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All Journal Jurnal Ilmu Dasar Journal of Islamic Pharmacy Bioscientist : Jurnal Ilmiah Biologi Berkala Ilmiah Kimia Farmasi Pharmaceutical Sciences and Research (PSR)
Bambang Widjaja
Departemen Farmasetika Fakultas Farmasi Universitas Airlangga Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Control & Systems Engineering Education Immunology & microbiology Mathematics Medicine & Pharmacology Public Health Social Sciences

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CHARACTERIZATION OF MELOXICAM AND MALONIC ACID COCRYSTAL PREPARED WITH SLURRY METHOD Najih, Yuli Ainun; Widjaja, Bambang; Riwanti, Pramudita; Mu'alim, Ade Ianaini
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6140

Abstract

Meloxicam (MLX) is a nonsteroidal anti-inflammatory drugs (NSAID) which belong to Biopharmaceutical Classification System (BCS) class II, which have a low solubility level with a high permeability. Therefore, to enchance is solubility level, physical modification of the meloxicam is required. It  can be done by the cocrystal formation. Cocrystal contained active ingredients and coformer which bind through the hydrogen bond. This study used malonic acid (MA), since it contained carboxylic group which expected to form hydrogen bonds. Slurry is a method of cocrystal formation by mixing two ingredients, i.e. active ingredients of the drugs and its cofomer, dissolved in a solvent and may be formed due to the heat energy released by the friction between particles and their crusher. This study aimed to determine the characteristic of meloxicam-malonid acid cocrystal by 1:1 mol ratio using PXRD, DSC and FTIR. The result of PXRD charaterization indicated a new peak at angle 9,4° and 18,5°. The result of DSC characterization indicated an endothermic peak with a low melting point at 97,64°C ; 152,62°C ; 176,87°C temperature. The result of FTIR characterization indicated a shirt of the O-H uptake band from at wave number 3126-2980 cm-1 to 3292-2951 cm-1, the N-H uptake band of meloxicam at wave number 3492 cm-1 to 3525 cm-1
Karakterisasi Sistem Dispersi Padat Meloksikam Dengan Matriks PEG 6000 Dan Poloxamer 188 Dibuat Dengan Menggunakan Metode Peleburan Najih, Yuli Ainun; Nailufa, Yuyun; Rakhma, Dita Nurlita; Widjaja, Bambang; Silviyah, Lailatul; Mujahida, Choirun
Journal of Islamic Pharmacy Vol 6, No 1 (2021): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v6i1.11284

Abstract

Meloxicam is included in the class II Biopharmaceutical Classification System (BCS). This drug has low solubility and high permeability. The solubility is one of the factors that affect in the dissolution rate of drug. One of the effort to increase dissolution of meloxicam is by forming a solid dispersion system made using melting method. The addition of PEG 6000 and poloxamer 188 carriers determine in the solid dispersion system aims to increase the dissolution rate of meloxicam. The purpose of this study is to characterize the meloxicam solid dispersion system with PEG 6000 and poloxamer 188 matrices at a ratio of 99:1 and 98:2 made by the melting method when compared with the physical mixture and its pure compound using Powder X-Ray Diffaction, DSC and FTIR. The results of meloxicam solid dispersion with a ratio 99:1 and 98:2 showed the disappearance of the typical peak of meloxicam at an angel of 2θ 6.5° and 11.2°. The thermogram data using DSC shows a decrease in melting point of solid dispersion system with a ratio of 99:1 and 98:2 namely 64.33°C and 64.21°C. The result of the characterization of meloxicam solid dispersion with FTIR showed that the identified spectrum were in the spectrum range of meloxicam, PEG 6000, poloxamer 188 indicating there was no incteraction in the meloxicam solid dispersion system.Keywords: Meloxicam, PEG 6000, Poloxamer 188, Solid Dispersion, Melting Method, Characterization
Pengaruh Avicel PH 102 Terhadap Karakteristik Fisik dan Laju Disolusi Orally Disintegrating Tablet Piroksikam Dengan Metode Cetak Langsung Setyawan, Dwi; Widjaja, Bambang; Ningtyas, Zimy Fianti
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

The influence of Avicel PH 102 as disintegrant on physical characteristic and dissolution rate of piroxicam Orally Disintegrating Tablet prepared by direct compression method was observed in this research. Concentration of Avicel PH 102 used were 5%, 10%, 15% and 0% as a control. Physical characteristics of the powder blend including flow rate and angle of repose showed good attributes. The powder blend was pressed into tablet by hydraulic press with a pressure of 1 ton and diameter of 8 mm. The physical characteristic of piroxicam orally disintegrating tablet including hardness, friability, disintegration time, and dissolution rate were examined. The hardness of all formulas were between 0,99 – 2,78 kP, friability were between 3,45% – 1,25%, disintegration time were between 223,67– 18,33 sec and drug released at 45 minutes were between 32,71%– 88,63%. The results showed that increasing the concentration of Avicel PH 102 would increase the hardness, and dissolution rate and decrease the friability and disintegration time of piroxicam orally disintegrating tablet . From statistical analysis (µ = 0,05), it could be seen that there was significant difference in physical characteristics and dissolution rate of all formulas. Among all formulas, it could be concluded that formula with 10% concentration of Avicel PH 102 was the optimum formula
Pengaruh Ac-Di –Sol Terhadap Karakteristik Fisik dan Laju Disolusi Orally Disintegrating Tablet Piroksikam dengan Metode Cetak Langsung Setyawan, Dwi; Widjaja, Bambang; Sayekti, Indah
Majalah Ilmu Kefarmasian Vol. 7, No. 2
Publisher : UI Scholars Hub

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Abstract

Orally Disintegrating Tablet (ODT) or Fast Release Tablet is solid dosage form which disintegrated rapidly in mouth and its residue easy to swallowed. This research observed the influence of Ac-Di-Sol concentration as disintegrant on physical characteristics and dissolution rate of piroxicam orally disintegrating tablet which were prepared by direct compression. Ac-Di-Sol was used in concentration of 1%, 3% and 5%, and 0% as control. The powder blend was pressed into tablet by hydraulic press with a pressure of 1 ton and diameter of 8 mm and its hardness, friability, disintegration time and dissolution rate were examined. The results showed that the increasing of Ac-Di-Sol concentration would increase hardness, disintegration time, dissolution rate and decrease friability of the tablet. From statistical analysis (µ =0,05), it was showed that there was significant difference among formulas on the hardness, friability, disintegration time and dissolution rate. The hardness of piroxicam Orally Disintegrating Tablet of all formulas were between 0.99 - 2.77 kP, friability were between 3.45 – 1.35%, disintegration time were between 223.67 – 20,0 sec and drug released at 45 minutes were between 32.71 – 96.25%. From this research, it could be concluded that formula with 3% concentration of Ac- Di-Sol give the most desirable output, even though there was a problem with the friability.
Solubility and Dissolution Study of Salicylamide Isadiartuti, Dewi; Widjaja, Bambang; Wijaya, Hendra; Ardhani Dwi Lestari, Maria Lucia
Berkala Ilmiah Kimia Farmasi Vol. 9 No. 2 (2022): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v9i2.42706

Abstract

Salicylamide belonged to the class of NSAIDs (non-steroidal anti-inflammatory drugs) which had analgesic and antipyretic effects similar to salicylic acetyl acid but were not converted to salicylic acid in the body. When used orally, salicylamide did not cause inflammation and bleeding in the stomach. Salicylamide was a weak acid compound (pKa 8,2) whose solubility was affected by the environmental pH. On oral administration, salicylamide passed through the digestive tract in the pH range of about 1,5 - 8,0. According to the Noyes-Whitney equation, drug dissolution was affected by its solubility. The aim of this study was to evaluate the relationship between the solubility and dissolution of salicylamide in several pH dissolution media. Solubility tests were carried out in dissolution media with pH 1,2, 4,5, and 6,5 with an ionic strength (µ) of 0,2 in a water bath at 37 ± 0,5 °C until a saturated solution was formed. The dissolution test was carried out in a dissolution media solution with the same pH as the solubility test, using a paddle type stirrer at 50 rpm at 37 ± 0,5 °C for 60 minutes. The level of dissolved salicylamide in the solubility test and dissolution test was determined using a spectrophotometer at λmax for each pH of the medium. Salicylamide solubility and dissolution efficiency values in 60 minutes (ED60) were analyzed by one-way ANOVA at α 0,05. The results showed that the solubility of salicylamide increased with increasing pH. Increasing the solubility of salicylamide increased its dissolution.Keywords: Salicylamide, Ph Effect, Solubility, Dissolution, Noyes-Whitney equation
Optimization of Povidone K-30 and Sodium Starch Glycolate on Levofloxacin Tablet by Factorial Design Setyawan, Dwi; Soeratri, Widji; Nuruddin, Mahrus Naufal; Paramita, Diajeng Putri; Widjaja, Bambang
Jurnal ILMU DASAR Vol 21 No 1 (2020)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (174.483 KB) | DOI: 10.19184/jid.v21i1.10220

Abstract

The aim of this study was to determine the effect of binder and disintegrant excipients toward tablet properties of levofloxacin as the latter tends to suffer brittle fracture upon compression. The excipients used were povidone K-30 as the binder and sodium starch glycolate (SSG) as the disintegrant which the tablets were formulated according to factorial design 22 with two factors and two levels on each factor. Four formulas were prepared by wet granulation method using 2 and 4% of each povidone K-30 and sodium starch glycolate in various compositions. Tablet properties were evaluated for its hardness, friability, and disintegration time as well as dissolution profile. The data obtained was statistically analyzed using Minitab® 17 software to optimize the formulation and resulted in different impacts caused by each excipient. Povidone K-30 exhibited an increment in hardness, friability, disintegration time but a decrease indissolution profile of levofloxacin tablet. SSG decreased hardnessand disintegration time, but increased friability and dissolution profile of levofloxacin tablet. Overlaid contour plot showed that the optimal formula regarding tablet properties of friability, disintegration time, and dissolution profile is in composition of 2.01% povidone K-30 and 2.01% sodium starch glycolate. Keywords: levofloxacin tablet, povidone K-30, sodium starch glycolate, factorial design.
Pengaruh Perbedaan Suhu dan Waktu Pengeringan Terhadap Parameter Mutu Karagenan Dari Eucheuma spinosum Andayani, Rina; Andhiarto, Yanu; Muslikh, Faisal Akhmal; Widjaja, Bambang; Della, Desi Mujiastuti; Farida, Agustini
Bioscientist : Jurnal Ilmiah Biologi Vol 12, No 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.13583

Abstract

Carrageenan is widely used in various industries, such as food and beverages, cosmetics, and pharmaceuticals, due to its important role as a viscosity regulator, stabilizer, thickener, developer, gelling agent, and excellent stabilizing agent. Temperature and drying duration are important factors that affect the quality of the final product. This study aims to examine the quality characteristics of carrageenan from Eucheuma spinosum dried using the oven method, considering variations in temperature and drying time. This study used a completely randomized design (CRD) with two factors: temperature and drying time, each of which was repeated three times. Eucheuma spinosum was extracted using the microwave-assisted extraction (MAE) method with 10% KOH solvent in a ratio of 1:10 for 8 minutes. The first factor is the drying temperature, which consists of three levels: 40°C, 50°C, and 60°C. The second factor is the drying time, which also consists of three levels: 24 hours, 27 hours, and 30 hours. The results of the study showed that (1) temperature and drying time affect the quality characteristics of carrageenan from Eucheuma spinosum dried using the oven method, (2) the parameters affected include water content, ash content, sulfate content, viscosity, and gel strength of carrageenan, and (3) the higher the temperature and duration of drying, the more the water content, ash, protein, and crude fiber in the product tend to decrease. This decrease is in line with the viscosity and gel strength of the resulting carrageenan.
Pengaruh Perbedaan Suhu dan Waktu Pengeringan Terhadap Parameter Mutu Karagenan Dari Eucheuma spinosum Andayani, Rina; Andhiarto, Yanu; Muslikh, Faisal Akhmal; Widjaja, Bambang; Della, Desi Mujiastuti; Farida, Agustini
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.13583

Abstract

Carrageenan is widely used in various industries, such as food and beverages, cosmetics, and pharmaceuticals, due to its important role as a viscosity regulator, stabilizer, thickener, developer, gelling agent, and excellent stabilizing agent. Temperature and drying duration are important factors that affect the quality of the final product. This study aims to examine the quality characteristics of carrageenan from Eucheuma spinosum dried using the oven method, considering variations in temperature and drying time. This study used a completely randomized design (CRD) with two factors: temperature and drying time, each of which was repeated three times. Eucheuma spinosum was extracted using the microwave-assisted extraction (MAE) method with 10% KOH solvent in a ratio of 1:10 for 8 minutes. The first factor is the drying temperature, which consists of three levels: 40°C, 50°C, and 60°C. The second factor is the drying time, which also consists of three levels: 24 hours, 27 hours, and 30 hours. The results of the study showed that (1) temperature and drying time affect the quality characteristics of carrageenan from Eucheuma spinosum dried using the oven method, (2) the parameters affected include water content, ash content, sulfate content, viscosity, and gel strength of carrageenan, and (3) the higher the temperature and duration of drying, the more the water content, ash, protein, and crude fiber in the product tend to decrease. This decrease is in line with the viscosity and gel strength of the resulting carrageenan.
Co-Authors Andhiarto, Yanu Ardhani Dwi Lestari, Maria Lucia Della, Desi Mujiastuti Dewi Isadiartuti Dwi Setyawan Faisal Akhmal Muslikh Farida, Agustini Hendra Wijaya Indah Sayekti, Indah Mu'alim, Ade Ianaini Mujahida, Choirun Nailufa, Yuyun Najih, Yuli Ainun Najih, Yuli Ainun Nuruddin, Mahrus Naufal Paramita, Diajeng Putri Pramudita Riwanti Rakhma, Dita Nurlita Rina Andayani, Rina Silviyah, Lailatul Widji Soeratri Zimy Fianti Ningtyas, Zimy Fianti