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Acta Pharmaceutica Indonesia
Published by Institut Teknologi Bandung
ISSN : 0216616X     EISSN : 27760219     DOI : -
Core Subject :
Acta Pharmaceutica Indonesia merupakan jurnal resmi yang dipublikasikan oleh Sekolah Farmasi Institut Teknologi Bandung. Jurnal ini mencakup seluruh aspek ilmu farmasi sebagai berikut (namun tidak terbatas pada): farmasetika, kimia farmasi, biologi farmasi, bioteknologi farmasi, serta farmakologi dan farmasi klinik. Acta Pharmaceutica Indonesia is the official journal published by School of Pharmacy Institut Teknologi Bandung. The journal covers all aspects of pharmaceutical issues which includes these following topics (but not limited to): pharmaceutics, pharmaceutical chemistry, biological pharmacy, pharmaceutical biotechnology, pharmacology and clinical pharmacy.
Arjuna Subject : -
Articles 254 Documents
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UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAN SUBFRAKSI DAUN PEPAYA (CARICA PAPAYA L.) TERHADAP BAKTERI PENYEBAB JERAWAT Rika Hartati
Acta Pharmaceutica Indonesia Vol. 49 No. 2 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Propionibacterium acne and Staphylococcus epidermidis are the major bacteria that infect skin which can cause many disease in the skin, one of them is acne. Papaya is one of the plants that has many activities, such as antibacterial activity. In traditional use, papaya leaves used for treatment of acne. In this study, the antibacterial activity of n-hexane, ethyl acetate, and ethanol papaya leaves extract were tested against Propionibacterium acne and Staphylococcus epidermidis ATCC 12228 using agar diffusion disc method, microdilution method to determine minimum inhibitory concentration (MIC), and bioautography test. The preliminary result with diffusion disc showed that at 5% concentration of n-hexane extract of papaya leaves produced the largest inhibit zone for both bacteria, 7,43 mm for Propionibacterium acne and 7,78 mm for Staphylococcus epidermidis. The result showed that the MIC of n-hexane extract of papaya leaf were >4096 µg/mL. The result of the bioautography test of n-hexane extract showed the inhibition zone at Rf 0,09-0,28 and Rf 0,63 in chloroform-n-hexane system (6:3) for Propionibacterium acne. Based on the test result, the n-hexane extract of papaya leaves was continued to the fractination stage by chromatotron method and the compound at Rf 0,27 were selected as the target. The fraction was monitored by thin-layer chromatography (TLC) and the fraction contained the active compound was continued to subfractination stage by preparative chromatography method. The subfraction was tested against Propionibacterium acne and Staphylococcus epidermidis by bioautography method at 600 µg/mL concentration. It resulted an inhibitory zone at Rf 0,25-0,27 for Staphylococcus epidermidis and Rf 0,27 for Propionibacterium acne. Based on the result characterization of subfraction of n-hexane extract of papaya leaves by specific visualization reagent, the subfraction was predicted contain steroid/triterpenoid compound. Keywords: antibacterial, acne, papaya leaves, Carica papaya L., biootografi
The THE RELATIONSHIP BETWEEN KNOWLEDGE AND ADHERENCE OF BLOOD SUPPLEMENTED TO THE INCIDENCE OF ANEMIA IN PREGNANT AND LACTATING WOMEN IN PALU CITY: Indonesia Parumpu, Firdawati; Rumi, Amelia; Putri, Amanda
Acta Pharmaceutica Indonesia Vol. 49 No. 2 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Anemia is one of the conditions that often occurs in pregnant and lactating women when hemoglobin levels in the body are below normal, therefore pregnant and lactating women are strongly encouraged to take Blood Supplemented during pregnancy and lactation. This study was conducted to determine the incidence of anemia, the level of knowledge of respondents, the level of compliance of respondents, and to determine the effect of the level of knowledge and compliance on the incidence of anemia in pregnant and lactating women in Palu City. This research method uses a cross sectional design with accidental sampling technique by giving questionnaires to respondents. The results obtained were that the level of knowledge of respondents in the good category obtained a greater percentage of 63%, the level of compliance of respondents in the low category of 37%, and the level of anemia incidence in respondents obtained anemia respondents as much as 60%. The results of the chi-square test on compliance obtained a sig probability value ≤ 10% (0.1) P-value of 0.000, while the knowledge obtained a value of 0.103. The conclusion of this study is that there are many respondents who are anemic, at the level of knowledge obtained in the good category, while at the level of compliance the respondents are said to be low, so there is a relationship between the level of compliance of respondents to the incidence of anemia in pregnant and lactating women in Palu City.
OVERVIEW OF ANEMIA SUSPECT STATUS AND CONSUMPTION BEHAVIOR OF BLOOD SUPPLEMENTED (TTD) FOR ADOLESCENT GIRLS IN PALU CITY Parumpu, Firdawati; Hardani, Ririen; Purwanto, Ananda Putri; Kusumawati, Afriani
Acta Pharmaceutica Indonesia Vol. 49 No. 01 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v49i01.22588

Abstract

Anemia adalah suatu kondisi seseorang mengalami kehilangan zat besi dalam darah yang ditandai dengan rendahnya kadar hemoglobin (Hb) dalam tubuh. Berdasarkan data dinas kesehatan Kota Palu Tahun 2022, terjadi peningkatan kasus baru anemia pada remaja putri sebesar 21% dari tahun 2020 ke tahun 2021. Penelitian ini dilakukan untuk mengetahui gambaran status suspek anemia dan perilaku konsumsi tablet tambah darah remaja putri di kota Palu. Metode penelitian ini menggunakan desain deskriptif non-eksperimental dan pendekatan cross sectional dengan teknik pengambilan sampel purposive sampling yang diperoleh secara langsung dari 80 responden di kota Palu melalui pengisian kuesioner dengan kriteria inklusi dan eksklusi. Hasil yang didapatkan yaitu status anemia remaja putri di kota Palu yaitu sebanyak 55 responden (68,75%) suspek anemia dan sebanyak 25 responden (31,25%) bukan suspek anemia, sedangkan pada gambaran perilaku konsumsi tablet tambah darah yaitu 57,50% responden setuju pernah mencari informasi tentang anemia secara mandiri, 66,25% setuju untuk tidak langsung mempercayai informasi yang beredar di internet terkait anemia dan penggunaan tablet tambah darah, 52,50% tidak setuju bahwa tidak dapat menangani efek samping saat mengkonsumsi tablet tambah darah, 52,50% ragu-ragu bahwa lemas dan lesu yang dirasakan adalah akibat dari kekurangan zat besi, 67,50% setuju perlu bantuan tenaga kesehatan (apoteker/tenaga kefarmasian) terkait efek samping dari mengonsumsi tablet tambah darah, dan 60,00% setuju lebih mempercayai informasi langsung dari tenaga kesehatan dibandingkan pada media internet. Kesimpulan penelitian yaitu kejadian suspek anemia pada remaja putri di kota Palu masih tinggi dan oleh karena itu diperlukan perhatian pada beberapa faktor perilaku konsumsi tablet tambah darah pada remaja putri.
INVOLVEMENT ARACHIDONIC ACID CASCADE IN MEMORY DEFICIT BY KRATOM (Mitragyna speciosa) IN MALE WISTAR RATS Ramadhani, Chelsea Aulia; Anggadiredja, Kusnandar
Acta Pharmaceutica Indonesia Vol. 49 No. 01 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v49i01.23562

Abstract

Kratom (Mitragyna speciosa) is a plant that is widely found in Southeast Asia particularly, in Indonesia. Mitragynine, which was the main alkaloid of kratom, has been reported associated with addictiveness and memory impairment in animal studies. However, the mechanism of memory impairment is still unclear. In the present study, we investigated the involvement of the arachidonic acid cascade in memory impairment caused by kratom. Male Wistar rats were divided into seven groups, namely vehicle (CMC Na 0.5%; oral), kratom ethanolic extract (50, 100 and 200 mg/Kg; oral (p.o)), and the group given Diclofenac Sodium (5 mg /Kg; Intraperitonial (i.p)) 30 mins before administration of kratom ethanolic extract (50, 100 and 200 mg/Kg; oral) for 14 days. Memory impairment was carried out using a spatial memory test on days 10-16 using the Morris Water Maze and a working memory test using the Y Maze on the 17th day. Kratom administration was shown to impair spatial memory and working memory when compared with the vehicle group (P<0.05). Diclofenac sodium prevents spatial memory and working memory impairment due to Kratom when compared to the group administered by kratom monotherapy at the equivalent dose (P<0.05). In this study, it was found that there was involvement of the arachidonic acid cascade in memory impairment by kratom.
EVALUASI PENGETAHUAN MAHASISWA FARMASI DAN MASYARAKAT UMUM TERKAIT PENGGUNAAN SUPLEMEN PADA COVID-19 Reyaan, Irianti Bahana Maulida; Dwiyanti, Jessica; Damayanti, Sophi
Acta Pharmaceutica Indonesia Vol. 49 No. 01 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v49i01.23613

Abstract

COVID-19 adalah penyakit yang disebabkan oleh virus SARS-CoV-2. Selain obat, banyak penelitian yang juga dilakukan untuk menentukan efikasi serta keamanan suplemen untuk COVID-19, misalnya vitamin C, vitamin D, dan zink yang memiliki peran bagi sistem kekebalan tubuh termasuk potensiasi efek antivirus. Pengetahuan dan penggunaan suplemen yang tepat dapat menjadi salah satu upaya untuk menunjang pengobatan COVID-19. Survei dengan menggunakan kuesioner merupakan metode yang dapat dipilih untuk mendapatkan gambaran pengetahuan mahasiswa farmasi dan masyarakat umum terkait hal tersebut. Tujuan penelitian ini adalah menentukan tingkat pengetahuan mahasiswa farmasi dan masyarakat umum terkait suplemen dan penggunaannya dalam kondisi COVID-19. Survei dilakukan pada 412 responden yang terdiri dari mahasiswa farmasi dan masyarakat umum pada bulan Januari 2021-April 2021. Hasil survei dari 412 responden menunjukkan bahwa pengetahuan mahasiswa farmasi dan masyarakat umum terkait suplemen dan penggunaannya untuk COVID-19 masih kurang dengan 18,4% mahasiswa farmasi dan 4,5% masyarakat umum berada pada kategori pengetahuan tinggi. Berdasarkan analisis, tingkat pengetahuan mahasiswa farmasi lebih baik dari masyarakat umum terkait penyakit COVID-19, penggunaan suplemen secara umum, dan penggunaan suplemen untuk COVID-19 (p<0,001).
Front Matter Vol 49 No. 1 Indonesia, Acta Pharmaceutica
Acta Pharmaceutica Indonesia Vol. 49 No. 01 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Pengaruh Pemberian Minyak Biji Kelor (Moringa seeds oil) Terhadap Kadar Trigliserida Pada Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Amalia, Nurul; Norhayati; Chandra, M. Andi; Rusida, Esty Restiana
Acta Pharmaceutica Indonesia Vol. 49 No. 2 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

ABSTRACT Elevated triglyceride levels can be managed through non-pharmacological approaches, including the use of moringa seeds. These seeds are rich in fatty acids that exhibit potential in reducing hyperlipidemia. This research is designed to assess the impact of moringa seed oil on triglyceride concentrations in male Wistar strain white rats (Rattus norvegicus) administered with different doses. Utilizing a Posttest-Only Control Group Design, the experiment was conducted across five groups: K1 (positive control), K2 (negative control), K3 (3 mL moringa seed oil), K4 (6 mL moringa seed oil), and K5 (9 mL moringa seed oil). Measurements were taken after treatment. Statistical analysis revealed a significant difference in triglyceride levels between the negative control group and the groups treated with moringa seed oil (p = 0.018, p < 0.05), indicating the oil's effectiveness in reducing triglyceride levels. Furthermore, Post-Hoc LSD analysis showed a significant difference between K4 and K5, with p = 0.045 (p < 0.050). These findings suggest that moringa seed oil significantly reduces triglyceride levels, particularly at higher doses. This research determided the therapeutic potential of moringa seed oil in managing hyperlipidemia by lowering blood triglyceride levels in male Wistar rats (Rattus norvegicus).
THE ROLE PHARMACIST OF IN IDENTIFYING AND REDUCING THE INCIDENCE OF DRUG-RELATED PROBLEMS IN HOSPITALIZED PATIENTS USING STRESS ULCER PROPHYLAXIS nugraha putra, oki
Acta Pharmaceutica Indonesia Vol. 49 No. 2 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Intervensi apoteker dalam managemen tim multidisiplin dapat mencegah maupun menurunkan masalah terkait obat atau drug-related problems (DRPs) yang berdampak terhadap perbaikan luaran klinis dan kualitas hidup pasien. Terapi stress ulcer prophylaxis (SUP) seringkali diberikan pada pasien yang menjalani perawatan di rumah sakit dan ditemukan adanya DRPs dari penggunanan obat tersebut. Review ini bertujuan untuk mengkaji intervensi apoteker dalam menurunkan drug-related problems (DRPs) pada pasien rawat inap yang mendapatkan terapi stress ulcer prophylaxis (SUP). Review ini merupakan narrative review dengan menggunakan artikel dari database Pubmed maupun Google Scholar yang mengulas intervensi apoteker dalam mencegah maupun menurunkan DRPs, yakni biaya pengobatan, pemilihan terapi, hingga efek samping dari penggunaan terapi SUP pada pasien yang dirawat di rumah sakit. Delapan artikel yang memenuhi kriteria inklusi dimasukkan ke dalam kajian ini. Mayoritas studi melaporkan bahwa intervensi apoteker melalui pencocokan penggunaan SUP dengan pedoman dari American Society of Health-System Pharmacists (ASHP) mampu untuk menurunkan biaya pengobatan, menurunkan penggunaan SUP yang tidak diperlukan terutama pada pasien yang tanpa faktor risiko, dan menurnkan terjadiya efek samping terkait Clostridium difficile associated diarrhea (CDAD) akibat penggunaan obat golongan proton pump inhibitors. Intervensi apoteker berhubungan dengan penurunan penggunan terapi SUP yang tidak sesuai, penurunan biaya pengobatan, dan penurunan insiden efek samping obat pada pasien yang dirawat di rumah sakit. Penelitian lanjutan diperlukan untuk mengidentifikasi intervensi apoteker yang paling cost-effective. Kata Kunci: DRP; Stress Ulcer Prophylaxis; Apoteker; Rawat Inap
Perbandingan Aktivitas Antioksidan Pada Ekstrak Serta Krim Kobinasi Ekstrak Jeruk Nipis (Citrus Aurantifolia) Dan Daun The Hijau (Camellia Sinensis) Untuk Treatment Striae Gravidarum Rahman, Alief Putriana
Acta Pharmaceutica Indonesia Vol. 49 No. 2 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Striae Gravidarum (SG) are stretch marks seen in pregnant and postpartum women. Treatments for SG aim to reduce redness and enhance pigmentation and collagen. Chemical peeling treatment can be harmful. They may cause liver, kidney, and skin issues, including inflammation and skin loss. Meanwhile, laser treatments may lead to skin inflammation for 2-4 days post-procedure. Despite this, they remain popular. Topical retinoic acid can cause birth defects and miscarriages if used in pregnancy. This highlights the need for natural treatments for SG. This study aimed to find the content and the antioxidant activity of lime peel extract, green tea, and cream combination both of extract. Besides, another goal was to determine physical characteristics formulation in the cream preparation. Method of this research is phytochemical screening for extract. Measure Vitamin C, EGCG and antioxidant activity using UV-Vis spectrophotometry. The cream contains 10% lime and 6% green tea extracts. This study found lime peel and green tea extracts each yielded less than 10%. Phytochemical tests revealed lime extract has alkaloid, Steroid, Saponin, Flavonoids, Tannins, and Antraquinone. Lime peel extract has vitamin C 16,56103 mg/100 mg of extract. Green tea extract contains EGCG 22,5114 mg/100 mg of extract. Lime peel extract's antioxidant activity is 268,3130 ppm. For green tea, it's 154,4009 ppm . The combination cream has 115,7629 ppm of antioxidant activity. Its physical properties meet good cream standards. The conclution of this research is combination cream of lime peel and green tea extract has the highest antioxidant activity
The VALIDASI METODE DAN PENETAPAN KADAR FLAVONOID TOTAL SEDIAAN PEMBERSIH WAJAH ROSELLA BERBASIS AIR MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Fitri, Hidayah Anisa
Acta Pharmaceutica Indonesia Vol. 49 No. 2 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Rosella flower extract is known rich in flavonoid anthocyanin that has activity as antipollutants. So it has potential to be developed as a facial cleansing products. On previous studies, the optimum formula of roselle flower extract facial wash gell and micellar water has been obtained as water-base cleansing face products. Analysis of the of chemical compounds in both formula is essential to be conducted in order to determine their flavonoid content for their quality evaluation. In the analysis process, validated method should be used to ensure the method is performed in accordance to its purpose. This study aimed to validate the method and analyze total flavonoid content in the optimum formula of facial wash gell and micellar water containing rosella flower extract. The research was conducted using a UV-Vis spectrophotometry and method's validity was determined by analyzing linearity, LOD, LOQ, precision and accuracy parameter. Based on the results of the validation, all parameters of the analysis tested were qualified. The total flavonoid content of facial wash gell and micellar water determined by the valid method were 0.482 ± 0.008 mg QE/g and 0.136 ± 0.001 mg QE/g.

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