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INDONESIA
Acta Pharmaceutica Indonesia
Published by Institut Teknologi Bandung
ISSN : 0216616X     EISSN : 27760219     DOI : -
Core Subject :
Acta Pharmaceutica Indonesia merupakan jurnal resmi yang dipublikasikan oleh Sekolah Farmasi Institut Teknologi Bandung. Jurnal ini mencakup seluruh aspek ilmu farmasi sebagai berikut (namun tidak terbatas pada): farmasetika, kimia farmasi, biologi farmasi, bioteknologi farmasi, serta farmakologi dan farmasi klinik. Acta Pharmaceutica Indonesia is the official journal published by School of Pharmacy Institut Teknologi Bandung. The journal covers all aspects of pharmaceutical issues which includes these following topics (but not limited to): pharmaceutics, pharmaceutical chemistry, biological pharmacy, pharmaceutical biotechnology, pharmacology and clinical pharmacy.
Arjuna Subject : -
Articles 254 Documents
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AKTIVITAS ANTIINFLAMASI INFUSA BAWANG PUTIH SEGAR DAN BAWANG HITAM (Allium sativum L.) PADA TIKUS PUTIH (Rattus norvegicus L.)YANG DIINDUKSI KARAGENAN Deden Winda Suwandi; Siti Imaroh; Neng Fisheri Kurniati
Acta Pharmaceutica Indonesia Vol. 47 No. 2 (2022)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v47i2.19627

Abstract

Inflamasi merupakan respon perlindungan normal terhadap berbagai kerusakan pada jaringan. Bawang putih (Allium sativum L.) secara tradisional digunakan untuk mengobati diabetes, kolesterol, dan tekanan darah tinggi serta terbukti memiliki aktivitas sebagai antiinflamasi. Bawang hitam merupakan olahan lain dari bawang putih yang dikembangkan untuk mengurangi rasa dan bau yang tak sedap dari bawang putih segar tanpa menghilangkan aktivitas biologisnya. Penelitian ini bertujuan untuk mengetahui aktivitas antiinflamasi dari bawang putih segar dan bawang hitam dengan menggunakan metode pembengkakan telapak kaki tikus putih jantan galur Wistar yang diinduksi lambda karagenan. Hasil pengujian menunjukkan bahwa infusa bawang putih segar dan bawang hitam dosis 100 dan 300 mg/kg BB menunjukkan aktivitas sebagai antiinflamasi. Infusa bawang putih segar dosis 100 dan 300 mg/kg BB dapat menurunkan volume radang telapak kaki tikus dengan persen inhibisi radang masing-masing sebesar 33,97% dan 37,21%. Infusa bawang hitam dosis 100 dan 300 mg/kg BB juga memiliki aktivitas yang relatif sama yang ditandai dengan persen inhibisi radang masing-masing sebesar 35,08% dan 42,38%. Meskipun tidak ada perbedaan aktivitas antiinflamasi secara statistik antara infusa bawang putih dengan infusa bawang hitam, namun infusa bawang hitam menunjukkan aktivitas antiinflamasi yang lebih cepat dan menunjukkan peningkatan aktivitas dengan peningkatan dosis.
IMPACT OF ADVERTISEMENT TOWARDS FERTILE AGED WOMEN PERCEPTION AND BEHAVIOR IN DYSMENORRHEA TREATMENT Bhekti Pratiwi; Gabriella Yovanda; Cindra Tri Yuniar
Acta Pharmaceutica Indonesia Vol. 47 No. 2 (2022)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v47i2.19803

Abstract

Dismenorea adalah nyeri menstruasi yang kerap dialami oleh wanita dalam usia subur sehingga informasi mengenai terapinya menjadi penting untuk diketahui. Iklan sebagai salah satu cara penyampaian informasi terapi dismenorea. Penelitian ini bertujuan untuk mengevaluasi pengaruh iklan terhadap persepsi dan perilaku wanita usia subur dalam mengatasi dismenorea. Selain itu, dilihat juga pengaruh profil dismenorea, karakteristik demografi terhadap persepsi dan perilaku responden, serta potensi peran tenaga kesehatan dalam menjamin ketepatan informasi dalam iklan. Desain penelitian berupa cross-sectional dengan teknis pengambilan sampel purposive sampling. Penelitian dilakukan pada bulan Januari-April 2022. Penelitian dilakukan secara daring dengan menyebarkan kuesioner yang diisi oleh 342 responden. Metode analisis statistik yang digunakan adalah non parametrik yaitu Kruskal-Wallis pada semua analisis pengaruh variabel independen pendidikan terakhir, umur, dan penghasilan perbulan) terhadap variabel dependen (persepsi dan perilaku) dan korelasi Spearman Rank pada pengaruh sumber iklan terhadap variabel dependen. Hasil penelitian menunjukkan adanya pengaruh iklan terhadap persepsi responden (p<0,05, r=0,156) tetapi tidak ada pengaruh terhadap perilaku (p>0,05, r=0,097). Karakteristik demografi seperti pendidikan terakhir dan umur (p<0,05) berpengaruh terhadap perilaku sedangkan penghasilan per bulan tidak berpengaruh terhadap persepsi maupun perilaku.  
Kajian Aktivitas Neurofarmakologi Tinospora cordifolia Anggadireja, Kusnandar; Sidik, Callista Sandrine Azalea
Acta Pharmaceutica Indonesia Vol. 48 No. 1 (2023)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v48i1.21348

Abstract

The traditional medication system Ayurveda prescribes herbal remedies, called Medhya Rasayana, to promote brain rejuvenation. Tinospora cordifolia is one of the popular Medhya Rasayana herbs. This review encompasses its potential alongside the underlying mechanisms in the treatment of numerous ailments that affect the nervous system, namely neurodegenerative diseases, brain cancer, depression, substance abuse, as well as touching upon its role in boosting cognitive function.
MAMAN PLANT BIOACTIVE COMPOUNDS (Cleome gyandra L), DRY POWDER (SIMPLISIA) AND JORUK MAMAN Restusari, Lily; Yaman, Elfahmi
Acta Pharmaceutica Indonesia Vol. 48 No. 2
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v48i2.21564

Abstract

Joruk Maman is a food product that has been known to contain crude fiber and lactic acid bacteria that function as probiotics. Currently, the use of Joruk Maman as an alternative medicine for chronic diseases and functional food with high nutritional value is not too much. This study aimed to determine the antioxidant activities content of bioactive compounds from of fresh and dried-plants and Joruk Maman so that the utilization of Joruk Maman can increase. This type of research was a laboratory research with quantitative descriptive method to determine the fiber content, total phenol, and antioxidant activity in fresh plants, dry powder and joruk maman. Analysis of data from phytochemical test and bioactive compounds were analyzed descriptively with the mean and standard deviation using computerized data processing software. The results of this study showed the highest crude fiber content in the maman powder sample with a percentage of 7.84%. The highest total phenol content was found in fresh maman plant extract which contained total phenol of 35.33 mg of gallic acid equivalent/g extract. The antioxidant activities of dried, fres and fermented manan (joruk manan) using DPPH method was shown with IC50 values > 1000, 276,58 dan 323,88 μg/ml repectively, while quercetin as a tandard which is predicted also found in manan gave IC50 2,06 μg/ml. And the strongest antioxidant content was obtained with an IC value of50 in the quercetin sample of 2,06 g/ml based on the DPPH method. Further study testing is needed on the antioxidant activity of the Joruk Maman plant from each plant organ including roots, flowers and seeds with other methods to determine the potential of each part.
Kajian Efektivitas, Toksisitas, dan Cost-Effectiveness Obat-Obatan Penyakit Alzheimer Salsabila Andiyanti Putri; Anggadiredja, Kusnandar
Acta Pharmaceutica Indonesia Vol. 48 No. 1 (2023)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v48i1.22224

Abstract

Alzheimer is a neurological disease characterized by loss of cognitive and non-cognitive functions. Drugs that can be used to treat Alzheimer’s disease include donepezil, galantamine, rivastigmine, and memantine. This literature review covers the effectiveness, toxicity, and cost-effectiveness of these four drugs as Alzheimer's therapy options. Review of the pertinent literatures from the databases Google Scholar, Pubmed, and Science Direct showed that galantamine has the best effectiveness compared to other drugs because it can improve all aspects of Alzheimer’s disease. The four drugs do not have a fixed toxic dose, but the effects they cause are not much different from one drug to another. Donepezil, galantamine, and memantine were cost-effective, whereas rivastigmine was not. Key words: Alzheimer’s disease, Alzheimer's drugs
Kajian Aktivitas Neurofarmakologi Acorus calamus Linn Rafika Thahirani Safira; Anggadiredja, Kusnandar
Acta Pharmaceutica Indonesia Vol. 48 No. 1 (2023)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v48i1.22227

Abstract

ABSTRACT Jeringau (Acorus calamus Linn) is one of the plants often used in traditional Indian medicine, practiced to treat various disorders, including nervous, digestive, respiratory, metabolic, renal and hepatic. This study provides an overview of Acorus calamus Linn in terms of morphology, active constituents and neuropharmacological activity. A review of related literature from the Google Scholar, Pubmed, Reserch Gate, and Science Direct. databases showed the of neuroprotective, antiamnestic, anticholinesterase, antidepressant and anticonvulsant activities. Key words: Acorus calamus Linn, jeringau, chemical contents, neuropharmacological activites
Front Matter Vol 48 No. 1 Indonesia, Acta Pharmaceutica
Acta Pharmaceutica Indonesia Vol. 48 No. 1 (2023)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

KARAKTERISASI DAN PENAPISAN FITOKIMIA SIMPLISIA WORTEL SERTA REVIEW KANDUNGAN KIMIA DAN AKTIVITAS FARMAKOLOGI WORTEL (DAUCUS CAROTA L.) Rika Hartati; Fidrianny, Irda; Fitria, Alfiyani
Acta Pharmaceutica Indonesia Vol. 48 No. 2
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v48i2.22428

Abstract

Carrot is an important source of nutrition for humans and a good source of dietary fiber. Carrot are rich in bioactive compounds such as phenolic compounds, carotenoids, polyacetylene, and ascorbic acid which has health effects. Carrot are known to have many health benefits such as antioxidants, antidiabetic, antiinflammatory, antihypertensive, antibacterial, and antifungal. This study aims to determine the characteristics and phytochemical screening of root, leaves and stem carrot (Daucus carota L) and prepare a review article about chemical compounds and pharmacological activities of carrot. Characterization performed of crude drug included macroscopic and microscopic, determination of total ash content, acid insoluble ash, water soluble ash, water content, water soluble extract, ethanol soluble extract, and loss on drying. Phytochemical screening was carried out to check the presence of secondary metabolite in crude drug. Root, leaves and stem of carrot extracted by reflux method with n-hexane, ethyl acetate, and 96% ethanol. Review article was prepared by considering and analyzing literatures. Water content of roots, leaves and stem of carrot were 5%, 4,17% and 6,67%, respectively. All crude drugs contained flavonoid, phenol, quinone and steroid/triterpenoid groups. Article review was done by collecting and analysing 82 literatures. The water of all crude drugs fulfilled the requirement. Wortel (Daucus carota L.) has many chemical compounds and pharmacological activities. Keywords: carrot, characterization, phytochemical screening, chemical compounds, pharmacological activities
Biological activities study of Cinnamon (Cinnamomum burmanni (Nees & T.Nees) Blume) as Cosmetic Ingredients Rizaldy, Defri; Insanu, Muhamad; Hartati, Rika; Fadhilah, Ismah Ibtihal; Putri, Rian Destiyani; Cheong, Min Kyoung
Acta Pharmaceutica Indonesia Vol. 48 No. 2
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v48i2.22472

Abstract

Objectives: The goals of this research were to study the biological activities of cinnamon bark extract related to its use as cosmetic ingredients. The potential use of cinnamon bark as cosmetic preparations was studied by confirming its antioxidative, antimicrobial, and its inhibition towards tyrosinase activity. Methods: Extraction was performed by maceration using 70% ethanol. Antioxidative activity using the DPPH methods, melanin inhibitory effect was determined using in vitro anti tyrosinase assay. MHC and MIC of cinnamon bark extract were determined towards Staphylococcus aureus, Staphylococcus epidermidis, and Cutibacterium acnes. Results: The standardization result of the crude drugs showed positive result on qualitative analysis of Flavonoid, Tannin, and Quinone groups. Flavonoid content also found on the ethanolic extract. The IC­50 antioxidative activity of cinnamon ethanolic was 7.52 ± 0.13 μg/mL compared to ascorbic acid with 2.54 + 0.02 μg/mL. The Ethanolic extract of cinnamon inhibited tyrosinase with IC­50 of 9.44 ± 0.26 mg/mL. Lowest minimum inhibitory concentration of ethanolic extract was found towards Cutibacterium acne with 1000 μg/mL. Whereas weak antimicrobial activity was showed towards Staphylococcus aureus and Staphylococcus epidermidis with MIC and MBC value started from 2000 μg/mL. Conclusion: Comparable result on antioxidative and anti-tyrosinase analysis shows that cinnamon bark have fair potential to further developed and formulated for topical maintenance product.
Studi Literatur Tatalaksana Preeklampsia di Indonesia Nur Samsi, Mujiyanti
Acta Pharmaceutica Indonesia Vol. 49 No. 01 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v49i01.21589

Abstract

Preeklampsia adalah gangguan kehamilan multisistem pada usia di atas 20 minggu ditandai dengan adanya tekanan darah tinggi disertai gangguan dari sistem lain seperti proteinuria, gangguan sistem hati, ginjal, liver, nyeri epigastrium, trombositopenia, edema paru, gejala neurologis, dan gangguan pertumbuhan janin. Preeklampsia menjadi salah satu penyebab tingginya Angka Kematian Ibu (AKI) di Indonesia. Hal tersebut terjadi karena adanya permasalahan yang kompleks dalam penyakit dan penanganannya. Penelitian ini bertujuan untuk mengetahui antihipertensi yang digunakan dalam menangani preeklampsia. Metode yang digunakan dalam penelitian ini adalah studi literatur yang bersumber dari Keputusan Menteri Kesehatan Republik Indonesia, Konsensus Penatalaksanaan Hipertensi Perhimpunan Dokter Hipertensi Indonesia tahun2019, dan beberapa artikel ilmiah dari dari pangkalan data the National Center for Biotechnology Information (NCBI). Hasil studi ini menunjukkan bahwa kunci utama dari penanganan preeklampsia adalah deteksi dini diikuti dengan intervensi dengan tujuan pengontrolan tekanan darah menggunakan antihipertensi dan pencegahan progresivitas penyakit. Antihipertensi yang dapat digunakan dalam penanganan preeklampsia antara lain nikardipin, metildopa, nifedipin, labetalol, hidralazin, dan natrium nitropusida.

Page 23 of 26 | Total Record : 254

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