Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan
Jambi Medical Journal is a Journal for Medical And Health Issues, in Scope: Medical Education, Farmakology, Mikrobiology, PUblic Health, Clinical Patology, Medical Nutrition, Clinical Medicine, Pediatric, Immunology, Patology Anatomi, Orthopedy, Obstetri and Gynekology, Internal Medicine, Endocrine and Metabolic, Genetics & Molecular Biology.
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<![CDATA[SKRINING THALASSEMIA PADA SUKU ANAK DALAM DI PROVINSI JAMBI ]]>
<![CDATA[Sotianingsih, Sotianingsih]]>;
<![CDATA[AS, Charles]]>;
<![CDATA[M, Ita]]>
<![CDATA[ JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 6 No. 2 (2018): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan ]]>
Publisher : <![CDATA[FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI ]]>
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DOI: 10.22437/jmj.v6i2.5946
<![CDATA[Background: thalassemia mutations are very diverse and can be ethnic-specific. Prevention is done through screening of carrier traits, counseling and prenatal diagnosis; which will be optimal when accompanied by carrier frequency data and spectral data type of mutation Purpose of research: to determine the frequency of carrier of thalassemia character of suku anak dalam in Jambi Province Methods of research: descriptive, as many as 35 respondents of suku anak dalam in of Sei Ulak village. Performed the making of blood smear and venous blood sampling. Blood smear were given Wright-Giemsa staining. A complete blood examination was performed with a Sysmex Xs-800i hematology analyzer. Hb analysis using Capillary electrophoresis model Minicap Flex-piercing from Sebia. DNA analysis was performed by SEA, Fil and Thai Delight, Delete 3.7 and 4.2kb, and HbCS and Hb Adana point mutations Results: Haemoglobin <normal at age 5 - <12 years 2.86% mild and moderate 2.86%, age> 15 years, women 2.86% mild, age> 15 years, men 5.71% mild, peripheral blood 8.57% found microcytic hypochromic cells 5.71% of the mixed HbA averages 97.1, 97.0 (33.3%) while HbA1 2.8, 3.0 (33.3%). HbF is present in 1 sample. DNA analysis not found mutation Conclusions and suggestions: Conclusions: In Suku Anak Dalam we found mild anemia 11.42% and moderate anemia 2.86%. Smear of blood found 8.57% hypochrome microscopic cells and 5.71% mixture. HbA 97.0 (33.3%), HbA2 highest 3.0 (33.3%). HbF 1 (2.86%). There is 1 (2.86.7%) suspect carrier of thalassemia a and there is 1 (2.8%) suspect variant Hb. This result excludes the possibility of carrying thalassemia trait a mild 3 respondents (8.57%). Suggestion: Advanced molecular examination of DNA sequencing Keywords: Suku Anak Dalam, Haemoglobin, Hb Analysis, Thalassemia a, Thalassemia]]>
<![CDATA[SECUNDUM ATRIAL SEPTAL DEFECTS COMPLICATED WITH SEVERE PULMONARY HYPERTENSION IN PREGNANCY: MANAGEMENT AND OUTCOME ]]>
<![CDATA[ JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 6 No. 2 (2018): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan ]]>
Publisher : <![CDATA[FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI ]]>
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DOI: 10.22437/jmj.v6i2.5948
<![CDATA[Background: Atrial septal defects (ASD) are the third most common type of congenital heart disease, that allows shunting of blood between the systemic and the pulmonary circulations. ASD complicated with severe pulmonary hypertension (PH) often occurs in median age, and pregnancy should be prevented since this will contributed to both high maternal mortality, and complication in pregnancy. Objective: To discuss management and outcomes of secundum atrial septal defects complicated with severe pulmonary hypertension in pregnancy. Case: A 21-year-old woman, G2P1AO, referred to Maternal Fetal Medicine Division on March 30, 2017 with 31 weeks of pregnancy and shortness of breathing. Further investigation revealed that she had history of atrial septal defects that was diagnosed 2 years before admission. Ultrasound examination was performed with conclusion 31 weeks intrauterine pregnancy with intrauterine growth restriction (IUGR). Echocardiography result indicated large secundum ASD, severe PH, severe tricuspid regurgitation (TR), severe pulmonary regurgitation (PR), and ejection fraction (EF) 43%. After closed discussion with the patient and family, the team decided to perform C-section after lung maturation. On April 10, 2017 patient underwent C-section under epidural analgesia with the pregnancy results female baby, 1170 g, APGAR Score 7/8. The patient treated in ICCU for 3 days and went home after 7 days of treatment. Conclusion: Large secundum ASD complicated with severe PH in pregnancy should be carefully managed. Pregnancy termination should be considered, particulary if the disease threatened the mother and caused IUGR in pregnancy. Keywords: Pregnancy, ASD, PH, management.]]>
<![CDATA[PERANAN CYCLIN D1 DAN VEGF TERHADAP RESPONS RADIOTERAPI PADA KARSINOMA NASOFARING TIDAK BERDIFERENSIASI STADIUM LANJUT ]]>
<![CDATA[ JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 6 No. 2 (2018): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan ]]>
Publisher : <![CDATA[FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI ]]>
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DOI: 10.22437/jmj.v6i2.5949
<![CDATA[Background: Nasopharyngeal carcinoma has a high incidence and mortality rate in Southeast Asia and Indonesia. Radioresistance is a major obstacle to successful treatment of nasopharyngeal carcinoma. DNA repair in the cell cycle and angiogenesis factors affects the response of tumor cells to radiotherapy. Cyclin D1 that functions in the cell cycle process and VEGF as an angiogenesis factor are considered to play a role in the occurrence of radioresistance. The objective of this study is to find the association between immunoexpression of Cyclin D1 and VEGF with radiotherapy response in undifferentiated nasopharyngeal carcinoma. Methods: This study used a retrospective case control analysis design, secondary data from medical records of patients diagnosed as undifferentiated nasopharyngeal carcinoma who received complete radiotherapy at the Radiation Oncology Department Dr Hasan Sadikin Bandung were taken. There were 44 samples divided into radiosensitive (22 samples) and radioresistant (22 samples) groups. Immunohistochemical examination of Cyclin D1 and VEGF was performed on paraffin blocks of patients' nasopharyngeal biopsy. Data analysis using Chi-Square test with p ≤0.05 and OR 95% CI. Results: Cyclin D1 expressed strongly in 86.4% of the radioresistant group and 59.1% in the radiosensitive group (p<0.05) and the OR 4,385 (0.993-19.356), VEGF was strongly expressed in 77.3% of the radioresistant group and 54.5% in the radiosensitive group (p>0.05). Conclusion: There were significant association between Cyclin D1 with radiotherapy response in undifferentiated nasopharyngeal carcinoma. The stronger immunoexpression of Cyclin D1, the higher likelihood of radioresistancy. VEGF immunoexpression showed no significant association with radiotherapy response. Key words: cyclin d1, nasopharyngeal carcinoma,radiotherapy, VEGF]]>
<![CDATA[HUBUNGAN KOMPOSISI SARAPAN DENGAN KADAR GULA DARAH DAN FUNGSI KOGNITIF PADA MAHASISWA KEDOKTERAN ]]>
<![CDATA[ JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 6 No. 2 (2018): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan ]]>
Publisher : <![CDATA[FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI ]]>
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DOI: 10.22437/jmj.v6i2.5951
<![CDATA[Background: Breakfast is the first meal in the early days and is mentioned as the most important food in a day. Breakfast aims to meet nutritional needs in the morning, as part of a balanced and beneficial nutritional fulfillment in helping prevent hypoglycemia, stabilizing blood glucose levels, and preventing dehydration after fasting throughout the night. Some studies suggest that breakfast habits can affect cognitive function, including concentration, learning performance, and memory. Method: The research method is cross sectional analytic with sampling is done by consecutive sampling method, each subject that meets the research criteria is included as research subject until the required amount is met. Interviews, anthropometric examination, blood glucose examination and cognitive function assessment were performed on the respondents. Result: Nutritional status based on body mass index (BMI) of study subjects was 22.07 ± 4.11, 60% of subjects included in normal nutritional status category. While the breakfast energy intake in this study obtained 361.57 ± 10.8 kcal which sufficient 15-20% of total calorie intake. In this study there was no relationship between breakfast composition with blood glucose level (p> 0,05) and cognitive function (p> 0,05) Conclusion: In this study there was no significant relationship between breakfast composition with glucose level and cognitive function in medical students.]]>
<![CDATA[PERBEDAAN IMUNOEKSPRESI CD10 DAN MMP9 ANTARA HIPERPLASIA ENDOMETRIUM TIPE ATIPIK DAN KARSINOMA ENDOMETRIOID YANG BERDIFERENSIASI BAIK ]]>
<![CDATA[ JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 6 No. 2 (2018): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan ]]>
Publisher : <![CDATA[FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI ]]>
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DOI: 10.22437/jmj.v6i2.5952
<![CDATA[Background: Endometrial hyperplasia is one of the malignancy triggers for endometrium. Based on histopathologic features, it is divided into two types: atypical and non-atypical. Endometrial carcinoma is one of the gynecological malignancies, ranked 5th the world for its malignancy. Endometrial carcinoma is divided into two types, type I (endometrioid), and type II (non endometrioid). In histopathology, particularly in the sample of tissue curettage process, It is difficult to distinguish between endometrial hyperplasia atypical and well-differentiated endometrioid carcinoma. CD10 plays a role for homeostasis in extracellular matrix (ECM). If there is regulation disruption, it can lead to carcinogenesis. Whilst, MMP9 plays its role in the occurrence of invasion and metastasis. The aim of this study is to investigate the immunoexpression differences of CD10 and MMP9 in atypical endometrial hyperplasia and well-differentiated endometrioid carcinoma. So, this study can be used to determine a more accurate diagnosis especially on the tissue curettage sample. Methods: This study is an observational study by using cross sectional design. Total sample was 52 cases from hysterectomy which are consist of 26 cases atypical endometrial hyperplasia and 26 cases well-differentiated endometrioid carcinoma. Those samples and cases were obtained from the Department of Anatomical Pathology in three hospitals in Bandung: Hasan Sadikin, Advent and Santosa. Therefore, the whole samples were marked by immunohistochemical CD10 and MMP9. Results: The results of this study found a statistically, significant differences between immunoexpression of CD10 and MMP9 with atypic endometrial hyperplasia and well-differentiated endometrioid carcinomas. The p values for CD10 and MMP9 are 0.003 and 0.008, respectively. Atypical endometrial hyperplasia and well-differentiated endometrioid carcinomas are significantly influenced by CD10 and MMP9, CD10 immunoexpression is the most influential variable. Conclusion: Based on the results of this study it can be concluded that Immunoxpression of CD10 and MMP9 can be used as an immunohistochemical marker to differentiate atypical endometrial hyperplasia from well-differentiated endometrioid carcinoma, particularly on tissue curettage sample. Keywords: CD10, MMP9, endometrial hyperplasia atypic type, well-differentiated endometrioid carcinoma.]]>
<![CDATA[EFEK PEMBERIAN TUNGGAL PINANG MUDA DOSIS TINGGI PADA HEPAR TIKUS ]]>
<![CDATA[ JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 6 No. 2 (2018): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan ]]>
Publisher : <![CDATA[FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI ]]>
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DOI: 10.22437/jmj.v6i2.5953
<![CDATA[Introduction : Raw betel nuts juice is a traditional herbal supplement in Jambi that is consumed for stamina booster. According to previous study, raw betel nut has median lethal dose >15.000 mg/kg weight. Hepatotoxicity is often caused by herbal supplement in high dose. Purpose : This study is to determine the effect of single high dose of raw betel nut on rat’s liver. Methods : this experimental study used rats strain sprague dawle, health and active, age 2-3 month, weight 150-200 gram. There are 6 rats in each groups. Experimental group receveid raw betel nut juice single dose 20.000gram/kg weights and control group received aquadest. Observation of mortality rate during 7 days. Termination of rats were done on 8th days. Histopathology used Hematoxilin Eosin stain. Results : One rats (16,6%) was found died on 24 hours after treatment with raw betel nut Histopatholgy examination showed portal inflamation, hepatocellular cholestasis, and steatosis in group of raw betel nut. Conclusions : raw betel nut in single high dose could cause liver damages. Keywords : betel nuts, histopatholohy, liver]]>
<![CDATA[AKTIVITAS SITOTOKSIK PROPRANOLOL TERHADAP SEL KANKER PAYUDARA MCF7 IN VITRO ]]>
<![CDATA[ JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 6 No. 2 (2018): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan ]]>
Publisher : <![CDATA[FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI ]]>
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DOI: 10.22437/jmj.v6i2.5970
<![CDATA[Background: Propranolol is a nonselective beta-blocker drug which is commonly used as an antihypertensive. In vitro studies showed that propranolol has anti-proliferative, anti-migratory and cytotoxic effects on cancer cells of lung, colon, breast, nasopharynx, ovarian pancreas and gastric. Therefore, this study is conducted to assess whether propranolol has cytotoxic activity of MCF7 breast cancer cells. Research objectives: This study aimed to assess the effects of propranolol on the cytotoxic activity of MCF7 breast cancer cells. Research methods: This quasi-experimental research using post-test with a non-equivalent control group design. Cytotoxicity test using MTT assay was performed to determine the IC50 propranolol against MCF7 cells. Results: Propranolol showed cytotoxic activity against MCF7 breast cancer cells with IC50 value of 227.91 ± 14.74 µM (67,41±4,35 µg/mL). Conclusion: Propranolol has cytotoxic activity against MCF7 breast cancer cells. Keywords: propranolol, cytotoxic, MCF7]]>
<![CDATA[KORELASI KLINIKO-SITOPATOLOGI PADA APUSAN SERVIKS DENGAN GAMBARAN EPITHELIAL CELL ABNORMALITIES ]]>
<![CDATA[ JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 6 No. 2 (2018): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan ]]>
Publisher : <![CDATA[FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI ]]>
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DOI: 10.22437/jmj.v6i2.5972
<![CDATA[Cervical cancer is one of the most cancer experienced by women in the world. Periodic examination of cervical smears can reduce cancer mortality by 40%, especially in women aged over 50 years. In populations with extensive screening coverage, the incidence of cervical cancer drops to 70-90%, while in non-screening populations, the incidence of cervical cancer continues to be in preliminary conditions as when screening has not yet been implemented in developed countries. This study aims to assess the correlation between clinical features and cytopathology of cervical smears that have epithelial cell abnormalities in accordance with the Bethesda classification. This research is an analytical research with cross sectional technique to know the correlation of clinical characteristic with cytopathology picture on cervical smear. The study was conducted in May-October 2017 at Anatomical Pathology Laboratory of Medical and Health Sciences, and examination of cervical smear in pubic health centre of Tembesi. Cytopathologic variables were epithelial cell abnormality according to Bethesda criteria of NILM, ASCUS, LSIL, HSIL, squamous cell carcinoma and glandular cell abnormalities. There were 80 people who met the inclusion criteria. In this study, the most age group was found in 30-45 years as many as 48 or 60.0%, multiparity as much as 67 or 83.8%, the most widely used type of contraception is IUD as much as 33 or 41.3%. Of all the variables only significant correlation of clinical characteristic was found on contraceptive pill using pill / ASCUS (100%) and SIL (100%), and implant with HSIL (100%). Keywords : Clinico-cytopathology, Cervical, Epithelial Cell Abnormality]]>
<![CDATA[PENGARUH DIET KETOGENIK TERHADAP EKSPRESI Ki-67, CASPASE-3, DAN MDA PADA JARINGAN HATI ]]>
<![CDATA[Harahap, Huntari]]>;
<![CDATA[Irfannuddin, Irfannuddin]]>;
<![CDATA[Murti, Krisna]]>
<![CDATA[ JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 6 No. 2 (2018): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan ]]>
Publisher : <![CDATA[FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI ]]>
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DOI: 10.22437/jmj.v6i2.5973
<![CDATA[Obesity is a problem of global epidemics and arise a health threat to people. The prevalence of obesity in the United States in 2016 was around 39.8% in adults aged 40-59 years and 18.5% in young adults aged 20-39 years. One of the dietary patterns used to overcome obesity is the ketogenic diet. The main metabolic reaction due to the ketogenic diet occurs in the liver which make lesion. The ketogenic diet is a high-fat diet, quite protein, low in carbohydrates (usually less than 50 g / day). The effect of the ketogenic diet on the liver is help maintain TCA cycle homeostasis, prevents the accumulation of intermediate fatty acids that are not oxidized, maintains the redox balance of the liver, and supplies energy to extrahepatic organs in the glucose deficiency stage. The ketogenic diet can reduce cell proliferation which is characterized by a decrease in the percentage of cells in ki-67 positive staining and increase cell apoptosis which is characterized by an increase in caspase-3 positive staining and reduce oxidative stress as assessed by MDA reduction. Key Words : Obesity, Ketogenic Diet, Ki-67, Liver, Caspase-3, MDA]]>
<![CDATA[UKURAN ANTROPOMETRI GIZI YANG BERHUBUNGAN DENGAN PREDIABETES PADA OBESITAS DI PEJAGALAN, JAKARTA ]]>
<![CDATA[ JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 6 No. 2 (2018): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan ]]>
Publisher : <![CDATA[FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI ]]>
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DOI: 10.22437/jmj.v6i2.5974
<![CDATA[Prevalence of prediabetes in Indonesia is increasing Type 2 Diabetes prevalence and its complications. Its complications is causing economic burden since one third of the costs of Indonesia national health insurance’s claim. Based on this problem, prediabetes is the right strategy to do but in practice it is an effective and efficient method for high-risk groups, namely obesity. The current assessment is the Body Mass Index (BMI) but has limitation for those with big muscle . Waist circumference is debated. Similarly, waist to height ratio is shown to have corellation to prediabetes. But, studies that explain which are the best anthropometry indicator that have strongest corellation to prediabetes is still limited. This study aims to determine the greatest association among these anthropometry indicators to predict prediabetes in the obese group. Methods: The study used a cross sectional study design for 166 adult respondents 21-65 years who met one of the criteria for obesity: BMI> 25 kg / m2; waist circumference> 80 cm in women or> 90 cm in men; weight to height ratio 0,5. Respondents had fasting for 8-10 hours before checking sugar with a glucometer. Analysis using SPSS 18.00 program, univariate analysis to describe characteristic respondents in the Pejagalan area, then performed linear regression analysis to see the difference between BMI, waist circumference, or the waist to height ratio with most related to prediabetes. Results: The prevalence of prediabetes in obesity was 81 people (48.2%). Different age, BMI, and behavior in male and female respondents. Regression analysis showed that weight-to-height ratio is has strongest corellation in increasing risk of prediabetes. Conclusion: Waist to heigt ratio can be a measure of nutritional anthropometry that is most associated with prediabetes. Keywords: BMI, waist circumference, waist circumference - height, prediabetes]]>
