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Journal of Islamic Pharmacy
Published by Universitas Islam Negeri Maulana Malik Ibrahim Malang
ISSN : 24605182     EISSN : 25276123     DOI : http://dx.doi.org/10.18860/jip
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
Welcome to Journal of Islamic Pharmacy (e-ISSN : 2527-6123) formerly Jurnal Farmasains (p-ISSN : 2460-5182) Department of Pharmacy, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia. The journal was established in 2015 and online publication was begun in 2016. Since 2016, the journal has been published in English and only receives manuscripts in English.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 7 Documents
 1 
Search results for , issue "Vol 2, No 1 (2017): J. Islamic Pharm." : 7 Documents clear
HAEMAGLUTINATION OF Shigella flexneri SUBUNIT PILI PROTEIN 18 KDA AS A MOLECULE ADHESION IN MICE ENTEROCYTES Fitrianingsih, Avin Ainur
Journal of Islamic Pharmacy Vol 2, No 1 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i1.4248

Abstract

Diarrhoeal diseases are still a major cause of the high morbidity and mortality of children globally, especially in children under five years. Diarrhea caused by Shigella flexneri usual dealt with antibiotics seen it is getting resistant with various antibiotic.  Prevention shigellosis with a vaccine that was developed and used now are still limited. This study attempts to explore hemaglutinin protein pili S . flexneri allegedly role in adhesion bacteria on the mice enterocyte. This research using  hemaglutination test then adhesion test  by means of reacting protein sub unit pili 18 kDa S. flexneri with mice enterocyte cells and observed the amount of bacteria inherent in a mice cell enterocyte. The research found that proteins sub unit pili with molecules weight 18 kDa is a protein that capable to agglutinate mice red blood cells with highest dilution and capable to inhibit adhesion bacteria on the mice enterocyte significantly. Keywords: Shigella flexneri, protein sub unit pili , hemagglutinin protein, adhesin protein.
INFLUENCE OF JAMU MADURA “EMPOT SUPER” ON THE VAGINAL EPITHELIUM THICKNESS OF WHITE MICE (Rattus norvegicus) – AN IN VIVO STUDY Listiyana, Anik
Journal of Islamic Pharmacy Vol 2, No 1 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i1.4251

Abstract

The aim of this research is to determine the influence of jamu Madura “Empot Super” (JMES) on the vaginal epithelium thickness of Rattus norvegicus in vivo. This research is kind of “true experimental-post test only control group design”. The rats were given drinking JMES once daily PS (Per-Sonde) for a month, then the vagina was taken to be sample for HE colouring. The sample was observed by the binocular microscope (100 times magnification) to identify the changes in the thickness of their vaginal epithelium. Calculation of the vaginal epithelium thickness was counted on the 10 field of view chosen randomly by the blind method. The result show that the vaginal epithelium thickness increased with dose 0,17mg/BW, 0,34mg/BW, and 0,68mg/BW of JMES compared with negative control group. But, the vaginal epithelium thickness decrease at the dose 0,51mg/BW compared with negative control group. Keywords: Jamu Madura “Empot Super” (JMES), vaginal epithelium thickness, white mice (Rattus norvegicus), In Vivo study
THEEFFECTS OF CURCUMA RHIZOME EXTRACT (Curcuma xanthorrhiza Roxb.)TREATMENT USING VARIOUS DOSES TOWARDS ENDOMETRIAL THICKNESSIN MICE (Mus musculus) TREATED WITH MONOSODIUM GLUTAMATE (MSG) Inayatilah, Fidia Rizkiah
Journal of Islamic Pharmacy Vol 2, No 1 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i1.4250

Abstract

Monosodium Glutamate (MSG) is a food seasoning that is widely used. Consumption of MSG in excessive doses can cause an excess of free radicals in the body that trigger oxidative stress and finally affect the reproductive system hormones. These free radicals can be suppressed by administration of antioxidants. Rhizomes of Curcuma xanthorrhiza extracts containantioxidants and they are widely grown. Theyare used as traditional medicine in Indonesia. This experiment was conducted to investigatewhether rhizomes of Curcuma xanthorrhiza extracts areable to inhibit decreasing endometrial thickness in female mice after receiving orally MSG-treatment.This research adoptedtrue experimental posttest only control group design. It includes 25 mice that were divided into 5 groups: control K1 (CMC) and K2 (MSG), treatment group (MSG and rhizomes of Curcuma xanthorrhiza extracts with dose of 0,4 mg/gBW, 0,8 mg/gBW, 1,2 mg/gBW).In addition, the mice’s endometrium were removed to be subsequently stained using Hematoxillin-Eosin. Thickening of uterus was observed and measured with 40x magnitude using Microphoto Microscope Olympus. Data was analized using One Way ANOVA. The research finally comes with a result showing that there were not any significant differences discovered from the endometrium thickening from the five tested groups (p0,05). Therefore, it is implied that rhizomes of Curcuma xanthorrhiza extracts has no effect on endometrial thickness of uterus by oral MSG-treatment. Keywords: MSG, curcuma, endometrium
THE EFFECT OF ADMINISTERING RHIZOME EXTRACT OF CURCUMA (Curcuma Xanthorrhiza Roxb.) AT VARIOUS DOSES ON THE THICKNESS OF VAGINAL EPITHELIUM IN MICE (Mus Musculus) EXPOSED TO MSG Atmaja, Ria Ramadhani Dwi
Journal of Islamic Pharmacy Vol 2, No 1 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i1.4249

Abstract

The usage of Monosodium Glutamate (MSG) as flavour enhancer in food is increasing and has reached alarming condition. Excessive consumption of MSG results in the formation of a number of free radicals in the body and affects the function of hypothalamus. A disturbed hypothalamus results in the decline of estrogen levels, and in turn, this estrogen deficiency causes a decrease in vaginal epithelial proliferation in which epithelial cells become thinner. Giving antioxidants might help to address these problems. One of the plants that is rich in antioxidant and grow in mass in Indonesia is curcuma. This study is aimed at analyzing the effect of giving curcuma extract (Curcuma Xanthorrhiza Roxb.) with varying doses on the thickness of vaginal epithelium in mice that are exposed to MSG. The research design employed in the study is true experimental posttest only control group by using 5 groups, namely: K1 (CMC-Na), K2 (MSG), P1 (MSG + curcuma rhizome extract dose of 0,4mg/gr BW), P2 (MSG + curcuma rhizome extract dose of 0,8mg/gr BW), P3 (MSG + curcuma rhizome extract dose of 1,2mg/gr BW). Vagina of each mouse was taken and studied to measure its epithelial thickness by using a 40x magnification on Olympus micrograph microscope. Data were then analyzed using One Way ANOVA. The results show that there is no significant difference in the thickness of vaginal epithelium in each treatment (ρ-value 0.341). Therefore, it can be concluded that the extract of curcuma rhizome does not have a significant influence on the thickness of vaginal epithelium in mice that are exposed to MSG. Keywords : MSG, Curcuma Xanthorrhiza, epithelium, vagina.
THE EFFECT OF GINGER RHIZOMES (Curcuma xanthorriza Roxb.) TOWARDS THE NUMBER OF OVARIAN FOLLICLES OF FEMALE MICE (Mus musculus) EXPOSED TO MONOSODIUM GLUTAMAT (MSG) Dianti, Meilina Ratna
Journal of Islamic Pharmacy Vol 2, No 1 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i1.4245

Abstract

Monosodium Glutamat activates an axis ablation in arcuate nucleus hypothalamus which happens to possibly initiate malfunctions in Hipothalamic Pituitary Adrenal axis. Yet, it is known that hypothalamus produces Gonadotropin Releasing Hormone which is able to stimulate the secretion of Gonadotropin Follicle Stimulating Hormon and Luteinizing Hormone from the anterior pituitary gland. These two hormones, however, are essentials for the development of gonad and during the cycles of oogenesis. Hence, any malfunctions resided in the human’s hypothalamus can possibly put endocrine gland into troubles, such as reproduction hormones which affect the workings of gonad. Therefore, the extract of Temulawak is promoted to be the attempt to resolve the issue for its antioxidant properties. Temulawak extract contains antioxidant, properties for as much as 87.01 ppm, according to Rosidi research’s result, analyzing the Temulawak’s potentials. The amount of antioxidant found Temulawak extract is categorized as active and applicable as natural antioxidant source. However, this research adopts true experimental post-test only control group design. It includes 5 (five) groups of female mice as which are K1 (CMC), K2 (CMC+MSG), P1 (MSG+0.4 mg Temulawak extract), P2 (MSG+0.8 MG Temulawak extract), P3 (MSG+1.2 mg Temulawak extract). In addition, the mice’s ovaries are removed to be subsequently tested using Hematoxillin-Eosin and the ovaries’ follicles quantity is observed and counted. The data is analyzed using One Way ANOVA. The research finally comes with a result showing that there are not any significant differences discovered from the ovaries’ follicles quantity from the five tested groups (p0.05). Therefore, it is implied that Temulawak extract does not provide any influential results to the house mice’s ovaries’ follicles quantity which has been exposed to MSG. Keywords: Monosodium Glutamate (MSG), Temulawak (Curcuma xanthorriza Roxb.), Ovarian follicles quantity 
INFLUENCE OF MEDIA COMMUNICATION ON ATTITUDES AND KNOWLEDGE PREGNANT WOMEN CONSUMING FE TABLET IN THE MATERNITY CLINIC DELTA MUTIARA SIDOARJO Faristasari, Evvin
Journal of Islamic Pharmacy Vol 2, No 1 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i1.4246

Abstract

The effectiveness of learning and teaching processes are influenced by the precision of the use of methods and media used. The role of Fe tablet in pregnancy is very important for the health of the mother or her fetus. This research aims to know the influence of the communications media towards the knowledge and attitude to pregnant mothers in consuming Fe tablets in Maternity Clinic Delta Mutiara Sidoarjo.This type of research is a true experimental design with pretest-posttest Design. The treatment using the the extension with lectures and outreach with leaflets. The population of as many as 40 people, the sample as many as 36 people, the sampling technique used simple random sampling of each group is made up of 18 people aged 20-25 years old and high school education. Tested with Chi-Square.In the control group, pregnant women who have good knowledge score of 33,33% and obtained results of 44,44% are being received while on a group of experiments, pregnant women are knowledgeable well as much 77,78% and obtained results 93,03% of pregnant women who received. The research result obtained from X2 to calculate X2 table (7.85 5) on knowledge so Ho denied and H1 are accepted. On the attitude of expectant mothers count X2 X2 tables (4.98 3.84), so Ho denied and H1 are accepted. From the results of this research it can be concluded that there is an influence of media communication to knowledge and attitude of pregnant women to consume Fe tablets.Keywords: leaflets, Fe tablet, knowledge, attitude
LIPASE ACTIVITIY OF MIXTURE OF FERMENTED AVOCADO (Persea americana), BANANA (Moses paradisiaca) AND SNAKEFRUIT (Salacca zalacca) Yazid, Edy Agustian
Journal of Islamic Pharmacy Vol 2, No 1 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i1.4252

Abstract

Fermentation is one of the bioconversion processes to produce anaerobic microbes which are beneficial and can produce enzymes. One of the enzymes that can be produced is lipase. Mixed fruit fermentation is an effort to produce lipase that can be done simply. The purpose of this research is to know the activity of lipase enzyme from mixture of fermented avocado fruit (Persea americana), bananas (Musa paradisiaca) and snakefruit (Salacca zalacca). Lipase enzyme activity is tested by measuring of free fatty acid (FFA) content obtained from olive oil hydrolysis process by lipase enzyme. The results showed the highest activity obtained 17.425 U/ml and the percentage of FFA produced was 12.94%. The highest activity of lipase enzyme was obtained at 450C and pH 6.5. From this research can be concluded that the fermentation of the mixture of avocado, bananas and snakefruit can produce lipase enzyme that has relatively high activity. Keywords: Enzyme Activity, Fruits, Fermentation, Lipase. 

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