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MNJ (Malang Neurology Journal)

MNJ
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Published by Universitas Brawijaya

ISSN : 24076724 EISSN : 24425001 DOI : -

Core Subject : Science,

Neuroscience

Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.

Arjuna Subject : -

Articles 7 Documents

Search results for , issue "Vol 2, No 1 (2016): January" : 7 Documents clear

CORRELATION OF SEVERE HEAD INJURY EPIDURAL HEMATOMA TREPANATION RESPOND TIME WITH OUTCOME Santoso, Mochamad Istiadjid Eddy; Rahayu, Masruroh; Balafif, Fachriy
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. Epidural hematoma is intracranial hemorrhage, due to skull fracture caused by head injury which there is a blood accumulation between the layers of duramater and the skull. Objective. To determine the corellation of epidural hematoma trepanation respond time with outcome. Methods. A retrospective observational analytic study (cross sectional) with 30 samples taken in Saiful Anwar Hospital Malang from June to August 2012. The independent variable in this study is trepanation respond time that divided into trepanation respond time less than 6 hours, between 6-12 hours, between 12-18 hours, between 18-24 hours, and more than 24 hours while the dependent variable in this study is the outcome of the patient. Secondary data were taken using medical records. The data were analyzed using independent T-test, spearman correlation test, kruskall walis test, and ROC test with confidence level 95% (Î±=0.005). Results. The analysis shows a significant corelation between severe head injury epidural hematoma trepanation respond time with the outcome.Conclusion. Faster trepanation respond time will have better outcome.

BRAIN NEURON REGENERATION IN POST-STROKE REHABILITATION TREATMENT USING GRAPE PEEL AND SEED EXTRACT (Vitis vinifera) IN INDUCING ERK1 / 2 PATHWAY Lie, Zanella Yolanda; Tandiono, Meliantha; Pricillia, Lucy; Lukito, Astrid Nandikasari; Gasmara, Cakra Parindra
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. Ischemic stroke can cause hypoxia in brain tissue and damage the neuron. The defense ability and plasticity is activated by ERK1/2 pathway. Grape peel and seed extract (Vitis vinifera can induce release neurotrophic factor that contribute in ERK1/2 pathway mechanism.Objective. To prove that grape peel and seed extract can regenerate neuron in anatomical and functional view.Methods. This research use true experimental design with sample in this research is 20 male 8-10 weeks old wistar strain rats which are induced stroke by internal and external carotid artery occlusion method.Results. The repairment is monitored from four parameters, namely cylinder test score, ladder rung walking test score, extensive infarct volume, and number of damaged neuron. Conclusion. The result is 50mg/KgBW is effective in repairing neuron. It is seen from the result of improvement in four parameters explained above.

OCCIPITAL LOBE SYNDROME Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

The ability to recognize objects and words is not just depend on the integrity of visual pathway andÂ primary vision area on cerebral cortex (Brodmann area 17), but also secondary vision area 18 and tertiary vision area 19 on occipital lobe. Lesion in occipital lobe could disturb of human visual function such as visual field defects, inability to recognize colors, inability to recognize words, visual hallucinations and illusions, occipital lobe epilepsy, and Antonâ€™s syndrome. Some causes of occipital lobe lesion are head trauma, chemical intoxicity, neoplasma, stroke, degenerative disease, and vascular disease. Prognosis of occipital lobe syndrome is depend on the initial condition but prognosis from the majority of cases with occipital lobe lesions is not good because the exact intervention is not discovered yet and included one ofirreversible disease.

THE RELATIONSHIP OF CARPAL TUNNEL SYNDROME CLINICAL SYMPTOMPS AND ELECTRONEUROMYOGRAPHY RESULTS IN RSSA MALANG Kurniawan, Shahdevi Nandar; Husna, Machlusil; Rasyid, Harun Al; Bilqis, Nadiya Elfira
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. Carpal tunnel syndrome (CTS) is caused by entrapment neuropathy of the median nerve in the carpal tunnel that can be detected with electroneuromyography (ENMG).Objective. To determine whether there are significant differences in parameters of ENMG examination between CTS groups with mild-to-moderate and severe clinical symptoms.Methods. The study design was observational analytic using cross sectional design approach of the patient's medical record data as many as 61 samples.Results. From 61 samples, there were dominancy of age â‰¥ 40 years old as many as 80.32% and gender female as many as 88.52%. There was no significant differences in age and gender between the two groups (p=0.073 and p=1.000 respectively). Sensory amplitude, MSDL, and Ring Diff are significantly different between the two groups (p=0.005, p=0.020, and p=0.031 respectively). There are no significant difference of motor amplitude and MMDL between the two groups (p=0.384 and p=0.196 respectively).Conclusion. Sensory amplitude value having a relationship with the severity of clinical symptoms. ENMG examination and clinical symptoms of CTS were independent parameters, that should not be used alone to make a diagnosi both of them could enhance the accuracy of diagnosis.

THE COMPARISON BETWEEN DEFICIT FUNCTIONAL NEUROLOGIST WITH VON WILLEBRAND FACTOR LEVELS IN ACUTE THROMBOTIC STROKE PATIENTS Sari, Ita Muharram; Islam, Mohammad Saiful
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. There are limited studies of von Willebrand factor (vWF) and thrombotic stroke, escpecially the relationship between level of vWF and functional neurological deficit. Objective. To determine the difference between functional neurological deficit; measured by the NIHSS scale with the vWF level. Methods. Design study was cross sectional, sampling by consecutive admission according to inclusion and exclusion criteria. Blood samples were taken for vWF measurement. Patients are divided into two categories, low vWF level and high vWF levels. Deficit functional neurologist was measured by NIHSS scale.Results. The results were analyzed by chi square. From 80 patients, the result compares the level of NIHSS scale. In grup with mild NIHSS and low vWF levels (50 %) higher than grup with mild NIHSS and high vWF levels (27,27 %). In other side, grup with moderate NIHSS and low vWF levels (50 %) lower than grup with moderate NIHSS and high vWF levels (72,73 %). The difference is not significant statistically (p=0.067).Conclusion. There was no difference between deficit functional neurologist measured by NIHSS scale with von Willebrand factor levels in acute thrombotic stroke patients.

ASSOCIATION BETWEEN CARBAMAZEPINE INDUCED SEVERE CUTANEOUS ADVERSE DRUG REACTION AND HLA POLIMORPHISMS Ratnaningrum, Safrina Dewi
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Carbamazepine as an antiepileptic drug that is used widely and was known can cause severe cutaneous adverse drug reactions like SJS-TEN. These adverse drug reactions is known to be associated with some specific HLA polymorphism in European populations (HLA-A*31: 01), China (HLA-A*31: 01; HLA-B*15: 02), Japan (HLA-A*31 : 01; HLA-B*15: 11), Korea HLA-A*31: 01; HLA-B*15: 02; HLA-B*15: 11), India (HLA-B*15: 02), Thailand (HLA-B*15: 02), and Malaysia (HLA-B*15: 02). Information related to certain HLA polymorphism is important to prevent adverse drug reaction but there is no sufficient data on the population of Indonesia.

THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE DECREASE OF ALPHA SYNUCLEIN EXPRESSION IN THE BRAIN SUBSTANTIA NIGRA OF PARKINSONâ€™S WISTAR STRAIN RATS (Rattus novergicus) MODEL INDUCED WITH ROTENONE Rahayu, Masruroh; Kurniawan, Shahdevi Nandar; Husna, Machlusil; Hermawan, Hanestya Oky
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. One of the regenerative therapy modalities in Parkinson is using the beta glucan effect contained in Saccharomyces cerevisae.Objective. To identify the effect of reduction in alpha synuclein expression on the brain substantia nigra in Parkinson's rat model after given Saccharomyces cerevisae. Methods. This research applied true experimental design by in vivo with draft randomized post test only controlled group design. The sample was divided into five groups, each of them consisted of 5 rats. Variables measured were the decreasing level of alpha synuclein. Results. There was a significant difference between positive control and negative control group.Conclusion. The addition of Saccharomyces cerevisae is able to lower the alpha synuclein expression in Parkinsonâ€™s Wistar strain rat models significantly with maximum at the dose of 72 mg/kgBB.

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