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Mutiara Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
Arjuna Subject : -
Articles 4 Documents
 1 
Search results for , issue "Vol 19, No 2: July 2019" : 4 Documents clear
Antioxidant Activity from the Combination of Ethanolic Extract of Tea Leaves (Camellia sinensis) and Soursop Leaves (Annona muricata l.) and Optimation of the Effervescent Granule Production Masitha, Fatma Sari; Febriansah, Rifki
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 19, No 2: July 2019
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.190230

Abstract

Soursop Leaves (Annona muricata L.) and Tea Leaves (Camellia sinensis) are plants that contain flavonoids which are considered to act as antioxidants and can become chemopreventive agents. This study aims to identify the potential of Soursop Leaves and Tea Leaves as chemopreventive agents. The first stage of this research was to determine the presence of flavonoids in both of ethanolic extract using TLC method. The second stage is to examine the antioxidant activity of the combination of ethanolic extract of soursop leaves and tea leaves against free radical DPPH (1,1-diphenyl-2-pikrihidrazil). Docking molecular test of acetogenin and catechin compounds at HER-2 and ER-α receptors which are biomarkers of breast cancer. Furthermore, the optimization of effervescent granule production using moist granulation method is carried out. The result shows that ethanolic extract of soursop leaves and tea leaves contains flavonoid shown with Rf value of 0.66 and 0.68, and the comparison of Rf 0.66. The combination of both ethanolic extract has very strong antioxidant activity with IC50 value 26,90 μg/mL. The result of molecular docking of acetogenin and catechin compounds at HER-2 receptors shows respective docking score of -6.3 kcal/mol and -6.7 kcal/mol while ER-α receptors shows a docking score of -6.5 kcal/mol and -7.6 kcal/mol. In addition, the most optimal effervescent granule production is formula four with physical test result such as moisture content of 1.07% with a dissolve time of 45.5 seconds and acidity of 6.18. The result shows that ethanolic extract of soursop leaf (Annona muricata L.) and Tea Leaves (Camellia sinensis) have potential activity as chemopreventive agents and can be formulated into effervescent granule production.
Life Quality of Pediatric Patient with Dengue Hemorrhagic Fever (DHF) Who Received Crystalloid and Colloid Fluid Treatment in PKU Muhammadiyah Hospital Yogyakarta Nasriyah, Chotijatun; Perwitasari, Dyah Aryani; Kurniawan, Nurcholid Umam
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 19, No 2: July 2019
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.190229

Abstract

Dengue hemorrhagic fever (DHF) in the community can have an impact of panic, death, and reduced age of hope in the family. Research on the quality of life of DHF pediatric patient who got the treatment of crystalloid and colloid fluids has never been done before. The purpose of this study was to determine the quality of life of DHF pediatric patients who received crystalloids and colloids with PedsQL instruments. The study design was a cohort with block randomization. The inclusion criteria in this study were hospitalized DHF pediatric patients aged one month -18 years from February to May 2018. The exclusion criteria were DHF patients who came with referrals from other hospitals who had received fluid therapy. Research data include the length of stay (LOS) and quality of life score with the PedsQL questionnaire. The statistical analysis was using an independent t-test and the Mann Whitney test. The length of stay for the crystalloid group is five days longer than the colloid group, which is four days. From a total of 48 subjects studied, the score for the physical function of the crystalloid fluid group 84.54 ± 9.90 was higher than the colloid group of 77.58 ± 19.30 (p = 0.125). The emotional functions in the crystalloid group obtained a score of 81.88 ± 12.14 higher than the colloid group, i.e., 79.17 ± 18.5 (p = 0.552). The social function in the crystalloid group had a score of 92.08 ± 8.84 higher than the colloid group of 86.67 ± 13.96 (p = 0.232). The school functions in the crystalloid group had a score of 50.42 ± 33.68 higher than in the colloid group of 37.92 ± 36.62 (p = 0.225). The results of this study showed that the crystalloid group had a higher quality of life score compared to the colloid group, although it was not significant. 
Long-Term Predictors of Disease Free Survival (DFS) in Ovarian Cancer Sensitive to Platinum Based Chemotherapy selvyana, Dita Ria; Kurnianda, Johan
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 19, No 2: July 2019
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.190232

Abstract

Until now, there has been progress in the treatment of ovarian cancer, but ovarian carcinoma is still a cause of high mortality. Various factors have been known to be associated with a poor prognosis, such as the absence of symptoms, lack of an effective screening tool, diagnosis of the disease that was only detected after an advanced stage, high recurrence of disease resistant to chemotherapy. There are more than 70% of cases detected in advanced stage, with long-term survival of only 15-30%; while those detected in early stages, the survival reaches 90%. The recurrence risk of IIIC stage disease is as high as 40% -50%. However, there is a small group of patients who can recover after standard therapy. There is variability in the recurrence-free period and survival, so it is difficult to predict the outcome with certainty. Ovarian cancer patients with the same characteristics can show a different prognosis, related to high molecular heterogeneity of tumor genetics. We report a rare case that is a 56-year-old woman who has experienced a 5-year free disease after complete remission after standard chemotherapy from stage IIIC ovarian cancer. The disease-free period of up to 5 years after therapy may be related to factors that can be predictors of prognosis, such as age at diagnosis, body mass index, physical performance, cancer cell biology, and the success of surgical response and chemotherapy in these patients.
Social Demography Study of Gonorrhea and Syphilis at RSUD dr. Soedono Madiun Musy, Rahajeng; Widyasari, Vita; Rosmelia, Rosmelia
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 19, No 2: July 2019
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.190227

Abstract

An understanding of the socio-demographic characteristics is the first step to conduct preventive and promotive measures to reduce the number of sexually transmitted infections. This study described the socio-demographic cha-racteristics of gonorrhea and syphilis in dr. Soedono Hospital Madiun. A descripttive study with a quantitative approach used secondary data from outpatient medical records. This research was conducted in dr. Soedono Hospital Madiun, East Java. The samples used in this study were 61 patients who had been diagnosed with gonorrhea and syphilis in the period from July 2013 - June 2016. The data consisted of 50 (82%) medical records with the diagnosis of gonorrhea and 11 (18%) medical records with a diagnosis of syphilis. Characteristics of patients/respondents are the highest age group of 21-30 years, 22 female patients (36.1%), 55 male patients (90.2%), unmarried status 33 people (54.1%), work as private employees 37 people (60.7%), pay without insurance 48 people (78.7%), and live around Madiun 52 (86.0%). The socio-demographic factors were dominant in patients with gonorrhea and syphilis in dr. Soedono Hospital period of 2013-2016 was 21-30 years old, male, unmarried, living as private sector employees, pay without insurance, and Madiun origin.

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