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NOOR HUBDRYAWATI
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Jurnal Kimia Mulawarman
Published by Universitas Mulawarman
ISSN : 16935616     EISSN : 24769258     DOI : DOI: https://doi.org/10.30872/jkm
Core Subject : Science,
Chemistry
Journal of Kimia Mulawarman is a peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry, including educational chemistry and applied chemistry.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 224 Documents
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AKTIVITAS ANTIKANKER SENYAWA PTEROKARPAN DARI KULIT BATANG AKA KALESI (Spatholobus ferrugineus) Ratih Dewi Saputri; Muhammad Fadjar Aldin; Tjitjik Srie Tjahjandarie; Eva Marliana; Mulyadi Tanjung
JURNAL KIMIA MULAWARMAN Vol 20 No 2 (2023)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v20i2.920

Abstract

Tujuan dari penelitian ini adalah untuk mengisolasi dan menguji aktivitas antikanker senyawa pterokarpan dari kulit batang Spatholobus ferrugineus (Zoll. & Moritzi) Benth terhadap MCF-7 yaitu sel kanker payudara. Terdapat dua senyawa turunan pterokarpan yang berhasil diisolasi yaitu senyawa variabilin (1) and medikarpin (2). Kedua senyawa tersebut dikarakterisasi dengan instrument 1D dan 2D NMR yang menyatakan bahwa kedua senyawa yang berhasil diisolasi adalah senyawa 1 dan 2. Senyawa 1 dan 2 menunjukkan aktivitas antikanker dengan nilai IC50 2,73 dan 14,36 μg/mL. Kata kunci : pterokarpan, antikanker, Spatholobus ferrugineus, MCF-7.
ANTIMICROBIAL ACTIVITY OF BACTERIAL CELLULOSE MODIFIED WITH PLANT EXTRACTS Riza Apriani; Nina Utami
JURNAL KIMIA MULAWARMAN Vol 20 No 2 (2023)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v20i2.1203

Abstract

Bacterial cellulose (BC) is utilized in numerous industries, including the cosmetic, biomedical, and packaging industries. Nonetheless, BC lacks antibacterial activity and must be combined with antimicrobial agents, including plant extracts. This review aims to give information on the antibacterial activity of BC that has been modified by the addition of plant extracts. The method used in this study is article review. Articles were selected from Q1-Q3 category international journals published within the recent decade. Based on the results, extracts of rhizomes, ethanol extracts of gwarri stems and leaves, oregano leaves, rosemary leaves, lovage leaves, parsley leaves, green tea leaves, rosella petals, and red and pink variants of hibiscus flowers, bitter melon seeds, gletang leaves, arabica coffee, and andaliman fruit, temu Kunci dimethyl sulfoxide extract, mulberry leaf NaOH extract, pomegranate skin water extract, and rosemary leaves have been used to modify BC. Antimicrobial activity showed the most significant increase in BC-modified ethanol extract of rosella petals at a concentration of 500 ppm with an OD600 of 0% against Pseudomonas aeruginosa. FTIR and SEM investigations of pure BC and BC modified with plant extracts revealed variations in functional group content and three-dimensional fibrillar network structure.
Pengujian Toksisitas dan Antioksidan Ekstrak Etilasetat dan n-Butanol Hipokotil Sarang Semut, Myrmecodia pendens Merr. & Perry Vino Soaduon Hamonangan Simanjuntak; Endah Wydiastuti; Lina Marlina; Partomouan Simanjuntak; Rudi Kartika
JURNAL KIMIA MULAWARMAN Vol 21 No 1 (2023)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v21i1.1288

Abstract

Sarang semut, Myrmecodia pendens Merr. & Perry (Rubiaceae) is an epiphytic plant from Papua which is used to cure various diseases. The purpose of this study is to see the chromatogram profile [Thin Layer Chromatography (TLC) and High Performance Liquid Chromatography (HPLC)] analysis, and biological test of ethyl acetate and n-butanol of Sarang semut’s hypocotyl extracts from methanol extracts. Meanwhile, the biological tests carried out were toxicity tests on Artemia salina L shrimp larvae and antioxidant assay with free radical scavenging methods (DPPH). The results of the antioxidant activity test showed that the antioxidant activity of the ethyl acetate extract was higher (IC50=18.23μg/ml) than the n-butanol extract (IC50=29.58μg/ml). The results of the toxicity test on the ethyl acetate extract were higher (LC50=101.84 g/ml) than the n-butanol extract (LC50=154.59 g/ml). TLC analysis results showed that the mobile phase for the best separation of chemical compounds in ethyl acetate extract was chloroform-methanol (10:1) and n-butanol extract was the mobile phase chloroform-methanol-water (5:5:1), while HPLC analysis showed that the mobile phase for the separation of chemical compounds in the ethyl acetate extract was n-hexane-ethyl acetate (10:1) and the n-butanol extract was methanol-water (10:1).
Synthesis and Characterization of Copper(II) Oxide (CuO-NP) Nanoparticles using Chemical Precipitation Method Charlena Charlena; Sri Sugiarti; Dila Ardiansyah
JURNAL KIMIA MULAWARMAN Vol 21 No 2 (2024)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v21i2.1260

Abstract

This study aims to optimize the calcination temperature and see the effect of adding surfactant on the bandgap, particle size, crystallinity level of CuO nanoparticles (CuO-NP), and the activity of CuO nanoparticles as an antibacterial agent. CuO-NP was successfully synthesized using the chemical precipitation method with variations in calcination temperature of 400, 600, and 800 °C with NaOH as a precipitating agent. The synthesized nanoparticles were further characterized using a UV-Vis, XRD, and SEM-EDX spectrophotometer. The value of the CuO-NP bandgap increases with increasing temperature. The bandgap gets bigger when the absorbance value gets smaller. Increasing the calcination temperature causes the crystal size of CuO-NP to become larger. The best level of crystallinity of CuO-NP was obtained at 68,31% with a calcination temperature of 600 °C. Adding 1% PVP did not significantly prevent agglomeration between CuO-NP particles, thereby increasing the size of CuO-NP particles. Keywords: bandgap, CuO-NP, PVP, temperature
Adsorption Of Methylene Blue Using Active Charcoal From Empty Fruit Bunch (EFB) Teguh Wirawan; Ishak Wiradikara Az; Noor Hindryawati
JURNAL KIMIA MULAWARMAN Vol 21 No 1 (2023)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v21i1.1013

Abstract

Research on the adsorption of methylene blue by activated charcoal from Empty Fruit Bunch (EFB) has been carried out. This study aimed to synthesize activated charcoal from EFB, characterize it, and use it as an adsorbent for methylene blue. Activated charcoal was synthesized by carbonation in a furnace at 300oC for 1 hour. Chemically, activation was carried out by immersion in HCl solution for 24 hours. Characterization was carried out by proximate test, determination of functional groups using Fourier Transform Infrared (FT-IR), and determining material shape with X-Ray Diffraction (XRD). The study of activated charcoal adsorption as methylene blue adsorbent was carried out by treating variations in contact time, adsorbent weight, and concentration. The results of the proximate test with the parameters of surface area, moisture content, and ash content were 162.12 m2/g, 0.52%, and 5.27%, respectively. The results of the FT-IR characterization test showed an aromatic C–H, C=C and C–O. Based on the results of characterization with XRD giving a pattern at a diffraction angle of 2 20 - 30o, it was seen that there was a wide peak, which indicated that it had an amorphous structure. The optimum conditions for methylene blue adsorption occurred at a contact time of 40 minutes, and the adsorbent weight was 0.1 g for 10 mL of 50 ppm methylene blue. The adsorption of methylene blue followed the Freundlich isotherm adsorption pattern and had a maximum adsorption capacity of 8.92 mg/g.
Determination of Secondary Compounds in Extracts from Catfish (Pangasius sp) Siti Rusdiana Puspa Dewi; Sadakata Sinulingga; Fatmawati Fatmawati; Maharani Natasya; Siti Devita Utami; Putra Ramadhan Algiffary Irianto Dunda
JURNAL KIMIA MULAWARMAN Vol 21 No 1 (2023)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v21i1.1009

Abstract

Ikan patin (Pangasius sp.) umumnya dijumpai pada perairan air tawar di Indonesia, seperti di Sumatera dan Kalimantan. Di Sumatera Selatan, ikan jenis ini digunakan sebagai salah satu kuliner seperti pindang dan brengkes. Tujuan dari penelitian ini adalah untuk mengetahui kandungan fitokimia metabolit sekunder dari ekstrak ikan patin (Pangasius sp.). Metode yang digunakan pada penelitian ini adalah studi deskriptif dengan menggunakan ekstrak yang diperoleh dari kulit, tulang, dan daging ikan patin. Ekstrak yang digunakan adalah ekstrak dari pelarut etanol, etil asetat, dan n-heksana dengan proses maserasi dan akudes dengan proses infusa. Hasil penelitian menunjukkan bahwa pada ekstrak etanol, kulit ikan mengandung alkaloid, saponin, dan steroid; pada tulang mengandung flavonoid dan saponin; pada daging mengandung alkaloid, saponin, dan flavonoid. Pada ekstrak etil asetat, kulit dan tulang ikan mengandung alkaloid; sedangkan pada daging mengandung flavonoid dan steroid. Pada ekstrak n-heksana, kulit ikan mengandung alkaloid dan steroid; tulang ikan mengandung alkaloid; dan daging ikan mengandung saponin dan terpenoid. Pada akuades, kulit ikan mengandung alkaloid, saponin, tanin, dan steroid; tulang ikan mengandung alkaloid; danging ikan mengandung alkaloid, flavoid, dan saponin. Kesimpulan dari penelitian ini bahwa Pangasius sp. memiliki metabolit sekunder alkaloid, flavonoid, saponin, tanin, terpenoid, dan steroid.
EKSTRAKSI ION Cd2+ DENGAN DITIZON SEBAGAI ZAT PEMBAWA DAN SPAN-80 SEBAGAI SURFAKTAN MENGGUNAKAN TEKNIK EMULSI MEMBRAN CAIR Aulia Syafitri Rachim; Dirgarini J. N Subagyono; Teguh Wirawan
JURNAL KIMIA MULAWARMAN Vol 21 No 2 (2024)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v21i2.1014

Abstract

Penelitian tentang ekstraksi ion logam kadmium Cd2+ dengan teknik emulsi membran cair telah dilakukan. Penelitian ini dilakukan secara eksperimental di laboratorium menggunakan ditizon sebagai zat pembawa, span-80 sebagai surfaktan, parafin cair sebagai fase membran, larutan HNO3 sebagai fase internal dan larutan kadmium 20 ppm sebagai larutan sampel. Tujuan penelitian ini adalah untuk menentukan kondisi optimum ion logam Cd2+ yang meliputi pH fase eksternal, konsentrasi fase internal, konsentrasi surfaktan, waktu ekstraksi konsentrasi ion logam Cd2+ yang dapat diekstraksi menggunakan teknik emulsi membran cair. Penentuan konsentrasi sisa ion logam kadmium hasil ekstraksi menggunakan alat Spektrofotometer UV-Vis pada panjang gelombang 518 nm. Kondisi optimum untuk mengekstraksi ion logam Cd2+ menggunakan teknik emulsi membran cair pada penelitian ini adalah pH fase eksternal 7, konsentrasi fase internal 1 M, konsentrasi surfaktan 3,5% dan waktu ekstraksi 15 menit. Pada kondisi optimum tersebut konsentrasi ion logam kadmium yang dapat diekstraksi mencapai 100 ppm dengan nilai persen ekstraksi 77,574%.
Modification Of Kaolin Capkala With Benzalkonium Chloride (Bkc) Surfactant And Antibacterial Activity Test Against Escherichia Coli Jeny Clarita; Puji Ardiningsih; Nelly Wahyuni
JURNAL KIMIA MULAWARMAN Vol 21 No 1 (2023)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v21i1.1021

Abstract

A study was conducted to determine the antibacterial activity of modified benzalkonium chloride (BKC) kaolin Capkala against Escherichia coli (E. coli) bacteria. Kaolin modification begins by melting kaolin with sodium hydroxide (NaOH) and reacting using a reflux device. Furthermore, the sample was reacted with BKC at a concentration variation of 0, 2.5×10-3; 5×10-3, and 2.5×10-2 M for 6 hours with a stirring speed of 150 rpm. The modified kaolin was characterized using Fourier Transformed Infrared (FTIR), and adsorption tests were performed on Cl-. The FTIR spectrum of the modified kaolin showed an absorption peak at 2926.19 cm-1 C-H symmetrical from CH2, which indicated the attachment of surfactant to the kaolin. BKC modified kaolin antibacterial activity test using the halo test method. The adsorption test on Cl- and the antibacterial activity test on kaolin and modified kaolin increased with increasing BKC concentration, namely 3545; 3828.6, 3970.4; 4183.1 mg/L and the inhibitory diameter were 2.1±0.14, 3.3±0.14, 4.5±0.14, and 6±0.14 mm, respectively. The results showed that BKC can increase the antibacterial activity of kaolin
Anti-Inflammatory Effect Of Extract And Fractions Of Gaharu (Aquilaria malaccensis Lamk.) Leaves Nur Hidayah; Ritbey Ruga; Chairul Saleh
JURNAL KIMIA MULAWARMAN Vol 21 No 1 (2023)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v21i1.1022

Abstract

Anti-inflammatory activity test of extract and fraction of gaharu leaf (Aquilaria malaccensis Lamk.) against protein denaturation inhibition in vitro has been carried out. This study aims to determine the percent inhibition of protein denaturation and the strength of anti-inflammatory activity of the concentrated methanol extract, ethyl acetate fraction, and methanol-water fraction of gaharu leaves (Aquilaria malaccensis Lamk.). BSA (Bovine serum albumin) is used as the protein to be heated. Diclofenac sodium was used as the positive control, and the negative control used the appropriate solvent. Based on phytochemical screening tests, methanol extracts are known to contain secondary metabolites, including flavonoids, triterpenoids, steroids, and phenolics. The n-hexane fraction contains triterpenoid and steroid compounds. The ethyl acetate fraction contains flavonoid, triterpenoid, steroid, and phenolic compounds, while the methanol-water fraction contains flavonoid, triterpenoid and phenolic compounds. The results of the anti-inflammatory activity test of crude extract methanol and ethyl acetate fraction showed moderate antiinflammatory potential with IC50 values of 181.58- 168.87 ppm, respectively, while the methanol-water fraction has strong anti-inflammatory potential with IC50 value of 60.84 ppm.
Adsorption of Methylene Blue using Composite Fe3o4-Activated Charcoal Cassava Skin (Manihot esculenta C.) Duwi Devi Wulandari; Soerja Koesnarpadi; Noor Hindryawati
JURNAL KIMIA MULAWARMAN Vol 21 No 2 (2024)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v21i2.1247

Abstract

Preparation of Fe3O4 activated cassava shell charcoal composite (Fe3O4-AAKS) by coprecipitation method, namely mixing activated cassava shell charcoal (AAKS) with FeCl3.6H2O and FeSO4.7H2O solutions using a mole ratio of 3:2 in alkaline conditions with the addition of 25% NH4OH has been carried out. The Fe3O4-AAKS composite was characterized using Fourier Transform Infra-Red (FTIR) and X-Ray Diffraction (XRD) instruments, then the composite material was applied to adsorb methylene blue with variations in the influence of contact time, optimum concentration and optimum adsorbent mass and determined the adsorption isotherm model. The results of the characterization of Fe3O4-AAKS with FTIR showed that a composite had been formed which was marked by the appearance of absorption at wave number 1033,85 cm-1 indicating the presence of a C-O group and the appearance of a typical absorption of Fe-O groups at 540,07 cm-1. Fe3O4-AAKS XRD results show an amorphous charcoal diffraction pattern at an angle of 20º-30º and a magnetic phase iron oxide diffraction pattern of Fe3O4 at 2 θ at angles of 18.59º, 30.38º, 35.62º, 43.56º, 53.85º, 57.30º, 62.90º and 74.62º. Methylene blue adsorption application using Fe3O4-AAKS composite showed optimum conditions at contact time of 30 minutes, optimum concentration at 60 mg/L with optimum adsorbent mass of 0.05 gram. The adsorption pattern of the composite material follows the Langmuir isotherm with a maximum adsorption capacity of 25.38 mg/g.

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