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Berkala Kedokteran

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Published by Universitas Lambung Mangkurat

ISSN : 14120550 EISSN : 25485660 DOI : http://dx.doi.org/10.20527

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and September.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 478 Documents

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Tinjauan Histologi Sawar Darah Otak Ida Yuliana
Berkala Kedokteran Vol 9, No 1 (2013)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Blood brain barrier is a membrane which is highly resistant to the diffusion process and separate the blood brain interstitial fluid. The blood brain barrier is a separation between the main compartment nervous system brain, CSF and the third compartment of the blood. Function of the blood brain barrier are protects the central nervous system to maintain homeostasis of blood milieu microenvironment. Blood-brain barrier layer is characterized as a perfect and continuous cell of endothelial cells in the connective by tight junctions. By using electron microscopy showed that the lumen of blood capillaries separated from the extra-cellular space by endothelial cells in the capillary wall (cell cerebral endhothelial), basement membrane outside the cell contains perisit endothelial cells and astrocytes feets are attached to the outer layer of the wall of the capillary. The third component has a specificity in terms of functional morphology and histology. Keywords: blood-brain barrier, endothelial cell, astrocyte, perisit cell Abstrak: Sawar darah otak adalah suatu membran yang sangat resisten terhadap proses difusi dan memisahkan cairan intersisial otak darah. Sawar darah otak merupakan pemisah antara kompartmen utama susunan saraf otak, LCS dan kompartmen ketiga yaitu darah. Sawar darah otak memiliki fungsi melindungi susunan saraf pusat dari milieu darah mempertahankan homeostasis lingkungan mikro. Sawar darah otak dicirikan sebagai lapisan seluler yang sempurna dan kontinu dari sel endotel yang di ikat oleh tight junction. Dengan menggunakan mikroskop elektron memperlihatkan bahwa lumen kapiler darah dipisahkan dari ruang ekstra seluler oleh sel endotelial di dinding kapiler (cell cerebral endhothelial), membran basalis di luar sel endotel berisi sel perisit dan kaki-kaki astrosit yang menempel pada lapisan luar dari dinding kapiler. Ketiga komponen tersebut memiliki kekhususan dalam hal morfologi dan fungsional secara histologi. Kata-kata Kunci: sawar darah otak, sel endotel, astrosit, sel perisit

The Differences Analysis of Temperature, Salinity, and Dissolved Oxygen of Aedes aegypti Breeding Place Water in Endemic and Non-Endemic Areas Nurul Hidayah; Dwi Rahmawati
Berkala Kedokteran Vol 15, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: The study aims to determine differences in water quality of breeding sites in endemic and non-endemic areas. The method used is quantitative observational analytic with a case control study design. Case group was water parameters in endemic areas and the control group is in non-endemic areas. 43 samples of breeding water were taken from each area then water quality measurements were carried out. Data were analyzed using independent t-test. The results obtained mean temperature in endemic areas 27.51 ± 0.739 oC, salinity 2,544 ± 0.638 gr/l, and DO 7,253 ± 1,097 mg/l. The mean temperature in non-endemic areas is 25.7 ± 1.124 oC, salinity is 2.472 ± 2.365 gr/l, and DO is 6.479 ± 1.059 mg/l. P-value of statistical tests of differences in temperature, salinity, and DO parameters in endemic and non-endemic areas are 0.000, 0.266, and 0.001. It was concluded that temperature and DO parameters in endemic areas proved to be significantly different from those in non-endemic areas. However, for salinity variables there are no significant differences. Keywords: Aedes aegypti, dissolved oxygen, salinity, temperature

Hubungan Antara Status Keakraban Orang Tua-Anak Dan Kecenderungan Antisosial: Pada Pelajar SMK YPK Kota Banjarbaru Annisa Avicenna; Achyar Nawi Husein; Mohammad Bakhriansyah
Berkala Kedokteran Vol 9, No 2 (2013)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v9i2.942

ABSTRACT: Juvenile delinquency is a form of antisocial behavior. Teenagers who have no proximity with their parents tend to have antisocial behaviors compared to them who have it with their parents. This study aimed to determine the relationship between the status of the parents-child proximity and the antisocial tendency on students at YPK Senior High School Banjarbaru. This was a descriptive analytical study with cross sectional approach. Samples involved in this study were 48 students and were selected by purposive sampling technique. Status of the parents-child proximity and the antisocial tendency were determined by using ‘Instrumen Keakraban Remaja-Orang tua (IKRO)’ and The Manson Evaluation Test, respectively. The samples consisted of 16 students had no proximity with their parents and 32 students who had it. The data showed that students who had no proximity with parents having antisocial tendency were 16 (33%) and none of students with no antisocial tendency (0%), whereas, students who had proximity with parents having antisocial tendency were 24 (50%) and those with no antisocial tendency were 8 (17%). Statistical analysis using Fisher test at 95% confidence level showed a significant relationship between proximity status of parents-child and the antisocial tendency on students at SMK YPK Banjarbaru (p=0,039). Keywords: proximity of parents-child, antisocial behavior, YPK Senior High School Banjarbaru. ABSTRAK: Kenakalan remaja merupakan salah satu bentuk perilaku antisosial. Remaja yang tidak memiliki keakraban dengan orang tua cenderung memiliki perilaku antisosial dibandingkan dengan remaja yang memiliki keakraban dengan orang tua. Penelitian ini bertujuan untuk mengetahui hubungan antara status keakraban orang tua-anak dan kecenderungan antisosial pada pelajar SMK YPK Kota Banjarbaru. Penelitian ini adalah penelitian deskriptif analitik dengan pendekatan cross-sectional dengan sampel penelitian sebanyak 48 orang dan dipilih secara purposive sampling. Status keakraban orang tua-anak dan kecenderungan antisosial ditentukan dengan menggunakan masing-masing kuesioner yaitu Instrumen Keakraban Remaja-Orang tua (IKRO) dan The Manson Evaluation Test. Sampel terdiri atas, 16 orang pelajar yang tidak memiliki keakraban dengan orang tua dan yang memiliki keakraban dengan orang tua berjumlah 32 orang. Hasil pengumpulan data tersebut menunjukkan bahwa pelajar SMK YPK yang tidak memiliki keakraban dengan orang tua memiliki kecenderungan antisosial sebanyak 16 orang (33%), sementara tidak ada pelajar yang tidak memiliki kecenderungan antisosial (0%). Selain itu, pelajar SMK YPK yang memiliki keakraban dengan orang tua memiliki kecenderungan antisosial sebanyak 24 orang (50%) dan tidak memiliki kecenderungan antisosial sebanyak 8 orang (17%). Hasil analisis statistik dengan menggunakan uji Fisher pada tingkat kepercayaan 95% menunjukkan terdapat hubungan yang bermakna antara status keakraban orang tua-anak dan kecenderungan antisosial pada pelajar SMK YPK Kota Banjarbaru (p=0,039). Kata kunci: keakraban orang tua-anak, perilaku antisosial, SMK YPK Banjarbaru

Imunitas Selular – Netrofil Huldani Huldani
Berkala Kedokteran Vol 10, No 2 (2014)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i12.969

Abstract: Neutrophils play a role in nonspecific cellular immune system which can be found in circulation. Neutrophils are white blood cells (leukocytes) are characterized histologically by its ability to stained by the dye neutral and functional with its role in mediating the immune response against infectious microorganisms. . Neutrophil granules are usually pink or purple - blue with dye. Neutrophil Approximately 50 to 80 percent of all white blood cells in the human body. Neutrophils are quite uniform in size with a diameter between 12 and 15 micrometers. The core consists of 2-5 lobes joined together by the hairlike filaments. Neutrophils move by amoeboid movement. In neutrophils migrate to the area of the body to infection or tissue injury. Tensile strength which determines the direction in which neutrophils will move known as chemotaxis and is associated with substance released from the damaged tissue. Neutrophils are active phagocytes that engulf bacteria and other microorganisms and microscopic particles. The granules of neutrophils is a powerful enzyme that can digest various types of cellular material. During the inflammatory response, chemotactic factors of different origin and proinflammatory cytokine signals attracting neutrophils to the site of infection and / or injury. Injured area will issue a neutrophil chemo attractant attractive to the injured area, followed by the formation of reactive oxygen species (ROS) which is used as the body's defenses. Neutrophils also synthesize and secrete small amounts of several cytokines including IL-1, IL-6, IL-8, TNF-α, and GM-CSF. Keywords: Cellular Immunity - Neutrophils - Chemo attractant Abstrak: Netrofil berperan dalam sistem imun nonspesifik selular yang dapat ditemukan dalam sirkulasi. Neutrofil adalah sel darah putih ( leukosit ) yang ditandai secara histologi oleh kemampuannya untuk ternoda oleh pewarna netral dan fungsional dengan perannya dalam mediasi respon imun terhadap mikroorganisme menular. . Granul neutrofil biasanya berwarna merah muda atau ungu - biru dengan zat pewarna . Netrofil Sekitar 50 sampai 80 persen dari semua sel darah putih dalam tubuh manusia. Neutrofil cukup seragam dalam ukuran dengan diameter antara 12 dan 15 mikrometer . Inti terdiri dari 2-5 lobus bergabung bersama oleh filamen mirip rambut . Neutrofil bergerak dengan gerakan amoeboid. Dalam tubuh neutrofil bermigrasi ke daerah infeksi atau cedera jaringan . Kekuatan tarik yang menentukan arah di mana neutrofil akan bergerak dikenal sebagai kemotaksis dan berhubungan dengan zat yang dilepaskan dari tempat kerusakan jaringan. Neutrofil adalah fagosit aktif yang dapat menelan bakteri dan mikroorganisme lain dan partikel mikroskopis . Granul neutrofil merupakan enzim kuat yang mampu mencerna berbagai jenis bahan selular. Selama respon inflamasi, faktor chemotactic asal yang berbeda dan sinyal sitokin proinflamasi menarik neutrofil ke tempat infeksi dan / atau cedera. Daerah yang mengalami cedera akan mengeluarkan chemo attractant yang menarik neutrofil ke daerah cedera tersebut, diikuti pembentukan reactive oxygen species (ROS) yang digunakan sebagai pertahanan tubuh. Neutrofil juga mensintesis dan mensekresi sejumlah kecil beberapa sitokin termasuk IL-1, IL-6, IL-8, TNF-α, dan GM-CSF. Kata-kata Kunci : Imunitas Selular – Netrofil – Chemo attractant

HUBUNGAN KONDISI VENTILASI RUMAH DENGAN KEJADIAN TB PARU DI WILAYAH PUSKESMAS KELAYAN TIMUR Ferdy Ricardo Sinaga; Farida Heriyani; Husnul Khatimah
Berkala Kedokteran Vol 12, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract : Pulmonary TB is an infectious disease which is transmitted through air contaminated by Mycobacterium tuberculosis. TB remains a main health problem in all over the world and also one of leading causes of death from infectious disease. Enviromental characteristic is the key factor to the risk of transmition. Ventilation condition is one factor that contributes to the house’s environmental characteristic. This research aims to know the correlation between ventilation condition and the incidence of pulmonary TB in working area of Kelayan Timur Community Health Center. This is an analitic observasional research with study design of case control. Subjects were selected using the simple random sampling technique. Subjects were divided into 2 groups, 30 subjects for the case group and 30 subjects for the control group. Data was analyzed using Chi Square test with 95 % confidence interval. The result shows that 29 of 30 houses (96,67 %) from the case group have an inproper ventilation meanwhile only 9 of 30 houses (30 %) from the control group which have an inproper ventilation. The analysis shows a significant correlation between ventilation condition and the incidence of pulmonary TB with ρ = 0,000. Keywords: ventilation condition, pulmonary TB, Kelayan Timur Community Health Center. Abstrak : TB paru merupakan penyakit infeksi yang ditularkan melalui udara yang terkontaminasi Mycobacterium tuberculosis. TB masih menjadi masalah utama kesehatan di seluruh dunia dan merupakan salah satu penyebab kematian akibat penyakit infeksi. Keberlangsungan hidup kuman TB ditentukan oleh karakteristik lingkungannya. Kondisi ventilasi rumah merupakan salah satu faktor yang mempengaruhi karakteristik lingkungan dalam rumah. Penelitian ini bertujuan untuk mengetahui hubungan kondisi ventilasi rumah dengan kejadian TB paru di wilayah Puskesmas Kelayan Timur. Penelitian ini adalah penelitian observasional analitik dengan desain studi kasus kontrol. Subjek penelitian dipilih dengan menggunakan teknik simple random sampling. Subjek penelitian terdiri dari 2 kelompok yaitu 30 sampel kelompok kasus dan 30 sampel kelompok kontrol. Data dianalisa menggunakan uji Chi Square dengan tingkat kepercayaan 95 %. Hasil penelitian menunjukkan 29 dari 30 kelompok kasus (96,67 %) memiliki kondisi ventilasi rumah yang tidak memenuhi syarat, sedangkan hanya 9 dari 30 kelompok kontrol (30 %) yang memiliki kondisi ventilasi rumah yang tidak memenuhi syarat. Hasil analisa mendapatkan nilai ρ=0,000 sehingga dapat disimpulkan bahwa terdapat hubungan yang bermakna antara kondisi ventilasi rumah dengan kejadian TB paru. Kata-kata kunci: kondisi ventilasi, TB paru, Puskesmas Kelayan Timur.

HUBUNGAN TIPE KEPRIBADIAN INTROVERT DENGAN KECANDUAN INTERNET PADA SISWA KELAS X DI SMAN 1 BANJARMASIN Muthia Anggraeni; Achyar Nawi Husain; Syamsul Arifin
Berkala Kedokteran Vol 10, No 1 (2014)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

ABSTRACT: Internet addiction disorder is an impulse-control disorder that is caused by excessive internet usage who spent 19 hours everyweek. The internet addictive behavior can be caused by a variety of factors, one of which is personality type (introvert-ekstrovert). The aim of this research was to determine the relationship between introvert personality type and internet addiction disorder. The research used analytical observasional methods with cross sectional approach. Respondents were selected by using proportional random sampling based on the criteria samples of Fraenkel and Wallen. Fifty respondents were asked to fill the Personality Types questionnaires and Young Internet Addiction Scale. The results then analyzed with Fisher test. The results showed, respondents who had introvert personality type were 40 (80%), respondents who had extrovert personality type were 10 (20%), respondents who had internet addiction behavior were 38 (76%), and respondents who did not have internet addiction behavior were 12 (24%). Statistical analysis using Fisher test showed the value of P=0,046 with Odds Ratio 4,714. It was concluded that introvert personality type was 40 respondents (80%), internet addiction was 38 respondents (76%), and there is a significant relationship between introvert personality type and internet addiction disorder at X grade of SMAN 1 Banjarmasin’s Students. Keywords: introvert personality type, internet addiction, SMAN 1 Banjarmasin. ABSTRAK: Kecanduan internet adalah suatu impulse-control disorder yang disebabkan oleh pemakaian internet berlebihan yang menghabiskan waktu 19 jam perminggu. Perilaku kecanduan internet dapat disebabkan oleh berbagai faktor, salah satunya adalah tipe kepribadian (introvert-ekstrovert). Tujuan penelitian adalah untuk mengetahui hubungan tipe kepribadian introvert dengan kecanduan internet. Metode penelitian menggunakan metode observasional analitik dengan pendekatan cross sectional. Responden dipilih menggunakan teknik proporsional random sampling dengan jumlah sampel berdasarkan kriteria Fraenkel dan Wallen. Sebanyak 50 responden kemudian diminta untuk mengisi kuesioner tipe kepribadian dan kuesioner Young Internet Addiction Scale, hasilnya kemudian dianalisis menggunakan uji Fisher. Hasil penelitian menunjukkan, responden yang memiliki tipe kepribadian introvert sebanyak 40 orang (80%), sedangkan yang memiliki tipe kepribadian ekstrovert sebanyak 10 orang (20%). Responden yang memiliki kecanduan internet sebanyak 38 orang (76%), sedangkan yang tidak memiliki kecanduan internet sebanyak 12 orang (24%). Uji Fisher menunjukkan nilai p=0,046 dengan Odds Ratio 4,714. Dapat disimpulkan, tipe kepribadian introvert adalah sebanyak 40 responden (80%) dan kecanduan internet sebanyak 38 responden (76%) serta terdapat hubungan yang bermakna antara tipe kepribadian introvert dan kecanduan internet pada siswa kelas X di SMAN 1 Banjarmasin. Kata-kata kunci: tipe kepribadian introvert, kecanduan internet, SMAN 1 Banjarmasin.

HUBUNGAN DUKUNGAN KELUARGA DENGAN NIAT KONSUMSI TABLET TAMBAH DARAH PADA REMAJA PUTERI Nur Syaima Dhiya Savitry; Syamsul Arifin; Asnawati Asnawati
Berkala Kedokteran Vol 13, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Iron deficiency anemia is a condition caused by iron reserve depletion that reduces iron used for hemoglobin formation. A teenage girl is more hazardous to suffer anemia than the boy because girl needs more iron mainly in menstruation. Consuming blood booster tablet is one of the efforts to prevent and overcome anemia which is containing iron and folic acid. There are many teenage girls with anemia in PGRI 4 High School Banjarmasin. The girl intention to consume blood booster tablet is mainly related to family support. This research aimed to understand the correlation between family support and intention of blood booster tablet consumption on the teenage girls in PGRI 4 High School Banjarmasin. This was an analytic observational with cross-sectional approach research. There were 50 samples selected with stratified random sampling. This research was using questionnaire. The result showed the percentage of high, medium and low family supports were 32%, 32% and 36% meanwhile the percentage of strong and weak intentions were 66% and 34%. Chi-square data analysis test with 95% confidence level shows p value=0,029 (<0,05) which mean there is a significant correlation between family support and intention of blood booster tablet consumption on teenage girls in PGRI 4 High School Banjarmasin. Keywords: blood booster tablet, intention, family support Abstrak: Anemia defisiensi besi merupakan anemia yang timbul akibat kosongnya cadangan besi sehingga penyediaan besi untuk pembentukan hemoglobin berkurang. Remaja puteri lebih berisiko mengalami anemia dibandingkan remaja pria karena remaja putri memerlukan lebih banyak zat besi terutama pada saat menstruasi. Salah satu upaya untuk mencegah dan menanggulangi anemia pada remaja puteri adalah dengan mengkonsumsi tablet tambah darah, yakni tablet yang mengandung besi dan asam folat. Niat remaja puteri untuk mengkonsumsi tablet tambah darah terutama dipengaruhi oleh dukungan keluarga. Sementara itu, SMA PGRI 4 Banjarmasin tercatat sebagai Sekolah Menengah yang remaja puterinya banyak mengalami anemia. Dengan demikian, akan diteliti hubungan dukungan keluarga dengan niat konsumsi tablet tambah darah pada remaja puteri di SMA PGRI 4 Banjarmasin. Penelitian ini menggunakan metode observasional analitik dengan pendekatan crossectional. Sampel penelitian berjumlah 50 orang dengan teknik pengambilan stratified random sampling. Instrumen penelitian berupa kuesioner. Hasil penelitian menunjukkan distribusi persentasi dukungan keluarga tinggi 32%, sedang 32%, dan rendah 36%, serta distribusi persentasi niat kuat 66% dan niat lemah 34%. Analisis data menggunakan uji Chi-square.dengan tingkat kepercayaan 95% didapatkan nilai p value = 0,029 (<0,05) yang menunjukkan adanya hubungan yang bermakna antara dukungan keluarga dan niat konsumsi tablet tambah darah pada remaja puteri di SMA PGRI 4 Banjarmasin. Kata-kata kunci: Tablet tambah darah, niat, dukungan keluarga

POTENSI ANTIINFLAMASI JUS BUAH BELIMBING (Averrhoa carambola L.) TERHADAP DENATURASI PROTEIN IN VITRO Farizka Erianti; Dona Marisa; Eko Suhartono
Berkala Kedokteran Vol 11, No 1 (2015)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Starfruit (Averrhoa carambola L.) is an Asian tree that has been used in traditional medicine. Flavonoids, saponins, and tannins is thought to have antiinflammatory in inhibiting protein denaturation. Protein denaturation is a cause of inflammation. This study aims to determine the antiinflammatory potential of starfruit in inhibiting protein denaturation in vitro. This study is a quasi experimental, using a model reaction between 5 % BSA were heated to form protein denaturation by two groups: the juice as the test group and diclofenac sodium as the standard group, which is divided to a concentration of 10%, 20%, and 30%. Potential inhibition of protein denaturation is known to determine the value of IC50 . The results of this study indicate that the starfruit juice has the IC50 value of 11.896 % (r=0.842), whereas for diclofenac sodium by 11.872 % (r=0.866). Positive r values indicate the existence of a positive relation between concentration and inhibiting protein denaturatiom potential. These results indicate that the starfruit juice as a potential inhibitor of protein denaturation for inflamamatory process in vitro. Keywords: antiinflammatory, Averrhoa carambola L., protein denaturatin

Pengaruh Latihan Aerobik Ringan dan Sedang terhadap Kadar Interleukin 8 dan Jumlah Netrofil pada Remaja Huldani Huldani
Berkala Kedokteran Vol 12, No 1 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Aerobic exercise with mild to moderate intensity will improve health and fitness. Aerobic exercise stimulates an increase in the concentration of IL-8 and will attract neutrophils out of circulation and infiltrate into the damaged tissue for physical activity. To determine the effect of mild and moderate aerobic exercise on levels of interleukin 8 and the number of neutrophils in adolescents, semi-experimental research laboratory with the entire population of male students of SMAN I Banjarbaru. Determination of the sample with inclusion and exclusion criteria obtained 31 samples (9 mild aerobic exercise, moderate aerobic exercise 12 and 10 as a control). The implementation of data collection (blood plasma) immediately after the sample is finished doing aerobic exercise. Blood plasma samples were analyzed by flowcytometri to see the number of neutrophils and elisa to see the levels of Interleukin 8 (IL-8). The results showed that mean plasma levels of IL-8 in mild aerobic group (605.69 ± 123.28) and moderate (718.75 ± 132.55) is lower than the control group (720.80 ± 213.11). Kruskal Wallis statistic test in the three groups no significant difference with p = 0.320. The average number of neutrophils mild aerobic exercise group (52.42 ± 8.29) and moderate (63.60 ± 8.73) was higher than the control group (50.11 ± 5.55), which means that there is an increase in the number of neutrophils after aerobic exercise , with one-way ANOVA statistical test showed different significant with p = 0.001. LSD test found significant differences between mild and moderate aerobic group with p = 0.003, 95% CI. There is no difference between the control group mild aerobic with p = 0.519. There are differences between the groups of moderate aerobic and control with p = 0.000. It can be concluded that mild and moderate aerobic exercise did not affect the increased plasma levels of interleukin-8 in adolescents. Mild aerobic exercise had no effect on the increase in the number of neutrophils in adolescents. Moderate aerobic exercise influence on the increase in the number of neutrophils in adolescents.Keywords : Aerobic exercise, Interleukin 8, Neutrophyl Abstrak: Latihan aerobik dengan intensitas ringan sampai sedang akan meningkatkan kesehatan dan kebugaran tubuh. Latihan aerobik merangsang peningkatan konsentrasi IL-8 dan akan menarik netrofil dari sirkulasi dan menyusup kejaringan yang rusak karena aktivitas fisik. Untuk mengetahui pengaruh latihan aerobik ringan dan sedang terhadap kadar interleukin 8 dan jumlah netrofil pada remaja, dilakukan penelitian semi eksperimental laboratorik dengan populasi seluruh pelajar laki-laki SMAN I Banjarbaru. Penentuan besarnya sampel dengan kriteria inklusi dan ekslusi didapatkan 31 sampel (9 latihan aerobik ringan, 12 latihan aerobik sedang, dan 10 sebagai kontrol). Pelaksanaan pengambilan data (plasma darah) segera setelah sampel selesai melakukan latihan aerobik. Plasma darah sampel dianalisa dengan flowcytometri untuk melihat jumlah netrofil dan pemeriksaan elisa untuk melihat kadar Interleukin 8 (IL-8). Hasil penelitian menunjukkan bahwa rerata kadar IL-8 plasma pada kelompok aerobik ringan (605,69 ± 123,28) dan sedang (718,75 ± 132,55) lebih rendah dari kelompok kontrol (720,80 ± 213,11). Secara uji statistik Kruskal Wallis ketiga kelompok tidak ada perbedaan bermakna dengan nilai p = 0,320. Jumlah rerata netrofil kelompok latihan aerobik ringan (52,42 ± 8,29) dan sedang (63,60 ± 8,73) lebih tinggi daripada kelompok kontrol (50,11 ± 5,55), artinya ada peningkatan jumlah netrofil setelah latihan aerobik. Dengan uji statistik ANOVA satu arah didapatkan hasil yang bermakna berbeda dengan nilai p = 0.001. Uji LSD didapatkan perbedaan bermakna antara kelompok aerobik ringan dan sedang dengan nilai p = 0,003, IK 95 % . Tidak terdapat perbedaan antara kelompok aerobik ringan dengan kontrol dengan nilai p = 0,519. Terdapat perbedaan antara kelompok aerobik sedang dan kontrol dengan nilai p = 0,000. Dapat disimpulkan bahwa latihan aerobik ringan dan sedang tidak berpengaruh terhadap peningkatan kadar Interleukin-8 plasma pada remaja. Latihan aerobik ringan tidak berpengaruh terhadap peningkatan jumlah netrofil pada remaja. Latihan aerobik sedang berpengaruh terhadap peningkatan jumlah netrofil pada remaja. Kata Kata Kunci : Latihan Aerobik, Interleukin 8, Netrofil

Anti Inflammatory Effect Of Toman Fish (Channa micropeltes) Extract In Wound Healing Process Maharani Laillyza Apriasari; Dewi Puspitasari; Amy Nindia Carabelly
Berkala Kedokteran Vol 14, No 2 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: One phase of wound healing is the inflammatory phase. Haruan fish extract has shown to accelerate the healing process up because it has anti-inflammatory effects. Toman fish originates from the same genus as the Haruan fish, but its anti-inflammatory effect remains unknown. It was done to analyzed anti-inflammatory effects of Toman fish extract. This study was true experimental design with posttest-only control design. Twenty-seven male mice of Balb-C strain were divided into 3 groups. Incision wound of 1 cm was made along the back of the mice. Nine mice in each group were sacrificed on 3rd days, then histopathology examination was conducted with Haematoxylin eosin. There were significant differences between treatment group given Toman fish extract and positive control group given Haruan fish extract, and also compared to the negative control group in PMN cell examination. There were significant differences between treatment group given Toman fish extract and positive control group given Haruan fish extract compared to negative controls on the number of macrophage cells. Toman fish extract could lower the number of PMN cells and was able to increase the number of macrophages on the 3rd days. Toman fish has anti-inflammatory effects on the wound healing process. Keywords: Anti-inflammatory effects, haruan fish extract, macrophages, PMN cells, toman fish extract

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Eko Suhartono

Contact Email
esuhartono@ulm.ac.id

Phone
+6281251126368

Journal Mail Official
jbk@ulm.ac.id

Editorial Address
Jalan Veteran No.128 Banjarmasin

Location
Kota banjarmasin,

Kalimantan selatan

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Eko Suhartono

Contact Email esuhartono@ulm.ac.id

Phone +6281251126368

Journal Mail Official jbk@ulm.ac.id

Editorial Address Jalan Veteran No.128 Banjarmasin

Location Kota banjarmasin, Kalimantan selatan INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Eko Suhartono

Contact Email
esuhartono@ulm.ac.id

Phone
+6281251126368

Journal Mail Official
jbk@ulm.ac.id

Editorial Address
Jalan Veteran No.128 Banjarmasin

Location
Kota banjarmasin,

Kalimantan selatan

INDONESIA