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Acta Pharmaceutica Indonesia
Published by Institut Teknologi Bandung
ISSN : 0216616X     EISSN : 27760219     DOI : -
Core Subject :
Acta Pharmaceutica Indonesia merupakan jurnal resmi yang dipublikasikan oleh Sekolah Farmasi Institut Teknologi Bandung. Jurnal ini mencakup seluruh aspek ilmu farmasi sebagai berikut (namun tidak terbatas pada): farmasetika, kimia farmasi, biologi farmasi, bioteknologi farmasi, serta farmakologi dan farmasi klinik. Acta Pharmaceutica Indonesia is the official journal published by School of Pharmacy Institut Teknologi Bandung. The journal covers all aspects of pharmaceutical issues which includes these following topics (but not limited to): pharmaceutics, pharmaceutical chemistry, biological pharmacy, pharmaceutical biotechnology, pharmacology and clinical pharmacy.
Arjuna Subject : -
Articles 254 Documents
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ISOLASI DAN IDENTIFIKASI GLIKOSIDA FLAVONOID BIOAKTIF DARI SYZYGIUM JAMBOS DAN AKTIVITAS PENGHAMBAT ENZIM α-GLUKOSIDASE Meilani, Lani; Nor, Islan; Insanu, Muhamad
Acta Pharmaceutica Indonesia Vol. 49 No. 2 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Diabetes has grown into a demanding global public health problem, with generally 537 million individuals afflicted worldwide. Without appropriate intervention, the risk of developing chronic complications increases. One of the practical actions for controlling type 2 diabetes mellitus is suppressing carbohydrate-hydrolyzing enzymes such as α-glucosidase. Syzygium jambos has a long history as a traditional medicine. It's commonly used to treat diabetes, rheumatism, inflammatory pain, and as a diuretic. This study aimed to investigate the α-glucosidase inhibitory properties of S. jambos leaves and their isolated compounds. Ethanol was used as the solvent for maceration, followed by fractionation using liquid-liquid extraction, vacuum liquid chromatography, column chromatography, and radial chromatography. The isolated compounds were identified using thin-layer chromatography (TLC), TLC densitometry, shifting reagents, infrared (IR) spectroscopy, mass spectrometry, and nuclear magnetic resonance (NMR) spectrometry. The ethyl acetate fraction presented the most potent activity of α-glucosidase inhibitory, with an IC50 value of 0.31 ± 0.01 µg/mL, exceeding the acarbose as positive control (IC50 62.86 ± 1.24 µg/mL). Two flavonoid glycosides, quercetin 3-O-xylosyl-(1→2)-rhamnoside and myricetin 3-O-xylosyl-(1→2)-rhamnoside, were identified inside this fraction, with IC50 values of 65.63 ± 1.36 µg/mL and 188.96 ± 2.85 µg/mL, respectively. These findings suggest that S. jambos has potential as a natural source for developing dietary supplements to control hyperglycemia affiliated with type 2 diabetes mellitus.
AKTIVITAS PENGHAMBAT LIPASE AKTIVITAS PENGHAMBAT LIPASE PANKREAS In Vitro dan STANDARISASI EKSTRAK BANGLE (Zingiber cassumunar ROXB.) Aryantini, Dyah
Acta Pharmaceutica Indonesia Vol. 49 No. 2 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

A body mass index of ≥30 kg/m2 indicates obesity, which is brought on by an excess of fat deposits. blocking obesity can be achieved in part by blocking the pancreatic enzyme lipase from doing its job. A plant belonging to the Zingiberaceae family, bangle rhizome has been used traditionally for body slimming and stomach reduction. Standardization is required to guarantee the quality of Bangle extract as a basic material for traditional medicine. The study aim were evaluate specific and non-specific character to standardize Bangle extract and to conduct the inhibitory activity of lipase enzyme activity in vitro. Maceration is used to create the extract, and the extract is subsequently examined for loss of drying, microscopic, phytochemical screening and ethanol and water-soluble extract content. In vitro tests were carried out using the colorimetric method to determine the percentage of inhibition of bangle extract against lipase. The ideal lipase incubation conditions were maintained at 37 OC, pH 7, for 10 minutes. The water content and total ash content yield respectively of 9.42% ± 0.36 and 0,7%±0,02 while the water and ethanol soluble extract levels were 16.96 and 15.13%, respectively. When tested against the pancreatic lipase enzyme at a concentration of 100 ppm, the bangle extract shown a 27.21%±1.59 inhibition of the enzyme. Bangle extract exhibits strong activity in suppressing the pancreatic lipase enzyme in vitro, and overall, both specific and non-specific parfameters of the extract have met the standard requirements.
Efektivitas Analgesik Ekstrak Temu Blenyeh (Curcuma Pupurascens Blume) pada Mencit Putih Jantan Girly Risma Firsty; Indah Pramesti; Oktariani Pramiastuti
Acta Pharmaceutica Indonesia Vol. 49 No. 2 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Pain is a sign of tissue damage in the body. Extracts from the Zingiberaceae family have been proven to be hypoalgesic agents and are superior to non-steroidal anti-inflammatory drugs. The aim of the research was to determine the analgesic effectiveness of the ethanol extract of temu blenyeh (Curcuma purpurascens Blume). The analgesic effectiveness test was carried out using the writhing method (Sigmund) on male white mice (Mus musculus) as test animals. The test animals used were 25 mice grouped into 5 consecutive treatment groups, namely Group 1 (aquadest), Group 2 (antalgin), group 3 (Dose 50 mg/kg BW), group 4 (Dose 100 mg/kg BW) and group 5 (Dose 150 mg/kg BW). The test sample was given orally, after 30 minutes the sample wasthen induced with 1% acetic acid intraperitoneally. Observed and calculated the cumulative number of writhing for 1 hour and calculated the percent writhing protection and percent analgesic effectiveness. The data obtained in the form of the cumulative number of stretches was analyzed by Anova test. The research results showed that the ethanol extract of temu blenyeh provided a percentage of protection respectively (44.5%; 50.14%; 57.64%) and the greatest percentage of analgesic effectiveness at a dose of 150 mg/kg BW of 99.07%. Data analysis showed that ethanol extract with a dose of 50; 100 and 150 mg/kg BW did not have a significant difference to the positive control, which means the sample had analgesic effectiveness.
STUDI KOMPARATIF PREDIKSI PROFIL ADMET OBAT SINTETIS DENGAN SENYAWA AKTIF TANAMAN HERBAL ANTIMALARIA MELALUI PENDEKATAN IN SILICO Rima Rasida; Pinanga, Yangie Dwi Marga; Anjar Hermadi Saputro; Damayanti, Sophi
Acta Pharmaceutica Indonesia Vol. 49 No. 2 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Resistance to antimalarial drugs has become a global challenge in achieving the target of malaria eradication. To address this issue, effective and safe alternative treatments are urgently needed. This study compares the ADMET profiles (absorption, distribution, metabolism, excretion, and toxicity) of synthetic antimalarial drugs with active compounds derived from herbal sources using an in-silico approach. The analyzed herbal compounds, including piperine, kaempferol, berberine, quassin, and limonin, demonstrated high intestinal absorption (>30%), good water solubility, and sufficient skin permeability. In the distribution analysis, kaempferol exhibited high volume distribution due to its lipophilic interactions with body tissues, although most compounds were unable to penetrate the blood-brain barrier. The herbal compounds piperine and kaempferol inhibited metabolic enzymes CYP2C19 and CYP1A2, whereas synthetic drugs tended to act as substrates. Regarding excretion, piperine served as a renal OCT2 substrate, while pyrimethamine exhibited low clearance. Toxicity assessments revealed that herbal compounds generally exhibited better toxicity profiles compared to synthetic drugs, with limonin showing the lowest acute and chronic toxicity. These findings suggest that herbal active compounds hold significant potential for development as alternative antimalarial agents, particularly in addressing drug resistance. This study highlights the importance of further developing herbal-based drugs through in silico approaches to enhance the efficacy and safety of malaria therapy. Keyword : malaria drug resistance, active herbal compounds, ADMET, In silico
LITERATURE REVIEW: KORELASI PENGETAHUAN TERHADAP KEPATUHAN PENGOBATAN PASIEN HIPERTENSI Fatimah, Sitti; Hanifa, Hanina Liddini; Pratiwi, Bhekti
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.24638

Abstract

Hypertension is often referred to as a “silent killer” because it is typically not accompanied by clinical symptoms, yet it silently damages vital organs in the body. Medication adherence among patients influencing the success of hypertension therapy, and medication adherence is strongly affected by the level of patient knowledge. The purpose of this literature review to analyze the relationship between patient knowledge and medication adherence based on previous studies. This review was conducted by searching primary literature in the PubMed and Google Scholar databases, focusing on articles published within the last 15 years, using keywords such as hypertension, medication adherence, and knowledge level. The results showed that there were 14 articles demonstrated a positive correlation between the level of hypertension-related knowledge and patient’s medication adherence. However, medication adherence is influenced by several factors, including the patient's motivation for treatment, the role of healthcare professionals, the accessibility of healthcare services, and the complexity of the therapy. Therefore, interventions aimed at improve medication adherence should not be limited to enhancing patient knowledge alone. Additional improvements can be made by strengthening the role of healthcare professionals to build patient trust, improving healthcare service systems, and selecting treatments that are appropriate to the patient's condition.
PEGEMBANGAN DAN VALIDASI METODE HEPARIN ATAU ENOKSAPARIN MENGGUNAKAN KROMATOGRAFI CAIR KINERJA TINGGI PASANGAN ION Astuti, Engrid Juni; Hidayati, Ika Ratna; Ibrahim, Slamet; Zulfikar, Muhammad Ali
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.24659

Abstract

One of the drugs used to treats and prevents COVID-19 thromboembolic problems is heparin or enoxaparin sodium. Heparin and enoxaparin have the side effect of bleeding when used, so monitoring of therapy is necessary. This present study aims to validate an ion pair high-performance liquid chromatography (HPLC) condition to analyse the adsorption of heparin or enoxaparin at molecularly imprinted polymer (MIP) after synthesis. The chromatographic system consists of a C8 column with a Diode Array Detector (DAD). The optimal chromatographic condition was obtained using mobile phase A (300mM NaCl + 10mM tetra n-butyl ammonium hydroxide) and mobile phase B (acetonitrile) under gradient elution, and 100 µl injection volume. The heparin or enox was detected at 231 nm, generating symmetrical peaks and good separation in 4.1 minutes after injection. The method indicated good selectivity with a resolution of 3.49 for heparin and 3.74 for enox. A linear detector response with R2 of 0.9965 and 0.9994 for heparin and enox. The method yields good precision and good accuracy. The proposed method has met the method validation requirements for adsorption heparin or enox analysis before using validation in biological samples.
ANALISIS KAJIAN RESEP DAN WAKTU TUNGGU PADA PERESEPAN KERTAS DAN ELEKTRONIK NONRACIKAN DI SALAH SATU KLINIK Wikaningtyas, Pratiwi; Shafira, Riyani Intan
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.24695

Abstract

Prescription service is a written request from a doctor to a pharmacist to provide and deliver medication for patients and it could prevent medication errors. Prescription service and waiting time are important points in pharmaceutical services. . Electronic prescription can minimize the incidence of medication errors and reduce waiting time. This study was conducted to compare paper-based prescriptions and electronic prescriptions on medication errors and waiting time using an analytical observational method with a cross-sectional study design. Data was collected prospectively using prescription review. Qualitative data was analyzed using Chi-Square and quantitative data was analyzed using Wilcoxon Rank Sum Test. The results showed the average number of medication errors was higher in paper-based prescriptions (10.66%) than in electronic prescriptions (5.82%). The waiting time was longer for paper-based prescriptions (10 minutes 10 seconds) compared to the average for electronic prescriptions (8 minutes 23 seconds).  The results showed that the implementation of electronic prescriptions in one of the clinics is better than paper prescriptions.
Formulasi dan Karakterisasi Minyak Atsiri Pala (Myristica fragrans) di Dalam Sistem Nanostructured Lipid Carrier Satrialdi, Satrialdi; Fadilah, Alinda Nur; Rahma, Annisa
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.24776

Abstract

Essential oil extracted from nutmeg (Myristica fragrans) contains various beneficial compounds that can be used in medicines and cosmetics. Nevertheless, nutmeg essential oil (NEO) use in pharmaceuticals is limited by its high lipophilicity and tendency to degrade. Encapsulating NEO into a nanostructured lipid carrier (NLC) can be an alternative to overcome these problems. Thus, this study aimed to develop an NEO formula in an NLC system (NEO-NLC) for topical use, to characterize NEO-NLC, and to elucidate its potential as an antioxidant. The optimization of the NEO-NLC formula included selecting liquid lipid components, adjusting their ratios, choosing a sonicator, selecting a surfactant system, and optimizing sonication amplitude. The optimum NEO-NLC formula was then characterized by determining particle size and distribution, measuring zeta potential, estimating encapsulation efficiency, and evaluating antioxidant activity. The optimum NEO-NLC formula was obtained with a composition of 1.8% cetyl alcohol, 3.0% almond oil, 1.2% NEO, 3.2% Tween 80, 0.8% Plantacare® 1200, and demineralized water. The resulting NEO-NLC exhibited a particle size of 124.4 ± 4.7 nm, a polydispersity index of 0.35 ± 0.05, a zeta potential of -39.0 ± 3.6 mV, and an encapsulation efficiency of 95.3 ± 0.6%. Encapsulation of NEO into an NLC system resulted in a 2.9-fold increase in antioxidant activity compared to unencapsulated NEO. The developed NEO-NLC showed potential for pharmaceutical or cosmetic raw material use.
STUDI FARMAKOGNOSTIK SERBUK JUS KULIT NANAS (Ananas comosus (L.) Merr) Farobbi, Muhammad Iqbal; Pratama, Iman Surya; Hidayat, Lalu Husnul
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.24955

Abstract

Pineapple (Ananas comosus (L.) Merr) is plant that can be utilized as traditional medicine. Pineapple is used as remedy for constipation, nausea, hemorrhoids, flu, anemia, urinary tract disorders, and various skin diseases. In addition, pineapple peels are used as anthelmintic. Pineapple peel has many therapeutic effects, but there is no pharmacognostic standardization related to pineapple peel to verify its validity and effectiveness.  Purpose of this research is to evaluate various pharmacognostic parameters, such as organoleptic, botanical, and physical aspects of pineapple peel. This research conducted organoleptic, microscopic, specific gravity, pH, water-soluble and ethanol-soluble extract content, acid number, and fluorescence tests. This research produced organoleptic profile pineapple peel solution with brownish-yellow color,  characteristic pineapple aroma, and  sour taste. Microscopic observations revealed parenchyma, vascular bundles, meristematic cells, raphide calcium oxalate crystals, epidermis, stone cells, phloem, and fibers. Specific gravity of pineapple peel powder is 1.04 g/mL. pH of  extract at 1% and 10% concentrations is 5 and 4. Water-soluble and ethanol-soluble content is 7.4 ± 0.23% and 5.3 ± 0.17%. Acid number of pineapple peel juice powder is 26.37 mg KOH/g. Pineapple peel juice powder fluoresces upon the addition of DMSO, ether, water, glacial acetic acid, petroleum ether, chloroform, toluene, acetic acid, dichloromethane, and ethyl acetate reagents
KARAKTERISASI DAN PEMERIKSAAN FITOKIMIA DARI SIMPLISIA DAUN ANGGREK MERPATI (Dendrobium crumenatum Sw.) Yudha Putra, Diky Okta; Syamsurizal, Syamsurizal; Elisma, Elisma
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.24961

Abstract

This study examined the characterization of crude drugs made from pigeon orchid leaves (Dendrobium crumenatum Sw.) and conducted phytochemical screening to identify the secondary metabolites present in them. Medicinal plants, particularly those from the orchid family, have significant potential for developing modern therapies due to the wide range of pharmacological compounds they contain, including anthocyanins, bibenzyl derivatives, and the main bioactive compound, dendrobine. In addition to their beauty, orchids are also beneficial for treating various diseases, making them a potential option for pharmaceutical preparations. The characterization results for the crude drugs derived from pigeon orchid leaves indicated water extractable matter of 42.01% and  ethanol extractable matter of 79.11%. The moisture content was measured at 16.04%, and a total ash content of 22.10%. Phytochemical screening showed the presence of alkaloids, phenolic compounds, flavonoids, saponins, and tannins in the pigeon orchid leaves, while no steroids were detected.

Page 25 of 26 | Total Record : 254

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