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Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 22529764     EISSN : 26859165     DOI : 10.18196/idj
Core Subject : Health,
Dentistry
Insisiva Dental Jurnal memberikan informasi tentang ide, opini, perkembangan dan isu-isu di bidang kedokteran gigi meliputi klinis, penelitian, laporan kasus dan literature review.
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Articles 28 Documents
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Search results for , issue "Vol 1, No 2 (2012)" : 28 Documents clear
Uji Pemanfaatan Daun Binahong (Anredera Cardifolia (Tenore) Steenis) Pada Proses Penyembuhan Luka Gingiva Tikus Wistar (Rattus norvegicus) Melalui Pengamatan Kepadatan Serabut Kolagen Dan Ketebalan Epitel Putri Adriani, Wika; Ardianingtiyas, Idha; Husna Wulansari, Nurul; Nur’aini Safitri, Dian; Primalia AP, Ike; Sih Mahanani, Erlina
Insisiva Dental Journal Vol 1, No 2 (2012)
Publisher : Insisiva Dental Journal

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Abstract

Rongga mulut sebagai bagian integral tubuh, sering mengalami trauma saat melakukan fungsinya. Trauma ini dapat terjadi secara disengaja maupun tidak, yang pada akhirnya akan menimbulkan luka pada mukosa mulut. Perlukaan pada jaringan akan menyebabkan terjadinyareaksi radang. Reaksi radang merupakan tahap awal dari serangkaian proses penyembuhanluka. Daun Binahong (Anredera cordifolia (Ten.) Steenis) mengandung flavonoid, saponin, dan alkaloid yang dapat berpengaruh pada proses penyembuhan luka. Penelitian ini bertujuan untuk mengetahui uji pemanfaatan daun Binahong (Anredera cardifolia (Ten) Steenis) pada penyembuhan luka di gingiva melalui pengamatan kepadatan serabut kolagen dan ketebalan epitel, serta untuk membandingkan efektifitas penggunaan daun Binahong (Anredera cardifolia (Tenore) Steenis) dan Povidone Iodine pada penyembuhan luka di gingiva. Sampel penelitian menggunakan tikus jantan galur Wistar (Rattus norvegicus) berusia 3 bulan sebanyak 30ekor dibagi menjadi 3 kelompok : kelompok I (kontrol negatif), kelompok II (povidoneiodine), kelompok III (binahong). Tikus yang digunakan dalam penelitian ini memiliki beratbadan 150-250 gram dan telah diadaptasikan selama 1 minggu. Perlakuan dibuat pada gingivarahang bawah dengan luka gores sonde, dengan panjang ± 3mm dan kedalaman hingga tulangalveolar. Luka pada kelompok II diberi Povidon Iodine 1cc, sedangkan pada kelompok III diberi tumbukan binahong 1gram, masing-masing selama 3 menit secara topikal. Dekapitasi dilakukan sesuai hari perlakuan 1, 3,5 hari masing-masing 3 ekor tikus. Penghitungan kepadatanserabut kolagen dilakukan pada preparat histologi Trikom Mallory dan ketebalan epitel dilakukan pada preparat histologi HE. Data kepadatan kolagen dan ketebalan epitel dianalisisdengan One Way Anova dilanjutkan dengan tes LSD untuk mengetahui perbandingan antarkelompok. Hasil tes LSD kepadatan serabut kolagen menunjukkan adanya perbedaan yangbermakna antar kelompok sesuai hari perlakuan. Sedangkan hasil tes LSD ketebalan epitelmenunjukkan adanya perbedaan yang bermakna antara masing-masing kelompok perlakuandibandingkan dengan normal. Namun, tidak ada perbedaan bermakna antar kelompok perlakuan. Penelitian ini mengindikasikan bahwa pemberian tumbukan binahong secara topikaldapat meningkatkan kepadatan kolagen dan ketebalan epitel, sehingga mempercepat prosespenyembuhan luka pada gingiva tikus wistar.
Potensi Ekstrak Etanol Daun Keladi Tikus (Typhonium flagelliforme Lodd.) Sebagai Induktor Apoptosis Sel Kanker Lidah Manusia (SP-C1) Rosyid Ridlo, Himmaturojuli; Supriatno, Supriatno; Medawati, Ana; Driana Rahmawati, Atiek
Insisiva Dental Journal Vol 1, No 2 (2012)
Publisher : Insisiva Dental Journal

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Abstract

Typhonium flagelliforme Lodd has been used traditionally to cure breast cancer, lung, colon, rectum, liver, prostate, kidney, cervix, throat, bone, brain, spleen, bladder, leukimia and pancreas cancer. The ethanolic extract of Typhonium flagelliforme Lodd contained active compounds that could inhibit cancer cell growth. One of the active compounds was saponin and phenolic. The aim of study was to examine the potency ethanolic extract of Typhoniumflagelliforme Lodd. as inductor of apoptosis in human oral tongue cancer cell Supris Clone-1 (SP-C1). The desingn of used in this study was pure laboratoris experimental with human oral tongue cancer cells line (SP-C1) as a sample which treated by ethanolic extract of Typhonium flagelliforme Lodd in various concentrations (0, 25, 50, 75, 100, 125 µg/ml) for 48 hours. Apoptosis examination was carrried out by painting with etidium bromide-acridin orange. The result of the study showed that etanolic exstract of Typhonium flagelliforme Lodd. induced apoptotic SP-C1 cell line. Statistical analisis with One Way Anova revealed etanolic extract in various concentration have significant differences (P=0,00) after treated with etanolic extract Typonium flagelliforme Lodd. It also found that the most effective concentration inducing apoptosis of human tongue cancer cells Supris Clone-1 (SP-C1) was the 125 µg/mL. The conclusion of this research, ethanolic extract of Typhonium flagelliforme Lodd. has a potency to induce apoptosis human oral tongue cancer cells (SP-C1).
Oral Habits That Cause Malocclusion Problems Joelijanto, Rudy
Insisiva Dental Journal Vol 1, No 2 (2012)
Publisher : Insisiva Dental Journal

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Abstract

Oral habits that place pressure on the teeth may slowly move the teeth out of place. The aim of this study was to review the literature for articles referring the most common oral habits that cause malocclusion. The oral bad habits that cause malocclussion problems include: Thumb sucking, It is a normal habit for babies, but causes serious orthodontic problems if it continues long after the eruption of permanent teeth. Prolonged thumb sucking can create crowded, crooked teeth, or bite problems and speech problems. Protrusion and displacement of front teeth are usual results of thumb sucking. Lip-biting or fingernail biting, both habits can shift the teeth out of alignment. Tongue thrusting, some children thrust their tongue forward, pressing it against the lips with a force that can result in teeth malocclusions such as ‘open bite’ or teeth protrusion (overjet). While parents can not do much to prevent an orthodontic problem caused by hereditary factors, they can help their kids to avoid the need for braces, by maintaining good oral hygiene and avoiding bad oral habits that could cause teeth malocclusion problems. Modern orthodontics are usually able to treat most teeth malocclusions successfully, but prevention can help the family to avoid the large cost of orthodontic treatment and the child will not have to wear dental braces and feel uncomfortable.
Effect Of Apple Juice On Whitening Teeth After Immersion In Coffee Solution In Vitro Puspasari, Nuzulya; Effendi, Chair; Nugraeni, Yuli
Insisiva Dental Journal Vol 1, No 2 (2012)
Publisher : Insisiva Dental Journal

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Abstract

The Background of this research because one of the extrinsic cause teeth discoloration is excessive coffee consumption. To cope teeth discoloration whitening teeth done either with chemicals or natural ingredients. Apples (Malus sylvestris Mill) is one of the fruits that contain malic acid, substance that can whitening teeth. The General Objective is to determine the effect of giving apple juice (Malus sylvestris Mill) on a teeth that has been soaked in coffee solution on teeth whitening in vitro. Materials and Methods research is experimental laboratory use elements of the permanent maxillary premolar tooth from extraction indications orthodontic treatment, free of caries and hypoplasia as a sample of 12 pieces, divided into 2 groups. The first group as a control group with 100 ml distilled water immersion. The second group as the treatment group using apple juice immersion with 75% concentration. Samples of tooth element has immersed first in coffee solution during 2 weeks until discoloration then immersed according to the group for 2 weeks (3x@5minutes a day), then measured the color changes of tooth. The Result with Paired T-test showed significant effect on the group before treatment and after treatment (p <0.05). Independen T-test result showed significant difference between the control group immersed in 100 ml distilled water and treatment group, immersed in apple juice 75% concentration. Conclusion of the results showed that apple juice has the ability to whiten the tooth enamel surface that changes color because of immersion in coffee solution so it can return to the original color before discoloration.
Infection Control Implementation At Private Dental Practice In Yogyakarta City Dewanto, Iwan; Septario, Medi
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 1, No 2 (2012)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.v1i2.533

Abstract

Dentist As A Health Worker Claimed To Be Responsible Widely In A Variety Of Existing Public Health Efforts, Especially In The Dental Clinic. Infection Control Is An Effort To Control And Prevent The Spread Of Infectious Diseases In Practice Setting. This Study Aimed To Describe The Implementation Of Infection Control In Dental Practices In The Yogyakarta City In The Availability And Utilization Of Facilities And Infrastructure. A CrossSectional Study Was Conducted In Yogyakarta City With Subjects Of 30 Dentist Who Has Independent Private Practice Chosen By Simple Random Sampling. Observational Techniques Using Check List Was Applied To Assess The Implementation Of Infection Control. Results Showed Existing Deficiencies Of Control Infection In The Components Of Equipment, Dentist, And Room. It Can Be Concluded That The Implementation Of Infection Control In The Yogyakarta City Has Not Gone Well, It Is Source Of Concern As The Possibility Of Infectious Disease Transmission In Dental Clinic Occured. This Because The Level Of Awareness Is Still Lacking And The Dentist Thinks Will Impact The Length Of The Culture Is Still Neglected
Pengaruh Komplikasi Neuropati Terhadap Xerostomia Pada Penderita Diabetes Mellitus Tipe Ii Kartika Sari, Rina; Widiajmoko, Agung
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 1, No 2 (2012)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.v1i2.527

Abstract

Diabetes Mellitus merupakan The Great Initiator, yaitu salah satu penyakit yang dapat menimbulkan banyak sekali komplikasi salah satunya neuropati (Neuropati diabetik). Neuropati diabetik yaitu sekumpulan gejala (sindrom) yang disebabkan oleh degenerasi saraf perifer atau otonom sebagai akibat dari diabetes mellitus. Diabetes mellitus sering menimbulkan banyak manifestasi oral salah satunya xerostomia (sindrom mulut kering). Hubungan antara xerostomia pada penderita diabetes mellitus tipe II masih banyak menimbulkan kontroversi, salah satunya dikarenakan adanya kerusakan saraf pada kelenjar saliva, namun banyak juga studi yang menyebutkan xerostomia tersebut dikarenakan gejala poliuri pada penderita diabetes mellitus tipe II. Penelitian ini bersifat observasional dengan pendekatan cross sectional. Bertujuan meneliti pengaruh komplikasi neuropati terhadap xerostomia pada penderita diabetes mellitus tipe II dengan metode meludah. Subyek penelitian dipilih dengan teknik purposive sampling sebanyak 30 orang. Kelompok I terdiri atas 10 orang penderita diabetes mellitus tipe II dengan komplikasi neuropati, kelompok II 10 orang penderita diabetes mellitus tipe II tanpa komplikasi neuropati dan kelompok III 10 orang normal. Tiap subyek diukur curah saliva rata – ratanya(ml/menit) dengan stimulasi asam sitrat 2% dan tanpa stimulasi. Hasil penelitian menunjukkan nilai rata – rata curah saliva tidak stimulasi adalah; kelompok I 0,14±0,69; kelompok II 0,33±0,12; kelompok III 0,73±0,16. Sedangkan nilai rata – rata curah saliva stimulasi adalah; kelompok I 0,43±0,24; kelompok II 1,00±0,35; kelompok III 2,44±079. Berdasarkan anamnesis keluhan subyektif, insidensi xerostomia kelompok I sebanyak 7 dari 10 orang (70%) ; kelompok II 2 dari 10 orang (20%); kelompok III tidak ada. Uji one way ANOVA menunjukkan hasil yang signifikan antar kelompok baik stimulasi maupun tidak stimulasi (p0,05), kecuali curah saliva stimulasi antara kelompok II dan kelompok III (p0,05). Uji Chi-square menunjukkan hasil yang signifikan antar kelompok (p0,05) kecuali antara kelompok II dan kelompok III (p0,05) Kesimpulan penelitian ini adalah terdapat pengaruh antara komplikasi neuropati terhadap xerostomia pada penderita diabetes mellitus tipe II. Hal ini dilihat dari rata-rata curah saliva stimulasi maupun tidak stimulasi dan keluhan subyektif yang menyertai
The Prospect Of Heat Shock Protein (Hsp) As Biomarker Of Oral Disease Muhammad Nurul Amin
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 1, No 2 (2012)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.v1i2.535

Abstract

The prevalence of oral diseases is increasing and caused by many factors. It can be caused by environmental, genetic, malignancy or side effects of dental treatment. The research detect these disease has been done, but still not getting satisfactory results. Heat shock proteins (HSP) are intracellular proteins that mediate the cytoprotective function and other essential functions. This protein is expressed and synthesized under conditions of stress/harmful or nonstress. The oral disease is a form of adverse conditions, and the course will also trigger HSP expression.
Potential Of Mangosteen Xanthones As Anti-Oral Cancer Agents By Induction Of Apoptosis Yani Corvianindya Rahayu
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 1, No 2 (2012)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.v1i2.529

Abstract

The pericarp of mangosteen (Garcinia mangostana L.) is rich in various xanthones that are known to possess unique biological activities. The aim of this study was to determine of antiproliferative and cytotoxic activities of mangosteen xanthones. The researchers found that all tested xanthones inhibited the growth of the cancer cells. They observed cytotoxic properties against three human cancer cell lines, epidermoid carcinoma of the mouth, breast cancer, and small-cell lung cancer. The specific xanthones include alpha-mangostins, showed that mangosteen xanthones not only inhibit the proliferation of target cells but also induce their death by apoptosis that involves the activation of the caspase cascade. To establish a more precise mechanism of action, a cell free biochemical kinase assay against multiple cyclins/CDKs involved in cell cycle progression; the most significant inhibition in the cell free based assays was CDK4, a critical component of the G1 phase.Through molecular modeling α-mangostin against the ATP binding pocket of CDK4, and propose three possible orientations that may result in CDK4 inhibition. Histopathological evaluation and biochemical analysis of tumors that received mangosteen xanthones indicate the induction of apoptosis in tumors, which resulted in the repression of their growth and the reduction of their sizes. The study concluded that mangosteen xanthones potentially as an agent for cancer prevention and the combination therapy with anti-cancer drugs.
Effect Extract Rosella (Hibiscussabdariffa) As An Alternative To Natural Tooth Bleaching Agent On External Discoloration Case Nanik Sugianti
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 1, No 2 (2012)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.v1i2.524

Abstract

Tooth bleaching is one effort that has long been known in the science of dentistry. Unfortunately material used to whiten tooth until now they are still nature are toxic to tissues of the mouth cavity. Whereas with traditional natural materials exploration in Indonesia, give all one plant used as a safe teeth bleaching, rosella (Hibiscus sabdariffa). The research to find out effect extract rosella (Hibiscus sabdariffa) to external discoloration. Methods: An experimental research with Pre and Post Controlled Group Design. The sample consist of 12 teeth which divided into two groups. The first group, as control, were soaked in aquadest and the second group, as treatment were soaked in extract rosella (Hibiscus sabdariffa) for 3 days. Colour analysis is conductedbyCIELAB method. The colected data were analized by Pairing t-test. Discussion: Rosella (Hibiscus sabdariffa) containing bioactive compounds, saponins that foam can bind colourants. With the power of his work which can bind the colourants can be used to whiten teeth. In addition, vitamin C (Ascorbic acid) that high can cause email erosion. The compound is capable of damaging colour substance molecules become neutral color so that the color and causing bleaching effects. Conclusion: Rosella (Hibiscus sabdariffa) can be used as an alternative natural tooth bleaching agent because it contains the active agent of saponin and vitamin C are high.
Oral Habits That Cause Malocclusion Problems Rudy Joelijanto
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 1, No 2 (2012)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.v1i2.536

Abstract

Oral habits that place pressure on the teeth may slowly move the teeth out of place. The aim of this study was to review the literature for articles referring the most common oral habits that cause malocclusion. The oral bad habits that cause malocclussion problems include: Thumb sucking, It is a normal habit for babies, but causes serious orthodontic problems if it continues long after the eruption of permanent teeth. Prolonged thumb sucking can create crowded, crooked teeth, or bite problems and speech problems. Protrusion and displacement of front teeth are usual results of thumb sucking. Lip-biting or fingernail biting, both habits can shift the teeth out of alignment. Tongue thrusting, some children thrust their tongue forward, pressing it against the lips with a force that can result in teeth malocclusions such as ‘open bite’ or teeth protrusion (overjet). While parents can not do much to prevent an orthodontic problem caused by hereditary factors, they can help their kids to avoid the need for braces, by maintaining good oral hygiene and avoiding bad oral habits that could cause teeth malocclusion problems. Modern orthodontics are usually able to treat most teeth malocclusions successfully, but prevention can help the family to avoid the large cost of orthodontic treatment and the child will not have to wear dental braces and feel uncomfortable.

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