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All Journal e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Abdimas Universal Jurnal Karinov MDJ (Makassar Dental Journal) Majalah Biomorfologi (Biomorphology Journal) Denta: Jurnal Kedokteran Gigi Odonto dental journal Jurnal Kedokteran Meditek
Yani Corvianindya Rahayu
Departement Of Oral Biology Faculty Of Dentistry University Of Jember
Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Public Health Social Sciences

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PERAN AGEN REMINERALISASI PADA LESI KARIES DINI Rahayu, Yani Corvianindya
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 10, No 1 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Remineralization is a natural repair process for caries lesions. It is now well-accepted that the primary modes of action of fluoride are enhancement of remineralization, inhibition of demineralization, and inhibition of plaque bacteria, with remineralization being the most important. This study to aimed to understanding the role of remineralization methods to alter mineral balance on management of non-invasive dental caries. Calcium and phosphate delivery can be enhanced to improve remineralization, especially in persons with reduced salivary function. There is a great need for improved and novel remineralization methods to alter the caries balance for the better, especially in individuals with a high cariogenic bacterial challenge. There was also influence of fluoride and carbonate on the remineralization process. Dentinal tubules were occluded by apatite crystallites is a feature also shared by transparent dentin beneath caries lesions and age-induced transparent dentin. It is based on unstabilized amorphous calcium phosphate (ACP), where a calcium salt and a phosphate salt are delivered intra-orally or delivered in a product with a low water activity. As the salts mix with saliva, they dissolve, releasing calcium and phosphate ions. The mixing of calcium ions with phosphate ions to produce an ion activity product for amorphous calcium phosphate that exceeds its solubility product results in the immediate precipitation of ACP or, in the presence of fluoride ions, amorphous calcium fluoride phosphate (ACFP). In the intra-oral en vironment, these phases (ACP and ACFP) are potentially very unstable and may rapidly transform into a more thermodynamically stable, crystalline phase (e.g., hydroxyapatite and fluorhydroxyapatite). However, before phase transformation, calcium and phosphate ions should be transiently bioavailable to promote enamel subsurface lesion remineralization.
Potential Of Mangosteen Xanthones As Anti-Oral Cancer Agents By Induction Of Apoptosis Corvianindya Rahayu, Yani
Insisiva Dental Journal Vol 1, No 2 (2012)
Publisher : Insisiva Dental Journal

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Abstract

The pericarp of mangosteen (Garcinia mangostana L.) is rich in various xanthones that are known to possess unique biological activities. The aim of this study was to determine of antiproliferative and cytotoxic activities of mangosteen xanthones. The researchers found that all tested xanthones inhibited the growth of the cancer cells. They observed cytotoxic properties against three human cancer cell lines, epidermoid carcinoma of the mouth, breast cancer, and small-cell lung cancer. The specific xanthones include alpha-mangostins, showed that mangosteen xanthones not only inhibit the proliferation of target cells but also induce their death by apoptosis that involves the activation of the caspase cascade. To establish a more precise mechanism of action, a cell free biochemical kinase assay against multiple cyclins/CDKs involved in cell cycle progression; the most significant inhibition in the cell free based assays was CDK4, a critical component of the G1 phase.Through molecular modeling α-mangostin against the ATP binding pocket of CDK4, and propose three possible orientations that may result in CDK4 inhibition. Histopathological evaluation and biochemical analysis of tumors that received mangosteen xanthones indicate the induction of apoptosis in tumors, which resulted in the repression of their growth and the reduction of their sizes. The study concluded that mangosteen xanthones potentially as an agent for cancer prevention and the combination therapy with anti-cancer drugs.
Analisis Peningkatan Remineralisasi Enamel Gigi setelah Direndam dalam Susu Kedelai Murni (Glycine max (L.) Merill) Menggunakan Scanning Electron Microscope (SEM) (The Analysis of Enamel Remineralization Increase in Pure Soy Milk (Glycine max (L.) Merill) Vievien - Widyaningtyas; Yani Corvianindya Rahayu; Izzata - Barid
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Pure soy milk has a high mineral content, they are calcium and phosphor. Both minerals are important mineral in enamel remineralization process. Remineralization is the return process of mineral teeth that has detached to back return be hidroxyapatite cristal enamel. This research was aimed to analyze the enamel remineralization increase after being immersed in pure soy milk (Glycine max (L.) Merill). The type of this research is experimental laboratories with the post test control group design. The sampel of this research was first maxillary premolar which caries-free. The sample was divided into two groups (control and  pure soy milk treatment) and each group had four samples. The sample immersion was incubated in 14 days by incubator in 37°C, control group was immersed in artificial saliva and the treatment group was immersed in pure soy milk. The analysis of enamel remineralization used Scanning Electron Microscope with remineralization indicator was the depth of enamel microporocity. The result of this research showed that the enamel tooth samples that was immersed in pure soy milk had less microporocity depth than the sample that was immersed in artificial saliva, with significance level 0.000 (p<0.005). The conclusion of this research was pure soy milk can increase enamel remineralization. Keywords: calcium, enamel microporocity, phosphor, pure soy milk, remineralization, SEM
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Kamboja Putih (Plumeria acuminata) Terhadap Pertumbuhan Streptococcus mutans (Antibacterial Activity Of Etanol Extract Of White Frangipani leaf (Plumeria acuminata) Against The Growth Of Streptococcus mutan Affian Hudatama Putra; Yani Corvianindya Rahayu
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Background : Most of caries are caused by Streptococcus mutans. Etanol extract of white frangipani leaf are supposed to inhibit the growth of Streptococcus mutans. This extract contains antibacterial compound such us flavonoid, saponin, tannin, and alkaloid. Purpose : This study was to determine the antibacterial activity of etanol extract of white frangipani leaf in variant concentration on growth of Streptocossus mutans. Method : This study was used well diffusion method with 6 treatment groups. Each petridish were filled BHI-A and inoculated by S. mutans followed by making 6 wells using the borer (diameter 5 mm) and filled 20 µL of white frangipani leaf extract 50%, 25%, 12,5%, 6,25%, povidone iodine as positive control, and aquadest sterile as negative control into the well. Each petridish were incubated at 37ºC for 24 hours. The inhibitory zones were measured by using digital calliper. Results: The result showed that there were inhibitory zones in positive control, extract 50%, and 25% treatment groups and there is no inhibitory zones in negative control, extract 12,5%, and 6,25%. Conclusion: Etanol extract of White frangipani leaf has antibacterial activity against the growth of Streptococcus mutans with minimum inhibitory concentration of 25% . Keywords : Antibacterial activity, Streptococcus mutans, Etanol extract of white frangipani leaf.
EFEKTIVITAS EKSTRAK BUNGA KAMBOJA PUTIH (Plumeria alba. L) SEBAGAI DENTURE CLEANSER TERHADAP PERTUMBUHAN Candida albicans PADA BAHAN BASIS GIGI TIRUAN NILON TERMOPLASTIK (Valplast) Effectiveness Of Cambodia White Flower Extract (Plumeria alba L.) As Dent Fitriana Wadianur; Lusi Hidayati; Yani Corvianindya Rahayu
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.7148

Abstract

Background: Nylon thermoplastic (Valplast) is a flexible denture base that is used in the denture. The problem that often occurs in the use of denture namely the denture stomatitis are commonly caused by C. albicans. Denture cleanser is needed to prevent denture stomatitis by lowering the amount of C. albicans. Recently, denture cleanser from natural materials is being develope, one of them is cambodia white flower (Plumeria alba L.) extract. Cambodia white flower (Plumeria alba L.) contains bioactive compounds that are antibacterial and antifungal. Objective: To determine the effectiveness of immersion extract of cambodia white flower (Plumeria alba L.) with various concentrations as denture cleanser to amount of C. albicans in nylon thermoplastic (Valplast). Material and Methods: 25 plates nylon thermoplastic (10x10x1mm) were prepared and divided into 5 groups. The plates then contaminated with C. albicans, after that it was soaked in cambodia white flower extracts with varying concentrations for 30 minutes. The plates are subsequently placed in SDB media. Method to test the effectiveness of extract was done by looking at the SDB media turbidity with a spectrophotometer. Results and Conclusion: Cambodia white flower extract was effective in lowering the amount of C. albicans in denture base thermoplastic nylon. Cambodia white flower contained tannin, flavonoid, alkaloid and saponin which acted as antifungal that could decrease the amount of C. albicans. Keywords: Antifungal, Candida albicans, Nylon Thermoplastic and Cambodia White Flower
Potential Of Mangosteen Xanthones As Anti-Oral Cancer Agents By Induction Of Apoptosis Yani Corvianindya Rahayu
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 1, No 2 (2012)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.v1i2.529

Abstract

The pericarp of mangosteen (Garcinia mangostana L.) is rich in various xanthones that are known to possess unique biological activities. The aim of this study was to determine of antiproliferative and cytotoxic activities of mangosteen xanthones. The researchers found that all tested xanthones inhibited the growth of the cancer cells. They observed cytotoxic properties against three human cancer cell lines, epidermoid carcinoma of the mouth, breast cancer, and small-cell lung cancer. The specific xanthones include alpha-mangostins, showed that mangosteen xanthones not only inhibit the proliferation of target cells but also induce their death by apoptosis that involves the activation of the caspase cascade. To establish a more precise mechanism of action, a cell free biochemical kinase assay against multiple cyclins/CDKs involved in cell cycle progression; the most significant inhibition in the cell free based assays was CDK4, a critical component of the G1 phase.Through molecular modeling α-mangostin against the ATP binding pocket of CDK4, and propose three possible orientations that may result in CDK4 inhibition. Histopathological evaluation and biochemical analysis of tumors that received mangosteen xanthones indicate the induction of apoptosis in tumors, which resulted in the repression of their growth and the reduction of their sizes. The study concluded that mangosteen xanthones potentially as an agent for cancer prevention and the combination therapy with anti-cancer drugs.
The role of Msx1 and Pax9 in pathogenetic mechanisms of tooth agenesis Yani Corvianindya Rahayu; dyah Setyorini
Dental Journal (Majalah Kedokteran Gigi) Vol. 42 No. 3 (2009): September 2009
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (893.215 KB) | DOI: 10.20473/j.djmkg.v42.i3.p141-146

Abstract

Background: Tooth agenesis is one of the most common developmental anomalies in human, which one or a few teeth are absent because they have never formed, may cause cosmetic or occlusal harm, while severe agenesis which are relatively rare require clinical attention to support and maintain the dental function. Molecular studies have demonstrated that tooth development is under strict genetic control. Purpose: This article want to review the genetic regulating that are responsible for tooth agenesis especially the role of Msx1 and Pax9 in pathogenetic mechanisms of tooth agenesis. Review: Tooth agenesis is a consequence of a qualitatively or quantitatively impaired function of genetic networks, which regulate tooth development. Mutations in Msx1 and Pax9 genes are dominant for tooth agenesis in humans. The Pax9 gene, which codes for a paired domain-containing transcription factor that plays an essential role in the development of mammal dentition, has been associated with selective tooth agenesis in humans and mice. Conclusion: Reduced amount of functional Msx1 or Pax9 protein in the tooth forming cells is able to cause severe and selective tooth agenesis. There are differences in the frequency of agenesis of specific teeth associated with the defects in Msx1 and defects in Pax9.
Molecular study of the dentin-pulp complex responses to caries progression Yani Corvianindya Rahayu
Dental Journal (Majalah Kedokteran Gigi) Vol. 40 No. 1 (2007): March 2007
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.872 KB) | DOI: 10.20473/j.djmkg.v40.i1.p11-15

Abstract

The dentin-pulp complex exhibits various responses to caries, including events of injury, defense, and repair. The overall responses dependent on pulp cell activity and the signaling processes, which regulate the behavior of these cells. The signals for tissue repair are thought to be mediated by dentin-bound growth factors released during caries progression. Growth factors are a key of molecules responsible for signaling a variety of cellular process following dental injury. The endogenous proteolytic enzymes (Matrix metalloproteinases, MMPs) present in dentin matrix might also participate in releasing bioactive molecule. Several members of the MMP family are found in the soft and hard tissue compartment of dentin-pulp complex. Their presumed role in many physiological process during the development and maintenance of the dentin-pulp complex, they may also contribute to the pathogenesis of dentin caries and the responses elicited by caries.
The potency of Andrographis paniculata Nees extract to increase the viability of monocytes following exposure to Porphyromonas gingivalis Yani Corvianindya Rahayu; Didin Erma Indahyani; Sheila Dian Pradipta; Anis Irmawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 4 (2019): December 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i4.p219-223

Abstract

Background: Periodontitis is a chronic infectious disease affecting the global population. In Indonesia, the prevalence of periodontal disease has reached 57.6% across all age groups. The bacterium considered as the orginator factor of periodontitis is Porphyromonas gingivalis (P. gingivalis). Herbal ingredients are currently being promoted as a form of treatment because of the minimal side effects they induce. Andrographis paniculata Nees (ApN) extract produces pharmacological effects, including ones immunomodulatory in character, rendering possible its application as a preparation for treating periodontitis. Purpose: The purpose of the study was to prove the potency of Andrographis paniculata Nees extract in increasing the viability of monocytes following exposure to P. gingivalis. Methods: The sample was divided into four groups, namely; Control negative (C-): monocytes in the medium, not exposed to P. gingivalis; Control positive (C+): monocytes in the medium, exposed to P. gingivalis; Treatment I (AP25): monocytes with 25% ApN extract, exposed to P. gingivalis; Treatment II (AP50): monocytes with 50% ApN extract, exposed with P. gingivalis. The monocytes were exposed to 100 uL P. gingivalis for 4.5 hours and stained with trypan blue. Observations were conducted using an inverted microscope at 200x magnification. The percentage of viable monocytes was calculated based on the ratio of the number of the cells which absorbed trypan blue staining to that which did not. Data was tested using a one-way ANOVA followed by an LSD test. Results: There were significant differences between the treatment groups in the number of viable monocytes (p=0.001) they contained. Monocyte viability was higher in the 25% ApN extract group than that exposed to 50% P. gingivalis. Conclusion: Andrographis paniculata Nees extract demonstrates the potency to increase monocyte viability following exposure to P. gingivalis.
Uji Sitotoksisitas Hidroksiapatit Cangkang Telur Ayam Ras (Gallus gallus) terhadap Sel Fibroblas Ligamen Periodontal Manusia Devi Komala; Muhammad Nurul Amin; Yani Corvianindya Rahayu
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 19 No 1 (2022)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v19i1.30702

Abstract

Periodontitis is an inflammation disease of the periodontal tissues surrounding the teeth, include periodontal ligament fibroblast cell. The recently researches developed tissue engineering concept to accelerate regeneration and proliferation periodontal ligament cells. One of the major components of tissue engineering is scaffold. The hydroxyapatite is biomaterial that can be used as scaffold. The egg shell has the potential biowaste to be a source of hydroxyapatite biomaterial. Before being applied as a scaffold in the medical field, cytotoxicity testing needs to be done. This study aimed to examine toxicity effect of egg shell hydroxyapatite in various concentration toward human periodontal ligament fibroblast cells. This study used human periodontal ligament fibroblast primary cells (5x103) in microplate 96 wells which divided into 7 groups, control cells, control media without cells and the treatment groups with concentration egg shell hydroxyapatite100 μg/ml, 75 μg/ml, 50 μg/ml, 25 μg/ml dan 25 μg/ml and incubated for 24 hours. Cytotoxicity test was conducted using MTT assay. Optical density values describe the viability of living cells and the readings were done using ELISA readers, subsequently the data were analyzed using One way ANOVA. The number of human periodontal ligament cells at all concentration showed that the percentage of cell life is more than 90%. Egg shell hydroxyapatite at all concentrations tested is not toxic toward human periodontal ligament fibroblas cells.
Co-Authors Affian Hudatama Putra Agung Sosiawan Agustin Wulan Suci Dharmayanti Anis Irmawati Anya Tania Larasati Atik Kurniawati Atik Kurniawati, Atik Banun Kusumawardani Budi Yuwono Devi Komala Dewi Yunita Sari Didin Erma Indahyani Dwi Merry Christmarini Robin Dwi Merry Christmarini Robin Dyah Setyorini Ernie Maduratna Setiawatie Falah, Pilar Menara Fitriana Wadianur Fitriyana, Nurul Isnaini Iin Eliana Triwahyuni Izzata Barid Kristanti, Yuli Dwi Kumala, Efa Ayu Ratnaning Luh Putu Ratna Sundari Lusi Hidayati, Lusi Mei Syafriadi Muhammad Nurul Amin Parawita Dewanti Parawita Dewanti Rahmat, Naila Azifatur Ramadan, Doaa Elsayed Retno Pudji Rahayu Rudi Joelijanto Sheila Dian Pradipta Siti Komariyah TRI HANDOYO Vievien - Widyaningtyas Wachju Subchan Yudha Nurdian Zainul Cholid