicine, & Natural Product Chemistry Vol 8, No 2 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.82.27-32

Abstract

Digital information technology has become the nerve of information for industry-based companies. However, there are still data or information that retrieved manually, one of them is measurement of the human body dimension. The problem is seemed solved by invention of digital anthropometer application. Yet, the application requires a further improvement especially in its accuracy and user interface. The improvement of accuracy quality of its measurement uses the capability process analysis method. As a result, the current Cp and Cpk is 0.26 and -0.209 while in the developed application is 2.56 and 1.218. Thus, the developed application is stated that quality of measurement increases to meet the criteria of good process capability. The user interface is improved based on the user voices. Data storage databases and percentile calculation in the application was added as one on the significant user-interface improvement.
A Simple Method for Clearing and Staining Specimens for The Demonstration of Animal Skeleton Muhammad Ja’far Luthfi; Nyoman Puniawati Soesilo
Biology, Medicine, & Natural Product Chemistry Vol 8, No 1 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.81.17-21

Abstract

Teaching skeletal system would be more attractive using real/preserved specimen compared to those using only book. The aim of the research was to develop clearing and staining method of animal skeleton specimen using Alizarin Red S-Alcian Blue as teaching aid tool. The specimen were eviscerated, fixed, stained, cleared, and keep in glycerine solution. The spesimen will increase effectiveness in elementary school science teaching and learning.
Echinoderms Diversity and Abundance in Gunung Kidul Beach Yogyakarta Supriyati, Hikmah; K, Setyawati Dwi; Ahzami, Ahzami; Sodiq, Farhani; Khoiriyah, Septiana
Biology, Medicine, & Natural Product Chemistry Vol 8, No 1 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.81.23-26

Abstract

Echinoderms are one of marine invertebrate animals that have an important role, as a recycle of nutrients in the functioning of ecosystems. Echinoderms usually appear in the intertidal zone of the coast. The existence of echinoderms in the intertidal zone is affected by external and internal factors. This study aims to determine the level of abundance and diversity of Echinoderms in the intertidal zone in the Krakal and Drini coastal areas, Gunung Kidul, Yogyakarta. Data were collected using transect method. The main transect along 50 meters was divided into 5 sampling points, and the distance between sampling points was 10 meters. After that, each point was taken for 3 observation plots with an area of 1x1 meters and the distance between plots is 5 meters. The results showed that, the diversity index on the krakal coast had a higher value (0.139) when compared to the Drini coast (0.129). Calculation of echinonderm abundance index shows that the Drini beach location has a high abundance value when compared to the abundance value at the Krakal beach loc ation. The parameter measurement results can be seen that both the pH and temperature parameters on both the Krakal and Drini coast have values that correspond to the optimum parameter in the waters.
Novel Approaches for Detection Fluorescent-Labeled by Cellvizio Lab System on Hippocampal CA1 Region Shaimi, Asma Ulhusna; Aasim, Wan Raihana Wan; Abdullah, Hasmah; Choon, Tan Soo; Wei, Ang Chee; Ismail, Zalina
Biology, Medicine, & Natural Product Chemistry Vol 8, No 1 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.81.1-6

Abstract

Neurosteroids have been identified in the 1981. Dehydroepiandrosterone sulphate (DHEAS) is one of the vital neurosteroids that de novo synthesized in the nervous system from cholesterol precursor (Baulieu & Robel, 1998). The aim of the study is to develop a method for fluorescence labelling. Alexa Fluor 488 dye with DHEAS antibody can binds the DHEAS antibody in the rat brain monitored by Cellvizio Lab System. DHEAS antibody (IgG isotype antibodies) was fluorescently conjugated by an amine-reactive compound, Alexa Fluor 5-SDP ester 488 dye. The resultant Alexa Fluor 488-conjugated antibodies were collected and analyzed by UV-Vis spectrophotometer instrument. The absorbance of the protein-dye conjugate at 280 nm and 494 nm were measured. Then, the degree of labeling (DOL) was calculated to achieve the desired results. Fluorescence labelling were carried out into the CA1 region of hippocampus Sprague-Dawley rat. We reported that the conjugation was successful. Optimal labeling depending on degree of labeling (DOL) needs some necessity to achieve and effective binding to the target neurosteroid, DHEAS. Cellvizio Lab system connected with Fiber Fluorescence Microscopy (FFM) probe is presented as a new approach in real-time imaging of DHEAS. In conclusion, we have developed a new method of DHEAS-Alexa Fluor fluorescence labelling to visualize and evaluate the changes of DHEAS fluorescence level in the rat hippocampus. This novel approach as a diagnostic tool and can be used to better understand the mechanisms and functions of DHEAS and other neurosteroids in future research.
The Effects of Wet Cupping Therapy in Blood Pressure, Glucose, Uric Acid and Total Cholesterol Levels Sutriyono Sutriyono; Muhammad Rodham Robbina; Meksianis Zadrak Ndii
Biology, Medicine, & Natural Product Chemistry Vol 8, No 2 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.82.33-36

Abstract

Wet cupping therapy is a simple, cheap, and effective alternative medical treatment. In China wet cupping therapy become a formal treatment in the hospital. 14 centuries ago Prophet Muhammad implemented wet cupping therapy or hejamah as a curing treatment and become sunnah for muslim. Today in a modern world, many studies proved the advantages of wet cupping therapy, which is a sunnah since 14 centuries ago. The aims of this study were to measure the effects of wet cupping therapy treatment on blood pressure, blood glucose, uric acid, and total cholesterol level. 21 participants were treated with hejamah/wet cupping, blood pressure and blood samples were collected from all the participants one week before and one week after hejamah. Blood pressure, either systolic or diastolic was significantly decreased following therapy (p|<|0.05), blood glucose had a slight decreased but not significant (p|>|0.05). uric acid and total cholesterol level was also significantly decreased following therapy (p|<|0.05). With only just one time treatment, hejamah had a significant effects on blood pressure, uric acid and total cholesterol level, that is proved the advantages of hejamah.
Mathematical Model of Cervical Cancer Treatment Using Chemotherapy Drug Murtono Murtono; Meksianis Zadrak Ndii; Sugiyanto Sugiyanto
Biology, Medicine, & Natural Product Chemistry Vol 8, No 1 (2019)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2019.81.11-15

Abstract

Cervical cancer is a malignant disease that causes problems in women's health, especially in developing countries such as Indonesia. Cervical cancer cells will develop quickly, uncontrollably, and will continue to divide and then infiltrate the surrounding tissue and continue to spread to connective tissue, blood, and attack important organs and spinal nerves. The aim of the research is to study the mathematical model of cervical cancer by chemotherapy treatment. The results of this study are that cervical cancer treatment using chemotherapy is effective enough to kill abnormal cells such as infected cells, pre-cancerous cells and cancer cells, although there are side effects, namely the killing of normal cells due to chemotherapy drugs.
Antioxidant Activities of the Leaf Extract and Fractions of Dryopteris filix-mas (L.) Schott could be Attributed to The Abundance of Polyphenol Compounds Earnest Oghenesuvwe Erhirhie; Emmanuel Emeka Ilodigwe; Daniel Lotanna Ajaghaku; Blessing Ogechukwu Umeokoli; Peter Maduabuchi Eze; Festus Basden Chiedu Okoye
Biology, Medicine, & Natural Product Chemistry Vol 9, No 1 (2020)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2020.91.1-6

Abstract

Dryopteris filix mas (D filix-mas) is wildly used in ethnomedicine for the management of rheumatoid arthritis, wounds and other diseases. We investigated the anti-oxidant activities of its leaf extract, and chromatographic fractions. The ethanol leaf extract was partitioned into four fractions; n-hexane, ethyl acetate, n-butanol and water. Ferric reducing anti-oxidant power (FRAP), 1, 1-diphenyl-2-picrylhydrazil (DPPH) and nitric oxide (NO) scavenging in vitro assays were carried out on the extract and fractions at 6.25, 12.5, 25, 50, 100, 200, 400 and 800 µg/mL. The most active fraction (ethyl acetate fraction) was further purified using chromatographic techniques to isolate its major compound whose structure was elucidated using ID nuclear magnetic resonance (NMR) and mass spectrometry. The ethyl acetate fraction produced the highest free radical scavenging activity among the other fractions. The fraction (VLC-E7) from which the bioactive compound, quercetin-3-O-αL-rhamnopyranoside, was isolated had the best FRAP and DPPH scavenging activities with EC50 and IC50 values of 88.81 ± 3.41 and 26.87 ± 0.24 respectively more than the ethyl acetate fraction. This study revealed that the polyphenol flavonoid, quercetin-3-O-αL-rhamnopyranoside could be responsible for antioxidant activity of ethno-medicinal property of D filix-mas leaf.

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