cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota bandung,
Jawa barat
INDONESIA
Acta Pharmaceutica Indonesia
Published by Institut Teknologi Bandung
ISSN : 0216616X     EISSN : 27760219     DOI : -
Core Subject :
Acta Pharmaceutica Indonesia merupakan jurnal resmi yang dipublikasikan oleh Sekolah Farmasi Institut Teknologi Bandung. Jurnal ini mencakup seluruh aspek ilmu farmasi sebagai berikut (namun tidak terbatas pada): farmasetika, kimia farmasi, biologi farmasi, bioteknologi farmasi, serta farmakologi dan farmasi klinik. Acta Pharmaceutica Indonesia is the official journal published by School of Pharmacy Institut Teknologi Bandung. The journal covers all aspects of pharmaceutical issues which includes these following topics (but not limited to): pharmaceutics, pharmaceutical chemistry, biological pharmacy, pharmaceutical biotechnology, pharmacology and clinical pharmacy.
Arjuna Subject : -
Articles 261 Documents
 23   24   25   26   27 
EVALUASI PENYIMPANAN OBAT HIGH ALERT DI GUDANG DAN APOTEK RAWAT INAP DI INSTALASI FARMASI RUMAH SAKIT JIWA DAERAH PROVINSI JAMBI Luthfiyyah, Annisa; Yudha Putra, Diky Okta; Sani K, Fathnur
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.24976

Abstract

The storage of high alert medications at the Regional Mental Hospital (RSJD) of Jambi Province is a crucial aspect of healthcare that impacts patient safety. This study aims to evaluate the compliance of high alert medication storage in the warehouse and inpatient pharmacy of RSJD Jambi Province based on the applicable Standard Operating Procedures (SOP). The research was based on observation with a qualitative descriptive approach, where data is collected through a checklist containing indicators of storage compliance. The results show that all storage procedures for high alert medications have been implemented effectively, with a compliance percentage of 100%. The medications are stored separately from other drugs, in accordance with FIFO and FEFO principles, and are clearly labeled. The conclusion of this study emphasizes that the management of high alert medications at RSJD Jambi Province has met the established standards, thereby minimizing the risk of errors in medication handling.
FORMULASI DAN EVALUASI GRANUL EFERVESEN EKSTRAK DAUN SALAM (SYZYGIUM POLYANTHUM (WIGH) WALPERS) Akbar, Nanda Dwi Akbar; Rizky Uswatun Arifah, Anisya; Setyaningsih, Wahyu; Putri Pitarisa Sudarsono, Agustina
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.25032

Abstract

Bay leaves (Syzygium polyanthum (Wigh) Walpers) contain flavonoid compounds which act asantioxidants for the treatment of diabetes mellitus. The ethanol extract of bay leaves can reduceblood glucose levels in white rats that have been induced by streptozotocin. Effervescentgranules dissolve easily in water and provide a fresh taste like fizzy drinks making it easier toconsume, especially for consumers who cannot take capsules or tablets. The aim of this researchwas to formulate and evaluate bay leaf extract effervescent granules. The research stage wasbegun by producing bay leaf extract by maceration. The effervescent granule formulation wasmade in 3 formula that contain 1% bay leaf extract, citric acid, tartaric acid, sodium bicarbonate,aspartame, magnesium stearate, talc, lactose and PVP K-30 concentrations of 2% (F1), 4% (F2),and 5% (F3). Effervescent granules were prepared by dry granulation. The physical propertiesof bay leaf extract effervescent granules that were observed included organoleptic, watercontent, flow time, angle of repose and effervescent cessation time. The results showed that F1had the greatest water content (2.485%), flow time (10.274) and angle of repose (24.70), but F3had the greatest effervescent cessation time (4.1 minutes) compared to F1 (3, 3 minutes) and F2(3.5 minutes). This research can be concluded that effervescent granules containing 1% bay leafextract and PVP K-30 with varying concentrations of 2, 4 and 5% meet the requirements forwater content, flow time, angle of repose and effervescent cessation time.
STUDI EFEK SAMPING ANTITUBERKULOSIS PADA PASIEN RAWAT JALAN DI SALAH SATU RUMAH SAKIT DI GARUT Fadhilla, Genialita; Fatimah P.H, Sitti; Rahma, Asilia
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.25067

Abstract

Tuberculosis remains a global health problem with high incidence and mortality rates, 724,309 people infected with tuberculosis. One of the challenges in the treatment of tuberculosis is side effects of antituberculosis (OAT) which can lead to treatment discontinuation and drug resistance. This study aimed to identify the incidence of OAT side effects in outpatient tuberculosis patients at DOTS clinic in one of  hospitals at Garut. This study used a descriptive survey design with a cross-sectional. Data were collected from 31 tuberculosis patients who met the inclusion criteria through interviews and medical records review during May-June 2024. Respondents used fixed dose combination (FDC) therapy (94% ) and  single drug formulation(6%). OAT side effects are divided into mild and severe effects. The mild side effects most often experienced by respondents were redish urine (94%), flu-like symptoms (81%), and joint pain (77%). Meanwhile, the most common severe side effect experienced by respondents was visual (23%). Side effects are managed by administering symptomatic drugs such as antiemetics, analgesics, antipyretics, and vitamin B6. Intensive monitoring and appropriate management of side effects are essential to improve treatment adherence, prevent drug resistance, and reduce morbidity and mortality from tuberculosis.  
Front Matter: Acta Vol 50 (1) Indonesia, Acta Pharmaceutica
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.26023

Abstract

Penentuan Kadar Selenium dalam Suplemen Kesehatan dengan Metode Spektrofotometri Menggunakan Reagen Kolorimetri 2,3-Diaminonaftalena Gumilar, Anggi; Putri, Adinda Triani; Dewi, Mira Andam; Ibrahim, Slamet
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.24847

Abstract

Health supplements containing selenium are now increasingly used by public . However, so far, a simple analytical method for determining selenium in health supplements are still rare. The latest method for determining selenium is based on  Inductively Coupled Plasma (ICP) spectrometry. The cost of this method is very expensive. This study aims to apply and validate the UV-Vis Spectrophotometry method for determining selenium in health supplements using 2,3 Diaminonaphthalene as  reagent. The study began by testing the specificity of reaction between Selenium with the reagent, that it is showed in specific spectrum with maximum absorbance wavelength at 483 nm. The linearity test using calibration curve, the results obtained were a linear regression equation y = 0.0126x + 0.0736 with the value of r2 = 0.9974 and Vx0 = 0.01%. Limit of detection = 0.00917 mg/mL and limit of quantitation = 0.02777 mg/mL. The accuracy of this method expressed as an average of % Recovery was 97.84% and the precision expressed as % RSD was 0.02%. The final step of this study was the determination of selenium in supplement samples using the standard addition method. The average results obtained based on the determination of selenium levels in supplements were 58.82% (sample A); 111.17% (sample B); and 98.08% (sample C) calculated against the selenium levels listed on the label of each sample, namely 25, 30, and 50 mg Se, with the requirement being in the range of 90 - 110% of the levels listed on the label. Thus, only sample C meets the requirements.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN DEODORAN SPRAY EKSTRAK ETANOL DAUN KUPU-KUPU (Bauhinia purpurea L) TERHADAP Staphylococcus epidermidis DAN Pseudomonas aeruginosa Humaira, Yara; Nasution, Muhammad Amin; Yuniarti, Rafita; Nasution, Haris Munandar
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.25001

Abstract

Body odor affects a person's social relationships, unpleasant odors are caused by bacteria that appear on parts of the body that are from sweat. One of the cosmetic products that is believed to prevent body odor is deodorant. Deodorant  spray has more hygiene because it is used without direct contact with the skin. An important component in deodorant sprays formulation is antimicrobial agents. Long-term use of synthetic antimicrobials can lead to resistance, so it must to use natural antimicrobials. Butterfly leaves (Bauhinia purpurea L) can be a natural antimicrobial agent, because  contain secondary metabolites such as flavonoids, phenols, alkaloids and saponins that can inhibit bacterial growth. This research began with phytochemical screening, making deodorant spray F0 (without extract), F1 (10% ), F2 (15% t), and F3 (20%) extract, evaluation and testing of antibacterial activity against Staphylococcus epidermidis dan Pseudomonas aeruginosa. The data analyzed with SPSS using One Way ANNOVA method. The results of this study showed that the pH value decrease along with the increase in the concentration of the extract in the preparation, but it was still within the normal pH range of 4.5-6.5. The results of the irritation test did not show an irritation and the preparation was preferred by the panelists. The antibacterial activity of deodorant spray  against both bacteria has a strong inhibitory power, there are F0 (0 mm), F1 (12.92 mm), F2 (13.82 mm), and F3 (16.85 mm) against Staphylococcus epidermidis, and F0 (0 mm), F1 (12.57 mm), F2 (13.47 mm), and F3 (15.32 mm). 
REVIEW: PENDEKATAN METABOLOMIK DALAM EKSPLORASI TANAMAN ANTIHIPERTENSI: PROFIL SENYAWA BIOAKTIF DAN PERUBAHAN METABOLIT ENDOGEN Khoirunnisa, Intan; Patonah
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.25029

Abstract

Metabolomic techniques represent an analytical strategy that supports the discovery of natural product-based drugs, including antihypertensive agents. This article aims to review various metabolomic techniques and approaches used to identify and characterize bioactive compounds in medicinal plants, highlighting two primary strategies: (1) plant metabolite profiling to identify potential bioactive biomarkers, and (2) analysis of endogenous metabolite changes in biological samples from hypertensive models treated with plant-based interventions. Literature was searched through databases such as PubMed and Google Scholar using relevant keywords. This review focuses on analytical methods such as LC-MS, NMR, and HPLC, data processing strategies including PCA, PLS-DA, and OPLS, and the integration of metabolomic techniques in the validation and exploration of plant-derived antihypertensive compounds. The findings demonstrate that metabolomic approaches significantly contribute to accelerating natural drug discovery by identifying biomarkers and elucidating mechanisms of action through related endogenous metabolic pathways. 
UJI VALIDITAS DAN RELIABILITAS KUESIONER PDQ39 VERSI BAHASA INDONESIA PADA PASIEN PARKINSON Oktariza, Yasinda; Amalia, Lia; Sobaryati, Sobaryati; Kurniawati, Media Y
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.25127

Abstract

The PDQ-39 questionnaire is a disease-specific instrument used to measure the health-related quality of life (HRQoL) in Parkinson's disease patients. HRQoL assessment is one of key parameter for evaluating patient outcomes after receiving pharmacological and non-pharmacological treatments. The PDQ-39 questionnaire has been widely used in various countries, including Indonesia. However, no studies about validating and assessing the reliability of the Indonesian version of the PDQ-39 questionnaire have been published. This study aims to evaluate the validity and reliability of the Indonesian version of the PDQ-39 questionnaire. A cross-sectional study was conducted using a consecutive sampling technique. The study began with a language adaptation process. Questionnaire validity was assessed using Pearson’s Product-Moment correlation, while reliability was tested using Cronbach’s Alpha coefficient (>0.6). The questionnaire was administered to 31 outpatients at the Neurology Clinic of RSUD Arifin Achmad, Riau Province, and RSAU Dr. M. Salamun Bandung. Validity testing demonstrated that most correlation coefficients (r) between domains were acceptable (0.470–0.892) and statistically significant at p<0.01, except for item number twenty (r=0.345). Reliability testing showed a high overall Cronbach’s Alpha value of 0.924. Based on these findings, the Indonesian version of the PDQ-39 questionnaire is a valid and reliable instrument for measuring the quality of life in Parkinson's disease patients.
ANALISIS BIBLIOMETRIK TREN DAN KEBAHARUAN STUDI PERMEABILITAS DENGAN CHEMINFORMATICS BERBASIS DATAWARRIOR Matthew Valentino, Tambunan; Putri, Mulan Gevika Amara; Damayanti, Ni Ketut Anggun; Sianturi, Tiarma Kristiana
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.25181

Abstract

Cheminformatics is a discipline that employs computational methods on chemical data and has emerged as a cutting-edge approach in pharmaceutical sciences. DataWarrior, an open-source software that integrates big data, offers a variety of features to support cheminformatics studies. This study aims to examine permeability research using DataWarrior-based cheminformatics and evaluate the potential for research innovation, particularly within the field of pharmacy. A bibliometric analysis using the Dimensions, Biblioshiny, and ResearchRabbit databases reveals that publications on permeability studies employing DataWarrior have increased, although the number of citations has declined due to a lack of novelty in the topics. Moreover, the limited use of the keyword "cheminformatics" in permeability studies indicates that the connection between these two fields needs to be strengthened. The integration of pharmacokinetic and physicochemical data via DataWarrior enables the development of more reliable methods by enhancing the prediction of compound similarity through its built-in descriptors, thereby supporting the practicality of molecular permeability and pharmacokinetic studies for new compounds. On the other hand, this research potential for Indonesia to increase its contributions to publications and citations in this field.
PENGARUH VARIASI KONSENTRASI EKTRAK DAUN TEH HIJAU (Camellia sinensis (L.) Kuntze) TERHADAP MUTU FISIK SEDIAAN EYE CREAM Nofita sulistiawati; Putriana Rahman, Alief; H, Syaifiyatul
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.25600

Abstract

Premature aging of the eye area is characterized by the appearance of wrinkles, fine lines, eye bags and dark circles due to exposure to ultraviolet (UV) light, free radicals, and decreased collagen production. Green tea leaves (Camellia sinensis (L.) Kuntze) are known to contain high antioxidants, especially catechins such as epigallocatechin gallate (EGCG), so it has the potential to be used as an anti-aging agent to slow down the skin aging process. This study aims to determine the effect of variations in green tea leaf extract concentration on the physical quality of eye cream preparations and determine the best formula. The study was conducted experimentally with four eye cream formulas, namely formula 0 (0% extract), formula 1 (0.5% extract), formula 2 (5% extract), and formula 3 (10% extract). Physical quality evaluation included organoleptic test, homogeneity, pH, viscosity, spreadability, stickiness, cream type, and centrifugation test. Data were analyzed using One-Way ANOVA test and compared with eye cream physical quality standards. The results showed significant differences (p < 0.05) in the parameters of pH, viscosity, spreadability, and stickiness between formulas. Formula 1 (0.5%) fulfilled all physical quality parameters according to the standard, including even homogeneity, pH according to the skin, optimal viscosity and spreadability, and no phase separation. It was concluded that formula 1 was the best formula.

Page 26 of 27 | Total Record : 261

 23   24   25   26   27 

Filter by Year

2011 2025


Reset
Filter By Issues
All Issue Vol. 50 No. 2 (2025) Vol. 50 No. 1 (2025) Vol. 49 No. 01 (2024) Vol. 49 No. 2 (2024) Vol. 48 No. 2 Vol. 48 No. 1 (2023) Vol. 47 No. 2 (2022) Vol. 47 No. 1 (2022) Vol. 46 No. 2 (2021) Vol. 46 No. 1 (2021) Vol. 43 No. 1 (2018) Vol. 42 No. 2 (2017) Vol 42, No 1 (2017) Vol. 42 No. 1 (2017) Vol. 39 No. 3 & 4 (2014) Vol 39, No 3 & 4 (2014) Vol. 39 No. 1 & 2 (2014) Vol 39, No 1 & 2 (2014) Vol 38, No 4 (2013) Vol. 38 No. 4 (2013) Vol 38, No 3 (2013) Vol. 38 No. 3 (2013) Vol 38, No 2 (2013) Vol. 38 No. 2 (2013) Vol. 38 No. 1 (2013) Vol 38, No 1 (2013) Vol. 37 No. 4 (2012) Vol 37, No 4 (2012) Vol 37, No 3 (2012) Vol. 37 No. 3 (2012) Vol 37, No 2 (2012) Vol. 37 No. 2 (2012) Vol. 37 No. 1 (2012) Vol 37, No 1 (2012) Vol 36, No 3 & 4 (2011) Vol. 36 No. 3 & 4 (2011) Vol. 36 No. 1 & 2 (2011) Vol 36, No 1 & 2 (2011) More Issue