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Jurnal Kimia (Journal of Chemistry)

jchem
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Published by Universitas Udayana

ISSN : 19079850 EISSN : 25992740 DOI : 10.24843/JCHEM

Core Subject : Science,

Chemistry

Jurnal Kimia (Journal of Chemistry) publishes papers on all aspects of fundamental and applied chemistry. The journal is naturally broad in scope, welcomes submissions from across a range of disciplines, and reports both theoretical and experimental studies.

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 18 Documents

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Search results for , issue "Vol. 8, No. 2 Juli 2014" : 18 Documents clear

PEMANFAATAN TEH KOMBUCHA SEBAGAI OBAT HIPERURISEMIA MELALUI PENGHAMBATAN AKTIFITAS XANTIN OKSIDASE PADA Rattus norvegicus Dewa Ayu Windu Manik Anandagiri; I. B. Putra Manuaba; Ni G. A. M. Dwi Adhi Suastuti
Jurnal Kimia (Journal of Chemistry) Vol. 8, No. 2 Juli 2014
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

The formation of high levels of uric acid and problems of its excretion from the body can lead to hyperuricemia. This study serves to examine the kombucha tea as a hyperuricemia drug activity through the inhibition of the enzyme xanthine oxidase. Kombucha tea was used with three different variations of fermentation namely: tea A (4 days), tea B (8 days), tea C (12 days), and two variations of the dose, i.e. 10 mL/kg BW and 40 mL/kg BW. This study uses a “posttest only control group” design. A total of 27 Wistar rats (Rattus norvegicus) are grouped into 9 groups, K (negative control), H (control hyperuricemia), A (control allopurinol), P1 (tea A dose of 10 mL/kg BW), P2 (tea A dose 40 mL /kg BW), P3 (tea B dose 10 mL/kg BW), P4 (tea B dose 40mL/kg BW), P5 (tea C dose 10 mL/kg BW), P6 (tea C dose 40 mL/kg BW). The rats were given high feed purine for research, namely chicken liver juice and melinjo so that they contracted the hyperuricemia condition. The high purine feeds were administered on all groups of rats except the negative control group. Experiment was undertaken to compare the effectiveness of allopurinol with kombucha tea. This experiment was done for nine days. On the last day, an analysis of the levels of uric acid and xanthine oxidase activity was undertaken and the data was analyzed using ANOVA. The conclusion was that the biggest decline in drug for the treatment of hyperuricemia was kombucha tea B with the dose of 40 mL/kg BW.

PEMANFAATAN TEH KOMBUCHA SEBAGAI OBAT HIPERURISEMIA MELALUI PENURUNAN KADAR ASAM URAT DAN MALONDIALDEHID Ni Luh Putu Kartika Mardiani; Ida Bagus Putra Manuaba; I Wayan Suirta
Jurnal Kimia (Journal of Chemistry) Vol. 8, No. 2 Juli 2014
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Research has been conducted to determine the decrease in uric acid levels and malondialdehyde (MDA) of rats hyperuricemia after being given kombucha tea. The research was carried out with the draft post-test control group design. Kombucha tea with various fermentation time of 4, 8 and 12 days were given to hyperuricemia rats with doses of 10 mL/kg body weight and 40 mL/kg body weight. The results showed that kombucha tea can lower uric acid levels and MDA with the most significant decrease showed by the 8 day fermented kombucha tea with a dose of 40 mL/kg body weight. The decreases were 2.00±0.09 mg/dL and 1.68±0,34 umol/L respectively.

SENYAWA STEROID PADA DAUN GAYAM (Inocarpus fagiferus Fosb) DAN AKTIVITASNYA SEBAGAI ANTIOKSIDAN TERHADAP DIFENILPIKRIL HIDRAZIL (DPPH) I Gusti Agung Putu Surya Adi Krisna; Sri Rahayu Santi; Ni Luh Rustini
Jurnal Kimia (Journal of Chemistry) Vol. 8, No. 2 Juli 2014
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

This research aimed to identify steroid compound from leaf of gayam (Inocarpus fagiferus Fosb) and test its antioxidant activity. Dried leaf powder of gayam was extracted with 5000 mL of 96% ethanol to yield 28,05 g concentrated extract. This extract was then fractionated into n-hexane and choloform to yield 14,18 g n-hexane and 2,21 g choloform fractions respectively. The test using Lieberman Burchard reagent showed that both fractions contain steroid, but n-hexane fraction contained more steroid than chloroform fraction. Separation of n-hexane fraction was done using silica gel column chromatography with n-hexane : ethanol (7:3) as eluent and four groups of fraction were obtained. Fraction F1 contained steroid and was relatively pure therefore it was then identified. The infrared and ultraviolet-visible spectra suggest that the isolate (F1 fraction) has functional groups such as O-H, C=O, C-H, and unconjugated C=C and showed lmax at 279,407, and 669 nm. The antioxidant test showed that the isolate had antioxidant activity toward DPPH with IC50 of 4 ppm.

PENGGUNAAN KITOSAN DARI LIMBAH KULIT UDANG SEBAGAI INHIBITOR KEASAMAN TUAK Fikriatun Nurhikmawati; Manuntun Manurung; A. A. I. A. Mayun Laksmiwati
Jurnal Kimia (Journal of Chemistry) Vol. 8, No. 2 Juli 2014
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

The research has been conducted to determine the ability of chitosan from shrimp shell as an inhibitor of tuak acidity. Isolation of chitin is done through three stages, namely deproteination, demineralization, and depigmentation. The deacetylation process of chitin into chitosan was accomplished with 50% (w/v) NaOH with a ratio of 1:10 at 90oC for 120 minutes. 15.33 g chitin was gained (15.33%), and 9.94 g chitosan or 9.94% were obtained with a degree of deacetylation of 69.87%. The optimum concentration of kitosan to inhibit tuak pH changes was 2% (w/v) thus providing a longer shelf life with lowest acidity (pH).

SENYAWA ANTIMAKAN PADA MINYAK BIJI NYAMPLUNG (Calophyllum inophyllum L) Sri Rahayu Santi
Jurnal Kimia (Journal of Chemistry) Vol. 8, No. 2 Juli 2014
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Isolation of antifeedant active compound from sarcocarp of Calophyllum inophyllum L. with Epilachna sparsa larvae were use as bioindicator was conducted. The antifeedant assay was performed on crude extract, fraction, and isolate. Dried sarsocarp powder of nyamplung was extraction with 6L metanol to yield 186,38 g dark brown extract. This Active extract was then fractionated into n-hexane to yield 19,27 g yellow oil.. Separation of 2 g oil was done using silica gel column chromatography with chloroform n-hexane (2:1) as eluent and five group of fraction were obtained with F5 the most active isolat wich showed 27,89% antifeedant activity at 200 ppm was found and relatively pure . Base on analysis of Gas chromatography-mass spectroscopy and data base NISTO2.L the antifeedant active isolat were identify as methyl-14-methyl-pentadecanoid acid, n-hexanedecanoid acid, methyl-9,12-octadecadienoic, methyl-9-octadecenoic acid, methyl-octadecanoic, 9-octadecenoic acid, octadecanoic acid, and the last peak has a moleculer ion at 341.

AMPLIFIKASI DAN IDENTIFIKASI MUTASI PADA FRAGMEN 0,5 KB GEN rpoB ISOLAT 134 Mycobacterium tuberculosis MULTIDRUG RESISTANT DENGAN METODE NESTED POLYMERASE CHAIN REACTION Made Dharmesti Wijaya; I Nengah Wirajana; Sagung Chandra Yowani
Jurnal Kimia (Journal of Chemistry) Vol. 8, No. 2 Juli 2014
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Research has been conducted to amplify and identify mutations in the rpoB gene fragment, 0,5 kb, from the isolate 134 Mycobacterium tuberculosis multidrug resistance (MDR). Amplification was performed using the method nested polymerase chain reaction (nested PCR) while sequencing was conducted in one direction using forward inner primer. Nucleotide sequence obtained was translated into amino acids using MEGA4 program. Amplification of M.tuberculosis rpoB gene fragment, 0,5 kb, was successfully carried out and sequenced. Alignment result by using MEGA4 program showed that there had been missense mutations in the rpoB gene. It had two amino acids changes to rpoB protein, they were glutamic acid to aspartic acid at codon 418 and glutamine to arginine at codon 510.

ANALISIS KUALITATIF SENYAWA PARASETAMOL (ACETAMINOPHEN) PADA URIN DAN RAMBUT MENGGUNAKAN KROMATOGRAFI GAS – SPEKTROMETRI MASSA (GC-MS) Komang Ari Gunapria Darmapatni; A. A. Bawa Putra; Ni K. Ariati; Ni M. Suaniti
Jurnal Kimia (Journal of Chemistry) Vol. 8, No. 2 Juli 2014
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Paracetamol (acetaminophen) is one of analgesic-antipyretic drugs which can be commercially obtained. The research aimis to analyze qualitatively the presence of paracetamol (acetaminophen) in urine and human hair by gas chromatography-mass spectrometry (GC-MS). Urine and human hair sample were obtained from patients (volunteers) who consume paracetamol in therapeutic dose without consumption patterns change. Extraction of paracetamol in urine used ethyl acetate and in human hair used methanol. The extract was then derivatized with BSTFA and 1% TMCS and analyzed using gas chromatography-mass spectrometry (GC-MS). The result showed that urine samples after 1, 2, and 3 hours consuming paracetamol contained acetaminophen-TMS. Those after 24, 168, and 720 hours after consuming paracetamol did not contain acetaminophen-TMS. In human hair, the acetaminophen-TMS was found in samples of 1, 2, 3, 24, 168, and 720 hours after consuming paracetamol.

OPTIMASI ADSORPSI Cr(VI) PADA SILIKA GEL DARI ABU SEKAM PADI TERMODIFIKASI DIFENILKARBAZIDA (Si-DPZida) Henny Puspa Dewi Giri; I Wayan Sudiarta; Ida Ayu Raka Astiti Asih
Jurnal Kimia (Journal of Chemistry) Vol. 8, No. 2 Juli 2014
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Adsorption of chromium (VI) on silica gel modified by diphenilcarbazide (Si-DPZida) have been studied. Parameters analyzed were surface acidity by acid-base titration method, specific surface area by absorption of methylene blue method, optimum conditions of adsorption (pH, contact time), and isotherm adsorption. The results showed that Si-DPZida adsorbent has surface acidity (Kal) of 1,5996 mmol/g with the number of active sites of 9,6328 x 1020 atom/g with specific surface area of 4.4538 m2/g. The optimum adsorption process of chromium (VI) by both Si-DPZida occurred at pH 5 and 15 minutes of contact time. The isotherm adsorptions on both adsorbents tend to follow Freundlich adsorption pattern.

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Contact Name
Ni Putu Diantariani

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jurnalkimia@unud.ac.id

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+628123640424

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jurnalkimia@unud.ac.id

Editorial Address
Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Udayana Kampus Bukit Jimbaran, Jimbaran, Bali, Indonesia

Location
Kota denpasar,

Bali

INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Ni Putu Diantariani

Contact Email jurnalkimia@unud.ac.id

Phone +628123640424

Journal Mail Official jurnalkimia@unud.ac.id

Editorial Address Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Udayana Kampus Bukit Jimbaran, Jimbaran, Bali, Indonesia

Location Kota denpasar, Bali INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Ni Putu Diantariani

Contact Email
jurnalkimia@unud.ac.id

Phone
+628123640424

Journal Mail Official
jurnalkimia@unud.ac.id

Editorial Address
Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Udayana Kampus Bukit Jimbaran, Jimbaran, Bali, Indonesia

Location
Kota denpasar,

Bali

INDONESIA