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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 10 Documents
 1 
Search results for , issue "Vol 21 No 4, 2010" : 10 Documents clear
Scientific Aspects of Water Extract Katola (Arcangelisia flava L. Merr) as Antidiarrhea Agent in Mina South Sulawesi Muhammad Akhram Larisu; Sudarsono .; Susi Iravati; Arief Nurrochmad
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.881 KB) | DOI: 10.14499/indonesianjpharm0iss0pp283-289

Abstract

Water  extract  of  katola  (Arcangelisia  flava  L.  Merr)  stem  is  traditionally used in communities Muna Distric for the treatment of many diseases, including anti  diarrhea.  According  to  the  information  of  Muna  Distric  Health  Office, diarrhea  is  one  of  the  10  groups  diseases  in  this  district.  The  objective  of  this study was conducted to determine the potential antimicrobial, acute toxicity and identified  of  the  water  extract  of  bioactive  compounds  and  alkaloid  relative concentration content.  Infection of microbial was induced by oral administration of  Shigella  flexneri  ATCC  12022  1  x  108 CFU/mL.  Boiling  water  of  katola  dose 12  mg/kg,  24  mg/kg  and  48  mg/kg  body  weight  and  the  antibiotic  ampicillin 24  mg/kg  administered  2  times  daily  for  5  days.  The  number  of  S.  flexneri  in feces were determined every day. The toxicity of water extract of  katola stem  is determined  based  on  the  value  of  LD50  acute  oral  toxicity  testing  followed  by guidelines  OECD  423. The  bioactive compounds was determined by bioautografi method  and  the  concentration  alkaloid  relative  content  was  calculated  as berberine  hydrochloride.  The  results  showed  that boling  water extract of  katola stem  did  not  cause  toxic  symtoms,  with  LD50  >  31.5  g/kg  body  weight (unclassified)  or  104  times  the  dose  therapy  of  human.  In  vitro,  the  Minimum Inhibition  Concentration  (MIC)  and  Minimum  Bactericidal  Concentration (MBC)value  of  the  boiling  water  were  1.2  and  2.4%,  respectively.  In  vivo,  the boiling  water  dose  48  mg/kg  body  weight  given  twice  a  day  have  an  effect  on eradication the S. flexneri 100% by day 5. Bioactive compounds of antimicrobial in  the  water  extract  is  alkaloid  berberine  HCl.    A  cocentration  of  berberine hydrochloride  in  water  exract  stem  and  leaves  dosage  use  of  the  public  were 16.7% and 0.75% respectively.Key words: Katola, toxicity, anti diarrhea, antimicroba, Arcangelisia flava L. Merr 
Inhibitory effect of THPGV-0 on the histamine release from antigen-induced RBL-2H3 cells Agung Endro Nugroho; Ritmaleni Ritmaleni; Novrizal Abdi Sahid; Kazutaka Maeyama
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (383.85 KB) | DOI: 10.14499/indonesianjpharm0iss0pp242-249

Abstract

Tetrahydropentagamavunon-0  (THPGV-0)  is  assumed  to  be  main metabolite  product  of  biotransformation  process  of  PGV-0.  THPGV-0  was synthesized  by  converting  PGV-0  to  the  compound  by  hydrogenation  with  Pd/C as a catalyst. PGV-0 potently inhibited the histamine release from  rat mast cells in  vitro  and  in  vivo,  however,  ironically  only  traces  amount  of  compound  was found in the blood. THPGV-0 is assumed to have important roles in the biological effects of PGV-0 in vivo. In present study, we investigated the antiallergy effect of  THPGV-0  in  compare  to  this  of  PGV-0  in  vitro.  The  study  was  performed  by using  rat  basophilic  leukemia  (RBL-2H3)  cell  line,  a  tumor  analog  of  mucosal mast  cells.  DNP-BSA,  an  antigen,  was  used  as  an  inducer  for  stimulating  the histamine  release  from  mast  cells.  In  present  study,  THPGV-0  at  low concentration  did  not  succeed  to  inhibit  the  histamine  release,  but  at  higher concentration (30 and 100  M) showed strong effects. THPGV-0 at concentration of  100  M  depleted  the  histamine  release  by  96.10  0.51%.  In  compare  to PGV-0,  THPGV-0  has  higher  efficacy  but  less  potent.  In  the  study,  the possibilities  of  the  spontaneous  release  from  RBL-2H3  cells  by  the  compounds were also observed. All concentrations of THPGV-0 as well as PGV-0 showed low spontaneous histamine release, less than 10 % of the total histamine contained in RBL-2H3 cells.Key words: tetrahydropentagamavunon-0, allergy, histamine, RBL-2H3 cells
Optimization of formula sustained releaase captopril tablet using factorial design method Pratiwi, Melinda; Hadisoewignyo, Lannie
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (556.845 KB) | DOI: 10.14499/indonesianjpharm0iss0pp272-282

Abstract

Captopril is one of the most frequently used  medicine  in the treatment of hypertension  with  repeatedly  used  frequency  in  a  day.  Therefore  captopril should  be  formulated  in  the  form  of  sustained  release  and  find  the  optimum formula.  The  purpose  of  this  study  was  to  determine  the  influence  of  both factors  and  their  interactions,  which  are  the  ratio  of  polymer  HPMC  K4M  -xanthan gum  factor at the level of 1:1 and 4:1 and the concentration of tartaric acid  at  levels  of  0%  and  5%  on  physical  properties  of  tablets,  drug  release, floating  lag  time.  Furthermore,  find  the  optimum  formula  that  meets  the requirements  and  produce  tablets  with  drug  release  pattern  according  to  zero order  kinetics.  Based  on  Design  Expert  optimization  program  was  obtained  the optimum  formula  using  a  combination  of  polymer  HPMC  K4M  –  xanthan  gum ratio  3.75:1  and  concentration  of  of  tartaric  acid  4.5%  would  be  result  the hardness  respons  12.02  Kp  the  friability  0.47%,  the  floating  lag  time  0.32 minutes,  and  the  rate  of  dissolution  0.05  mg/min.  The  results  show  that combination of factors polymer HPMC K4M -  xanthan gum ratio can increase the tablet  hardness,  lower  tablet  friability,  accelerate  the  floating  lag  time,  and increase the rate  of dissolution.  Tartaric acid can  decrease  the  tablet  hardness, increase  the  friability,  accelerate  the  floating  lag  time,  and  increase   the  rate  of dissolution.  Interaction  of  both  can  reduce  the  tablet  hardness,  increase  the tablet friability, slow floating lag time, and increase the rate of dissolution.Key words: captopril, HPMC K4M, xanthan gum, tartaric acid, factorial design
Macroporous thermosensitive poly(HEMA-coNIPAAm) hydrogels for controlled drug delivery application Setiyorini, Yuli
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (510.139 KB) | DOI: 10.14499/indonesianjpharm0iss0pp250-257

Abstract

Controlled  delivery  systems  of  a  predetermined  dose  over  a  sustained period  have  been  used  to  overcome  the  shortcomings  of  conventional  dosage forms. This is because the controlled drug delivery system can provide sustained therapeutic  level  of  drug  concentration  without  toxicity  and  convenience  for patients. It would be more beneficial and ideal if the drug could be delivered by a  device  that  would  respond  to  external  environmental  change.  Therefore,  the correct  amount  of  drug  would  be  released  upon  the  stimulation  of  such  a temperature change. The purpose of study is synthesis  of macroporous thermal responsive  poly(HEMA-co-NIPAAM)  hydrogels  by  free  radical  polymerization  for controlled drug delivery applications. Effect of varying water and HEMA-NIPAAm ratio  in  the  monomer  mixture  were  resulted  interconnected  macroporous structure.  From  the  result,  5HEMA15NIPAAm  was  showed  the  most  rapid responsiveness  in  swelling  ratio,  polymer  volume  fraction,  swelling  and deswelling  kinetics.  The  high  drug  loading  capacity  was  achieved  at  or  below ambient  temperature,  whilst  the  release  profile  was revealed  sustain  release  of conventional  anti-inflammatory  drug;  prednisolone  21  hemisuccinate  sodium salt.  In  general,  incorporating  appropriate  amount  of  water  and  HEMA-NIPAAm ratio can improve the swelling properties, drug loading capacity and drug release profile, which can be use for sustained release of various medication.Key words: macroporous, thermosensitive hydrogel, controlled drug delivery application
Antibacterial activity of ethanolic extract of leaves and bulbs of Crinum asiaticum L. against acne-inducing bacteria Azrifitria .; Syaikhul Aziz; Chairul .
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (408.85 KB) | DOI: 10.14499/indonesianjpharm0iss0pp236-241

Abstract

The antibacterial activity of ethanolic extract of leaves and bulbs of Crinum asiaticum L. was tested against Propionibacterium acnes, Staphylococcus aureus and  Staphylococcus epidermidis, pathogenic bacteria that cause acne. Minimum Inhibitory  Concentration  (MIC)  and  Minimum  Bactericidal  Concentration  (MBC) were  determined  by  dilution  methods.  MIC  and  MBC  of  ethanol  leaves  extract were  found  for  P.  acnes  (1.25  and  2.5  mg/mL),  S.  aureus  (5  and  10  mg/mL) and  S.  epidermidis  (2.5  and  5  mg/mL).  While  MIC  and  MBC  of  ethanol  bulbs extract  were  found  for  P.  acnes  (7.5  and  15  mg/mL),  S.  aureus  (7.5  and 15 mg/mL) and  S. epidermidis  (3.75 and 7.5 mg/mL). Further study conducted on  the  ethanol  leaves  extract  against  P.  acnes  to  analyze  cell  leakage  (nucleic acid  and  protein)  by  ultraviolet  spectrophotometry,  metal  ion  (K+ and  Ca2+)  by atomic  absorption  spectrometry,  and  observed  alteration  of  the  cell  wall  by scanning  electron  microscopy  (SEM).  The  result  showed  that  ethanol  leaves extract could damage the cell wall and affect the permeability of cell membrane which  marked  by  release  of  nucleic  acid  (absorbance  0.3307-0.4299),  protein (absorbance  0.0616-0.101),  ion  K+ (8.167-15.757  mg/mL),  ion  Ca2+ (5.47-13.74 mg/L) from the cell and alter morphology of cell wall of P. acnes.Key words: Antibacterial, Crinum asiaticum L., Propionibacterium acnes
The effect of fumaric acid-sodium bicarbonate on the green tea effervescent granule’s quality made by dry granulation Lestari, Agatha Busi susiati; Trisusilawati, Maria Yuli
INDONESIAN JOURNAL OF PHARMACY Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (592.732 KB) | DOI: 10.14499/indonesianjpharm0iss0pp218-224

Abstract

Tea plant (Camellia  sinensis  L.)  had been  known  to  contains epigallocathecin gallate (EGCG) that can be used to maintain the healthy. In this research, the green tea was  tried to be formulated in effervescent dosage form, with  the  focus  on  the  effect  among  fumaric  acid,  sodium  bicarbonate,  and  the interaction  between  fumaric  acid  and  sodium  bicarbonate  on  the  green  tea extract  effervescent granule’s  physical properties, that made by dry granulation method.  Physical  properties  of  effervescent  granule  that  been  study  were moisture  content,  flow  rate,  disintegration  time,  and  pH  of  the  solution.  The result showed that sodium bicarbonate was dominant in determining pH, granule flow  rate  and  moisture  content  of  granule,  whereas  fumaric  acid  dominant  in disintegration time of effervescent granule.Key words: green tea, fumaric acid, effervescent granule, dry granulation
Radioiodination of andrographolide and its biodistribution in mice for inflammatory tracer Jutti Levita; Cahya Nova A.; As’ari Nawawi; Slamet Ibrahim
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (489.965 KB) | DOI: 10.14499/indonesianjpharm0iss0pp258-265

Abstract

Andrographolide,  a  bioactive  component  of  Andrographis  paniculata (Burm.F)  Nees,  is  the  major  lactone  diterpenoidal  bicyclic  constituent  in  this plant  which  has  proven  to  exert  anti-inflammatory  activity  in  vitro  which  was occurred via  several mechanism, e.g inhibition of inducible nitric oxide synthase (iNOS),  inhibition  of  radical  oxygen  species,  and  inhibition  of  NF-kappaB activation. The labeling with radionuclide is often used for therapy, detection and quantification of metabolites in the body. Even though the metabolites are very low  in  concentration  they  can  be  detected  by  the  energy  they  emitted. Radionuclide  can  be  used as  radiotracer  to  detect  whether  drug  really interacts with  its  target.  The  objective  of  this  research  is  to  synthesize 131I-labelled andrographolide  and  to  study  its  biodistribution  in  mice  to  understand  the location  of  its  organ  target.  Indirect  radioiodination  of  andrographolide  wascarried  out  by  using  bromine  as  the  leaving  group  and  followed  by  fast iodination  at  40oC,  yielded  72.6  %  purity  of  the  labeled  compound.  Iodination was occurred through proton substitution at C-12. Then the andrographolide-131I was  injected  into  lateral  vein  of  mice’s  tail  to  study  its  biodistribution.  The compound  was  distributed  in  all organs  with the  highest  accumulation  occurred in  the  stomach  (16.87  %/gram  organ).  The  result  showed  that  inducing  the animals  with  LPS  caused  inflammation  in  the  stomach  and  increased  the production  of  prostaglandin  as  proven  by  the  distribution  of  the  radioligand  in that organ.Key words: andrographolide, radioiodination, anti-inflammatory, biodistribution
Antimalarial activity of ethyl acetate extract of Garcinia dulcis kurz stem bark Gunawan Pamudji Widodo; Mamik Ponco Rahayu
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.562 KB) | DOI: 10.14499/indonesianjpharm0iss0pp225-229

Abstract

In-vivo antimalarial activity of ethyl acetate extract of Garcinia dulcis Kurz stem  bark  have  been  evaluated  against  Plasmodium  berghei  induced  mice. Antimalarial  test  was  conducted  by  paracitemia  investigation  and  leucocyte counting  of  paracite  induced  mice  blood,  after  oral  administration  of  Garcinia dulcis  stem  bark  extract  dose  of  25  mg,  50  mg,  as  well  as  75  mg/kg  bw.  The highest  antiplasmodial  activity  and  decresing  of  leucocyte  amount  was  showedby  extract  of  dose  of  50  mg/kg  bw.  The  compounds  identified  in  ethyl  acetate extract  of  Garcinia  dulcis  stem  bark  were  flavonoid,  saponin  and  tannin.  The compounds that have antimalarial activity weren’t yet known.Keywords: antimalarial, Garcinia dulcis Kurz, stem bark, paracitemia
The anticancer compound identification from chloroform extract of Rhizopora mucronata stem bark Diastuti, Hartiwi; ., Warsinah
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.963 KB) | DOI: 10.14499/indonesianjpharm0iss0pp266-271

Abstract

Previous  reasearch  reported  that  chloroform  extract  that  was  partitioned from etanol exctracts  of  R. mucronata  stem bark had sitotoxic against Myeloma cells  (Diastuti,  2008).  This  research  was  aimed  to  fractinate  the  chloroform extract  of  R.  mucronata  stem  bark  and  cytotoxicity  test  againts  Myeloma  cells, then  identification  the  cytotoxic  compounds.  The  ethanol  extracts  of R.  mucronata  steam  bark  was  partitioned  with  chloroform.  The  chloroform extracts was fractinated by coloum chromatography with gradient eluent were nhexane, chloroform, etilacetate  and methanol respectivelly. Cytotoxicity test the fraction  of  chloroform  extracts  were  conducted  on  Myeloma  cells  by  MTT methods.  Identification   the  compoud  of  fraction  that  had  a  highest  cytotoxic againts  Myeloma  cells  conducted  using  IR  spectrometer,  and  GCMS.  The  result showed  that  2b  fraction  of   R.  mucronata  stem  bark  had  a  highest  cytotoxic againts  Myeloma  cells,  having  IC50  equal  to  5.122   µg/mL.  Identification  of chemical compounds  showed that 2b fraction  contained two steroid compounds were 4 methyl- colest-24-en-3-ol and 4-methyl-stigmast-22-en-3-ol.Key words : R. Mucronata, anticancer, Myeloma cells, steroids
Testing of antiplasmodium activity substance from endophytic fungus of Artemisia annua L. ., Wahyono; ., Pudjono; P., Widyati
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.282 KB) | DOI: 10.14499/indonesianjpharm0iss0pp230-235

Abstract

Malaria is a life-threatening disease caused by  Plasmodium parasites. The rapid  spread  of  malaria-quinoline  resistance  enforce  to  find  of  new  antimalaria drug. Artemisia annua L having artemisinin as secondary metabolites, has been used as antimalaria agent for long time. One of source of bioactive compound is endophytic fungus. This fungus can produce similar bioactive compound to host plant.  The  thin  layer  chromatography  result  showed  that  endophytic  fungusfrom   A.annua    had  similar  chromatogram  profile  with  artemisinin.  This metabolite  was  not  secreted  in  the  fermentation  medium,  but  was  kept  in  the fungus  mycelium.  The  result  of  the  haem  polymerization  inhibitory  activity assay  showed  that  this  secondary  metabolites  inhibited  the  haem polymerization.  Ethyl  acetate  extract  of  fungus  A  had  IC50  value  0.824  ±  2.89 μM  to  inhibit  the  haem  polymerization;  fungus  E  was  0.861±  2.43  μM;  and fungus F was 1.394 ± 3.73 μM.Key words : endophytic fungus, antiplasmodium, the haem polymerization, IC50 

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