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Mutiara Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
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Articles 8 Documents
 1 
Search results for , issue "Vol 20, No 2 (2020): July" : 8 Documents clear
Risk Factors of Ovarian Cancer in PKU Muhammadiyah Teaching Hospital Yogyakarta Wenang, Supriyatiningsih; AN, Alfun Dhiya; Pratiwi, Witri Andi; Lelle, Ralph J.; Haier, Joerg
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 2 (2020): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200247

Abstract

Introduction: Ovarian cancer is non-communicable diseases that has a high mortality rate. In PKU Muhammadiyah Teaching Hospital Yogyakarta in 2014-2017, ovarian cancer is 5th out of all types cancers diagnosed. Most of them are asymptomatic in early stage and come to hospital at late stage. Recognize and identify the risk factors of ovarian cancer are very important to prevent the patient from morbidity and mortality. The purpose of this study was to know the relationship between low parity, infertility, age, and family history with ovarian cancer in PKU Muhammadiyah Teaching  Hospital Yogyakarta.Methods: This study was an observational analytical study with cross sectional design. The sample was medical record of women with ovarian cancer and non ovarian cancer in PKU Muhammadiyah Teaching Hospital Yogyakarta period of April 2014-September 2017 with inclusion and exclusion criteria. Data analysis used chi-square test.Result: The bivariat analysis showed that there is no relationship between low parity with ovarian cancer (p=0,790 OR=0,87; 95% CI 0,305-2,466), there is no relation between infertility with ovarian cancer (p=0,104 OR=2,48; 95% CI 0,815-7,545), and there is no relation between family history with ovarian cancer (p=0,304 OR=3,18; 95% CI 0,315-32,039). But there is a relationship between age with ovarian cancer (p=0,01 OR=0,11; 95% CI 0,022-0,510).Conclusion: There are no relations between low parity, infertility, and family history with ovarian cancer. But there is a relationship between age with ovarian cancer.
Sensitivity of Staphylococcus aureus Isolated from Nasal and Throat of Pre-Clerkship Students to Antibiotics Rahayu, Suci; Widiyanti, Dian; Arsyad, Muhammad
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 2 (2020): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200251

Abstract

Background: Cases of nosocomial infection are many caused by the bacteria of  S.aureus. Bacteria infection caused by S.aureus may result in various skin and soft tissue infections. The infection may become difficult to treat if the strain of  S.aureus responsible is the methicillin resistant strain or methicillin-resistant Staphylococcus aureus (MRSA). Currently there are two known types of MRSA: Hospital Acquired MRSA/HA-MRSA and Community Acquired MRSA/CA-MRSA. Transmission of the bacteria from one patient to another may be caused by unsterile medical equipment or from the hospital staff, especially pre-clinical students who will work in a hospital. The purpose of this study was to obtained the difference of bacteria colonisations S.aureus from nasal and throat swabs, and the sensitivity patterns of S.aureus when exposed to antibiotics (methicillin, vancomycin, imipenem, penicillin, ofloxacin, ciprofloxacin) and the prevalence of MRSA carriers and also to obtain an understanding of the characteristics of medical drug use through Islamic views. Metodes: This study used descriptive analysis method with samples taken from nasal and throat swabs applied to healthy pre-clinic student from Universitas YARSI. Statistical analysis using Mann-Whitney test in the program SPSS for windows. Results: The results bacteria colonisations S.aureus from nasal swabs was positive (23,3%), while from the throat sample was positive (10%). The results of statistical analysis (Sig. = 0.051 0.05) shows that there is no significant difference between the bacterial colonies of S.aureus originating from the nasal swabs and throat swabs of the pre-clinical students. From 60 samples a positive prevalence of (1.7%) was obtained for MRSA carriers. The result of the sensitivity test shows that the isolated sample of the bacteria S.aureus shows the highest sensitivity to the antibiotic imipenem and almost all the isolated samples show resistance to the antibiotic penicillin. Conclusion: There are more S.aureus bacteria colonies on nasal swabs compared to throat swabs. There was no significant difference between S.aureus bacteria colonization of nose and throat swabs in pre-clinical-students. The positive prevalence of MRSA carrier among pre-clinical-students of Yarsi University was (1.7%). In nasal swabs all isolates were still sensitive to the antibiotics methicillin, imipenem, ofloxacin and ciprofloxacin. But on the nasal swab there were three VISA isolates. In the throat swab, there was one MRSA isolate and one isolate that was resistant to ofloxacin. The inhibition zone of the highest sensitivity was obtained for imipenem antibiotics. Almost all isolates showed resistance to penicillin antibiotics. In Islamic medicine, drugs or antibiotics must not contain unclean and haram objects for human consumption.
Correlation between Middle Finger Length and Stature of Bataknese Students in Sumatera Utara University Iswary Halwadini; Hendra Sutysna
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 2 (2020): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200243

Abstract

Pendahuluan: Berbagai macam kejadian seperti bencana massal maupun mutilasi dapat menyebabkan anggota tubuh seseorang tidak dikenali bahkan potongan-potongan tubuhnya terpisah. Penelitian mengenai jari tangan ini penting dilakukan untuk menentukan identitas seseorang karena potongan jasad bisa ditemukan dalam bentuk potongan pendek seperti jari tangan. Tujuan: Untuk mengetahui hubungan panjang jari tengah tangan terhadap tinggi badan pada suku Batak di FK UMSU. Metode: Rancangan penelitian ini adalah analitik korelatif dengan pendekatan cross-sectional. Populasi penelitian ini adalah mahasiswa aktif, dosen tetap, dan pegawai tenaga pendidikan yang ber-suku Batak di FK UMSU yang memenuhi kriteria inklusi dan eksklusi. Teknik pengambilan sampel menggunakan metode total sampling dan berjumlah sebanyak 63 orang. Hasil: Panjang jari tengah tangan memiliki korelasi yang positif dan signifikan terhadap tinggi badan dengan koefisien korelasi yang berkisar antara 0,780 hingga 0,939 (p0,001). Persamaan regresi linear yang didapatkan menunjukkan Standard Error of the Estimate (SEE) yang berkisar antara 1,714 hingga 3,528 (p0,001). Kesimpulan: Terdapat hubungan antara panjang jari tengah tangan (digiti III manus) terhadap tinggi badan disertai koefisien korelasi yang kuat hingga sangat kuat, dengan demikian tinggi badan dapat diperkirakan dengan mengukur panjang jari tengah tangan melalui persamaan regresi linear. 
Polymorphism of CYP1A1 (Ile462Val) Gene Related to Uterine Myoma in Malays Ethnicity of South Sumatera Bella Ria Astuti; Ferry Yusrizal; Legiran Legiran
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 2 (2020): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200249

Abstract

ABSTRACTASSOCIATION BETWEEN CYP1A1 (Ile462Val) GENE POLYMORPHISM AND OCCURANTE OF UTERINE MYOMA IN MALAYS POPULATION IN SOUTH SUMATERA.Bella Ria Astuti1, Ferry Yusrizal2 dan Legiran3Biomedical Science Program, Faculty of Medicine, University Sriwijaya          Background :  Uterine myoma is a tumor in the myometrium. Uterine myoma is a disease associated with interactions between genes, hormones, growth factors, cytokines, and the environment. Myoma has never been found before menarche, whereas after menopause only about 10% of myomas still grow. In general the incidence of uterine myoma is predicted to reach 20-30% in women over 35 years. In Indonesia myoma was found 2.39% - 11.7%. Uterine myomas can cause various symptoms including menometroragia, pelvic pain, spontaneous abortion and infertility. that the growth and development of uterine myomas depends on estrogen. Cytochrome CYP450 system is a group of enzymes involved in biosynthesis of steroid hormones and metabolic activation of carcinogens. CYP1A1 is one of three members of the CYP1 family that plays a role in the metabolism of large numbers of xenobiotics. The purpose of this study is to analyze the relationship of CYP1A1 (Ile462Val) gene polymorphism with the incidence of uterine myoma in ethnic Malays in South Sumatra.          Methods : This study is an observational analytic study with a case control. This research was conducted in February 2019 in the laboratory of molecular Biology, Faculty of Medicine, Sriwijaya University. Test the statistics using the chi square test. The study sample used blood samples taken in 70 samples consisting of 35 case samples and 35 control cases. CYP1A1 (Ile462Val) gene polymorphism using the method PCR-RFLP.          Results : There is a relationship between Polymorphism between genotypes and gene alleles CYP1A1 (Ile462Val) with the incidence of uterine myoma in ethnic Malays in South Sumatra. Key words      :  Polymorphism, Gene CYP1A1 (Ile462Val), Uterine leiomyoma.Citations          :  63 (2001-2015)          
Nurse Workloads Affecting Negative on Patient Safety in Hospital (Case Study at X Hospital) Mersy Delty Kainama; Ratna Indrawati; Rina Mutiara
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 2 (2020): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200244

Abstract

Patient safety is a serious global health problem. The results showed that in developed countries one in ten patients who get injured during treatment in the hospital. Developing countries, patients who are harmed during the hospitalization process are likely to be more likely than those in developed countries. Based on the results of the 2018 evaluation at RSIA Bunda Aliyah, it shows that compliance with the risk of injury due to a patient falling in the inpatient department reaches 99% of the 100% standard, where only 1% is still a problem in preventing the risk of falling. Compliance in hand washing was 65.3% with a standard of 85%, the data also showed that patient and family satisfaction reached 70.9% with a standard of 80%. The purpose of this study was to analyze the effect of nurses' workload on the implementation of patient safety at RSIA Bunda Aliyah with service quality as an intervening variable. The method used in this research is multiple regression path analysis, which was conducted on 74 respondents. The results of this study indicate that there is a significant influence between the workload of nurses on patient safety, but service quality cannot be an intervening variable on both variables and service quality does not have a significant effect on patient safety. The results showed that the dominant influence was the workload of nurses on patient safety. Where the significant value of workload and service quality for patient safety is P = 0.044, workload on patient safety is P = 0.012, workload on service quality is P = 0.019, and service quality for patient
Angioedema in Systemic Lupus Erythematosus (SLE) in Emergency Setting: A Case Report Nur Mujaddidah Mochtar; Ricky Indra Alfaray; Detty Irawaty; Yelvi Levani
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 2 (2020): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200252

Abstract

AbstractSystemic Lupus Erythematosus (SLE) is an autoimmune disease which causes chronic inflammation with its characteristics of the formation of autoantibody that attacks nuclear antigen. This disease may damage multisystem organs, and its diagnoses are barely implemented in the Emergency Department. However, cases of angioedema on SLE patient are quite uncommon not only in Indonesia but also globally. This article report an interesting case of 20 years old woman who came to the Emergency Department of Siti Khodijah Sepanjang Hospital with a complaint of swollen lips for three days. The complaint and examination led to the diagnosis of SLE. However, because the incidence rate of angioedema on SLE is low, doctors tend to unconsider the appropriate diagnosis management and administration on this breathing problem caused by SLE.Keywords: Systemic Lupus Erythematosus, angioedema, emergency AbstrakSistemic Lupus Eritematosus (SLE) adalah penyakit autoimun yang menyebabkan peradangan kronis dengan karakteristik pembentukan autoantibodi yang menyerang antigen. Penyakit ini dapat merusak organ multisistem, dan diagnosisnya hampir tidak diterapkan di Unit Gawat Darurat. Namun, kasus angioedema pada pasien SLE sangat jarang tidak hanya di Indonesia tetapi juga secara global. Artikel ini melaporkan kasus menarik dari wanita berusia 20 tahun yang datang ke Unit Gawat Darurat Rumah Sakit Siti Khodijah Sepanjang dengan keluhan bibir bengkak selama tiga hari. Keluhan dan pemeriksaan mengarah pada diagnosis SLE. Namun, karena tingkat kejadian angioedema pada SLE rendah, dokter cenderung tidak mempertimbangkan manajemen diagnosis yang tepat dan administrasi pada masalah pernapasan yang disebabkan oleh SLE ini.Kata kunci: Sistemik Lupus Eritematosus, angioedema, gawat darurat
Determination of Stunting Risk Factors Using Spatial Interpolation Geographically Weighted Regression Kriging in Malang Henny Pramoedyo; Mudjiono Mudjiono; Adji Achmad Fernandes; Deby Ardianti; Kurniawati Septiani
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 2 (2020): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200250

Abstract

Stunting is the condition toddlers have Stunting is the condition toddlers have less length or height if compared to age. The high percentage of stunting is influenced by several factors, namely access to healthy latrines, quality drinking water, hand washing behavior with soap, coverage of posyandu access and coverage of breast milk 1-6 months, and there are indications that if an area has a high stunting percentage, then there is a possibility that the nearest area has the same condition. So, the statistic method for this research use the spatial interpolation Geographically Weighted Regression Kriging. Geographically Weighted Regression (GWR) is a weighted regression in which the weighting function is used to describe the closeness of relations between regions. The weight used is distance based weight dan weighting by area (contiguity). Ordinary kriging method calculated with semivariogram which is one function to describe and model the spatial autocorrelation between data of a variable and function as a measure of variance. The results showed that based on value GWR model with weight Fixed Gaussian Kernel better to use then the weighted GWR model Rook Contiguity. The Predicted of prevelensi stunting in the form of map based on interpolation GWR Kriging. Keywords: Stunting, GWR, and Kriging.
Antioxidant Activity Potential of Red Pomegranate (Punica granatum L.) Peel as Herbal Tea Prima Vina Resti; Sri Utami; Muhammad Arsyad
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 2 (2020): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200245

Abstract

Latar Belakang: Diet yang tidak sehat, gaya hidup yang tidak sehat, kebiasaan yang salah, polusi lingkungan, radiasi, sinar ultraviolet (UV)UV, asap rokok, dan stress merupakan sumber radikal bebas. Buah delima merah (Punica granatum L.) adalah salah satu sumber antioksidan polifenol, khususnya punikalagin (elagitanin) yang telah dibuktikan memiliki aktivitas antioksidan yang kuat, antiinflamasi, dan antikarsinogenik pada beberapa penelitian. Pada penelitian ini dilakukan pengolahan kulit delima merah menjadi teh sebagai antioksidan. Dalam Al-Quran, buah delima merah disebut beberapa kali sebagai bentuk nikmat dari Allah SWT untuk menjaga kesehatan karena manfaatnya yang banyak.Tujuan: Mengetahui aktivitas antioksidan pada seduhan teh dari kulit delima merah yang diujikan dengan metode DPPH dan mengetahui tinjaunnya menurut pandangan Islam. Metode: Kulit delima merah dikeringkan, kemudian dipotong kecil-kecil, dan digerus dengan menggunakan blender agar mendapatkan bubuk kulit delima merah. Sebagian bubuk kulit delima merah yang telah diperoleh diseduh dengan air mendidih 100° C. Sisa bubuk kulit delima merah dimaserasi dengan etanol 70% kemudian disaring dan filtratnya dipekatkan menggunakan vacuum rotary evaporator sehinga didapatkan ekstrak kental. Masing-masing sampel diukur aktivitas antioksidannya metode DPPH.Hasil: Aktivitas antioksidan dinyatakan dengan nilai IC50. Nilai IC50seduhan teh dari kulit delima merah adalah 17,59 ppm, ekstrak etanol kulit delima merah 9,58 ppm, dan asam askorbat 2,98 ppm.Kesimpulan: Seduhan teh dari kulit delima merah dan ekstrak kulit delima merah mempunyai aktivitas antioksidan yang sangat kuat. Ekstrak kulit delima merah memiliki aktivitas antioksidan yang lebih tinggi dari seduhan teh dari kulit delima merah. Penelitian ini sejalan dengan perintah Allah SWT untuk memanfaatkan seluruh kekayaan alam dalam hal kebaikan seperti menjaga kesehatan tubuh agar dapat menjalankan kewajiban keagamaan.

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