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All Journal MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB Devotion: Journal of Research and Community Service Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Journal of Community Health and Preventive Medicine (JOCHAPM) Jurnal Info Kesehatan
Safrina Dewi Ratnaningrum, Safrina Dewi
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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ASSOCIATION BETWEEN CARBAMAZEPINE INDUCED SEVERE CUTANEOUS ADVERSE DRUG REACTION AND HLA POLIMORPHISMS Ratnaningrum, Safrina Dewi
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (593.721 KB) | DOI: 10.21776/ub.mnj.2016.002.01.7

Abstract

Carbamazepine as an antiepileptic drug that is used widely and was known can cause severe cutaneous adverse drug reactions like SJS-TEN. These adverse drug reactions is known to be associated with some specific HLA polymorphism in European populations (HLA-A*31: 01), China (HLA-A*31: 01; HLA-B*15: 02), Japan (HLA-A*31 : 01; HLA-B*15: 11), Korea HLA-A*31: 01; HLA-B*15: 02; HLA-B*15: 11), India (HLA-B*15: 02), Thailand (HLA-B*15: 02), and Malaysia (HLA-B*15: 02). Information related to certain HLA polymorphism is important to prevent adverse drug reaction but there is no sufficient data on the population of Indonesia.
THE RELATIONSHIP BETWEEN THE DIMENSION OF ANTENATAL CARE SERVICE QUALITY WITH THE PATIENT'S SATISFACTION AND THE INTEREST IN REVISITATION AT THE GONDANGLEGI PRIMARY HEALTH CENTER, MALANG REGENCY Budiarti, Maulida; Ratnaningrum, Safrina Dewi; Indriani, Anin
Journal of Community Health and Preventive Medicine Vol. 4 No. 1 (2024): JOCHAPM Vol. 4 No. 1 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jochapm.2023.004.01.4

Abstract

Antenatal care (ANC) is planned to prepare for a safe and comfortable delivery. Assessment of the quality of care received by patients is used as a guide to determine the best and weakest dimensions of service quality. Service quality aspects are evaluated based on five quality service dimensions, including tangible, reliability, responsiveness, assurance, and empathy. The purpose of this study is to analyze the relationship between the five dimensions of ANC service quality and patient satisfaction and revisit interest. The method in this study uses a quantitative research design with a cross-sectional approach, with a sample size of 86 pregnant mothers. Sampling was done using accidental sampling. Data were analyzed using chi-square. The results show that the tangible dimension has the strongest influence on satisfaction (OR 104.50) and revisit interest (OR 41.08) of patients in the KIA clinic at Puskesmas Gondanglegi. The conclusion from this study is the existence of a relationship between the dimensions of ANC service quality, including tangible, reliability, responsiveness, assurance, and empathy, with patient satisfaction and revisit interest in the maternal-children clinic at Gondanglegi primary health center.
ANALISIS GENDER TERHADAP VITAL SIGN, BORG SCALE, DAN KADAR KARBON MONOKSIDA PADA PENGGUNAAN MASKER UNTUK SENAM PERNAPASAN DI ERA PANDEMI COVID-19 Triandani, Ni Komang Revina; Listyoko, Aditya Sri; Ratnaningrum, Safrina Dewi; Widodo, Edwin; Djajalaksana, Susanthy
Majalah Kesehatan Vol. 12 No. 1 (2025): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2025.012.01.6

Abstract

Senam pernapasan merupakan olah napas yang bermanfaat untuk meningkatkan kesehatan dengan mengefektifkan semua organ dalam tubuh secara optimal. Pada era pandemi COVID-19 penggunaan masker telah menjadi kebiasaan baru termasuk pada saat berolahraga. Salah satu faktor yang mempengaruhi penggunaan masker yaitu perbedaan gender dimana laki-laki dan perempuan memiliki kapasitas volume paru-paru yang berbeda. Penelitian ini bertujuan untuk mengetahui pengaruh perbedaan gender dan penggunaan masker terhadap tanda-tanda vital, Borg scale dan kadar CO peserta senam pernapasan di RSUD Dr. Saiful Anwar Malang.  Pengamatan dilakukan pada 3 (tiga) sesi yaitu sebelum senam, tahap inti, aerobic, dan setelah tahap pendinginan.  Penelitian menggunakan data sekunder dengan pendekatan metode analitik case control, kemudian dilakukan uji independent t test dan Mann Whitney. Hasil analisis tanda-tanda vital pada setiap sesi menunjukkan bahwa tidak terdapat perbedaan heart rate, respiratory rate, dan kadar CO yang signifikan antara kelompok yang bermasker dan tidak bermasker pada gender yang berbeda (p > 0,05). Sedangkan terdapat perbedaan saturasi oksigen yang nyata (p < 0,05) antara kedua kelompok tersebut pada tahap inti, aerobik, dan setelah pendinginan. Hasil analisis Borg scale menunjukkan berbeda (p < 0,05) pada tahap inti dan aerobik. Penelitian ini menunjukkan bahwa tidak ada perbedaan bermakna penggunaan masker pada senam pernapasan pada gender laki laki maupun perempuan untuk kelompok dewasa muda sehat sehingga penggunaan masker bedah mungkin dapat di pakai ketika melakukan senam pernapasan dalam era pandemi COVID-19.
Perbedaan Tingkat Pengetahuan dan Pola Perilaku Pencegahan Dislipidemia pada Masyarakat Selama Pandemi Covid-19 Purwantiningrum, Danik Agustin; Cahayani, Wike Astrid; Rahayu, Indriati Dwi; Ratnaningrum, Safrina Dewi; Wijayanto, Fajar Hadi
TRI DHARMA MANDIRI: Dissemination and Downstreaming of Research to the Community (Journal of Community Engagement) Vol 1 No 2 (2021)
Publisher : SMONAGENES Research Center, Univeritas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jtridharma.2021.001.02.104

Abstract

Dislipidemia merupakan kondisi abnormalitas kadar lipid darah atau kolesterol. Dislipidemia sering memicu terjadinya berbagai penyakit berat seperti penyakit jantung koroner, strok, diabetes dengan penyerta, serta berkorelasi erat dengan gangguan sindrom metabolik seperti obesitas. Dislipidemia disebabkan oleh beberapa faktor seperti pola diet, merokok, kurangnya aktivitas olahraga, dan faktor genetik. Prevalensi dislipidemia di Indonesia masih tinggi hingga tahun 2018, ditandai dengan peningkatan LDL dan kolesterol total, serta meningkatnya kasus penyakit jantung koroner yang terdeteksi. Dari sejumlah studi meta analisis, dislipidemia diduga kuat berkorelasi dengan peningkatan morbiditas dan mortalitas Covid-19. Tujuan kegiatan pengabdian kepada masyarakat ini adalah sebagai sarana edukasi dan sosialisasi kepada masyarakat untuk meningkatkan pengetahuan seputar dislipidemia beserta upaya mengendalikannya melalui pola hidup yang sehat dan olahraga secara tepat dan teratur. Kegiatan dilaksanakan secara daring melalui acara webinar pada 8 Agustus 2021 dengan tema ”Bugar Selama Pandemi, Bebas Kolesterol Tinggi” yang diikuti kurang lebih 78 orang peserta terdaftar dengan tiga topik materi. Evaluasi kegiatan berupa pre-post-test pengetahuan dislipidemia, post-test sikap pola hidup sehat, dan kuesioner pelaksanaan webinar yang diisi lengkap oleh 29 peserta. Hasil uji Wilcoxon menunjukkan tidak ada perbedaan pengetahuan yang bermakna antara sebelum dengan sesudah mengikuti webinar, namun terdapat peningkatan pengetahun dari 82,8% menjadi 86,2% setelah mengikuti webinar. Hasil analisis post-test terhadap sikap menunjukkan 93,3% peserta memiliki sikap pola hidup sehat yang sangat baik sedangkan evaluasi terhadap jalannya webinar menunjukkan 91,1% peserta menilai pelaksanaan webinar berjalan sangat baik. Dengan demikian dapat disimpulkan bahwa tujuan kegiatan pengabdian kepada masyarakat berjalan dengan baik dan dapat meningkatkan pengetahuan peserta tentang dislipidemia.
Relationship Between Income and Husband's Support In Participation With Via Screening Method In Sexual Productive Women Kristina Haloho, Sri Dewi; Zuhriyah, Lilik; Ratnaningrum, Safrina Dewi
Devotion : Journal of Research and Community Service Vol. 3 No. 12 (2022): Devotion: Journal of Research and Community Service
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/dev.v3i12.235

Abstract

Cervical cancer is the second most common cancer in women worldwide after breast cancer. The high incidence of cervical cancer is due to delays in diagnosis and patients coming in with advanced cancer conditions; it is necessary to have cervical cancer screening so that it is not too late in treatment. One cervical cancer screening that can be done is the visual inspection with the acetic acid (VIA) method. Based on the existing phenomena, not all women of childbearing age want to do the VIA examination because they feel ashamed, lack knowledge regarding the importance of VIA, fear feeling sick during the examination, and lack of husband's support. This study aims to determine the relationship between income level and husband's help with participation in cervical cancer screening using the VIA method in women of childbearing age. This type of research is a quantitative study with a cross-sectional approach. The research sample is women of childbearing age, which meets the sample criteria by using simple random sampling of as many as 120 respondents. The instrument used is a questionnaire and data analysis using Chi-square. The results showed a relationship between the level of income and the husband's support with participation in cervical cancer screening using the VIA method at WUS in Tandun I District, with p-values of 0.010 and 0.028 (p-value <0.05). The conclusion is that an increase in income or the provision of material support and the husband's support can make his wife carry out an IVA examination. Therefore, it is hoped that what should give an increase in income or the provision of materials support and a husband's license to the wives of couples of childbearing age to prevent cervical cancer and reduce cervical cancer mortality
The Effect of Sub-Acute Inhalation Exposure to Polyethylene and Polyvinyl Chloride Micro-Nano Plastics on the Superoxide Dismutase (SOD) Level and Malondialdehyde (MDA) Level in Rat Ovary Sulistomo, Hikmawan Wahyu; Janasti, Laksmitha; Sari, Riana Trinovita; Kusworini, Kusworini; Ratnaningrum, Safrina Dewi; Kusuma, Ihda Dian; Nurdiana, Nurdiana
JURNAL INFO KESEHATAN Vol 22 No 3 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss3.1612

Abstract

Plastic is a synthetic or semi-synthetic organic polymer widely used in daily life and industrial production. Microplastics are widespread contaminants and can enter the human body by consuming foods containing microplastics, inhaling microplastics in the air, and making skin contact with microplastic particles in products. Microplastics can enter the ovaries as foreign bodies and can cause inflammation, oxidative stress, and even ovarian granulosa cell death. Polyethylene plastic shards generally have a higher ability to absorb environmental toxins than other types of plastic. Polyvinyl chloride (PVC) is one of the oldest thermoplastic polymers that is often used as water pipes. PVC has carcinogenic monomers and some harmful additives. This study aims to determine the effect of subacute exposure to micro-nanoplastics per inhalation on SOD and MDA levels in rat ovaries. The research method used is a true experimental design with a Randomize Post Test Only Group Design research design. This study used the ovarian organs of female white rats exposed to PVC and PE for 28 days. The number of samples used in this study amounted to 18 female rats. Subacute exposure to micro-nanoplastics per inhalation can lower SOD levels and significantly increase MDA levels in rat ovaries. This study is expected to provide knowledge and an overview for future research on the mechanism of toxicity of micro-nanoplastic exposure that has an impact on female infertility through free radicals in the ovaries.                   
Co-Authors Budiarti, Maulida Cahayani, Wike Astrid Danik Agustin Purwantiningrum, Danik Agustin Djajalaksana, Susanthy Edwin Widodo Ihda Dian Kusuma Indriani, Anin Indriati Dwi Rahayu Janasti, Laksmitha Kristina Haloho, Sri Dewi Kusworini Handono Lilik Zuhriyah Listyoko, Aditya Sri Nurdiana Nurdiana Sari, Riana Trinovita Sulistomo, Hikmawan Wahyu triandani, Ni Komang Revina Wijayanto, Fajar Hadi