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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
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Articles 10 Documents
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Search results for , issue "Vol 6, No 1 (2020): January" : 10 Documents clear
FACTORS AFFECTING THE KNOWLEDGE ABOUT STROKE RISKS AND EARLY SYMPTOMS IN EMERGENCY DEPARTMENT EAST JAVA - INDONESIA Rachmawati, Dewi; Ningsih, Dewi Kartikawati; Andarini, Sri
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.3

Abstract

BackgroundThe knowledge about stroke risks and early symptoms is pivotal to minimize the arrival delay in the hospital and maximize the effective treatments.ObjectiveInvestigating the factors affecting the knowledge about stroke risks and early symptoms in the emergency department (ED).MethodsThe study employed a cross-sectional design by means of a prospective approach. Samples were taken by consecutive sampling technique recruiting in a total of 58 respondents. The respondents were the family or relatives of acute ischemic stroke patients who happened to know and directly involved in taking the patients to the ED. Data analyzed by utilizing univariate analysis, independent t-test, and one-way ANOVA to determine the differences in the knowledge of every respondent based on several characteristics. Multivariate analysis was used to investigate the factors affecting the knowledge about stroke risks and early symptoms.ResultsThe average age of the 58 respondents was 34 – 57 years old. 46.5% of whom were graduating from primary school; 51.7% have never been equipped with the necessary information about stroke; 55.2% are female, and 50% of whom were unemployed. There were differences in the knowledge about stroke risks based on the prior information about stroke and education background. As for stroke early symptoms, there were differences towards occupations, prior information about stroke, and education background. The most affecting factor towards the knowledge of stroke risks is education background (p=0.000); while the knowledge about stroke early symptoms were mostly affected by prior information about stroke (p=0.012) and education background (p=0.000).Discussions Most respondents were less equipped with the necessary knowledge about stroke risks and symptoms. The respondents’ knowledge about stroke risks and early symptoms was considered less, while education background was the affecting factor towards the knowledge about stroke risks and symptoms.
IDENTIFICATION AND ANALYSIS OF GENETIC EPILEPSY AND EPILEPTIC ENCEPHALOPATHIES IN THE OUTPATIENT PRACTICE OF EPILEPSY SPECIALISTS Rakhmanina, Olga; Volkov, Iosif; Shestakova, Olga; Tomenko, Tatyana; Volkova, Oksana; Belyaev, Оleg; Levitina, Elena
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.7

Abstract

Background: Given the significant share of gene mutations in the etiology of epilepsy, it is important for the practitioners to evaluate progress in this area.Objective: To describe the spectrum of being detected gene mutations in patients with epilepsy or epileptic encephalopathy in clinical practice of neurologists specializing in epilepsy with an analysis of diagnosed epileptic syndromes, the characteristics of seizures, the timing of a genetic diagnosis, options and treatment efficacy.Methods: The study included 100 patients (40 boys, 60 girls) with epilepsy/epileptic encephalopathy and a gene mutation identified. The average age was 6.9±5.1 years. Through remote access, epilepsy specialists filled out a specially designed unified table containing information from outpatient case history.Results: In the outpatient practice of epilepsy specialists, there are patients with a wide range of gene mutations, the leading of which is a mutation in the SCN1A gene (15%). Nowadays, the main method (85%) of detection remains the next generation sequencing in the “Hereditary Epilepsy” panel. Years pass from the onset of the disease to the genetic diagnosis (Me - 3 years). In most cases, patients with severe (52% have epileptic encephalopathy, 88% have developmental disorders) and pharmacoresistant (mean amount of anti-epileptic drugs - 3,8±2,2, multitherapy -70%) syndromes have undergone genetic testing. In the treatment of these patients epileptologists are increasingly (52%) use alternative methods: steroids, ketogenic diet and others. The absence of seizures was observed only in 46% of patients.Conclusion: Thus, in the outpatient practice of epileptologists of Russia, patients with a wide range of gene mutations are found. As a rule, these are patients with severe, therapy-resistant epileptic syndromes.
COMPARISON OF THE EFFECTIVENESS OF THERAPY IN HYDRODISSECTION INJECTION USING ULTRASONOGRAPHY GUIDENCE BETWEEN NORMAL SALINE AND TRIAMCINOLONE IN CARPAL TUNNEL SYNDROME PATIENTS Santoso, Widodo Mardi; Rakhmatiar, Rodhiyan; Rakhmani, Alidha Nur; Sahidu, Muhammad Ghalvan
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.2

Abstract

Background: Carpal tunnel syndrome (CTS) is a peripheral nerve lesion because of the nontraumatic mechanism or a pressure or entrapment of the median nerve under the transverse ligament (flexor retinaculum). Hydrodisection is used for adhesiolysis to eliminate adhesion and release the median nerve from the retinaculum and connective tissue around it and avoid injury to the nerves. Objective: Compare the effectiveness of hydrodisection injection therapy using an ultrasound guide between normal saline and triamcinolone in patients with carpal tunnel syndrome.Methods: Experimental study was carried out in the outpatient clinic of the hospital Dr. Saiful Anwar Malang from August 2018 to October 2018. A total of 30 patients. All study subjects were subjected to NPS, FSS, SSS scoring compared to before and 4 weeks after injection of hydrodisection and compared the effectiveness of injection agents.Results: NPS before and after triamcinolone injection (sig 0.000; p <0.05), FSS (sig 0.020; p <0.05), and SSS (sig 0.001; p <0.05). NPS before and after injection of normal saline 0.9% NaCl  (sig 0.001; p <0.05), FSS (sig 0.005; p <0.05), and SSS (sig 0,000; p <0.05). NPS between triamcinolone injection results and normal saline 0,9% NaCl  (sig 0.341; p <0.05), FSS (sig 0.425; p <0.05), SSS (sig 0.350; p <0.05).Conclusion: There no significant difference between injection of hydrodisection USG guiding with triamcinolone and normal saline 0,9% NaCl to reduce symptom CTS. Both of injection hydrodisection USG guiding has more or less the same effectiveness in treatment of carpal tunnel syndrome.Keywords: CTS, Hydrodisection, NPS, FSS, SSS
PHYSICAL ACTIVITY AND SPORTS IN PATIENTS WITH EPILEPSY Odintsova, G.V.; Koloteva, A.V.; Lovyagina, A.E.
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.8

Abstract

Background: For many years, patients with epilepsy have been strongly advised to avoid sports and exercise, as it was believed that sporting activities can trigger seizures.Objective: To study the level of physical and sporting activity on the example of the patients of the Russian Epilepsy Center.Methods: The study includes 50 patients with a verified diagnosis of epilepsy. The survey has been conducted according to a specially developed questionnaire "Peculiarities of physical activity in patients with epilepsy", clinical and demographic study.Results: The average age is 29.6 years +/- 8.3. 57.2% of patients had restrictions on physical activity at school due to epilepsy. Motor activity was assessed as low by 12% of patients, as average — by 60%, as high — by 28%.Conclusion: Physical activity of patients with epilepsy remains insufficient due to medical and social restrictions. In most cases, physical activity and sports do not trigger seizures and worsening of the disease. Expansion of sports opportunities will improve social adaptation and reduce stigmatization with epilepsy. A differentiated approach to the definition of indications for sports and the engagement of a neurologist to determine contraindications are necessary.
COGNITIVE IMPAIRMENT AND DEPRESSION ARE THE MOST IMPORTANT RISK FACTORS FOR FRAILTY Hariyanti, Tita; Sunarti, Sri; Vistiandini, Seravina Ayu
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.4

Abstract

Background: Frailty is a condition that causes a decline or failure in homeostasis mechanism on older people resulting in increased susceptibility to stressor. The risk factors of frailty include: cognitive impairment and depression.Objective: To prove the relation between cognitive impairment and depression with frailty.Methods: This study is using cross-sectional approach. Samples are collected from 222 citizens from the elderly population of Malang using accidental sampling method. Variables measured in this study are frailty that is determined by Fried Criteria, cognitive impairment that is determined by MMSE score and depression status that is determined by GDS score.Results: The analysis result of relation between cognitive impairment and depression and frailty using the Spearman correlation test produces the value of p = 0,000 and the correlation coefficients for rare 0,500 and 0,508 respectively. Different levels of cognitive impairment and depression in the frail group compared to pre-frail and robust groups resulted in p = 0,000, whereas the level of cognitive impairment and depression in the pre-frail group compared to robust group yielding p values of 0.735 and 0.944 respectively.Conclusion: There is a relation between cognitive impairment and depression on frailty. There was a significant difference in the levels of cognitive impairment and depression in the frail group compared to the pre-frail and robust groups, whereas in the pre-frail group compared to robust group the levels of cognitive impairment and depression did not have a significant difference.
THE EFFECTS NEUROPROTECTION OF TELMISARTAN ON STROKE WITH HYPERTENSION Ernawati, Iin; Hidayati, Hanik Badriyah; ., Sumarno
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.9

Abstract

Stroke is the second deadly disease in the world after ischemic heart disease. According to data of RISKESDAS (Riset Kesehatan Dasar), stroke was the highest cause of death in Indonesia in 2013. Hypertension is the one of the most important risk factors for stroke. Hypertension therapy is done by modification and the use of antihypertensives. The antihypertensives used is Telmisartan which is a class of Angiotensin Receptor Blocker (ARB) that works by inhibiting bind to angiotensin II type receptors that is angiotensin II type 1 receptors (AT-1R) which directly make angiotensin II bind to AT-2R (angiotensin receptor type 2 receptors). Telmisartan has a neuroprotectant effect that works by inhibiting the appearance of inflammatory cytokines, production of ROS (Reactive Oxygen Species), PGE2 (prostaglandin E2) and NMDA (N-Methyl-D-Aspartate) activity. Telmisartan activates PPAR-gamma (PPAR-γ), which is very useful in carbohydrate and lipid metabolism which directly protect blood vessels. Telmisartan has the advantage of structure and pharmacokinetics that support the effects of nerve protection. Based on lipophilicity and chemical structure, Telmisartan easily penetrates the brain barrier and high affinity to PPAR-γ, supporting the effects of Telmisartan neuroprotection. Based on pharmacokinetic aspects, telmisartan has the advantage of having a rapid onset that ranges from 30-60 minutes, with T ½ (half life) elimination is 24 hours. T 1/2 elimination for up to 24 hours from Telmisartan is clinically beneficial to improve medication adherence.
MEASUREMENT OF MIDSAGITTAL CORPUS CALLOSUM AREA WITH THE MODIFIED CAVALIERI METHOD IN HEALTHY RIGHT- AND LEFT-HANDED TURKISH ADULTS Ozdikici, Mete
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.5

Abstract

Background: Numerous studies have been published on the anatomy and physiology of the corpus callosum (CC). There are many contradictory studies in the literature about the changes in the size of the CC by handedness, sex, and age.Objective: This study was carried out to examine the morphometric influence of these factors (handedness, sex, and age) on the CC in healthy Turkish adultsMethods: Two hundred thirty-seven normal individuals, 101 males, and 136 females, divided into 5 age groups (20-29, 30-39, 40-49, 50-59, and 60-69) were subjected to magnetic resonance imaging (MRI) study of the brain. Of the 237 subjects, 27 males and 36 females were left-handed. Midsagittal corpus callosum area (CCA) was represented by the mean ± standard deviation of the age groups in square centimeters, and also comparisons of the right- and left-handed were also represented in Table 1. For statistical evaluation, the SPSS 15.0 was used. All statistical tests were set at a 95% confidence level (p&lt;0.05).Results: The range of the reference values (mean values and standard deviation) for the performed measurements in the age groups and for men, women, and total are presented; and comparisons of the right- and left-handed were also represented in Table 1. In our study, CCA was found 6,46±1,05 cm2 in all men and 6,17±0,82 cm2 in all women. The values of CCA are 6,50±1,05 cm2 in right-handed men and 6,34±1,03 cm2 in left-handed men, 6,16±0,80 cm2 in right-handed women, and 6,19±0,91 cm2 in left-handed women. There is a statistically significant difference between males and females in CCA (p&lt;0.05). There is no statistically significant difference between the age groups for CCA, and there is no difference between right- and left-handed for men and women (p&gt;0.05) (Table 2).Conclusion: The results showed no statistical significance of the effect of age or handedness on the surface area of the CC. However, it was statistically significant that the size of men's CC was higher than that of women.Keywords:  Midsagittal corpus callosum area, modified Cavalieri method, handedness, Turkish adults, magnetic resonance imaging.
CLINICAL AND RADIOLOGIC APPROACH TO PROBABLE MIXED DEMENTIA (VASCULAR DEMENTIA AND PROGRESSIVE SUPRANUCLEAR PALSY) Lastri, Diatri Nari; Alwahdy, Ahmad Sulaiman
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.10

Abstract

Dementia as a global burden neurodegenerative disease need to be diagnosed as earlier as possible then treated accordingly. The varying aetiologies of dementia render specific diagnosis of dementia challenging. Other than clinical syndromes, cognitive function examination and neuroimaging are also important to determine the correct dementia diagnosis. This paper aims to provide a dementia case where the working diagnosis could not be decided at once and to show how cognitive function examination and neuroimaging are essential to determine the diagnosis. This paper reports an 80-year old male with dementia symptoms that was followed and regularly examined for one year. With time, additional neurological symptoms were observed thus the working diagnosis was established. The patient was diagnosed with mixed dementia that consisted of probable vascular cognitive impairment and probable progressive supranuclear palsy.
FACTORS AFFECTING PROGNOSIS OF TUBERCULOUS MENINGITIS IN SAIFUL ANWAR GENERAL HOSPITAL MALANG Munir, Badrul; Prayudi, Firman; Setianto, Catur Ari; ., Siswanto
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.1

Abstract

Background. The mortality rate of tuberculous meningitis (TBM) is approximately 20-41%. The prognosis is influenced by clinical and radiologic features, laboratory findings, and therapy. Objective. To report factors affecting the prognosis of TBM patients in Saiful Anwar Hospital.Methods. The study design was a retrospective cohort with consecutive sampling. Data were taken from medical records of 47 patients from 2016-2017. The prognostic value used modified rankin scale showing good (0-2) and poor prognosis (3-6). The impact of clinical, radiological, and laboratory factors were investigated by univariate analysis and multiple logistic regression. Results. In this study, good (n=21) and bad (n=26) prognosis were compared. Patients with good prognosis experienced more episodes of seizure than poor prognosis (17% vs 4%; p = 0.011). Focal neurologic deficits was more prevalent in poor prognosis (4% vs. 23%, p = 0.012). Meningeal enhancement was more common in poor prognosis (21% vs 42%; p= 0.038). From multivariate analysis, we found that seizure and focal neurological deficit are independent prognostic factors (p=0.023 dan p 0.033).Conclusion. Clinical factors influencing prognosis of TBM in Saiful Anwar Hospital are seizure and focal neurological deficit. Focal neurological deficit is a poor prognostic factor. However, seizure is a good prognostic factor.  Keywords: prognostic factors, tuberculous meningitis
VITAMIN D LEVELS IN MULTIPLE SCLEROSIS Durmaz, Zeynep Hulya; Ayan, Durmuş; Demir, Aslıhan Dilara; Demir, Hatice Dörtok
Malang Neurology Journal Vol 6, No 1 (2020): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2020.006.01.6

Abstract

Background: Multiple Sclerosis is a  neurologic  disease that effect  Central Nervous System(CNS).  Vitamin D is a liposoluble prohormone. İt is thought that vitamin D deficiency is responsible for Lots of diseases which includes MS . In this study, we aimed to show the relationship between serum vitamin D level and MS.Objective: In our research  we wanted  to show the serum vitamin D levels in MS patients.Methods: We included 106 patients (76 female, 30 male)  to our study. Participants were divided into two groups as patient and control group. Serum vitamin D levels were evaluated.We excluded patients with known liver or renal disease. Liver enzymes and blood creatinine of the patients included in the study were normal.Results: There was a statistically significant difference when comparing two groups of serum vitamin D results. Serum vitamin D levels were lower in the control group. No correlation was found between vitamin D and age. There was no correlation between vitamin D and gender. According to the vitamin D level reference interval in the MS group, 28 patients had deficiency, 17 patients had failure, and 12 patients were normal. In the control group, according to the vitamin D level reference range, 35 patients had deficiency, 11 patients had failure and 3 patients were normal.Conclusion: In this study conducted with limited facilities, lower vitamin D levels in the control group suggested that vitamin D levels may be low when the population is examined in general. Vitamin D support throughout the population may reduce the prevalence of other diseases thought to be caused by vitamin D deficiency as well as MS.

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