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Berkala Kedokteran

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Published by Universitas Lambung Mangkurat

ISSN : 14120550 EISSN : 25485660 DOI : http://dx.doi.org/10.20527

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and September.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 478 Documents

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CORRELATION BETWEEN THE PERCENTAGE OF HYPOCHROMIC ERYTHROCYTES AND FERRITINE LEVELS IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS IN PKU BANTUL HOSPITAL Seno Dwi Prasetyo; Linda Rosita; Utami Mulyaningrum
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstrak: The incidence of CKD in the world is more than 500 million patients and up to 1.5 million patients need to undergo renal replacement therapy in the form of hemodialysis. Chronic kidney disease is inseparable from several complications, one of which is anemia. Confirmation of the diagnosis of anemia in CKD patients can be confirmed through various examinations such as the classic examination of serum ferritine levels, but ferritine is known to be involved in the inflammatory process that occurs in CKD. The aims of this study were to determine the relationship between the percentage of hypochromic erythrocytes and ferritine levels, to determine the average percentage of hypochromic erythrocytes and to determine the average ferritin level in CKD patients undergoing hemodiliasis at PKU Bantul Hospital. This study was conducted using a cross-sectional method involving 50 CKD patients at PKU Bantul Hospital. Blood samples were taken to check ferritine levels and hypochromic erythrocyte percentage. Data analysis was carried out with two types, univariate analysis and bivariate analysis which were carried out with the Spearman correlation test. Based on the results of univariate analysis, the median percentage of hypochromic erythrocytes of the research subjects was 0.95%. The median ferritine in research subjects was 105.5 ng/mL. based on the results of bivariate analysis, there was no significant relationship between the percentage of hypochromic erythrocytes and ferritine levels (p=0.130, r=-0.217). There was no significant relationship between the percentage of hypochromic erythrocytes and ferritine levels. Keywords: anemia; ferritine serum, chronic kidney disease, reticulocytes hemoglobin

STRESS, DEPRESSION AND ANXIETY LEVELS AMONG PARENTS OF “LEARNING FROM HOME” DURING COVID-19 PANDEMIC Denny Anggoro Prakoso; Alya’ Laudza; Yusuf Oka Mahendra; Naufal Hanif; Fitria Nurul Hidayah
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: One of the consequences of the Covid-19 pandemic is the adaptation process and changes in the education process. During the Covid-19 crisis, the Indonesian Ministry of Education and Culture implemented a policy to aid in preventing Covid-19 spread through regulations governing the implementation of "Learning from Home" education. The implementation of this program which has been going on for quite a long time can create additional life burdens that produce a psychological impact on parents such as stress, anxiety, and depression. The purpose of this study is to determine the prevalence of stress, depression, and anxiety in parents of children who are "Learning from Home" as a response of the Covid-19 epidemic. An online survey was conducted from August 2020 until September 2020 among parents who have a minimum of one child with the age of children or adolescents. The Google Form was used to create a structured self-reported e-questionnaire, and the link was shared through WhatsApp. Respondents completed a survey measuring socio-demographic variables and the DASS-42 (Depression, Anxiety, Stress Scale) to measure stress, depression, and anxiety, after giving informed consent. Researchers received 225 online responses. Microsoft Excel and SPSS 21 were used to perform a univariate analysis on the data collection. Stress, depression, and anxiety were found to be prevalent among parents of “Learning from Home” children in 43.56%, 13.78%, and 18.22%, respectively. This research showed that during the Covid-19 pandemic, a significant number of parents of "Learning from Home" children encountered stress, anxiety, and depression symptomsKeywords: Stress-depression-anxiety; Learning from home; Parents; Covid-19

COST OF ILLNESS FOR CHRONIC KIDNEY DISEASE TREATMENT WITH HEMODIALYSIS IN YOGYAKARTA Ingenida Hadning; Muhammad Heyqal Wirakarsa; Muhamad Rinaldhi Tandah Tandah
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: The increase in the number of chronic kidney disease (CKD) sufferers and the expensive financing of this disease, the economic burden borne will certainly increase. This study aimed to determine the cost of illness of CKD patients undergoing hemodialysis, as well as to find out the comparison of real costs with INA-CBG’s rates. This was a pharmacoeconomic research, used the cost of illness method according to a societal perspective. The study was conducted in a type B government hospitals in Yogyakarta from January to March 2020. The population in this study were all CKD patients undergoing hemodialysis in need to mention the hospital at first. The research instruments were medical records, hospital financial data, and patient interviews. The complete data were analyzed statistically with the descriptive method and the Mann Whitney test. The number of samples was 65 patients. The results revealed the average cost of illness was 6,224,277.00 IDR for one month of treatment. The cost component that dominates was hemodialysis rate. The average real cost was 836,686 IDR for one procedure. It can be concluded that the average real cost of CKD patients with hemodialysis in the type B government hospital were significantly smaller than the INA-CBG’s rate.Keywords: Chronic Kidney Disease; Hemodialysis; Cost Of Illness; INA-CBG’s Rate

AMPUTATION OF CERVIX AND NEOCERVIX CREATION USING STURMDORF TECHNIQUE IN RECURRENT CERVICAL SARCOMA BOTRYOIDES: A CASE REPORT Pribakti Budinurdjaja; Ihya Ridlo Nizomy; Inas Tsurayya Fauziah Lahdimawan
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Sarcoma botryoides, or embryonal rhabdomyosarcoma, is soft tissue sarcoma arises from embryonic muscle cells and normally present with discharge, bleeding, or a visible mass at the vaginal introitus in infants and children. Aim of this study is to report a case of cervical sarcoma botryoides. Method used is a Case report. A 16-year-old girl, nulliparous, complained abnormal vaginal bleeding and a protruding vaginal mass. Patient underwent first surgery, mass recurrent five months later. The second surgery was performed by cervical amputation and neocervix creation using Sturmdorf sutures technique. Postoperative week 12 demonstrated a healthy neocervix in appearance, her menses have resumed, indicated patency. She has no evidence of disease 3 months after diagnosis. Cervical sarcoma botryoides is a rare malignancy. Clinicians must thoroughly examine any polyp or mass protrudes from vagina. Early diagnosis and treatment are essential for better prognosis. Sarcoma botryoides has a much improved prognosis with multimodality treatment. To determine the long-term survival and future potential fertility outcome, larger study and longer follow-up are needed. Keywords: sarcoma, botyroides, embryonal, rhabdomyosarcoma, neocervix

NEURO PROGENITOR CELLS (NPCS) AND PPARγ EXPRESSION IN THE BRAIN OF PROTEIN-DEFICIENT RATS AFTER ADMINISTRATION OF PASAK BUMI (Eurycoma longifolia Jack) EXTRACT Didik Dwi Sanyoto; Triawanti Triawanti; Dimas Ikhsan Airlangga
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Malnutrition due to protein deficiency disrupts the neurogenesis process that affects cell development and brain function. One of the efforts to overcome the matter is to use the pasak Bumi (Eurycoma longifolia Jack) which has compounds believed to increase the process of neurogenesis. The aim of study to analyze the effect of pasak bumi extract on the expression of NPCs (Tuj-1) and PPARγ cell in the brains of malnourished rats. Groups of experimental animals that were were divided into 5 groups, namely (P1) malnourished rats + placebo (aquades); (P2) malnourished rats + pasak bumi extract (EPB) 7,5 mg/kg BW; (P3) malnourished rats + EPB 15 mg/kg BW; (P4) malnourished rats + EPB 22,5 mg/kg BW; (P5) malnourished rats + EPB 30 mg/kg BW. As a control, normal rats were used which were given a placebo. Parameters examined include Tuj-1 and PPARγ using immunohistochemistry procedure. The results showed that the P3 group (15 mg/kg BW) had more cells expressing Tuj-1 than the other doses. There was a significant difference between the KP and the P3, P4, and P5 groups. There was no significant difference in the expression of PPARγ in all malnourished groups with EPB and KN intervention. Conclusion: extract of pasak bumi was able to improve the neurogenesis process in malnutrition but not PPARγ. Keywords: Malnutrition, pasak bumi extract, NPCs, Tuj-1, PPARγ

THE RELATIONSHIP BETWEEN KNOWLEDGE AND ATTITUDE WITH EFFORT OF SCHISTOSOMIASIS PREVENTION BY COMMUNITY IN THE WORK AREA PUBLIC HEALTH CARE CENTER OF WUASA Noviany Banne Rasiman
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Schistosomiasis is a disease caused by worm Schistosoma japonicum which requires an intermediate animal, namely a snail called Oncomelania Hupensis Lindoensis. In the work area Health Care Canter of Wuasa, the disease is still many cases, because most of the population are immigrants, they are open rice fields and plantations in the focus area of snail. The purpose was to determine the relationship between knowledge and attitudes with the effort of Schistosomiasis prevention by Community in the Public Health Care Center of Wuasa, North Lore District, Poso Regency. This type of research is analytic with cross sectional approach. The variables in this study are the knowledge and attitudes of the community with efforts to prevent Schistosomiasis. The types of data are primary and secondary. data collection using a questionnaire. Data analysis used univariate and bivariate analysis with Chi-square test. The population in this study were all people of North Lore District. Sampling using proportional random sampling technique with total 99 respondents. The results of the univariate analysis showed that 77.8% of respondents had good knowledge of schistosomiasis prevention efforts, 52.5% of respondents had good attitudes and 83.8% of respondents had quite good schistosomiasis prevention efforts. Bivariate analysis with Chi-square statistical test with 95% confidence level with a significance value of 0.05. The results showed that there was a relationship between knowledge and efforts to prevent Schistosomiasis with p-value = 0.000 (where p < 0.05) and there was a relationship between community attitudes and efforts to prevent Schistosomiasis disease with p-value = 0.003 (where p < 0.05). The conclusion of the study were there is a significant relationship between knowledge and attitudes of the community with efforts to prevent Schistosomiasis in the Public Health Care Center of Wuasa. Suggestions to the health workers in the work area of health care center to increase local community awareness in supporting the prevention of Schistosomiasis disease.Keywords: Knowledge; attitude; prevention; Schistosomiasis.

SENSITIVE SKIN: A NEW ENTITY PERSPECTIVE Putu Martha Gerynda Sukma; Windy Keumala Budianti; Sari Chairunnisa; Rinadewi Astriningrum
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: The phenomenon of “sensitive skin” is a relatively recent terminology in certain populations reporting sensory complaints that are more intense and more frequent than the normal population, especially after using cosmetic products. The incidence of sensitive skin is increasing along with the rapid widespread of skin care products availability. Various studies have been conducted but the pathophysiology of sensitive skin is still unclear. Physiological changes in sensitive skin are influenced by two main factors such as dysfunction in skin barrier and neurosensory. There are various quantitative sensory tests that can be done to determine skin sensitivity. Until now, there is no guideline for treating sensitive skin. Contributing factors, quantitative sensory tests, relation to skin diseases, and managements will be discussed in this literature review.Keywords: Dysfunction; Neurosensory; Sensitive skin; Skin barrier

IMPACT OF HEAVY METALS ON HEXOKINASE ISOFORMS: AN IN SILICO STUDY Ellen Ayuningtyas Pratidina; Eko Suhartono; Bambang Setiawan
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Coal mining activities in South Kalimantan produce waste that is very dangerous if not processed wisely. Coal waste produces heavy metals cadmium and mercury that can pollute the environment. Heavy metals that enter the human body will cause negative impacts in the field of health such as the disruption of the glycolysis process in humans. The purpose of this study was determine the interaction of heavy metals which is cadmium and mercury against hexokinase enzymes using hexokinase enzymes type I, II, III with PDB ID : 4F9O, 2NZT, 3HM8 taken from Protein Data Bank and using the molecular docking website MIB: Metal Ion Binding Site Prediction and Docking server. Docking results will be visualized using chimera app version 1.15. Molecular docking of the heavy metals cadmium and mercury can interact with all three types of hexokinase enzymes. Cadmium metal ions bind hydrophobicly to amino acid residues of hexokinase enzymes type I, II, and III, while mercury metal ions bind covalently coordinate with amino acid residues of hexokinase enzymes type I and III. Mercury metal ions bind more strongly than cadmium metal ions. Of the three types of hexokinase enzymes, mercury metal ions bind most strongly with hexokinase enzyme type II because mercury ions bind to the active site of the three amino acid residues of hexokinase enzymes type II.Keywords: Cadmium ; hexokinase enzyme ; mercury ; molecular docking

EOSINOPHILS PROFILE AND LUND-MACKAY SCORE OF NASAL POLYPS IN ARIFIN ACHMAD HOSPITAL, RIAU PROVINCE Yolazenia Yolazenia; Inayah Inayah; Febri Romaito Romaito; Retni Tri Handayani; Novisa Dwi Utami
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Theories suggest that nasal polyps occur as a result of chronic inflammation of the nasal and sinus mucosa. Eosinophils are the main inflammatory cells found in nasal polyp tissue. The severity of nasal polyps can be seen from the CT Scan of the Paranasal Sinus (PNS) using the Lund-Mackay score. The purpose of this study was to determine the description of the eosinophil count of nasal polyp tissue and the Lund-Mackay score of CT Scan PNS of nasal polyps patients in Arifin Achmad Hospital, Riau Province. Examination of the eosinophil count was carried out microscopically using histopathological preparations of nasal polyp tissue with semiquantitative assessment, and Lund-Mackay score was assessed from the CT Scan of the PNS. From the 14 samples collected, there were 8 men (57.1%) more than 6 women (42.9%) with an average age of 30.43 ± 17.36 years old. Eosinophil counts were obtained in 5 (35,7%) samples 1/2+, 5 (35.7%) samples 1+, and negative in 4 samples (28,6%). While the Lund-Mackay score obtained an average value of 10.21 ± 6.87 with a low category in 11 (78.6%) and high in 3 (21.4%) samples. Patients with high Lund-Mackay scores tend to have higher eosinophil counts which reflect a more severe degree of disease severity in nasal polyps.Keywords: Eosinophil; Lund-Mackay Score; Nasal polyp; Paranasal sinus

EFFECTS OF FAC CHEMOTHERAPY ON ANTI MULLERIAN HORMONE IN PREMENOPAUSAL BREAST CARCINOMA Winardi Budiwinata; Abdurahman Maman; Azhar Raden Yohana
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstrak: Breast cancer is the most common carcinoma in women in the world. Anti-Mullerian Hormone (AMH) is a hormone secreted by primary, secondary, and small antral ovarian follicles of <4mm. The chemotherapy regimen toxic to ovarian follicles is 5-fluorouracil-doxorubicin-cyclophosphamide (FAC). In Indonesia, there had been no study on the effect of FAC chemotherapy on AMH in premenopausal breast carcinoma patients. This study aims to determine the effect of FAC chemotherapy on AMH in premenopausal breast carcinoma patients. This study employed a prospective cohort study design. Inclusion criteria were breast carcinoma, premenopausal, and history of chemotherapy (-). Exclusion criteria were history of ovarian surgery, pelvic radiation, GnRH-agonist therapy, smoking for ≥10 years, obesity, and chemotherapy dropout. Subjects were examined for AMH before the 1st chemotherapy and after the 4th chemotherapy. Statistical test was done with Wilcoxon test, significant if p≤0.05. The average AMH level before FAC chemotherapy was 1.51±1.957; the average AMH level after the 4th FAC chemotherapy was 0.24±0.587. The result of the Wilcoxon test comparing AMH levels before and after 4th FAC chemotherapy was p<0.0001. FAC chemotherapy reduces AMH patients with premenopausal breast carcinoma.Keywords: Breast carcinoma, chemotherapy, AMH.

Page 41 of 48 | Total Record : 478

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Home Page

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Contact Name Eko Suhartono

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Editorial Address Jalan Veteran No.128 Banjarmasin

Location Kota banjarmasin, Kalimantan selatan INDONESIA

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Contact Name
Eko Suhartono

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esuhartono@ulm.ac.id

Phone
+6281251126368

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jbk@ulm.ac.id

Editorial Address
Jalan Veteran No.128 Banjarmasin

Location
Kota banjarmasin,

Kalimantan selatan

INDONESIA