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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 10 Documents
 1 
Search results for , issue "Vol 22 No 2, 2011" : 10 Documents clear
Analgesic and anti-inflammatory activities of combrang (Nicolaia speciosaHoran) stem the extract Susilowati, Sri Sutji; Martono, Sudibyo; Riyanto, Sugeng; Nugroho, Agung Endro
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (184.077 KB) | DOI: 10.14499/indonesianjpharm0iss0pp115-119

Abstract

Long-term  goal  of  this  study  is  the  use  of  combrang  (Nicolaia  speciosa Horan)  as  an  ingredient  of  traditional  medicine  after  being  evaluated  through preclinical  testing  and  clinical  trials  both  extract  and  its  bioactive  compounds. This  study  includes  analgesic-antiinflammatory  activity  test  of  n-hexane, chloroform,  ethyl  acetate  and  methanol  extract  of combrang stem.  Analgesic test against crude extract of n-hexane, chloroform,ethyl acetate and methanol, using acetate writhing method. Antiinflammatory test using inhibition method of paw oedema by carrageenan induced on Wistar rats. Analgesic-antiinflammatory activity  compared  to  Na-diclofenac.  The  result  is  four  extracts  have  analgesic and  antiinflammatory  activity,  ethyl  acetate  extract  has  the  highest  analgesic and antiinflammatory activity.Key words: analgesics, anti-inflammatory, extract of combrang stem
Antihyperurisemia activity of water extract of black seed (Coleus ambonicusLour) in balb-c mice and its standardization Andi Suhendi; Nurcahyanti .; Muhtadi .; EM Sutrisna
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (221.619 KB) | DOI: 10.14499/indonesianjpharm0iss0pp77-84

Abstract

Effect  of  water  extract  of  black  seed  on  uric  acid  metabolism  in hyperuricemia mice models were studied. The influence of water extract of black seed  on  uric  acid  biosynthesis  was  xamined  using  mice  treated  by  250  mg/ body  weight  potassium  oxonate  intra  peritoneal.  The result  showed  that  water extract of black seed (200 mg/kg body weight, per oral) have a significant effect in reduction in plasma uric acid levels in comparison to negative control, but less active  than  positive  control  (allopurinol).  The  levels  of  uric  acid  in  mice  plasma for negative control, black seed extract and positive control were 3.100 ± 0.346 mg/dL,  0.200  ±  0.100  mg/dL  dan  1.200  ±  0.561  mg/dL,  respectively.  The standardization  performed  by  determined  specific  and  non  specific  parameters based  on  National  Bureau  of  Food  and  Drug,  Republic of  Indonesia.  Specific parameters  of  water  extract  of  black  seed  are  phenolic  content,  and  flavonoid content  are  0.664  ±  0.035  %  and  0.400  ±  0.018  %,  respectively.  Non  specific parameters of water extract of black seed are loss of weight, water content, ash content,  ash  insoluble  acid  content,  heavy  metals  contamination  (Pb  and  Cd), and  aflatoxin  residue  are  14.93-14.99%,  6.09-7.89%, 7.12-7.49%,  5.20-6.66%, 6.405 +0.211 ppm, 0.0096 +0, not detected, respectively.Key words: antihyperuricemia effect, water extract of black seed, standardization
Analysis of the resistance of M. tuberculosis to fluoroquinolon and the implementation of nuclear based biomolecular technique. Mukh Syaifudin; Dewi Septiani
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (656.928 KB) | DOI: 10.14499/indonesianjpharm0iss0pp120-127

Abstract

Tuberculosis (TB) is still a problem in community health with high rate of mortality.  The  case  became  much  more  complicated  due  to  emerge  of Mycobacterium  tuberculosis which  are  resistant  to  the  drugs.  This  caused  the movement  of  attention  from  the  first  line  drugs  to  fluoro-quinolon  (FQ)  as alternative drug. The aim of this research was to do analysis the mutation which causing  the  resistance  of  bacterial  through  nucleic acid  alterations  with polymerase  chain  reaction  (PCR)  and  single  strand  conformation  polymorphism (SSCP)  technique.  Analysis  was  done  on  gyrA  and  gyrB  genes  encoding  DNA gyrase of bacterial and closely related to FQ resistance in 100 of sputa samples of  positive  BTA  test  results.  DNA  of  M.  tuberculosis strain  H37Rv  was  used  as control. From analysis on gyrA gene it was known that 57 samples were positive PCR  and  no  resistant  sample  was  found.  For  gyrB  gene,  only  12  of  them  were positive  PCR  and  again  there  was  no  samples  had  mutation  as  cause  of resistance.  These  mean  that  FQ  could  be  used  as  replacement  drug.  Molecular detection  technique  was  known  fast  and  specific  for assessing  bacterial resistance.  Researcher  proves  that  searching  for  P32-radioisotope  labeled  DNA alteration  was  more  sensitive.  Hopefully  this  results  of  experiment  can  be implemented  in  medication  with  more  effective  and  support  diagnose  results so that it will lowering the risk of patient mortality.Key words : M. tuberculosis, fluoro-quinolon, resistance, PCR, SSCP
Niosomes entrapment capacity of ketoprofen and prediction transdermal administration rahman, Latifah; Ismail, Isriany; Wahyudin, Elly
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.378 KB) | DOI: 10.14499/indonesianjpharm0iss0pp85-91

Abstract

Niosomes  are  vesicles  system  that  have  applications in  the  delivery  of lipophilic,hydrophilic  and  amphiphilic  drugs.  Ketoprofen,  is  very  insoluble  in water  and  cause  gastric  irritation  when  taken  orally.  It  is  very  important  to develop a transdermal delivery system for ketoprofen. This research was aimed to  design  niosomes  which  can  deliver  ketoprofen  via transdermal  route. Experiments  were  designed  to  incorporate  ketoprofen into  niosomes   with  lipid film  hydration  method.  Lipid  mixture  consist  of  cholesterol  and  sorbitan  ester (span  20,  60,  80).  Niosomes  which  can  deliver  ketoprofen  trough  the  skin barrier  determined  by  calculating  amount  of   ketoprofen  in  the  blood  of  rabbit. The  type  of  sorbitan  ester  was  chosen  based  on  the  highest  drugs  entrapment and  ketoprofen  as  drugs  model.  Preparation  of  niosomes  was  optimized  for  the highest  percent  drug  entrapment  by  increasing   molar  concentration  of  lipidmixture  with  the  stable  comparison  of  1:1.  This  research  result  are  niosomes with  lipid  mixture  span  60  and  cholesterol  have  the highest  drug  entrapment efficiency  of  niosomes  66.16%  with  range  size  1–6  µm.  Niosomes  can  deliver ketoprofen  to  the  systemic  circulation  via  transdermal  route  with  plasma  level concentration achieved in 1.5 hour.Key words: niosomes, ketoprofen, transdermal 
Econazole depleted calcium release-activated calcium (CRAC) current through blockade of voltage-dependent Ca 2+ channels Agung Endro Nugroho; Hari Purnomo; Kazutaka Maeyama
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (349.21 KB) | DOI: 10.14499/indonesianjpharm0iss0pp128-136

Abstract

Econazole  is  an  azole  antifungal  agent  which  can  block  the  calcium release-activated  calcium  (CRAC)  current  in  human  leukaemic  T  cell  line.  The phenomenon  is  also  possible  to  occur  in  mast  cell  such  as  RBL-2H3  (rat basophilic  leukemia)  cells,  a  tumor  analog  of  mast  cells.  In  the  study,  we investigated  effect  of  econazole  on 45Ca2+ uptake  into  the  cells  in  response  to thapsigargin, an ATP-dependent Ca2+ (SERCA) inhibitor, by direct measurement of  radiolabelled  Ca2+ uptake  in  cells.  The  mechanism  underlying  this  effect  of econazole  was  studied  using  molecular  modelling.  In present  study,  econazole inhibited 45Ca2+ influx  into  mast  cells  in  absence  of  mast  cells  inducer, thapsigargin.  Moreover,  econazole  potently  suppressed  the 45Ca2+ influx induced  by  thapsigargin.  It  was  supported  that  econazole  also  inhibited  Ca2+-induced  tracheal  contraction.  The  increase  of  Ca2+ was  stimulated  by  the opening of voltage-dependent Ca2+ channels activated by KCl-induced membrane depolarization. Based on molecular docking study, score of interaction (equal to  energy  of  interaction)  of  3FGO,  a  main  protein  target  on  Ca2+ -ATPase,  with native ligan, thapsigargin and econazole were -76.941, -117.205, and -92.277, respectively.  The  interaction  of  thapsigargin  and  Ca2+ -ATPase  was  more  stable than  this  of  econazole  and  Ca2+ -ATPase.   It  suggests  that  it  would  be  difficult for  econazole  to  block  the  interaction  of  thapsigargin  with  Ca2+ -ATPase  to increase  intracellular  Ca2+.In  conclusion,  econazole  inhibited  the  increase  of intracellular Ca2+involving the blokade of voltage-dependent Ca2+ channels, but not involving the Ca2+ -ATPase pathway.Key words :econazole, Ca2+ -ATPase, CRAC current, thapsigargin 
Optimization of chitosan and sodium carboxymethylcellulose as mucoadhesive system in theophylline tablet Irawan, Eka Deddy; ., Farhana
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.37 KB) | DOI: 10.14499/indonesianjpharm0iss0pp92-97

Abstract

Mucoadhesive  tablet  for  asthma  treatment  were  prepared  by  mixing theophylline  with  two  variations  of  polymers.  The  purpose  of  this  research  was to  controlled  drug  release  from  the  dosage  form.  Theophylline  mucoadhesive tablets  were  prepared  by  direct  compression  using  chitosan  and  sodium carboxymethylcellulose  as  mucoadhesive  polymers.  Mucoadhesive  strength measured  using  rabbit  gastric  mucosa  and  in  vitro  drug  dissolution  was subjected  in  a  hydroclorid  acid  buffer  pH  1.2  for  10  hours.  The  optimized formula  was  obtained  by  analyzing   both  evaluation  using  factorial  design. Formula  with  5.4  %  of  chitosan  and  14.5  %  of  sodium carboxymethylcellulose followed zero order kinetics. The optimized formulation showed by 8.38-10.91% of  chitosan  and  28.84-29.09%  of   sodium  carboxymethylcellulose  with mucoadhesive strength between 25-40 gram and 43.5%-55% drug was released in 10 hours.Key words: Mucoadhesive, chitosan, CMC Na, E, factorial design. 
Spectroscopic analysis and cytotoxic activity of quas-sinoid isolated from the seeds of Brucea javanicaon Hela cell Sonlimar Mangunsong; Dwiprahasto I; Mustofa .; Jumina .
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (268.981 KB) | DOI: 10.14499/indonesianjpharm0iss0pp137-143

Abstract

The  quassinoids  from  Brucea  javanica exhibit  biological  activities  as antimalarial,  antitumor,  antiviral  and  antiamoebic  activities.  These  quassinoids having  a  promising  antitumor  activity.This  research was  aimed  to  isolated quassinoid  (bruceine  A,  MW  522  g/mol)   compound  from  B.  javanica and  to investigate  the  cytotoxicity  of  bruceine  A  under  invitro conditions  in  Hela  cells. The  cytotoxicity  assays   using   MTT  assay.  The  bruceine   showed  a  good cytotoxic  activity  in  Hela cells  at  24  hours  with  doxorubicine  as  a  positive control.  Structural  elucidation  of   bruceine   is  done  by   using  UV  and  FT-IR spectra,  NMR  spectra   recorded  on  Tesla  av600,  (400 MHz) 1HNMR  in  pyridine (D5),  some  in  Gyro  (300  MHz) 1HNMR  in  acetone-(d6),  DMSO-(d6)  and  CdCl3 ,13CNMR,  75  MHz,  mass  spectra  on  biospectrometry  LC-MS.  Analytical  HPLC retention time,tRwas 4.617 minutes (Met/H20) 60:40. Its Molecular formula was determined  to  be  (  C26 H34  O11)  by  the  [M+H]+ ion  peak  at  m/z  523 and  m/z 1045 confirmed by High Resolution mass spectra Orbitrap (HRESIMS). From the results demonstrated that could be bruceine A compound refers to our spectral data.  Its  has   activity  in  IC50 value  191,5  µM  on  Hela  Cells  under  invitro conditions.Key words: Quassinoid, B. javanica,Brusein A, Spectroscopic, Anticancer 
The effect of avocado butter to stability of avocado emollient cream Teti Indrawati; Yuanita Sari
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.6 KB) | DOI: 10.14499/indonesianjpharm0iss0pp98-105

Abstract

The characteristic of emollient cream that contained of avocado butter as anti-aging  is  influenced  by  amount  of  avocado  butter  used.  The  research  has  a purpose to exploit and develop usage of avocado butter in the field of cosmetic. The  research  has  done  by  making  A/M  cream  used  1-11% avocado  butter  with melting  and  mixing  method  at  temperature  of  70-75  °C.  Stability  of  product creams  were  be  evaluated,  and  tested  with  accelerated  test  using  elevated temperature.  The  result  showed  that  concentration  of  avocado  butter  between 1-11%  can  be  made  become  W/O  emollient  cream.  The  cream  stability  was progressively influenced by amount of avocadobutter, the increasing of avocado butter  would  make  progressively  good  stability,  the stability  go  down  at  7% concentration.  The  best  stability  creams  has  shown  by  cream  that  contain  5% avocado butter,Key words: avocado butter, A/M cream type, emollient cream, stability of cream
Modeling of p-aminophenol compounds as analgesic antiinflammatory based on biologic activity and structure relationship ., Pudjono; Susilowati, Sri Sutji; ., Rehana
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.644 KB) | DOI: 10.14499/indonesianjpharm0iss0pp144-150

Abstract

This  research  aim  was  to  find  out  the  new  compounds model  of  paminophenol derivates which have analgesic anti-inflammatory activity based on structure  and  biologic  activity  relationship  analysis  by  computation  methods. Seventeen  compounds  of  p-aminophenol  derivates  were  used  in  this  research, and  six  compounds  known  its  analgesic-antiinflammatory  activity  were  used  for determine  QSAR  equation  model.  This  research’s  result  was  a  QSAR  equation that  can  be  using  for  synthesis  the  higher  activity new  compound  of  paminophenol. Key  words  :  p-aminophenol  compounds,  analgesic  anti-inflammatory activity,  structure and activity relationship, QSAR equation, computation methods
Optimization formula gastroretentive tablet of ranitidine HCl with floating system Sulaiman, T.N. Saifullah; Fudholi, Achmad; Nugroho, A. Kharis
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (387.929 KB) | DOI: 10.14499/indonesianjpharm0iss0pp106-114

Abstract

Ranitidine  HCl  is  an  H-2  receptor  antagonists  for  the  treatment  of  peptic gastric  secretion  with  a  small  bioavailability,  so  that  should  be  developed  in  a sustained  release  dosage  form  are  retained  in  the  stomach.  Ranitidine  HCl floating  tablet  was  formulation  by  effervescent  system.  Simplex  lattice  design was  applied  to  optimize  the  formula  of  ranitidine  HCl  floating  tablet  by varying levels of Methocel K15M 100-185 mg, sodium bicarbonate 15-100 mg, and  citric  acid0-85 mg.  The  Optimum  formula  determined  by  superimposed contour  plot  from  various  parameters:  flowability  of  granules,  physical properties of tablet and drug release using Design-Expert®program. Based on superimposed  contour  plot obtained  optimum  formula  for  the  area  in  the  range of Methocel K15M 100-145 mg, sodium bicarbonate 20-80 mg and citric acid 25-80 mg.Key words: Ranitidine HCl, Gastroretentive, Simplex lattice design 

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