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INDONESIA
Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
Arjuna Subject : -
Articles 404 Documents
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Predicting the Anti-Pulmonary Fibrosis Potential of Physalis angulata Compounds A Computational Study Farid, Muhammad; Kirana, Assa Aulia; Oktaviana, Nandita Diah; Rasyda, Sofia; Anggraini, Dwi; Ramadhania, Widya Aryana
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.817-824

Abstract

Pulmonary fibrosis is a progressive lung disease characterized by tissue scarring and respiratory decline. Existing treatments have limited efficacy and significant side effects. Physalis angulata, a traditional medicinal plant, shows promise for antifibrotic therapy due to its bioactive compounds potentially targeting key fibrotic pathways. This study aims to predict the potential of Physalis angulata compounds to PI3K/AKT protein as candidates for antifibrotic therapy. Ten active compounds from P. angulata were docked against the PI3K/AKT protein (PDB ID: 2UZT) using AutoDock Vina. Docking was validated by redocking the native ligand. Binding affinities and molecular interactions were analyzed. ADMET properties were predicted via the pkCSM platform to assess pharmacokinetics and toxicity. Myricetrin exhibited the strongest binding affinity (-9.6 kcal/mol), surpassing the native ligand (-9.1 kcal/mol). Other flavonoids, including eriodictyol (-8.9 kcal/mol), naringin (-8.8 kcal/mol), and apigenin (-8.5 kcal/mol), also showed favorable affinities. Critical amino acids involved were Asp184 and Glu121. The redocking RMSD value of 0.893 Ã confirmed methodological accuracy. ADMET predictions revealed high intestinal absorption for tangeretin and apigenin, with no mutagenic or hepatotoxic risks, indicating good pharmacokinetic profiles. Physalis angulata flavonoids exhibit strong PI3K/AKT binding and favorable pharmacokinetics, supporting their potential as antifibrotic agents.
Isolation, Morphological Characterization, Biochemistry, and Antagonistic Activity of Endophytic Bacteria from Rice Against Xanthomonas oryzae pv. Oryzae Sihotang, Saipul; Butar-Butar, Alfons Dwi Putra; Nasution, Lita; Rahma, Haliatur; Trizelia, Trizelia; Saragih, Magdalena; Kuswardani, Retna Astuti; Listiana, Ika; Napitupulu, Beatrix Sofranes
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.825-829

Abstract

Endophytic bacteria have the potential as environmentally friendly biocontrol agents in controlling bacterial leaf blight (BLB) in rice caused by Xanthomonas oryzae pv. oryzae (Xoo). This study aims to isolate, characterize morphology and biochemical tests, and test the antagonistic activity of endophytic bacteria from rice against Xoo. Isolation was carried out from healthy rice root tissue using a surface sterilization method. Morphological characterization included colony shape, color, edge, elevation, and Gram properties, while biochemical characterization included catalase, oxidase, motility, starch hydrolysis, and sugar fermentation tests. The antagonistic test used a dual culture assay method on NA (nutrient agar) media. The isolation results obtained six endophytic bacterial isolates (BETP 01–06) identified as the genus Pseudomonas and Bacillus with varying colony morphological characters. Antimicrobial activity test showed two potential isolates, BETP 03 (Pseudomonas) and BETP 05 (Bacillus), with an average inhibitory diameter of 16.3 mm and 16.5 mm against Xoo, respectively. Biochemical characterization showed that BETP 03 was bacillus, Gram-negative, citrate-negative, motile, gelatin hydrolysis positive, starch hydrolysis positive, and catalase positive; while BETP 05 was bacillus, Gram-positive, citrate-positive, motile, gelatin hydrolysis negative, starch hydrolysis positive, and catalase positive. These results indicate that both isolates have high potential as biological biocontrol agents in controlling bacterial leaf blight disease in rice.
Analysis of Nutritional Composition and Antioxidant Activity of Yogurt Enriched with Butterfly Pea (Clitoria ternatea L.) Extract Windarsih, Yulia; Budiarsa, I Made; Trianto, Manap; Akram, Akram; Ashari, Abdul
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.831-841

Abstract

The growing demand for functional foods has encouraged the development of dairy products enriched with natural bioactive ingredients to improve nutritional value and health benefits. This study aimed to analyze the nutritional composition and antioxidant activity of yogurt enriched with butterfly pea (Clitoria ternatea L.) extract. Yogurt was prepared from fresh goat milk with varying concentrations of butterfly pea extract and evaluated for protein, fat, carbohydrate, moisture, ash, vitamin C contents, antioxidant activity, and sensory acceptance. Proximate analysis, UV–Vis spectrophotometry, and the DPPH method were used for chemical determinations, while a hedonic test assessed color, taste, aroma, and texture. Results showed that increasing butterfly pea extract significantly decreased protein and fat contents but increased vitamin C and antioxidant activity, with the highest values observed in yogurt containing 60% extract and 4% formulation (N60K2). Moisture and ash contents were not significantly affected. Sensory evaluation indicated that yogurt with 60% extract and 2% formulation (N60K1) was preferred regarding color, taste, aroma, and texture. Considering compliance with the Indonesian National Standard (SNI) and consumer acceptance, N60K1 was the optimal formulation. The findings suggest that butterfly pea extract can enhance the functional properties of yogurt, particularly its antioxidant potential, while maintaining acceptable sensory quality. This provides insights for developing functional dairy products with natural plant-based bioactives.
DFT Study and ADMET Investigation of Bioactive 2-Phenoxyquinolines Aina, Oluwafemi S.; Rofiu, Mujeeb O.; Adams, Luqman A.; Familoni, Oluwole B.
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.843-856

Abstract

Pharmacologically active quinoline compounds show interesting functionalities. However, there is still a dearth of information on the potential wide applications of the quinoline scaffolds especially when the substituents on the rings or functionalities are modified. In this study 2-phenoxyquinoline-3-carbaldehyde derivatives were synthesized and investigated using DFT to determine the molecular parameters, electronic and chemical reactivity descriptors including their possible application as drug candidates. Geometry optimisations were carried out using Becke three-parameter hybrid functional combined with Lee-Yang-Parr correlation functionals and augmented basis set with added sets of diffuse s- and p-functions: BL3YP /6-311++G(d,p). Drug-likeness scores and bioactivity prediction were carried out using the webserver programs ADMET Sar 2. Our results showed slightly lower energy values in water than in ethanol depicting high reactiveness of the 2-phenoxyquinolines in water especially compounds with fluoro- and methoxy substituted having the lowest Egap of 3.79 eV and 3.381 eV respectively. The methoxy substitution confers higher susceptibility to electron transfer and chemical reactive in aqeous medium. The ionization potential energies were lower in water and ethanol when compared to the other gas states calculated values. The MEP surfaces of all the compounds investigated reveals the ether oxygen atoms and carbonyl groups as necessities for effective antioxidant properties. It is noteworthy that five of the compounds investigated have high activity values above 3.0 octanol–water partition coefficient value indicating an excellent inhibitory activity and strong chemical reactivity. Good oral bioavailability was shown by the compounds depicting their excellent activity as kinase inhibitors, nuclear receptor compounds and enzyme inhibitors. It is noteworthy that cytochromes CYP2C19, CYP2C29, CYP2D6 and CYP3A4 are not inhibited and therefore do not pose potential adverse drug reactions or toxicity. Interestingly, only one compound showed one violation. Consequently, such scaffolds are potential drug candidates.

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