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All Journal HAYATI Journal of Biosciences Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Journal of Noncommunicable Diseases (JOND)
Ritha Pratiwi
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Tadulako University, Sulawesi Tengah 94148, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PHYTOCHEMICAL SCREENING, TOTAL FLAVONOID, ANTIOXIDANT ACTIVITY, AND TOXICITY OF ETHANOL EXTRACT Cleome gynandra L. HERB Widodo, Agustinus; Pratiwi, Ritha
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6101

Abstract

Cleome gynandra L. is one of the plants that the people of Palu, Central Sulawesi use as food ingredients. This plant is empirically used in traditional medicine. This study aims to determine phytochemical constituents, total flavonoid, antioxidant activity, and toxicity of 96% ethanol extract of C. gynandra herb. C. gynandra herb extract was obtained by maceration. Phytochemical screening of the ethanol extract was carried out qualitatively according to the standard methods. Determination of total flavonoid using AlCl3 then determined by Spectrophotometric UV-Vis. Antioxidant activity using the DPPH method and determined IC50 value. Toxicity test was assessed using shrimp lethality as an indicator of toxicity. Phytochemical screening showed 96% ethanol extract containing alkaloid compounds, flavonoids, saponins, steroids, and tannins. Total flavonoid of the 96% ethanol extract was 4,778 ± 0,522 mg QE/g extract. Antioxidant activity (IC50) of the ethanol 96% extract was 189,455 µg/ml. Lethal concentration 50% of the 96% ethanol extract was 472,648 mg/L (toxic). The results of this study indicate that 96% ethanol extract of C. gynandra herb has antioxidant activity and has the potential to be further tested as an anticancer activity.
Development and Evaluation of Microemulsion-Based Sunscreen Cream Containing Lycopene from Tomato (Solanum lycopersicum L.) Ritha Pratiwi; Nandiska Maladjili; Evi Sulastri; Yusriadi Yusriadi; Nuur Aanisah; Armini Syamsidi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.003807

Abstract

This study aimed to formulate and determine the sun protection factor (SPF) of sunscreen made from tomato lycopene microemulsion creams. Lycopene was used as the active ingredient with varying concentrations in each formula, namely F1 5%, F2 7.5%, and F3 9%. The preparation of each formula was evaluated by conducting the globule size, polydisperse index, organoleptic test, homogeneity test, pH test, spreadability test, viscosity test, and determination of SPF value. The average globule size was 119 nm which had a uniform size distribution. The physical characteristics test of the cream preparations showed the three had a bright yellow color and lacked odor. The pH test results were 3.2 ± 0.12, 5.54 ± 0.25, 6.48 ± 0.22 for F1, F2, F3, respectively. Viscosity test results were F1 40,893.33 cPs, F2 41,746.67 cPs, and F3 43,106.67 cPs. The values obtained from the dispersion test were F1 6.71±0.63, F2 5.58±0.15, and F3 4.81±0.11. Moreover, F3 with a concentration of 9% tomato lycopene microemulsion met the acceptance criteria for all of the physical properties including low viscosity to promote good spreadability, pH that does not irritate the skin, aesthetic appeal, small particle size, and non-odorous and an SPF value of 4.9. The obtained microemulsion-based sunscreen cream exhibited a good physical property of lycopene besides showing sufficient SPF value.
Study of Traditional Drug Ethnopharmacology Used for The Treatment of Metabolic Disorders in Pamona Puselemba District Andi Atirah Masyita; Arwinda Alitsia Hasyim; Yuliet Yuliet; Ritha Pratiwi
JOURNAL OF NONCOMMUNICABLE DISEASES Vol 3, No 1 (2023): April 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jond.v3i1.662

Abstract

People in Pamona Puselemba Subdistrict in Poso Regency have used various plant species to maintain health and prevent various diseases, one of which is metabolic disorders. This study aims to determine the types and parts of plants, processing methods, use, duration of treatment, frequency of use, and chemical content contained in plants that are efficacious as drugs for metabolic disorders. The research was conducted descriptively using qualitative methods and the technique of taking informants (Hattra and sufferers) with the purposive sampling method. The results obtained were 32 types of plants, consisting of 24 families, for the treatment of metabolic disorders. The plant parts used were 49% leaves, 12% stems, 21% fruit, 6% tubers, 3% flowers, 3% rhizomes, 3% seeds, and 3% hair. Processing method: 77%, blended, brewed 13%, without processing 77%. How to use: drink 89%, eat directly 11%, duration of treatment 1 week, and frequency of use 2 times a day. The content of compounds contained in medicinal plants is very diverse, such as flavonoids, terpenoids, saponins, tannins, alkaloids, allisin, and other chemical compounds that can be used in the treatment of metabolic disorders. People in Pamona sub-district still use traditional medicine to treat metabolic diseases.
Isolation of Endophytic Fungi from Rui (Harrisonia perforata (Blanco) Merr.) and Determining Their Antibacterial, Antioxidant, and Cytotoxic Activity Anam, Syariful; Syamsidi, Armini; Tunreng, Muh. Fadil Usman; Djaleha, Helena Fransisca; Arisca, Windhy Nur; Syaputra, Gunawan; Iklima; Indriani, Meri Feki; Widodo, Agustinus; Pratiwi, Ritha; Yuliet; Razak, Abd. Rahman
HAYATI Journal of Biosciences Vol. 31 No. 3 (2024): May 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.3.443-456

Abstract

Endophytic fungi produce bioactive metabolites that exhibit antibacterial, antioxidant, and anti-cancer activity. Rui (Harrisonia perforata (Blanco) Merr.) is a traditional medicinal plant proven to be an antibacterial and anticancer. Endophytic fungi live in plant tissues without damaging or producing chemicals that infect the host cell. Endophytes produce the same and similar compound as an original plant. This study aimed to isolate the endophytic fungi from Rui and determine their antibacterial, antioxidant, and cytotoxic activity. 13 fungal isolates were successfully isolated using PDA for seven days at 30°C. Molecular identification using the ITS1 and ITS4 DNA sequences only revealed six species: Diaporthe sp., Phomopsis sp., Aspergillus tubingensis, Aspergillus viridinutans, Pseudofusicoccum sp., and Daldinia eschscholtz. Seven isolates showed antibacterial activity based on plate assay. Aspergillus tubingensis and RA-1 exhibited antibacterial activity against Staphylococcus aureus and Salmonella typhi, with the MIC and MBC starting from 24 to 32 mg/ml. The DPPH assay showed the most increased antioxidant activity in Daldinia eschscholtzii with an IC50 of 98.14±2.39 µg/ml. The Brine Shrimp Lethality Test (BSLT) showed the highest potential cytotoxic activity, as shown by Aspergillus tubingensis and Phomopsis sp. with LC50 of 7.78±7.48 and 30.83±0.39 µg/ml. In conclusion, our study demonstrates that the fungal extract from Rui could be a source of antibacterial, antioxidant, and cytotoxic agents.
Aktivitas Anti Mycobacterium tuberculosis Strain H37Rv dan MDR (Multi Drug Resistant) dari Ekstrak Rimpang Curcuma mangga Val.: Anti Mycobacterium tuberculosis Activity Strain H37Rv and MDR (Multi Drug Resistant) from Curcuma mangga Val. Rhizome Extract Pratiwi, Ritha; Alam, Gemini; Rante, Herlina; Massi, Nasrum
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (324.319 KB) | DOI: 10.22487/j24428744.2020.v6.i1.13102

Abstract

TB is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Empirically the plants that have long been used in medicine are Curcuma mangga rhizome, which shows pharmacological activity as an anti Mycobacterium tuberculosis drug. The objective of the research is to determine the ability of hexane and methanol extracts of Curcuma mangga in inhibiting the growth of Mycobacterium tuberculosis Strain H37Rv and MDR. The extraction of Curcuma mangga rhizome was conducted by maceration methode using hexane and methanol as the solvents, respectively. Both of extracts were made in 1000 dan 500 ppm concentration, then tested for anti Mycobacterium tuberculosis activity using MODS (Microscopic Observation Drug Suspectibility) method. Determination of anti M.tuberculosis activity was based on microscopic observation on Mycobacterium tuberculosis colony in cord formation. The results showed that hexane and methanol extract in 1000 ppm concentration inhibited the growth of Mycobacterium tuberculosis Strain H37Rv dan MDR. However in 500 ppm only n-hexane extract showing the inhibiton activity. In conclusion, n-hexane extract have the ability to inhibit the growth of Mycobacterium tuberculosis Strain H37Rv dan MDR.
Co-Authors Abd. Rahman Razak Agustinus Widodo Andi Atirah Masyita Arisca, Windhy Nur Armini Syamsidi Arwinda Alitsia Hasyim Djaleha, Helena Fransisca Evi Sulastri Gemini Alam Herlina Rante Iklima Indriani, Meri Feki Muh. Nasrum Massi Nandiska Maladjili Nuur Aanisah Syaputra, Gunawan Syariful Anam Tunreng, Muh. Fadil Usman Yuliet Yuliet Yusriadi Yusriadi