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Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
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Articles 15 Documents
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Search results for , issue "Vol 19, No 3 (2014)" : 15 Documents clear
EFEK HEPATOPROTEKTIF DAN NEFROPROTEKTIF BIJI ALPUKAT PADA TIKUS TERINDUKSI KARBON TETRAKLORIDA Phebe Hendra; Gidion Krisnadi; Ni Luh Putu Dian Perwita; Ike Kumalasari; Yuditha Anggarhani Quraisyin
Majalah Obat Tradisional Vol 19, No 3 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (491.145 KB) | DOI: 10.22146/tradmedj.8230

Abstract

The aim of this research to investigate the hepatoprotective and nephroprotecitve effects of Avocado seeds against carbon tetrachloride in rats. The rats was treated with the infusion and decoction of avocado seeds at doses 360.7, 642.1, 1142,9 mg/kg per oral once in a day for 6 days and carbon tetrachloride (2mL/kg) was given on the 7th day. Blood sample from all groups was obtained by sinus orbitalis after 24 hours application for the serum transaminase and creatinine. The increasing of serum transaminase and creatinine in carbon tetrachloride-treated rats, were significantly decreased (p<0.05) with both pretreatment of infusion and decoction of avocado seeds. Based on the research, it can be concluded that infusion and decoction of avocado seeds have a potent protective action upon carbon tetrachloride-induced hepatic and renal damage in rats.
UJI AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN SENYAWA DERIVAT PIRANON DARI MIKROBA ENDOFITIK Penicillium sp PADA TUMBUHAN KUNYIT PUTIH (Curcuma zedoaria (Berg.) Roscoe) Muharni Muharni; Fitrya Fitrya; Milanti oktaruliza; Elfita Elfita
Majalah Obat Tradisional Vol 19, No 3 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (859.669 KB) | DOI: 10.22146/tradmedj.8226

Abstract

Exploration of bioactive compound were continuously done as more new diseases appearing, from infection, cancer, and other degenerative diseases. The invention of new antibiotic compound and antioxidant compound is very needed to solve this problem. Endophytic microbes are microbes which lives in plant’s culture and produce the active secondary metabolite. In previous research, 2 compounds from endofitic microbes Penicillium sp in kunyit putih had been successfully isolated and identified as di-(2-ethylhexyl)phthalate   and  pyranon derivated as 5 (4’-ethoxy-2’-hydroxy-5’-methyl-2’,3’-dihydrofuran-3’-il (hydroxy) methyl-4-isopropyl-3-methyl-2-pyran-2-on). The goal of this research is to test antibacterial and antioxidant activitiy from derivate pyranon, which is resulting from endofitic microbes Penicillium sp in kunyit putih (Curcuma zeodaria). The method used to test the antibacterial activity is dic diffusion, using E. Coli, S. Dysenteriae, S. Aureus, and B. Subtilis. with variation of concentrations 250, 500, 1000, dan 2000μg/mL, and to test the antioxidant activity used 1,1-diphenyl-2- picrylhydrazyl ( DPPH)  method with variation of concentrations 1000, 500, 250, 125, 62.5, 31.25, 15.625, and 7.8125 µg/mL. The research         shown that  the antibacterial activity is strongest at S. aureus with 11mm-blocked-zone at 250µg/mL  concentration. Pyranon derivate also has active antioxidant manner with IC5016.05µg/mL.
PENGARUH ENKAPSULASI EKSTRAK DAUN MURBEI (Morus alba L.) TERHADAP TEKANAN DARAH ARTERI PADA TIKUS Siti Aminah; Suwaldi Suwaldi; Achmad Fudholi; Wahyono Wahyono
Majalah Obat Tradisional Vol 19, No 3 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1042.062 KB) | DOI: 10.22146/tradmedj.8372

Abstract

Rutin and quercetin are   flavonoid compounds containing in the extract of mulberry (Morus alba L.) leaves  have an influence on the cardiovascular system. This study aims to assessment of the blood pressure effect and cardiac puls after giving ethanolic extract of  mulberry leaves.  The extract was made using 95% ethanol by remaseration method. The content of rutin and quercetin in the extract were determined by using HPLC(High Performance Liquid Chromatography).  The formula of the encapsulation containing extract 0.25% w/v, chitosan 0.5mg/mL and TPP (sodium  tripolyphosphate) 1mg/mL. Characterization of extract encapsulated was done on the particle size, encapsulation efficiency and FTIR. Extract encapsulated was given to rats orally,  subsequently arterial blood pressure and heart rate were measured using Coda Non-Invasive Blood Pressure System. The results showed that mulberry extract contains rutin (0.879±0.138) mg/g  and  quercetin (4.427±0.065) mg/g. Ratio of chitosan-TPP with 0.5:1  forms particle size were   25.11-45.2 nm, encapsulation efficiency  (76.14±2.29)%. Mulberry leaves extract and encapsulated extract could decrease arterial blood pressure.  
GRANUL MINYAK SERAI DAPUR SEBAGAI LARVASIDA NYAMUK Aedes aegypti Sri Mulyani
Majalah Obat Tradisional Vol 19, No 3 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (724.752 KB) | DOI: 10.22146/tradmedj.8237

Abstract

One way to prevent the spread of Haemorrhage Dengue Fever is the use of abate. The use of abate as larvicides often complained causing an unpleasant smell, and can cause resistance. Lemongrass oil is reported to have activity as larvicides, and this study aims to make granules of lemongrass oil preparation, as well as determining the value of LC50, LC90 against larvae of Ae. aegypti instar III. The granules of lemongrass oil preparation are made with lactose filler and binder CMC-Na. Larvicidal activity test using 20 larvae, 5 concentration solution to each granules, and contacted for 24 hours. Measurement of total larvae deaths, and data were analyzed using probit analysis from Finney modification, to determine the LC50 and LC90 values. Results shown that lemongrass oil can be made as granules with lactose filler and CMC-NA binder. The LC50 and LC90 values of granules from lemongrass oil are 38,30ppm and 51,57ppm.
FORMULASI SERBUK EFFERVESCENT EKSTRAK AIR UMBI BAWANG TIWAI (Eleuterine palmifolia ) SEBAGAI MINUMAN KESEHATAN Eka Siswanto Syamsul; Supomo Supomo
Majalah Obat Tradisional Vol 19, No 3 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (826.273 KB) | DOI: 10.22146/tradmedj.8227

Abstract

Medicinal plants by the community is still in traditional form, boiling or brewed, so it requires innovation in their use more practical, comfortable consumed, and nutritious with the right dose. Eleuterine palmifolia (L) Merr  which are traditionally used for breast cancer drug, facilitating breastfeeding, and antioxidants developed in effervescent powder preparation. This study uses a randomized block design (RBD) consists of 3 groups with different formulations to mix effervescent compositions containing tartaric acid, citric acid, and sodium bicarbonate on the basis of the rules of stoichiometry, namely : Formula A (50%), Formula B (55 %), and Formula C (60 %). Tests include the physical and chemical properties of powders and hedonic test. Formula B is the best, with a moisture content (0.6%), flow-ability (11.36 g/sec), compressibility (12.5 %), solubility rate (1.52 min), and pH (5). These results meet the criteria of a good powder. Hedonic test results have shown that Formula B as the most preferred product.

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