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Majalah Obat Tradisional

TradMedJ
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Published by Universitas Gadjah Mada

ISSN : 14105918 EISSN : 24069086 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.

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Articles 8 Documents

Search results for , issue "Vol 21, No 3 (2016)" : 8 Documents clear

PENENTUAN AKTIVITAS ANTIOKSIDAN DARI DAUN BUAS-BUAS (Premna serratifolia L.) MENGGUNAKAN METODE DPPH (2,2-diphenyl-1-picrylhydrazyl) Isnindar Isnindar; Subagus Wahyuono; Sitarina Widyarini; Yuswanto Yuswanto
Majalah Obat Tradisional Vol 21, No 3 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Antioxidant is a substance that in small concentrations can significantly inhibit or prevent oxidation on the substrate. Buas-buas (Premna serratifolia L.) is one of the plants that have antioxidant effect. The antioxidant activities of the wasbenzen and ethanol extracts of buas-buas leaves were determined by DPPH method using spectrophotometer UV-Vis. Data resulted from the analysis of antioxidant activity (IC50) is 532.24 μg/mL of wasbenzen extract, 24.40 μg/mL of ethanol extract, and 1.83 μg/mL of vitamin C.

AKTIVITAS ANTIOSTEOPOROSIS EKSTRAK ETANOL 96 % DAUN Abelmoschus manihot L. MEDIK SECARA IN VITRO MENGGUNAKAN SEL PREOSTEOBLAS MC3T3-E1 Agnis Pondinekaria Aditama; Mangestuti Agil; Hening Laswati
Majalah Obat Tradisional Vol 21, No 3 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue. Estrogen deficiency causes loss of bone mineral density which causes osteoporosis. Phytoestrogen is a potential alternative of estrogen that can be used as Hormone Replacement Therapy on osteoporosis with minimum side effects. Many edible plants contain phytoestrogens that are believed to promote bone health. Abelmoschus manihot (L.) Medik has been known as a plant that is empirically used in the traditional medicine and has potency to prevent osteoporosis. The aim of this research is to determine whether the Abelmoschus manihot (L.) Medik leaves have the potential to increase bone formation in an in vitro assays using preosteoblast cell line MC3T3-E1. The results showed an increasing activity of Alkaline phosphatase using confocal laser scanning microscopy technique.

KOMBINASI EKSTRAK KULIT MANGGIS DENGAN EKSTRAK KELOPAK BUNGA DAN EKSTRAK SARANG SEMUT SEBAGAI PENURUN KADAR KOLESTEROL DAN TRIGLISERIDA PADA TIKUS PUTIH JANTAN Anjar Mahardian Kusuma; Erza Genatrika; Rossy Faizah Nur Utami; Trisna Rohmiyati; Susanti Susanti
Majalah Obat Tradisional Vol 21, No 3 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Hypercholesterolemia is a disease associated with high levels of cholesterol and LDL levels in the blood. Utilization of the commercial drugs can be given; however apart from the expensive price, adverse side effects might occur. It makes people choose alternative medication with herbal medicine through the use of natural materials. This study aimed to determine the effect of the combination of mangosteen peel extract-extract of roselle calyx and mangosteen peel extract-extract the ant nest plant as lowering cholesterol and triglyceride levels in male rats. The method used in this study was a laboratory experimental method using device posttest only control group design (simple experimental design). This study used 25 male rats of Wistar strain, divided into 5 groups; Group I: group without treatment, group II: control group solvent (NaCMC 1%), group III: positive control group (Simvastatin), Group IV: combination group mangosteen peel extract (200 mg / kg) - extract of roselle calyx (250 mg / kg), group V: group combination of mangosteen peel extract 200 mg / kg) - extract anthill (270 mg / kg). Induction of cholesterol in rats using quail egg yolk (10 ml / kg). The results showed that there was no significant difference in cholesterol and triglycerides between the combination of both extracts of mangosteen peel with a positive control (p<0,05).

KAPASITAS ANTIOKSIDAN DAN ANTIBAKTERI LOLOH SEMBUNG (Blumea balsamifera) BERDASARKAN METODE EKSTRAKSI IGA. Wita Kusumawati; IBA. Yogeswara
Majalah Obat Tradisional Vol 21, No 3 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Loloh sembung (Blumea balsamifera) is a traditional herbal drink which of the extraction methods can be done by boiling and brewing. Loloh sembung was prepared from fresh and dried leaves. Loloh sembung extracted by different methods producing phenolic content, tannin content, antioxidant capacity, are different. Dried leaves were extracted by brewing have high content of total phenolic was at 13.15±0.11 mg GAE/g sample, while dried leaves were extracted by boiling have high content of tannin and antioxidant capacity were at 1.65±0.01 mg TAE/g sample and 5.55±0.01 mg GAE/g sample respectiveliy. Both of fresh and dried leaves were extracted by boiling and brewing were not show inhibition against Escherichia coli and Staphylococcus aureus bacteria.

AKTIVITAS LARVASIDA EKSTRAK ETANOL, FRAKSI N-HEKSAN, ETIL ASETAT, DAN METANOL DAUN SEMBUKAN TERHADAP LARVA NYAMUK Aedes aegypti DAN ANOPHELES INSTAR III Rollando Rollando; Maywan Hariono
Majalah Obat Tradisional Vol 21, No 3 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Stinkvine (Paederia foetida L.) is known as a plant that has many properties that are empirically used in traditional medicine. However, information of utilization of Stinkvine leaf outside as a traditional medicine has not been discovered yet. This research aims to determine the potential larvicidal extracts and fractions of stinkvine leaf. The ethanol extract of stinkvine leaf fractionated using column chromatography with n-hexane, ethyl acetate, and methanol. Larvicidal activity test against Aedes aegypti and Anopheles III instar was done using 25 larvae for each treatment extracts and fractions in 5 series of concentration, and left exposed for 24 hours. Total mortality of larvae is calculated and analyzed using a modified Finney probit to determine the LC50 and LC90 values. The results showed larvicidal activity on larvae of Aedes aegypti mosquitoes with LC50 and LC90 value of n-hexane, ethyl acetate, and methanol fraction respectively 67,89 ; 10,92 ; 30,98 µg/mL and 114,11 ; 18,80 ; 54, 12 µg/mL. Larvicidal activity on larvae of Anopheles mosquitoes with LC50 and LC90 value of n-hexane, ethyl acetate, and methanol fraction respectively 50,76 ; 14,96 ; 60,82 µg/mL and 87,23 ; 25,65 ; 90,92 µg/mL. Ethyl acetate fraction of ethanol extract of stinkvine leaf (Paederia foetida L.) shows to have highest larvicidal activity against the mosquito larvae of Aedes aegypti and Anopheles. The results of GC-MS analysis of the ethyl acetate fraction showed there are 15 compounds, a constituent component consisting of lupeol (20,32 %), gamma-sitosterol (12,22 %), cyclohexanecarboxamide (11,82 %), campesterol (11,45 %), 3-butenol, 4- (2,6,6-trimethyl-1-sikloheksenil) (7,98 %), siklolanos-24-en-3-ol (7,87%), and there are 9 other components with a percentage amount of 0,18 to 5,86 %.

UJI ANTIHIPERTENSI KOMBINASI EKSTRAK HERBA SELEDRI, DAUN KUMIS KUCING DAN BUAH MENGKUDU PADA TIKUS GALUR SPRAGUE DAWLEY NORMAL DAN HIPERTENSI Rumiyati Rumiyati; Arif Rahman Hakim; Arini Dwi Winarti; Dea Nurma Septia
Majalah Obat Tradisional Vol 21, No 3 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Seledri (Apium graviolens L.), kumis kucing (Orthosiphon stamineus Benth.), and mengkudu (Morinda citrifolia L.) have been used to treat hypertension diseases in Indonesia. Previous researches have been done to determine antihypertensive activity of extracts of the sample in single extract. However, there are limited studies on effect of the extracts on a combination of three samples. This research was therefore aimed to study the effect of the combination on lowering blood tension on normotensive and spontaneously hypertensive rats. Non Invasive Blood Pressure technique equipped with Non Invasive Blood Pressure System (CODA®) was used to measure effect of extracts on antihypertensive activity. Sprague Dawley rats were divided into 2 groups (normotensive and spontaneously hypertensive rats using fenilefrin) and treated with combination extracts in doses of 20.25 and 40.5 mg/kg BW of rats. The result showed that the combined extracts can decrease in blood pressure of both two of the groups. Normotensive group of the rats treated at doses of 20,25 and 40,5 mg/kg BW of rats had lower persentase of systolic blood pressure as much as 7,1 ± 1,8 % and 10,2 ± 2,6 %, whilst percentage of diastolic blood pressure had lower percentage as much as 13,8 ± 3,2 % and 12,3 ± 3,1 %, respectively. Furthermore, spontaneously hypertensive rats treated at doses of 20,25 and 40,5 mg/kg BW of rats also showed lower systolic blood pressure as much as 16,10 ± 0,90 % and 15,84 ± 1,55 % and diastolic blood pressure as much as 19,48 ± 1,03 % and 17,77 ± 1,34 %. These results suggest that administration of combination of three extracts exhibited antihypertensive in both of the rat groups.

PERBANDINGAN INHIBISI BERBAGAI EKSTRAK TUMBUHAN DAN VITAMIN C PADA FOTODEGRADASI TIROSIN YANG DIINDUKSI KETOPROFEN DAN KANDUNGAN FENOLIK TOTALNYA Tatang Irianti; Nanang Fakhrudin; Efendi Efendi; Sigit Hartomo; Siluh Putu Yuni Astuti; Ratih Anggar Kusumaningtyas; Argandita Meiftasari
Majalah Obat Tradisional Vol 21, No 3 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Antioxidant is known to inhibit free radical reaction. Tyrosine photodegradation can be caused by radical reaction. Nowadays, plant with antioxidants are widely used to inhibit free radical reaction. Study of inhibition of photodegradation used four groups. Those groups are: P1 consisted of 2mL tyrosine 0,05 %; P2 consisted of 2 mL tyrosine 0,05 %, and 600 μL Rhetoflam (topical ketoprofen) 1 %; P3 consisted of 2 mL tyrosine 0,05 %, 60μL Rhetoflam 1 %, and 100 μL tea leaf water ekstract 0,15 %; P4 consisted of 2 mL tyrosine 0,05 %, 600 μL Rhetoflam 1 %, and 100 μL mahkota dewa fruit water ekstract 0,15 %; P5 consisted of 2 mL tyrosine 0,05 %, 600 μL Rhetoflam 1 %, and 100 μL finger root etanolic ekstract 0,15 %; P6 consisted of 2 mL tyrosine 0,05 %, 600 μL Rhetoflam 1 %, and 100 μL vitamin C 0,15 %; each group is added with aquadest up to 5,0 mL and illuminated with mercuric lamp for four hours. Level of remaining tyrosine was measured with visible spectrophotometric method. We used ANOVA to analyse the data with convidence level of 0,95 and then continued by Tukey (HSD). Follin-Ciocalteu method with galic acid calibration curve was used to determine total phenolic level. The level of total phenolic of tea leaf aquoeus extract, mahkota dewa fruit aquoeus extract, fingerroot ethanolic extract were 29.64±0.86 %; 8.29 % 0.27 %; and 7.11 %, 0.15 %, respectively. Our investigation also found gallic acid equivalent (GAE) with the inhibition activity of 4.03; 1.58; and 2.09 and they were bigger than Vitamin C with the same concentration of 0.15 %.

EFEK IMUNOMODULATOR DARI KOMBINASI EKSTRAK ETANOL HERBA SAMBILOTO (Andrographis paniculata (Burm. f.) Nees) DAN RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb.) TERHADAP PROLIFERASI SEL LIMFOSIT MENCIT Balb/c SECARA IN VITRO Damriati Azimah; Yuswanto Yuswanto; Wahyono Wahyono
Majalah Obat Tradisional Vol 21, No 3 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Our susceptibility to various infectious diseases can be avoided by increasing the specific immune responses either by the proliferation of lymphocytes. Immunomodulator effect of Andrographis paniculata (Burm.f.) Nees) and Curcuma xanthorrhiza Roxb have been well evaluated. Empirically, the East Borneo’s tribe combined both herbs to treat jaundice disease. However, scientific evidence is still needed in their use as a drug candidate. This study explores further effect of the immunomodulator from 5 ethanol extract groups. Quantitative analysis was also completed using a densitometer to obtain andrographolide and curcumin levels of ethanol extract. Lymphocyte proliferation was tested by using MTT colorimetric method, the results was read by an ELISA reader and statistically analyzed with One-Way ANOVA test with 95 % of confidence level. The maceration yield of sambiloto ethanol extract (EES) and temulawak ethanol extract (EET) were respectively 5.78 % w / w and 3.92 % w / w. The results of quantitative analysis in 28.6 mg EES contained 11.43 % andrographolide and from the 251.8 mg EET contained 28.79 % curcumin. From the MTT test, all treatment groups were significantly different from the control group. Based on the OD values, the best combination to increase lymphocyte cell proliferation ETS was a group contained 56.25 mg of temulawak and 18.75 mg of sambiloto in 1 ml of solvent. Nonetheless, the value was not higher than the ability of ET in increasing cell proliferation.

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Pudyastuti Kusumaningrum

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mot.farmasi@ugm.ac.idm

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Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA