Article Per Year (5 Year)
p-Index From 2021 - 2026
0.888
P-Index
This Author published in this journals
All Journal INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JFIOnline ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar Sociality: Journal of Public Health Service
Isriany Ismail
Pharmacy, Faculty of Health Science, Universitas Islam Negeri Alauddin Makassar Jl. Sultan Alauddin No 36 Samata – Gowa SulawesiSelatan
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

Published : 8 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 8 Documents
Search

 1 
Niosomes entrapment capacity of ketoprofen and prediction transdermal administration rahman, Latifah; Ismail, Isriany; Wahyudin, Elly
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.378 KB) | DOI: 10.14499/indonesianjpharm0iss0pp85-91

Abstract

Niosomes  are  vesicles  system  that  have  applications in  the  delivery  of lipophilic,hydrophilic  and  amphiphilic  drugs.  Ketoprofen,  is  very  insoluble  in water  and  cause  gastric  irritation  when  taken  orally.  It  is  very  important  to develop a transdermal delivery system for ketoprofen. This research was aimed to  design  niosomes  which  can  deliver  ketoprofen  via transdermal  route. Experiments  were  designed  to  incorporate  ketoprofen into  niosomes   with  lipid film  hydration  method.  Lipid  mixture  consist  of  cholesterol  and  sorbitan  ester (span  20,  60,  80).  Niosomes  which  can  deliver  ketoprofen  trough  the  skin barrier  determined  by  calculating  amount  of   ketoprofen  in  the  blood  of  rabbit. The  type  of  sorbitan  ester  was  chosen  based  on  the  highest  drugs  entrapment and  ketoprofen  as  drugs  model.  Preparation  of  niosomes  was  optimized  for  the highest  percent  drug  entrapment  by  increasing   molar  concentration  of  lipidmixture  with  the  stable  comparison  of  1:1.  This  research  result  are  niosomes with  lipid  mixture  span  60  and  cholesterol  have  the highest  drug  entrapment efficiency  of  niosomes  66.16%  with  range  size  1–6  µm.  Niosomes  can  deliver ketoprofen  to  the  systemic  circulation  via  transdermal  route  with  plasma  level concentration achieved in 1.5 hour.Key words: niosomes, ketoprofen, transdermal 
PENGARUH KONSENTRASI ETANOL TERHADAP PENJERAPAN NIFEDIPIN PADA FORMULA ETHOSOME Rizal, Rizal; Ismail, Isriany
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i2.584

Abstract

Researched about the influence of ethanol consentration to entrapment of nifedipin in ethosome formula. This research suppose to know about the influence of etanol consentration tonifedipine entrapment, form and size of ethosome, to decide the optimal consentration of etanol forming ethosome with high PDE (Percent Drug Entrapment) in nifedipin, and to know the ethosome characteristic. Ethosome formula  made in by hot method, using variation consentration of ethanol, phosphatidilcholin 1.5% and nefidepin 0,05%. Nifedipin concentration that entrapment in ethosome measured byUV-VIS Spectrophotometer at wavelength 336 nm, form and ethosome size fixed by using microscope.  Ethosome with  high  percent drug entrapment have taken from formula by using ethanol 50% with entrapment 71.440%. The formed ethosome is Multy Lameral Vesicle (MLV) and Multy Vesicular Vesicle (MVV) with the size about 1 μm until 15μm.
PENGARUH KONSENTRASI ETANOL TERHADAP PENJERAPAN NIFEDIPIN PADA FORMULA ETHOSOME Rizal, Rizal; Ismail, Isriany
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (963.479 KB) | DOI: 10.35617/jfi.v10i2.584

Abstract

Researched about the influence of ethanol consentration to entrapment of nifedipin in ethosome formula. This research suppose to know about the influence of etanol consentration tonifedipine entrapment, form and size of ethosome, to decide the optimal consentration of etanol forming ethosome with high PDE (Percent Drug Entrapment) in nifedipin, and to know the ethosome characteristic. Ethosome formula  made in by hot method, using variation consentration of ethanol, phosphatidilcholin 1.5% and nefidepin 0,05%. Nifedipin concentration that entrapment in ethosome measured byUV-VIS Spectrophotometer at wavelength 336 nm, form and ethosome size fixed by using microscope.  Ethosome with  high  percent drug entrapment have taken from formula by using ethanol 50% with entrapment 71.440%. The formed ethosome is Multy Lameral Vesicle (MLV) and Multy Vesicular Vesicle (MVV) with the size about 1 μm until 15μm.
Effects of Enhancment Span-60 of Vernonia amygdalina Leaves Extract-loaded Niosomes Pratiwi, Afrianty; Syahrana, Nur Azizah; Ismail, Isriany; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.45956

Abstract

Introdiction: Niosomes are a promising drug carrier because of their bilayer structure and the fact that they are produced by the self-association of nonionic surfactants and cholesterol in an aqueous phase. Niosomes are non-toxic, biodegradable, and compatible with human cells. Aims: This research aimed to create niosomes from V. amygdalina leaves and investigate how span 60 addition affects niosome properties. Methods: Extraction V. amygdalina using maceration, niosomes synthesized using a thin-film hydration process, and characterization performed by SEM, particle size, polydispersity index, zeta potential, and FTIR. Conclusion: V. amygdalina succesfully to loaded into niosomes. Span-60 with various concentration affected of characterization of niosomes. Increased span-60 increasing particle size, polydispersity index, and %EE.
Studi Pustaka: Pengaruh Metode Ekstraksi Terhadap Kualitas Gelatin dari Ikan dengan Pretreatment Asam dan Basa Jaya, Adrian; Ismail, Isriany; Arsul, Muhammad Ikhlas
Jurnal Farmasi UIN Alauddin Makassar Vol 12 No 1 (2024): Jurnal Farmasi Edisi Mei
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jfuinam.v12i1.38150

Abstract

Pendahuluan: Gelatin ikan merupakan gelatin alternatif yang bersifat multifungsi yang diperoleh dari hidrolisis kolagen dari bagian ikan meliputi sisik, kulit maupun tulang dengan metode ekstraksi tertentu. Tujuan: Untuk mendapatkan informasi dari berbagai sumber literatur mengenai pengaruh metode ekstraksi gelatin ikan terhadap kualitas gelatin dalam upaya mengembangkan metode yang paling efisien dalam produksi gelatin ikan. Metode: Penulisan artikel ini adalah literature review yaitu sebuah pencarian literatur baik international maupun nasional yang dilakukan dengan menggunakan database pubmed, sciencedirect, dan google schoolar. Penelusuran dan analisis artikel menggunakan metode PICO (Population, Intervention, Comparison, Outcome). Hasil: Terdapt 28 artikel yang memenuhi kriteria untuk selanjutnya dilakukan analisis dengan melihat metode ekstraksi gelatin dan karakteristik gelatin. Kesimpulan: Semakin tinggi suhu ekstraksi, semakin rendah nilai Gel strength dan kadar abu dari gelatin yang dihasilkan. Semakin tinggi suhu ekstrkasi maka semakin tinggi nilai viskositas. Pada hasil analisis diperoleh bahwa pH optimum diperoleh pada ekstraksi gelatin berada pada kisaran 4,5-6,5.
Edukasi Kosmetik Sehat dan Halal Pada Anak Usia Sekolah Syarif, Alwiyah Nur; Maddeppungeng, Nurul Muhlisah; Syahrana, Nur Azizah; Ismail, Isriany
SAMATA JOURNAL OF PUBLIC HEALTH SCIENCE Volume 1, Issue 1, March-August 2022
Publisher : Program Studi Kesehatan Masyarakat UIN Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Orang yang berada di kelompok usia remaja sudah sangat memperhatikan penampilan mereka. Banyaknya kosmetik yang beredar dipasaran, jika tidak diketahui kriterianya keamanannya dapat mengakibatkan iritasi pada kulit. Studi ini bertujuan untuk menilai pengetahuan dan kebiasaan siswa mengenai penggunaan kosmetik yang sehat dan halal melalui pemberian direct socialization. Studi ini dilakukan di Madrasah Aliah Negeri 2 Model dengan memperioritaskan kehadiran siswi kelas XII dan guru perempuan yaitu sebanyak 53 peserta. Kajian ini dibagi menjadi tiga tahapan. Pada tahapan pertama, para siswi menerima informasi umum tentang kegiatan dan daftar hadir. Tahap kedua peserta kemudian diukur tingkat pengetahuan dan perilaku melalui pengisian kuesioner. Pada tahapan ketiga, diadakan penyuluhan kesehatan dengan topik yang tercakup dalam pertanyaan angket. Para fasilitator mengevaluasi hasil kegiatan dengan pembagian post-test pada tahap akhir kegiatan ini. Studi ini menyimpulkan terdapat perubahan pengetahuan sebelum dan sesudah diberikan penyuluhan penggunaan kosmetik yang aman, sehat dan halal. Kegiatan ini secara tidak langsung memberikan pengetahuan tentang pencegahan timbulnya dermatitis kontak alergi banyak terjadi pada remaja, terutama pada wajah.
Potential of Thibbun Nabawi Habbatusauda (Nigella sativa); Review of the Active Pharmacological Timoquinone Mardan, Mardan; Ismail, Isriany; Rauf, Afrisusnawati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 2 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Habbatusauda or Black Seed or Black Cumin (Nigella sativa) has been widely mentioned in various Islamic studies, including its potential as a "cure for all diseases except death. The hadith can be interpreted as improving immunity and enhancing memory (physical and cognitive aspects). Scientifically, the high content of thymoquinone and DHA in Black Seed plays a major role as an immunomodulator and brain nutrition. Black Seed contains both hydrophilic and lipophilic compounds. Amino acids, proteins, carbohydrates, essential oils, fixed oils, sterols, alkaloids, saponins and crude fiber, and minerals, thymoquinone, p-cymene, longifoline thujene, carvacrol, cubebene, pinene, limonene, pinene, sabinene are the ingredients. Timoquinone is present at a concentration of 3.5-8.7 mg/g in oil. Black Seed Oil is also high in DHA (3%). The content of the active compound Timoquinone is most responsible for its wide range of effects.
Peningkatan Kadar Ketoprofen Terdisolusi melalui Pembentukan Dispersi Padat menggunakan Polivinil Alkohol (PVA): The Increasing of Dissolved Ketoprofen Concentration through Solid Dispersion Formation using Polyvinyl Alcohol (PVA) Sultan, Asriana; Ida, Nur; Ismail, Isriany
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (80.773 KB) | DOI: 10.22487/j24428744.2019.v5.i1.12096

Abstract

Ketoprofen is included in the Class II of Biopharmaceutical Classification System (BCS) which has low solubility. Low solubility will affect the dissolution rate and the dissolved concentration, so the absorption and bioavailability are low as well. Several studies have been conducted to improve the solubility and the dissolution of drugs from these group, such as by solid dispersion system. This study aims to determine the effect of polyvinyl alcohol (PVA) on the dissolved concentration of ketoprofen in solid dispersion and in physical mixture, and to decidethe optimum formula.Solid dispersion and physical mixture of ketoprofen - PVA were formulated with the ratio of 1:1, 1:2 and 1:4, and then compared with the standard ketoprofen. Evaluation of solid dispersion was performed by the intervention test of PVA as a matrix on the maximum wavelength of standard ketoprofen using a UV-Vis spectrophotometer and the dissolution test in artificial gastric fluid media without pepsin using a basket stirrer at pH ± 1,2, the temperature of 37 ± 0.5ºC, and device speed of 50 rpm. The sample was collected at 10, 20, 30, 45, and 60 minutes. The amount of dissolved ketoprofen was determined by a UV-Vis spectrophotometer at a wavelength of 260 nm. The results showed that there was no shifting on maximum wavelength point in both solid dispersions and physical mixtures. The dissolved ketoprofen concentration that was represented in solid dispersion was greater than in physical mixture and standard ketoprofen. The highest dissolved ketoprofen concentration was indicated in solid dispersion formula with the ratio of 1:1.
Co-Authors Arsul, Muhammad Ikhlas Asriana Sultan Elly Wahyudin Jaya, Adrian Latifah Rahman Maddeppungeng, Nurul Muhlisah Mardan Mardan Nur Ida Pratiwi, Afrianty Rauf, Afrisusnawati Rizal Rizal Syahrana, Nur Azizah Syarif, Alwiyah Nur