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Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
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Articles 12 Documents
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Search results for , issue "Vol 30, No 1 (2025)" : 12 Documents clear
Cucumis melo L. ‘Gama Melon Parfum’ Extract: Volatile Compound Profile, Optimization, Preparation and Perfume Radar Gunawan, Indra; Daryono, Budi Setiadi; Noviana, Eka; Sulaiman, Teuku Nanda Saifullah
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95553

Abstract

Perfume notes are a sophisticated blend of essential or fragrance oils that give perfumes a distinct scent. Melon notes are highly favored aromatic elements in perfumes. Melon (Cucumis melo L. ‘Gama Melon Parfum’), known by the local name Gama Melon Parfum (GMP), is a melon breed that has unique phenotypic characteristics: bitter taste, batik-like pattern, and fragrant aroma. GMP has a fresh and fruity melon character, typically used as a top note in the perfume pyramid concept. Our study aimed to develop a perfume derived from GMP volatile extract as a fragrance ingredient. The process included collection, identification, extraction, physicochemical characterization, volatile compound analysis, perfume optimization, preparation, and perfumery radar. GMP can serve as the top note in a perfume formulation. From the D-optimal mixture design, an ideal perfume formula could be created from a mixture of 0.95 mL GMP, 0.55 mL rose, and 0.50 mL vanilla. The composition was found to produce a perfume that met sensory standards: a transparent and uniform liquid without impurities. It also had a unique aromatic scent with a relative density of 0.8102 g/cm3 which fell within the specified range of 0.7000-1.200 g/cm3, viscosity of 0.7931 cps within the required range of 0.7830-1.4030 cps, and a hedonic level of 9.72 cm out of a maximum of 15.00 cm. The perfume radar showed fruity-floral-musk characteristics. Results from this research indicate that enhancing GMP as a fragrance ingredient enables the creation of an optimal perfume that meets the required standards, is well-received, and demonstrates an inclination toward femininity.
Antibacterial and Antibiofilm of Cinnamomum burmanii Bark Oil (CbBO) against Klebsiella pneumoniae ATCC 700603: In Vitro Study Inayati, Inayati; Hartono, Hartono; Indarto, Dono; Suryawati, Betty
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.97396

Abstract

Many cases of multidrug-resistant (MDR) bacterial infections are caused by Klebsiella pneumoniae (K.pn), an infectious disease bacterium. Hospital inpatients can be exposed to this occurrence; MDR has transformed 26.96% of infections at Klaten Hospital into highly infectious biofilms, while 54.49% of infections have produced biofilms. Approximately 80% of bacterial illnesses resistant to antibiotics are caused by biofilm-forming bacteria. To reduce biofilm formation, antibacterial compounds, one of which comes from natural products, are necessary. Renowned for its essential oil, Cinnamomum burmanii Bark Oil (CbBO) has been utilized extensively in herbal medicine to combat pathogenic bacteria such as Pseudomonas aeruginosa, Candida albicans, Enterobacter spp., and Staphylococcus aureus. This study aims to evaluate CbBO’s antibacterial capabilities using the microdilution method and its antibiofilm properties against K. pneumoniae ATCC 700603 using the MTT test. A CbBO minimum bactericidal concentration (MBC) of 0.25 mg/mL and a minimum inhibitory concentration (MIC) of 0.125 mg/mL were employed for antibacterial activity. The antibiofilm potential was determined by measuring the minimum biofilm eradication concentration (MBEC) at 0.5 mg/mL and the minimum biofilm inhibition concentration (MBIC) at 0.25 mg/mL. In conclusion, CbBO demonstrated antimicrobial and antibiofilm qualities. However,                   a greater concentration of CbBO was required for antibiofilm formation than for antibacterial purposes.

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