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Mohammad Rizki
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Fakultas Kedokteran Universitas Mataram Jl. Pendidikan No. 37 Mataram, Nusa Tenggara Barat
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Nusa tenggara barat
INDONESIA
Jurnal Kedokteran
Published by Universitas Mataram
ISSN : 23015977     EISSN : 25277154     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
The Unram Medical Journal managed by the Medical Faculty of Mataram University is a scientific journal to publish the results of the latest research in the field of medical and health related. This journal promote medical sciences generated from basic sciences, clinical, and community research to integrate researches in all aspects of human health. This journal publishes original articles, reviews, and also case reports.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 8 Documents
 1 
Search results for , issue "Vol 1 No 1 (2012)" : 8 Documents clear
Penggunaan Psikotropika pada Anak dan Remaja Penderita Asma di Belanda 1999-2006 Aini, Siti Rahmatul
Jurnal Kedokteran Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

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Introduction: To determine the association between asthma and the use of psychotropic drugs by focusing on whether the asthmatic children receive more often psychotropic drugs compared with non asthmatic children in the population based cohort design. Method: Using InterAction Database (IADB), drug dispensing data from Dutch community pharmacies (55 community pharmacies) in 1999 – 2006, children and adolescents aged 0 to 19 years in the study period (1 Januari 1999 to 31 Desember 2006 were divided into two groups; the index (asthmatic children and adolescents) and the reference (antibiotic children and adolescents) groups. We calculated the incidences of psychotropic drugs use (in both groups) and the incidence risk ratio (IRR). Results: The incidences of psychotropic drug use were 0.058 cases/1000 person-days in index group and 0.048 cases/1000 person-days in reference group. The incidence risk ratio of anti psychotropic drug use was 1.21 ( CI 1.18-1.29). Conclusions : Asthmatic patients are 1.21 times more likely than non asthmatic patients to receive psychotropic drugs over the 8 years period in this study.
Kadar Glutation Pasca Pemberian Provitamin B5 pada Mencit BALB/c Terinfeksi Plasmodium berghei Ekawanti, Ardiana
Jurnal Kedokteran Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

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Introduction: Malaria was one of the health problem in developing country including Indonesia. Three hundred to five hundred million people suffered from malaria, and causing more than one million death annually. The objective of this study was to find out erythrocyte GSH level and compared to parasitemiapercentage due to provitamin B5 administration to Plasmodium berghei infected BALB/c mice. Method: 32 males BALB/c mice were infected by 200 µL blood which contain 106 Plasmodium berghei intraperitoneally. Then, samples were separated randomly into four groups, namely control group, group P1, group P2 and group P3. As soon as parasitemia reached 1 – 5 % the treatment should begin. Control group was administered aquades by gavage, group P1 administered 0.14 g/kgBW provitamin B5, group P2 administered 1.4 g/kgBW provitamin B5, group P3 administered 2.8 g/kgBW provitamin B5, all were treated by gavage. Provitamin B5 treatment followed the protocol in the 4-days suppressive test of blood schizontocidal action. On the fourth day the mice were terminated and blood samples from intracardiac was taken. Thus, blood samples conducted erythrocyte GSH measurement using Anderson method. Result: The results were analysed by using Anova α = 0.05, and continued by LSD if the result showed a significant difference. Erythrocyte GSH level decreased in all groups. Erythrocyte GSH in group P3 increased significant compared to group P1 ( P<0.05). Parasitemia measurement using Percent method showed a significant decrease in group P1 ( 48 % ) and in group P2 ( 62 % ) (P<0.05), while in group P3 no significant difference from control group. Conclusion: Erythrocyte GSH level decreased in administration of Provitamin B5 by increasing dosage, in contrast to parasitemia percentage.
Improvements of PCR Amplification of Guanine plus Cytosine-Rich Constructs of Mycobacterium tuberculosis Gene using DMSO Sabrina, Yunita; Lestarini, Ima Arum; Ekawanti, Ardiana; Sriasih, Made; Depamede, Sulaiman N.; Ali, Muhamad
Jurnal Kedokteran Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

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Vaccine research entered a new era when several useful molecular research tools were established. Instead of attenuated virulent microorganisms or killed virulent microorganisms, effective subunit vaccines were developed using recombinant DNA technology. By using the technology, selected genes of the virulent microorganisms can be amplified, cloned, expressed, and evaluated as vaccine components in challenge studies. However, a major bottleneck with the amplification of functional genes from Mycobacterium tubeculosis containing guanine plus cytosin-rich templates is often hampered by the formation of secondary structures like hairpins and higher melting temperatures. To solve this problem in this research, the amplification reaction was modified by addition of dimethyl sulfoxide (DMSO) into amplification reaction mixtures. It was found that 10% (v/v) of DMSO in the reaction mixture improved the amplification of GC-rich template of M. tuberculosis gene. This result indicating that amplification of unbalanced content of G and C deoxyribonucleotides genome could be improved using low-cost organic molecule, DMSO. Therefore, the DMSO should be widely useful as an enhancer to improve the amplification of GC rich construct from other genome. Keywords: Mycobacterium tubeculosis,vaccine, dimethyl sulfoxide, Guanine-Cytosine
Faktor-faktor yang Mempengaruhi Kualitas Hidup Pasien Tinitus di RSUD Provinsi NTB Primaditha, Dara; Kadriyan, Hamsu; Widiastuti, Ida Ayu Eka
Jurnal Kedokteran Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

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Introduction: Based on previous studies in Asia, the incidence of tinnitus was about 10.9%. Tinnitus shows a close association with psychological and social disorders and leads to a decline in quality of life. Most patients complain of sleep disorders, anxiety, and even depression. There are several factors that allegedly affect the quality of life of tinnitus patients such as age, sex and location of tinnitus. This study aims to prove the influence of these factors on the quality of life of tinnitus patients. Method: This is an analytic descriptive research with cross sectional design. The sample of this study was 37 patients tinitus who visited the ENT outpatient clinic of NTB Provincial Hospital that has met the inclusion and exclusion criteria. The respondents then filled out the Tinnitus Handicap Inventory (THI) questionnaire. The data obtained are then tested for validity and reliability, followed by Mann-Withney and Kruskall-Wallis tests to determine the effect of age, sex, and tinnitus on quality of life. Results: Based on the THI score, 86.8% of tinnitus patients experienced quality of life disorders of varying degrees. From the analysis of data about the effect of age on the quality of life, p = 0.957 (p> 0,05) means that there is no difference in the quality of life of tinnitus patients in all four age groups. The test results on the sex variables gave p = 0.430 (p> 0,05), this also means there is no difference in quality of life between men and women. The test of tinnitus location variable gives p value = 0,631 (p> 0,05). This means there is no difference in the quality of life between patients with bilateral and unilateral tinnitus. Conclusion: The quality of life of tinnitus patients is not affected by age, sex, and location of tinnitus.
Pengelolaan Nyeri Kanker Kresnoadi, Erwin
Jurnal Kedokteran Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

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Patients with cancer have diverse symptoms, impairments in physical and psychological functioning, and other difficulties that can undermine their quality of life. If inadequately controlled, pain can have a profoundly adverse impact on the patient and his or her family. The critical importance of pain management as part of routine cancer care has been forcefully advanced by WHO, international and national professional organizations, and governmental agencies.
Korelasi antara Dosis Eksposur Timbal dengan Kadar Ureum dan Kreatinin Serum pada Wistar (Rattus norvegicus) Atmawati, Baiq Jatna; Syamsun, Arfi
Jurnal Kedokteran Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

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Introduction: Clean air is hard to find these days, especially in big cities where industries and motor vehicles contribute to air pollution. It is almost about 85% of air pollution is caused by the emission of motor vehicles. One of the contaminants which are produced is lead. The lead which accumulates inside the tissues of the body will cause disorder mainly to the urinarius system (kidneys), liver, hematopoetic system, cardiovascular, and reproduction system. The objective of this research is to find out the correlation between the dosage of lead exposure with the level of serum ureum and creatinine on wistar rats (Rattus norvegicus). Method: This research applies a simple experimental research design which is called the post-test only control group design. This research participates with 6 research groups, that is, 4 for the treatment groups and 2 for the control groups. On the treatment groups, firstly, wistar rats are treated in a way which they are given a gradable dosageof acetic leads per orally. The level of acetic leads given in Treatment 1 (P1) is 1.1 ml, Treatment 2 (P2) is 0.825 ml, Treatment 3 (P3) is 0.55 ml, and Treatment 4 (P4) is 0.25 ml. After 24 hours (of acute exposure), the rats are anethesized by diethyl ether and then continue take the blood through the intracardiac. On control, on the other hand, no treatment at all is given to the rats. On Control 1, previously, the rats are anethesized with diethyl ether. On Control 2, however, they are not anesthesized but do decapytation. Result: Researchers have found the result that there is no significant correlation between the dosage of lead exposure towards the level of serum ureum and creatinine on wistar rats from the experiment of Control 1 and Control 2 (p>0.05). Researchers have found that the more reduced the dosage of the acetic lead, the more increasing the average of serum ureum. As for the creatinine, researchers have seen that there is no significant difference in the value between the treatment group and control group. Researchers have also found that there is no significant difference between the level of serum ureum and the level of creatinine on control group 1 and control group 2 (p>0.05). On the other hand, it is seen that there is difference on the value of ureum and creatinine in control 1 and in control 2. Conclusion: After conducting the experiment, researchers have found the result that there is no significant correlation between the dosage of lead exposure towards the level of serum ureum and creatinine on wistar rats from the experiment of Group 1 and Group 2 (p>0.05). On the other hand, it is seen that there is difference on the value of ureum and the value of creatinine in control group 1 (anesthesized with ether) and in control group 2 (without ether).
Standarisasi Pasien dan Ruang Simulasi Meningkatkan Kepuasan Mahasiswa Kedokteran Universitas Mataram dalam Pelaksanaan Keterampilan Medik Kardiovaskuler Syamsun, Arfi; Ansyori, Maz Isa
Jurnal Kedokteran Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

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Introduction: Cardiovascular diseases have high morbidity and mortality rates. Skills in administering diagnosis and treatment of the diseases is part of general physician competencies according to the Indonesian Doctors Competency Standards. The teaching of cardiovascular lab skills at the Medical Faculty of the University of Mataram has not optimally prepared standardized simulation rooms and patients. As a result, this complicates students’ clinical understanding in handling cardiovasdcular events at the hospitals and clinics with different facilities. The effectiveness of the standardization is measured from results of skill lab exams and students’ satisfaction scores. Objectives: To identify the difference in the satisfaction and skills lab scores of cardiovascular physical exam and electrocardiography (ECG) installation among students of simulation room and patient standardization groups as compared to non-standardization groups. Method: This cross sectional study involved 20 students of 5th semester of the Faculty of Medicine, Mataram University. Samples were taken randomly based on prior stratified lab skills scores. They comprised 2 treatment groups and 2 control groups as follows: group 1, simulation room and patient standardization for cardiovascular physical exam; group 2, simulation room and patient standardization for ECG examination; group 3, simulation room and patient non-standardization for cardiovascular physical exam; group 4, simulation room and patient non-standardization for ECG examination. The students then attended a Master Course, lab skills demonstration, and independent practices for 2 weeks. Satisfaction scores are measured by means of a questionnaire whose contents were validly tested, while lab skills exam scores are measured using a standard checklist issued by the Medical Faculty. Unpaired t-test is used to identify the differences in the students’ satisfaction scores and skill lab scores among the 2 groups. Study Findings: There are significant differences in the mean of students’ satisfaction scores in terms of simulation patients, lab skills room, and instructors for cardiovascular physical exam and ECG exam between the standardization and non-standardization groups. There was no significant difference in the mean of scores on communicative and eticomedicolegal competence, clinical skills competence and clinical reasoning competence on cardiovascular physical exam and ECG exam between standardization and nonstandardization groups. Conclusion: Standardization of simulation patients and rooms for cardiovascular physical exam and ECG exam significantly increases students’ satisfaction scores but does not significantly increases students’ lab skills scores. Keywords: standardization, simulation patients, simulation room, satisfaction scores, lab skills scores.
Polymorphism of Fat Mass and Obesity Associated (FTO) gene as a risk Factor for Type 2 Diabetes Mellitus with Metabolic Syndrome at DR Sardjito Hospital Yogyakarta Seto Priyambodo; Ahmad Hamim Sadewa; Maliyah Madiyan
Unram Medical Journal Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v3i2.741

Abstract

Introduction . FTO gen is one of the new recently studied and still requires a lot of studies on the role of this gen on the incidence of metabolic syndrome. FTO rs 9939609 polymorphism in some populations have mentioned as the risk factors for obesity, type 2 diabetes mellitus and metabolic syndrome. Protein FTO role in demethylations of the genes in the hypothalamus that helps maintain energy intake and expenditure. Methods This study used a case- control design with type 2 DM subjects with metabolic syndrome (n = 40) as cases and type 2 diabetes mellitus without metabolic syndrome (n = 40) as a control from DR.Sardjito Hospital Yogyakarta 2009-2010. FTO gen rs9939609 polymorphism was analyzed by PCR-RFLP. Chi square test and odds ratio test are used to examine FTO rs9939609 polymorphism and the relationship with the incidence of type 2 diabetes with metabolic syndrome and it’s components. Results The frequency of TT genotype in subjects with type 2 DM patients with metabolic syndrome 2(5%), AT genotype 35 (87.5%) and AA genotype 3 (7.5%) (n = 40). In subjects with type 2 DM patients without metabolic syndrome TT genotype frequency 6 (15%), AT genotype 32 (80%) and AA genotype 2 (5%) (n = 40).OR are significant for sistolic hypertension (OR=0,039) and for HDL plasma level (OR=0,046) as the components of metabolic syndrome. Conclusion The FTO gen rs9939609 polymorphism is the risk factor for hypertension and high HDL plasma level as the components of metabolic syndrome at DR Sardjito Hospital Yogyakarta.

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