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Berkala Kedokteran

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Published by Universitas Lambung Mangkurat

ISSN : 14120550 EISSN : 25485660 DOI : http://dx.doi.org/10.20527

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and September.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 478 Documents

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Correlation between Hemoglobin Reticulocytes and Ferritin in Chronic Kidney Disease Patients Undergoing Hemodialysis at PKU Bantul Muhammad Salman Shalahuddin; Linda Rosita
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: As many as 7 – 12% of the world's population has chronic kidney disease (CKD). CKD patients can experience various complications, one of which is anemia. Anemia can cause a variety of cardiovascular complications in CKD patients. Enforcement of the diagnosis of anemia and its type is carried out by laboratory examination, among others by examination of reticulocytes-hemoglobin (ret-he) and iron status such as serum ferritin. Examination of these parameters can help in planning the right treatment for CKD patients who have anemia. The purpose of this study was to determine the relationship of Ret-he with ferritin levels in CKD patients undergoing hemodialysis at PKU Bantul Hospital. This study used cross-sectional method. The data source used was secondary data obtained from medical records and the Indonesian Renal Registry (IRR). Sampling research used consecutive sampling method. The analysis used univariate analysis which was frequency distribution table, and bivariate analysis. Univariate analysis obtained that average levels of ret-he from 50 subjects was 28.87 ± 3.75 pg and median serum ferritin levels were 118,1 (9,76 – 1615) mL. Bivariate analysis with pearson correlation test found a significant correlation between serum ret-he and ferritin levels (r = 0.498, p = 0.000).There was a significant correlation between he-ret levels and serum ferritin levels Keywords: chronic kidney disease, anemia, reticulocytes-hemoglobin, serum ferritin.

Hand Soap Activity Against the Number oOf Bacterial Colonies from the Housewife's Hand Swab Samples in a Temporary Landfill in Kelurahan Gadang Banjarmasin Farida Heriyani; Lia Yulia Budiarti; Widya Nursantari; Ayu Apriliani
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Unhygienic waste handling in a temporary landfill, can make the surrounding environment a source of transmission of pathogenic bacteria and colonization of bacterial growth in the hands. The study aims to identify the type of bacteria on the hands and test the activity of hand wash soap in lowering the number of colonies of hand bacteria. The identification of bacteria against 30 hand swab samples derived from the hands of housewives in temporary landfill (TPS) in Kelurahan Gadang Banjarmasin, was carried out in conventional media. Test the activity of hand wash soap in lowering the number of colonies of hand bacteria using 2 different brands. Bacterial identification is carried out by descriptive method and experimental testing of hand wash soa p activity use pretest-posttest design with control group design. The data was analyzed using shapiro wilk test and wilcoxon test with 95% confidence level. Identification of hand swab bacterial isolates obtained Staphylococcus aureus (66.6%), Staphylococcus epidermidis (10%) and Escherichia coli (23.33%). Statistical analysis showed significant differences between the two brands of hand wash soap tested (sig. 0.000 >0.05). The conclusion of the type of gram-positive bacteria more widely found in the hands of housewives; Type B hand soap has a higher effectiveness in reducing the number of bacterial colonies on the hands than A-brand. Keywords: hand wash soap, housewife hand swab, number of colonies of hand bacteria.

Hesperidin Interaction with HMG-CoA-Reductase Enzyme in Hypercholesterolemia: A Study in Silico Annisa Rizqi Dwi Oktaviani; Veronica Shania Aprillia; Eko Suhartono; Noer Komari
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Dyslipidemia is a degenerative disease occurred with increased levels of fat and cholesterol levels in blood. One of the proteins used as anti-cholesterol is an HMG-CoA-Reductase. Hesperidin in orange peel can reduce cholesterol levels by interacting with HMG-CoA-Reductase. To prove this, an in silico method was used by using swissdock.ch (http://swissdock.ch/docking#). The receptor protein in dyslipidemia was obtained from the RCSB Protein Data Bank (https://www.rcsb.org) namely HMG-CoA-reductase receptor with code PDB: 1HW9. The natural ligand, hesperidin, was obtained from PubChem with code: 10621 (https://pubchem.ncbi.nlm.nih.gov/). Protein was prepared by omitting the natural ligand residues present in the protein. Ligand and protein preparations were used by the chimera 1.15. The result of this study indicated that the interaction of hesperidin with several amino acid recidues was predicted to provide inhibitory activity on HMG-CoA reductase as the protein target. Inhibition of HMG-CoA reductase will reduce mevalonate synthesis so that cholesterol levels will decrease. Keywords: hesperidin, HMG-CoA-Reductase, cholesterol, dyslhahipidemia

Correlation of Vitamin D with Ferritin in Pregnant Mothers Chronic Energy Deficiency of the Second Trimester Hendera Henderi; Salmon Charles P T Siahaan; Irwin Priyatna Kusumah; Heru Cahjono; Ferdinand A Tannus; Nimas Pristiwanto D S; Helen Octavia
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Based on the prevalence of the Kediri Health Office in 2013 and 2014, pregnancy in CED in Kediri was 6.6% and 6.7%, which was an increase of 0.1% from the previous year. According to the prevalence of CED pregnancy in Badas Puskesmas in 2013 and 2014, it was 7.8% and 6.1%. Aimed at knowing the differences in vitamin D levels in normal pregnancy with second trimester CED pregnancy; know the difference between ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and UAC in normal pregnancy and second trimester CED pregnancy. This study used an analytical test (case-control) with randomization of pregnant and pregnant CED patients in the Sukomanunggal district. The results showed that the difference in Vitamin D (33.5380 ± 5.60498 vs 32.4300 ± 4.40708) p = 0.166, the comparison was not significant. The difference in ferritin (17.4080 ± 10.90625 vs 24.7420 ± 21.79586) p = 0.388 comparison was not significant. The correlation between vitamin D and ferritin (p = 0.030) had a significant relationship. There was no significant correlation between Vitamin D and UAC (p = 0.730). The correlation between ferritin and UAC (p = 0.304) was not significant. Keywords: Vitamin D, Iron, Ferritin, UAC, CEDAbstract: Based on the prevalence of the Kediri Health Office in 2013 and 2014, pregnancy in CED in Kediri was 6.6% and 6.7%, which was an increase of 0.1% from the previous year. According to the prevalence of CED pregnancy in Badas Puskesmas in 2013 and 2014, it was 7.8% and 6.1%. Aimed at knowing the differences in vitamin D levels in normal pregnancy with second trimester CED pregnancy; know the difference between ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and UAC in normal pregnancy and second trimester CED pregnancy. This study used an analytical test (case-control) with randomization of pregnant and pregnant CED patients in the Sukomanunggal district. The results showed that the difference in Vitamin D (33.5380 ± 5.60498 vs 32.4300 ± 4.40708) p = 0.166, the comparison was not significant. The difference in ferritin (17.4080 ± 10.90625 vs 24.7420 ± 21.79586) p = 0.388 comparison was not significant. The correlation between vitamin D and ferritin (p = 0.030) had a significant relationship. There was no significant correlation between Vitamin D and UAC (p = 0.730). The correlation between ferritin and UAC (p = 0.304) was not significant. Keywords: Vitamin D, Iron, Ferritin, UAC, CED

Stabilization of the Interaction of the Compunds of Mallotus paniculatus Müll.Arg. on Gluthations S-Transferase (GSTs) Samsul Hadi
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Gluthathione s-transferases (GSTs) play an important role against carcinogens, therapeutic drugs, and various types of cellular oxidative damage. Judging from its role in overcoming cellular oxidative damage, the activity of GSTs is one of the antioxidant enzymes. One of the plants that has been tested for its antioxidant ability is M. paniculatus. The content of M. paniculatus has been found so that it can be used to test the stability of the interaction between ligands and receptors. The aim of this research is to find compounds from M. paniculatus that have the potential to stabilize the interaction with the receptors. This docking method begins with ligand preparation and protein preparation followed by docking, visualization of interactions and analysis of the results. The research resulted in various docking scores with the various proteins involved. The stability of the interaction is obtained when the ligand binds to Glutathione S-transferase type A3 is hesperetin, sitosterol and sitosterol, to Glutathione S-transferase type theta-2 is β-daucostero, to Glutathione S-transferase type P is quercetin. Keywords: GSTs, M. paniculatus, docking

PATTERN OF ANTIBIOTICS USE IN ADULT PATIENTS WITH URINARY TRACT INFECTION (UTI) Hidayatul Kurniawati
Berkala Kedokteran Vol 17, No 1 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v17i1.10199

Introduction: Urinary tract infection (UTI) is an infectious disease caused by the growth and proliferation of bacteria in the urinary tract, including infections in the bladder to the renal parenchyma with a certain number of bacteria in the urine. The use of antibiotics is therapy that commonly used to treat infectious diseases caused by bacteria. Irrational use of antibiotics can lead to bacterial resistance and toxicity. Objective: To determine the rationality of using antibiotics in adult patients with a urinary tract infection (UTI) in the X Hospital Yogyakarta from January-December 2017.Methods: This study is a non-experimental study with a descriptive observational study design and retrospective data collection. The sample of this study was inpatients with a diagnosis of urinary tract infection (UTI) and was recorded in the Medical Record X Hospital Yogyakarta for the period January-December 2017 which was included in the inclusion criteria. Results: Medical records that were included in the inclusion criteria were 61. The single most widely used antibiotic was ceftriaxone in 25 cases (44.64%) and the most widely used combination antibiotic was ceftazidime + levofloxacin in 2 cases (40%). The use of antibiotics with the right indication was 61 patients (100%), the right type was 61 patients (100%), the correct duration was 54 patients (88.52%), the right dose was 61 patients (100%), the right interval was 60 patients (98.36%) and the right route of administration was 61 patients (100%).

Platelet-to-Lymphocyte Ratio (PLR) Profile and Neutrophil-to-Lymphocyte Ratio (NLR) in Lung Cancer Patients in Ulin General Hospital Banjarmasin 2017-2018 Haryati Haryati; Holly Diany
Berkala Kedokteran Vol 16, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Lung cancer is the leading cause of malignancy in the world reaching up to 13% of all cancer diagnoses. Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR), are promising markers of inflammatory prognosis, clinical decisions for proper management of lung cancer patients. The research used a retrospective analytic observational study as its research method. Samples were taken from Pathology Anatomy Laboratory, and the medical record data of lung cancer patients in Ulin General Hospital Banjarmasin from 2017 to 2018. Male lung cancer patients have percentage of 72% with PLR NLR values by sex are not much different p>0.05. 23% of patients were aged ≥ 65 years and 77% were aged £ 65 years with value p>0.05. Adenocarcinoma reaches 65% with p>0.05. Most metastases are 44% pleural effusion with value p>0.05. Percentage of advanced stage is 90% with a higher PLR NLR value at the end stage. There is a meaningful relationship of NLR with lung cancer stage p<0.05, but no relantionship with PLR p>0.05. PRL and NRL are increased at advanced stage. NRL and PRL did not differ significantly based on age, sex and histology of lung cancer. Keywords: Platelet-to-lymphocyte ratio (PLR), Neutrophil-to-lymphocyte ratio (NLR), lung cancer

FLEXIBILITY RESTORATION OF ARTICULATIO METACARPOPHALANGEAL 1 IN CADAVER PRESERVED BY FORMALIN WITH ACETIC ACID EXPOSURE Fitri Fitri; Marisa Riliani; Edward Syam
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Cadaver rigidity due to formalin preservation often intricates students' understanding in anatomical learning. Various solutions have been trial, but there were no satisfactory results. In this study, acetic acid solution was used to restore the motion flexibility motion of small joint in the hand. Investigated the difference in motion angle of articulatio metacarpophalangeal 1 after being given acetic acid in cadaver post formalin preservation. A pair of cadaver hands conserved by formalin from the same body, were exposed to 5% acetic acid for 4 months. Angular measurements performed on flexion and extension before and after exposure. The flexibility of metacarpophalangeal joints 1 increased in the form of angular reduction in flexion movement (22.8° reduced, p<0.05) and the addition of angle to the extension movement (9.85° increased, p<0.05). Administration of acetic acid for 4 months may increase the motion flexibility of small joint like articulatio metacarpophalangeal 1 in cadaver post-formalin preservation. This result may help students to have better anatomical understanding in cadaver at anatomy laboratory. Keywords: Acetic acid; Articulatio metacarpophalangeal 1; Cadaver; Flexibility; Restoration

THE INFLUENCE OF CLIMATE FACTORS ON DIARRHEA CASES IN CHILDREN UNDER FIVE YEARS BEFORE AND AFTER THE COVID-19 PANDEMIC IN BANJARMASIN Budiyanto Budiyanto
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Background: Diarrhea still become one of the leading causes of morbidity and mortality in children, especially under 5 years. Anthropogenic climate change, mainly due to global warming process, is expected to change the epidemiological pattern of infectious diseases, including diarrhea. COVID-19 pandemic that has occurred globally since March 2020 may also have an impact. Banjarmasin as a city in a wetland area with tropical savanna climate that also affected by COVID-19 pandemic is also at risk. We conducted a research to study the influence of climate factors on diarrhea cases in children under 5 years before and after the COVID-19 pandemic in Banjarmasin.Methods: Data of monthly diarrhea cases in children under 5 years at public health centers from Banjarmasin City Health Office and monthly climate data (amount of rainfall, number of rain days, temperature, humidity, sunshine duration, wind speed) from BMKG and BPS between January 2010 to April 2021 were collected. Statistical analysis was carried out to determine the correlation between climate factors and diarrhea cases before and after COVID-19 pandemic.Results: There was a decrease in the average monthly visits of children under five years with diarrhea before (497 ±47.4) and after (132 ±45.8) COVID-19 pandemic. Among climate factors, amount of rainfall (r=-0.753; p=0.005), number of rain days (r=-0.774; p=0.003), and humidity (r=-0.590; p=0.044) were negatively correlated, while sunshine duration (r=0.674; p=0.016) was positively correlated with diarrhea cases in the period before COVID-19 pandemic. No correlation was found between any climate factor and diarrhea cases in the subsequent period.Conclusion: Diarrhea cases in children under 5 years in Banjarmasin tend to increase in dry season, however during COVID-19 pandemic there were some changes in society, such as working from home, reluctance to go to health facilities which might affect the usual trend. Keywords: Anthropogenic climate change; Climate factors; COVID-19 pandemic; Diarrhea under 5 years; Wetland

DETERMINANT FACTORS OF UNCONTROLLED HYPERTENSION AMONG ADULT Helmi Rumbo
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Uncontrolled high blood pressure can lead to stroke, heart attack, kidney failure, memory and vision disfunction, and also erectile dysfunction. Globally, data shows that 1.28 billon adults aged 30 – 79 years has hypertension and estimated only 46% of adults with hypertension are diagnosed and treated. In Indonesia, based on national survey in 2019, an estimated 34.11% of the population aged 18 years above has hypertension. Division of Disease Control and Environmental health in Central Sulawesi Province proofed that only 0.12 % of hypertensive patients have been recorded to get treatment or visited to the health Center in Parigi Moutong District. This study aims to identify the determinant factors of uncontrolled hypertension among hypertensive patients in Taniuge, Parigi Moutong District. Community- based cross sectional study design was conducted 25 July to 6 August 2021. Total sampling method was used to select 30 sample. Data was collected using the structured questionnaire. Chi-square test was used to identify the relationship between the variables. The results show that, there is relationship between life style and uncontrolled hypertension (p = 0.029); there were no relationship between genetic, family support and health center availability and uncontrolled hypertension (p = 0.6; p = 1.0; p = 0.5, sequentially). The conclusion is to control blood pressure, patients are recommended to take medication regularly, and also apply the Healthy Living Community Movement (GERMAS). All people are encouraged to adopt a healthy lifestyle, such as not smoking, consuming balanced nutrition, daily physical activity for at least 30 minutes; in order to reduce risk factors for hypertension.Keywords: Hypertension; Uncontrolled; Adult; Life-style

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Eko Suhartono

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esuhartono@ulm.ac.id

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+6281251126368

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jbk@ulm.ac.id

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Jalan Veteran No.128 Banjarmasin

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Kota banjarmasin,

Kalimantan selatan

INDONESIA