cover
Contact Name
Eko Suhartono
Contact Email
esuhartono@ulm.ac.id
Phone
+6281251126368
Journal Mail Official
jbk@ulm.ac.id
Editorial Address
Jalan Veteran No.128 Banjarmasin
Location
Kota banjarmasin,
Kalimantan selatan
INDONESIA
Berkala Kedokteran
ISSN : 14120550     EISSN : 25485660     DOI : http://dx.doi.org/10.20527
Core Subject : Health, Science,
Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and September.
Articles 478 Documents
Hubungan Antara Perilaku Merokok Dan Kejadian Insomnia: Pada Mahasiswa Fakultas Kedokteran Universitas Lambung Mangkurat Muhammad Annahri Mushoffa; Achyar Nawi Husein; Mohammad Bakhriansyah
Berkala Kedokteran Vol 9, No 1 (2013)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (372.607 KB) | DOI: 10.20527/jbk.v9i1.921

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ABSTRACT: Cigarettes contain about 4000 toxic substances thataffecting health status and cigarettes consumption leads to some diseases such as cardiovascular and respiratory diseases, malignancy, mental and other disorders, including insomnia. This researchwas aimed to analyze the association between smoking behavior and insomnia on Medical Faculty student of LambungMangkurat University. It was an observational analytic studywith cross-sectional approach. The population was108 male students who met the inclusion criteria. Insomnia was assessed by Insomnia Rating Scale questionnaire. The result showed that 5 smoker students with insomnia (15.15%), 28 smokers students without insomnia (84.85%), 2 non-smoker students with insomnia (2.67%), and 73 non-smoker students without insomnia (97.33%). The data were analyzed by usingFisher’s statistic test with 95% confidence interval.Statistical analysis revealed that the p value 0.027. Hence, there was anassociation between smoking behavior and insomnia. It couldbe concluded that there wasan significant association betweensmoking behavior and insomnia on Medical Faculty student of LambungMangkurat University.Keywords: smoking behavior, insomnia, male, Medical Faculty student of LambungMangkurat University.ABSTRAK: Rokok memiliki sekitar 4000 zat beracun yang dapat mempengaruhi kesehatan manusia. Berbagai gangguan seperti penyakit kardiovaskular, pernapasan, keganasan, mental dan gangguan lainnya, termasuk insomnia dapat muncul sebagai akibat konsumsi rokok. Penelitian ini bertujuan untuk mengetahui hubungan antara perilaku merokok dan kejadian insomnia pada mahasiswa FK UNLAM. Penelitian ini adalah penelitian observasional analitik dengan pendekatan cross-sectional. Populasi penelitian adalah 108 mahasiswa laki-laki di FK UNLAM yang memenuhi kriteria inklusi. Kejadian insomnia ditentukan dengan menggunakan kuesioner Insomnia Rating Scale. Dari kuesioner didapatkan data mahasiswa perokok dengan insomnia 5 orang (15,15%), mahasiswa perokok tanpa insomnia 28 orang (84,85%), mahasiswa nonperokok dengan insomnia 2 orang (2,67%), dan mahasiswa nonperokok tanpa insomnia 73 orang (97,33%). Data kemudian dianalisis dengan uji statistik Fisher’s.Hasil  analisis data menggunakan uji Fisher’s dengan tingkat kepercayaan 95% menunjukkan nilai p = 0,027. Berdasarkan penelitian ini dapat disimpulkan bahwa terdapat peningkatan risiko terjadinya insomnia pada mahasiswa perokok FK UNLAM. Kata-kata kunci:perilaku merokok, insomnia, laki-laki, FK UNLAM 
Indeks Stres Oksidatif (ISO) Plasma pada Model Tikus Putih (Rattus norvegicus) Hiperglikemia Adenan Adenan
Berkala Kedokteran Vol 10, No 1 (2014)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i1.937

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ABSTRACT: Hyperglycemia can lead to increased formation of reactive oxygen compounds (ROC). One is through the glycosylation reaction. These reactions lead to increased formation oxidants: superoxide radicals and H2O2. This situation stimulates the enzymatic antioxidant responses such as SOD, peroxidase and catalase to prevent the negative effects of the ROC. An imbalance between oxidants and antioxidants trigger  some oxidative stress. This study aims to determine the relationship of the long duration hyperglycemia to the magnitude of oxidative stress assessed risk of changes in oxidative stress indices (OSI) in rats (Rattus norvegicus). The research method is a purely experimental post-test only with control group design, consisting of 9 treatment groups which were induced streptozotocin (STZ) (50 mg / kg) and one control group was given 0.1 M citrate buffer pH 4.5. OSI values obtained from the comparison between the levels of H2O2 and the activity of SOD, peroxidase and catalase which were measured in blood plasma of mice. The control group was measured at day 0 and treatment groups at 3, 6, 9, 12, 15, 18, 21, 24 and 27 days after STZ induction. Data were analyzed by non-linear regression. The results show OSI plasma changing type to the duration of hyperglycemia that follows the cubic equation y = 9E-05x3 – 0,0035x2 + 0,0358x + 0,3069 with correlation coefficient r2 equal to 0,822 and signf. 0,025 (p < 0,05). This shows that there is a significant correlation between the duration of hyperglycemia and OSI plasma that is non-linear. Keywords: hyperglycemia, duration of hyperglycemia, oxidative stress index (OSI) ABSTRAK: Hiperglikemia dapat menyebabkan peningkatan pembentukan senyawa oksigen reaktif (SOR). Salah satunya adalah melalui reaksi glikosilasi. Reaksi tersebut menyebabkan peningkatan pembentukan oksidan yaitu radikal superoksid dan H2O2. Keadaan ini merangsang respon antioksidan enzimatik seperti SOD, peroksidase dan katalase untuk mencegah efek negatif dari SOR tersebut. Adanya ketidakseimbangan antara oksidan dan antioksidan memicu terjadinya stres oksidatif. Penelitian ini bertujuan untuk mengetahui hubungan lamanya durasi hiperglikemia dengan besarnya risiko stres oksidatif yang dinilai dari perubahan indeks stres oksidatif (ISO) pada tikus putih (Rattus norvegicus). Metode penelitian adalah eksperimental murni dengan post-test only with control group design, terdiri dari 9 kelompok perlakuan yang diinduksi streptozotocin (STZ) dosis 50 mg/kgBB dan 1 kelompok kontrol yang diberi 0,1 M buffer sitrat pH 4,5. Nilai ISO diperoleh dari perbandingan antara kadar H2O2 dan aktivitas SOD, peroksidase dan katalase yang diukur pada plasma darah tikus putih. Kelompok kontrol diukur pada hari ke 0 dan kelompok perlakuan pada 3, 6, 9, 12, 15, 18, 21, 24 dan 27 hari pasca induksi STZ. Data yang diperoleh dianalisis dengan uji regresi non linier. Hasilnya menunjukkan model perubahan ISO plasma terhadap durasi hiperglikemia yang mengikuti persamaan kubik y = 9E-05x3 – 0,0035x2 + 0,0358x + 0,3069 dengan nilai korelasi r2 sebesar 0,822 dan signf. 0,025 (p < 0,05). Ini menunjukkan bahwa terdapat hubungan yang bermakna antara durasi hiperglikemia dan ISO plasma yang bersifat non linier. Kata-kata kunci: hiperglikemia, durasi hiperglikemia, indeks stres oksidatif (ISO)
Pengaruh Lama Paparan Kebisingan Menurut Masa Kerja terhadap Nilai Ambang Dengar Pekerja : Studi Observasional di PT PLN (Persero) Sektor Barito PLTD Trisakti Banjarmasin Huldani Huldani
Berkala Kedokteran Vol 10, No 2 (2014)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i12.955

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Abstract: PT PLN (Persero), Trisakti Banjarmasin diesel Barito sector is an industry that uses diesel power to electric power generation using the machine and work tool that has a loud voice so that it will increase the noise exposure and increase the risk of harm to the workers. To determine the effect of long exposure noise according to the service life of the hearing threshold value workers of PT PLN (Persero) Sector Barito diesel Trisakti Banjarmasin, conducted observational study with a cross sectional study of the population of all workers at PT PLN (Persero) Sector Barito diesel Trisakti Banjarmasin. Determination of the respondents used the quota sampling with 30 responden.Hasil research found that the intensity of the noise in the diesel> 85 dB, there are 3 respondents (10%) increase in NAD and the average rate of loss in the case of the respondents is hearing loss in long service life (> 5 years) of 3 respondents (20%) and normal hearing as many as 12 respondents (80%) of the 15 respondents, while the new work (≤ 5 years) as many as 15 respondents (100%) of the 15 respondents. Mann-Whitney U analysis with a level of 95% between the long exposure noise according to the working lives of the employees hearing threshold value p value = 0.07 (p> 0.05). It can be concluded that there is no difference in the increase in NAD workers of PT PLN (Persero) diesel Barito Sector, Trisakti Banjarmasin on years of ≤ 5 years and> 5 years. Key words: noise, period of employment, the value of hearing threshold.  Abstrak: PT PLN (Persero) Sektor Barito PLTD Trisakti Banjarmasin merupakan industri yang menggunakan tenaga diesel untuk pembangkit tenaga listrik dengan menggunakan mesin dan alat kerja yang mempunyai suara keras sehingga akan meningkatkan pemaparan kebisingan serta menambah risiko bahaya pada pekerja. Untuk mengetahui pengaruh lama paparan kebisingan menurut masa kerja terhadap nilai ambang dengar pekerja PT PLN (Persero) Sektor Barito PLTD Trisakti Banjarmasin, dilakukan penelitian observasional analitik dengan studi pendekatan cross sectional dengan populasi seluruh pekerja di PT PLN (Persero) Sektor Barito PLTD Trisakti Banjarmasin. Penentuan responden digunakan dengan quota sampling dengan jumlah 30 responden.Hasil penelitian didapatkan bahwa intensitas kebisingan di PLTD > 85 dB, terdapat 3 responden (10%) peningkatan NAD dan rata-rata tingkat pendengaran pada responden adalah terjadi gangguan pendengaran pada masa kerja lama (> 5 tahun) sebanyak 3 responden (20%) dan pendengaran normal sebanyak 12 responden (80%) dari 15 responden sedangkan masa kerja baru (≤ 5 tahun) sebanyak 15 responden (100%) dari 15 responden. Analisis U-mann whitney dengan taraf kepercayaan 95% antara lama paparan kebisingan menurut masa kerja terhadap nilai ambang dengar pekerja didapatkan nilai p= 0,07 (p > 0,05). Dapat disimpulkan bahwa tidak ada perbedaan peningkatan NAD pekerja PT PLN (Persero) Sektor Barito PLTD Trisakti Banjarmasin pada masa kerja ≤ 5 tahun dan > 5 tahun. Kata-kata kunci: kebisingan, masa kerja, nilai ambang dengar.
Effect of Anti-Tuberculosis Multi Drug Resistance Regimen on Hematological Lung Tuberculosis Patients Profile with Multi Drug Resistance Pradana Maulana Putra
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (262.412 KB) | DOI: 10.20527/jbk.v14i1.4550

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Abstract: ATD administration of tuberculosis in combination and duration often causes multi drug resistance (MDR) ATD due to discontinuation of treatment. Reported hematologic abnormal changes due to ATD. This study investigated hematological changes before and during MDR therapy of MDR TB patients in Tuberculosis MDR RSUD Ulin Banjarmasin from September to December 2017. The study population was patients treated in TB MDR Poly and selected samples with a time-limiting method. Inclusion and exclusion criteria were MDR-TB patients detected by Gene Xpert® examination, treated <30 days, between 18 and 65 years of age, HIV negative, as well as identification and laboratory data recorded in the complete medical record. 17 samples collected by hematological parameters were collected. There were significant changes in hemoglobin, hematocrit, platelets, RDW-CV, MCV, eosinophils, lymphocytes, granulocytes, and monocytes after treatment. It was concluded that MDR regimen ATD did not cause anemia and thrombocytopenia. There was also no significant change in WBC even though the count of the species changed significantly Keywords:                  Tubeculosis, Multi Drug Resistency (MDR), Anti Tuberculosis Drugs (ATD), profil hematologis
PENGARUH LANSOPRAZOL DAN OMEPRAZOL TERHADAP AKTIVITAS ENZIM KATALASE HEPAR TIKUS Eria Sartika; Eko Suhartono; Agung Biworo
Berkala Kedokteran Vol 12, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v12i2.1875

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Abstract: Lansoprazole and omeprazole is a Proton Pump Inhibitor class of drugs that are often used for the treatment of peptic ulcers. Lansoprazole and omeprazole have an influence on the various target organs exposed. Mechanism of lansoprazole and omeprazole in influencing the activity of the enzyme catalase is competing with absolute catalase enzyme substrate (H2O2) in the binding of the enzyme active site. This study aims to determine the effect of lansoprazole and omeprazole against liver catalase enzyme activity. This study was a laboratory experimental study conducted in three groups, namely the control group (P0), the treatment group (P1) is given lansoprazole 30 mg and a treatment group (P2) given omeprazole 20 mg. The result showed the value of Km of the control group (P0) of 13.482 mmol/dm3, the treatment group (P1) of 11,227 mmol/dm3 and the treatment group (P2) of 6,327 mmol/dm3. Analysis of statistical data shows the regression correlation value of p for P1 was 0,01 adn for P2 was 0,02 (p <0.05) and the R value approaching 1 with a linear graph Lineweaver Burk meaningful. Concluded that lansoprazole and omeprazole may affect the activity of the liver enzyme catalase. Keywords: lansoprazole, omeprazole, enzyme catalase, rat liver Abstrak: Lansoprazol dan omeprazol merupakan obat golongan proton pump inhibitor yang sering digunakan untuk pengobatan tukak lambung. Lansoprazol dan omeprazol memiliki berbagai pengaruh terhadap organ target yang terpajan. Mekanisme lansoprazol dan omeprazol dalam mempengaruhi aktivitas enzim katalase adalah berkompetisi dengan substrat absolut enzim katalase (H2O2) dalam mengikat sisi aktif enzim. Penelitian ini bertujuan untuk mengetahui pengaruh lansoprazol dan omeprazol terhadap aktivitas enzim katalase hepar. Penelitian ini merupakan penelitian quasi eksperimental yang dilakukan pada 3 kelompok, yakni kelompok kontrol (P0), kelompok perlakuan (P1) diberikan lansoprazol 30 mg dan kelompok perlakuan (P2) diberikan omeprazol 20 mg. Hasil penelitian didapatkan nilai Km pada kelompok kontrol (P0) sebesar 13,482 mmol/dm3, pada kelompok perlakuan (P1) sebesar 11,227mmol/dm3 dan pada kelompok perlakuan (P2) sebesar 6,327mmol/dm3. Analisis data statistik korelasi regresi menunjukkan nilai p pada P1 0,01 dan pada P2 0,02 (p<0,05) serta nilai R mendekati 1 dengan grafik linear Lineweaver Burk yang menanjak. Disimpulkan bahwa lansoprazol dan omeprazol dapat mempengaruhi aktivitas enzim katalase hepar mencit. Kata-kata kunci: lansoprazol, omeprazol, enzim katalase, hepar mencit
KORELASI ANTARA PROTEINURIA DAN FRAMINGHAM RISK SCORE DALAM PENILAIAN RISIKO CARDIOVASCULAR DISEASE Kevin Prasetya Raharjo; Agus Yuwono; Erida Wydiamala
Berkala Kedokteran Vol 13, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.853 KB) | DOI: 10.20527/jbk.v13i1.3444

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Abstract: Diabetes mellitus (DM) is a metabolic disorder with elevated glucose level known as hyperglicemia which is caused by insulin resistance. One of the diabetes mellitus complications known is a cardiovascular disease (CVD). Proteinuria is affecting CVD risk on DM patient which is predicted by framingham risk score (FRS). This research aimed to discover the correlation between proteinuria and framingham risk score on cardiovascular disease risk evaluation of DM patient. This was analytic observational research with the cross-sectional design. Samples included in this study were 43 DM patients’ medical record data. Statistic analysis with Somers’d test resulted in r value=-0,067 and  p significance value=0,063 (p>0,05). Based on the result, it can be concluded that proteinuria has very weak, negative and nonsignificant correlation strength. Keywords: Proteinuria, framingham risk score, cardiovascular disease, diabetes mellitus Abstrak: Diabetes melitus (DM) adalah suatu kelainan metabolik yang ditandai dengan meningkatnya kadar glikemik dalam darah atau hiperglikemia yang ditimbulkan akibat adanya resistensi insulin. Salah satu komplikasi DM yang telah diketahui adalah cardiovascular disease (CVD). Risiko CVD yang dapat diprediksi dengan framingham risk score (FRS) pada pasien diabetes melitus dapat dipengaruhi oleh adanya proteinuria. Penelitian ini bertujuan untuk mengetahui korelasi antara proteinuria dengan framingham risk score dalam penilaian risiko cardiovascular disease pada pasien DM. Penelitian ini bersifat observasional analitik dengan pendekatan cross-sectional. Jumlah sampel yang digunakan sebanyak 43 sampel berupa data rekam medis pasien DM tipe 2. Hasil uji statistik dengan uji Somers’d mendapatkan hasil r=-0.067 dengan nilai signifikansi p=0.663. Berdasarkan hasil tersebut, dapat disimpulkan bahwa proteinuria memiliki korelasi yang sangat lemah, tidak searah dan tidak ada korelasi yang bermakna. Kata-kata kunci: Proteinuria, framingham risk score, cardiovascular disease, diabetes  melitus 
IDENTIFIKASI JENIS BAKTERI KONTAMINAN PADA TANGAN PERAWAT DI BANGSAL PENYAKIT DALAM RSUD ULIN BANJARMASIN PERIODE JUNI-AGUSTUS 2014 Ikhwanda Angga L.; Muhammad Darwin Prenggono; Lia Yulia Budiarti
Berkala Kedokteran Vol 11, No 1 (2015)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (268.327 KB) | DOI: 10.20527/jbk.v11i1.180

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Nosocomial infection is an infection by viruses , bacterias, and fungal pathogens that attack a patient undergoing treatment at a hospital. The source of nosocomial infections can be derived from one's body own endogenous flora and cross-infection through the hands of health care workers. The aim of this study was to identify the types of contaminants bacterias on the hands of the nurses of Disease Ward at RSUD Ulin Banjarmasin from June to August 2014. This is a descriptive study with cross sectional approach. A total of 26 samples were selected using total sampling method. The results of the nurses' hand swab which had been cultured in an isolation media were viewed using a microscope. Descriptive analysis showed that there were four types of bacteria on the hands of nurses hand swab results: Staphylococcus aureus (53,85%), Staphylococcus epidermidis (34,62%), Escherichia coli (7,69%), and Bacillus sp.(3,84%). Therefore it can be concluded that bacterial contaminants found on the hands of nurses were Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Bacillus sp. Keywords: nosocomial infection, contaminant bacterias, nurses' hand
CD4 LYMPHOCYTE IN HIV / AIDS BEFORE AND AFTER ANTIRETROVIRAL THERAPY Rangsang Bagus Prabowo; Dewi Indah Noviana Pertiwi; FX. Hendriyono
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.63 KB) | DOI: 10.20527/jbk.v13i2.4074

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Abstract: Human Immunodefficiency Virus (HIV) is a virus that decreases the human immunity system, therefore the infected people become susceptible to any kind of infections. Examination of CD4 lymphocyte count periodically is one of the antiretroviral therapy success indicators. The purpose of this research was to determine the difference of CD4 lymphocyte count before and after antiretroviral therapy at Ulin General Hospital Banjarmasin on 2013-2015. The method of this research was observational analytic with cross-sectional approach. The study population was 55 patients which were selected by inclusion and exclusion criteria. Results portrayed an increase of the CD4 lymphocyte count in 51 patients after being given four kinds of antiretroviral for 6 months with the mean increase in CD4 lymphocyte count was 92,72 cell/µL. Data analysis result with Wilcoxon test portrayed a difference of the CD4 lymphocyte count before and after antiretroviral therapy with p value=0,000. In conclusion, there was a significant difference of the CD4 lymphocyte count before and after antiretroviral therapy. Keywords: Human Immunodeficiency Virus, CD4, lymphocyt, antiretroviral therapy
Efek Pemberian Cairan Koloid dan Kristaloid terhadap Tekanan Darah Rebika Nurul Azizah; Kenanga Marwan Sikumbang; Asnawati Asnawati
Berkala Kedokteran Vol 12, No 1 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.35 KB) | DOI: 10.20527/jbk.v12i1.352

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Abstract: Maternal hypotension is a serious problem that most commonly occurs after spinal anesthesia in cesarean section. To reduce the incidence of maternal hypotension, mother with spinal anasthesia for cesarean section can be given fluids intravenously using crystalloid or colloid.The purpose of this study was to determine the effect of colloid and crystalloid fluid to blood pressure in mother with spinal anesthesia for cesarean section. This study was cross sectional observational analytic. There were 2 groups in this study, crystalloid group and colloid group. Sampels in each group were 20 subject. Generalized linier models test showed the value of P > 0.05 for each hemodynamic markers (Systolic and diastolic pressure at 5th, 10th, and 15th minutes). On the statistical test value of systolic ( P= 0.379) and diastolic ( P= 0.654). It can be concluded that crystalloid and colloid fluid were equally efective to defend blood pressure in patients with spinal anesthesia for caesarean sectionKeywords: blood pressure, spinal anesthesia, cesarean section, crystalloid, colloid. Abstrak: Hipotensi pada ibu hamil adalah masalah serius yang paling umum terjadi pasca anestesi spinal pada seksio sesarea. Untuk mengurangi kejadian hipotensi tersebut dapat diberikan cairan intravena berupa kristaloid atau koloid. Tujuan penelitian ini untuk membandingkan efek penggunaan cairan koloid dan kristaloid terhadap tekanan darah pasien seksio sesaria dengan anestesi spinal. Penelitian ini bersifat observasional analitik cross sectional. Dua puluh pasien yang telah diberikan cairan kristaloid dan 20 pasien lainnya yang diberikan cairan koloid. Dari uji statistik dengan generaliz linier model didapatkan nilai P= >0.05 pada setiap penanda hemodinamik (TDS dan TDD pada menit ke-5, 10, dan 15). Pada uji statistik tersebut nilai TDS (P = 0.379) dan TDD (P = 0.654). Dapat disimpulkan bahwa cairan kristaloid dan koloid sama efektifnya dalam mempertahankan tekanan darah pada ibu hamil dengan seksio sesarea yang dilakukan anestesi spinal. Kata-kata kunci: tekanan darah, anestesi spinal, seksio sesarea, kristaloid, koloid.
Peroneal Nerve Function and Knee Stability after Resection Giant Cell Tumour of Proximal Fibula, A Serial Case Warih Anggoro Mustaqim; Satria Pandu Persada Isma; Istan Irmansyah Irsan
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (541.41 KB) | DOI: 10.20527/jbk.v14i1.4588

Abstract

Abstract: Giant-cell  Tumour (GCT ) is a benign Tumour, locally aggressive neoplasm which is composed of sheets of neoplastic oviod mononuclear cells uniformly distributed large, osteoclast like giant cell. Incidence GCT of proximal fibula is rare. Peroneal nerve function and stability of knee joint must be considered at the proximal fibula GCT. In 2017 we found three cases of GCT of the proximal fibula in the outpatient clinic Saiful Anwar General Hospital. All three of these patients had a confirmed GCT of proximal fibula  which planned for Tumour resection, peroneal nerve presevation and LCL ligament reconstruction. This is study of three patients with  GCT of proximal fibula was confirm with Clinical Pathological Confrence (CPC). All of patient had presented of lump,  slowly growing pain in lateral side of knee, limping when they walk and numbness in dorsal side of foot. One patient cannot dorsoflexion of ankle. We evaluated a peroneal nerve function and stability of knee after operation and one year after resection of tumour. All patient had occurred peroneal nerve lesion with no instability of knee post operatively. Two patient had complaint with numbness in dorsal side of foot and weakness ankle dorsoflexion and after one year both of patient had improved ankle dorsoflexion but still numbness in dorsal side of foot. One patient  still complaining numbness in dorsal side of foot and weakness ankle dorsoflexion post operation and one year after operation. There is no LCL ligament instability  in all of patient post operation and one year after operation. The peroneal nerve function and LCL ligament stability must consider when facing benign tumours in proximal fibula such as giant cell tumour proximal fibula. These resections result in an unavoidable loss of knee stability because of resecting the lateral collateral ligament (LCL) insertion site on the fibular head. Based on the literature, the incidence rate of postoperative peroneal nerve palsy ranges from 3% to 57%. Giant cell tumour in proximal fibula is rare and require wide excision with intraarticular resection of the proximal tibiofibular join. We must consider about peroneal nerve function and LCL ligament stability during resection of GCT proximal fibula. Keywords: Giant Cell Tumour Proximal Fibula, Peroneal Nerve function, LCL Ligament stability