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Journal of Islamic Pharmacy
Published by Universitas Islam Negeri Maulana Malik Ibrahim Malang
ISSN : 24605182     EISSN : 25276123     DOI : http://dx.doi.org/10.18860/jip
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
Welcome to Journal of Islamic Pharmacy (e-ISSN : 2527-6123) formerly Jurnal Farmasains (p-ISSN : 2460-5182) Department of Pharmacy, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia. The journal was established in 2015 and online publication was begun in 2016. Since 2016, the journal has been published in English and only receives manuscripts in English.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol 3, No 2 (2018): J. Islamic Pharm." : 5 Documents clear
ESTIMATION OF CEPHALOSPORINS (CEFTRIAXONE, CEFTAZIDIME) ANTIBIOTICS AS PURE AND PHARMACEUTIC FORMS BY COLOR PRODUCED REACTION IN UV-VIS SPECTROPHOTOMETIC TECHNIQUE Al-Rufaie, Mohauman Mohammad Majeed; Motaweq, Zahraa Yosif
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6098

Abstract

A new simple, accurate and low cost-effective UV-VIS spectrophotometric methods has been developed for the analysis of chosen cephalosporins (ceftriaxone, ceftazidime) in bulk samples and pharmaceutical dosage forms by using a specific  color-generated reaction. This method involves the Schiff 's base formation reaction between selected cephalosporins with alcoholic 5-sulfo salicylaldehyde reagent 5SSA with heating to establish a yellow colored product displaying λmax at 426 nm as well as 412 nm sequentially. These methods applied to the Beer’s law through the range of concentration was  (4 - 60 µg.ml-1), (5 -50µg ml-1) respectively for two drugs. The analysis results for these studies  have been tested statistically by the studies of recovery. These methods were successfully applied to the determination of the cephalosporins in bulk form and in Pharmaceuticals additionally it was shown that these methods have equivalent accuracy with the common method(BP)estimation procedures for the studied  drugs. The interferences from frequently taken excipients were  no influence on the estimation process .The study could discover a good  as an employment cost-influence and speed method which that possibility used for making quality control for  these cephalosporin antibiotics.
EVOLUTION AND EFFECTIVENESS OF COLORMETRIC APPROACH FOR INVESTIGATION OF CEFTRIAXONE MEDICINE AS IN PURE FORM AND IN FORMULATION VIALS Al-Rufaie, Mohauman Mohammad Majeed
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6099

Abstract

A third-generation cephalosporin antibiotic was aceftriaxone medicine. Similar another (3rd generation cephalosporins), it has wide broad spectrum effectiveness versus gram positive as well as gram negative bacteria. Diverse approachs for analyses of the studied medicine are obtainable but are costly additionally time consumption. Therefor we have sophisticated developed novel, easy, simple as well as accurate colormetric approach for investigation of ceftriaxone medicine as pure form as well as in formulation vials by depending on  a specific color-generated reaction. This reaction involves the Schiff 's base formation reaction between ceftriaxone drug  with alcoholic 4- di ethyl amino benzaldehyde  (DEAB) reagent to produce a new ligand that reacts with cobalt (II) ion with heating to (50°C) in acidic media to form green colored complex exhibiting λmax at 496 nm. The medicine conformed with the Beer’s law with the linearity was observed between (2 –52) μg/ml additionally that  correlation coefficient was 0.9992 .The analyses outcomes were supported with LOD, LOQ, accuracy, recovery studies, ruggedness as well as precision. The approach was establish to be robust as well as economical.
PHYTOCHEMICAL SCREENING, TOTAL FLAVONOID, ANTIOXIDANT ACTIVITY, AND TOXICITY OF ETHANOL EXTRACT Cleome gynandra L. HERB Widodo, Agustinus; Pratiwi, Ritha
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6101

Abstract

Cleome gynandra L. is one of the plants that the people of Palu, Central Sulawesi use as food ingredients. This plant is empirically used in traditional medicine. This study aims to determine phytochemical constituents, total flavonoid, antioxidant activity, and toxicity of 96% ethanol extract of C. gynandra herb. C. gynandra herb extract was obtained by maceration. Phytochemical screening of the ethanol extract was carried out qualitatively according to the standard methods. Determination of total flavonoid using AlCl3 then determined by Spectrophotometric UV-Vis. Antioxidant activity using the DPPH method and determined IC50 value. Toxicity test was assessed using shrimp lethality as an indicator of toxicity. Phytochemical screening showed 96% ethanol extract containing alkaloid compounds, flavonoids, saponins, steroids, and tannins. Total flavonoid of the 96% ethanol extract was 4,778 ± 0,522 mg QE/g extract. Antioxidant activity (IC50) of the ethanol 96% extract was 189,455 µg/ml. Lethal concentration 50% of the 96% ethanol extract was 472,648 mg/L (toxic). The results of this study indicate that 96% ethanol extract of C. gynandra herb has antioxidant activity and has the potential to be further tested as an anticancer activity.
DETERMINATION OF THIAMINE HYDROCHLORIDE AND PYRIDOXINE HYDROCHLORIDE ON RICE WITH WASHING, MILLING AND POUNDING BY SPECTROMETRIC METHODS Yazid, Edy Agustian; Ati, Damar Pasunaring; Mahardika, Aulia
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6136

Abstract

Rice is a principal food source for most of the world's population. Rice has many nutrients including thiamin hydrocloride (THC) and pyrodoxine hydrocloride (PHC). Before consumption, rice is usually processed such as milling, washing, and cooking. Determination of THC on IR-64 and Rojolele rice with washing three times has been conducted. Also determined of PHC on the milled IR-64 rice and the pounded IR-64 rice. The THC was determined by spectrophotometric method at 246 nm. Determination of PHC based on the coupling reaction with diazo reagent in alkaline solution to form azo dye then the absorption was measured at 440 nm. The result of determination of THC on IR-64 and Rojolele rice after washing three times can decrease THC level 12,93% and 12,88% respectively. Determination of PHC on the milled IR-64 rice obtained 1.54 ± 0.027 mg/g and on the pounded IR-64 rice 1.80 ± 0.048 mg/g. The result of statistical test with independent T test showed there were significant difference (α = 0,05) PHC level on both treatments.
CHARACTERIZATION OF MELOXICAM AND MALONIC ACID COCRYSTAL PREPARED WITH SLURRY METHOD Najih, Yuli Ainun; Widjaja, Bambang; Riwanti, Pramudita; Mu'alim, Ade Ianaini
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6140

Abstract

Meloxicam (MLX) is a nonsteroidal anti-inflammatory drugs (NSAID) which belong to Biopharmaceutical Classification System (BCS) class II, which have a low solubility level with a high permeability. Therefore, to enchance is solubility level, physical modification of the meloxicam is required. It  can be done by the cocrystal formation. Cocrystal contained active ingredients and coformer which bind through the hydrogen bond. This study used malonic acid (MA), since it contained carboxylic group which expected to form hydrogen bonds. Slurry is a method of cocrystal formation by mixing two ingredients, i.e. active ingredients of the drugs and its cofomer, dissolved in a solvent and may be formed due to the heat energy released by the friction between particles and their crusher. This study aimed to determine the characteristic of meloxicam-malonid acid cocrystal by 1:1 mol ratio using PXRD, DSC and FTIR. The result of PXRD charaterization indicated a new peak at angle 9,4° and 18,5°. The result of DSC characterization indicated an endothermic peak with a low melting point at 97,64°C ; 152,62°C ; 176,87°C temperature. The result of FTIR characterization indicated a shirt of the O-H uptake band from at wave number 3126-2980 cm-1 to 3292-2951 cm-1, the N-H uptake band of meloxicam at wave number 3492 cm-1 to 3525 cm-1

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