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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
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Articles 19 Documents
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Search results for , issue "Vol. 9 No. 2 (2023): July" : 19 Documents clear
THE RELATIONSHIP OF EPILEPTIFORM WAVES IN ELECTROENCEPHALOGRAM WITH EPILEPSY TYPE OF SCHOOL-AGE EPILEPSY PATIENTS Jerome Constantine Lekatompessy; Bertha Jean Que; Laura Bianca Sylvia Huwae
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.5

Abstract

Background: Epilepsy in children causes memory problems in the learning process, so an early diagnosis of epilepsy is needed. The modality for determining the diagnosis of epilepsy is an electroencephalogram (EEG) examination. EEG recording results in epilepsy patients are epileptiform waves that can vary according to the type of epilepsy suffered. Objective: This study aims to determine the relationship of epileptiform waves on an electroencephalogram (EEG) with the type of epilepsy in school-age epilepsy patients. Methods: This study is an analytical study that uses secondary data in the form of medical records with cross sectional design. The research subjects were 106 patients taken with total sampling technique. Data collection is done by recording medical record data on the data collection form made by researchers. Correlation analysis between variables in this study used the Fisher test. Results: The results of this study indicate there is a relationship between epileptiform waves on the electroencephalogram (EEG) with the type of epilepsy in school-age epilepsy patients, with p = 0.018 in 0.050 significance value. Conclusion: It can be concluded that there is a correlation between epileptiform waves on an electroencephalogram (EEG) with the type of epilepsy in school-age epilepsy patients.
POOR COGNITIVE RESERVE STATUS AS PREDICTORS OF MEMORY IMPAIRMENT AMONG ELDERLY Herpan Syafii Harahap; Yanna Indrayana
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.6

Abstract

Background: Cognitive impairment in the elderly population is commonly associated with age-associated neurodegenerative processes in the brain. The integrity of the cognitive reserve status may be an important factor that can compensate this age-associated neurodegenerative processes. Objective: To investigate the predictor role of poor cognitive reserve status on memory impairment among elderly subpopulation in Mataram, West Nusa Tenggara. Methods: This cross-sectional study involved elderly subjects recruited at Panti Jompo Tresna Werdha Puspa Karma. Data collected included age, gender, hypertension, diabetes, cognitive reserve status (years of education, leisure activity, occupation, and exercise), and memory status. Memory status obtained based on scores of 3 neuropsychological tests (wordlist memory task, recall, and recognition tests). Subjects with normal memory status had normal scores on at least 2 of the 3 neuropsychological tests. Multivariate regression analysis was performed to examine the role of cognitive reserve as a predictor of memory impairment in subjects. Results: In Model 1 of multivariate regression analysis, the main predictors for memory impairment in elderly subjects are shorter years of education (odds ratio: 13.1; 95% confidence interval: 1.8 – 95.0) and absence of leisure activity (odds ratio: 5.9; 1.2 – 28.8). In model 2, the main predictors for memory impairment are consistently shorter years of education (OR: 11.0; 95% CI: 1.4 – 84.0) and absence of leisure activity (OR: 5.3; 95% CI: 1.0 – 27.7). Conclusion: Shorter years of education and the absence of leisure activity were predictors for memory impairment in the subpopulation of the elderly in Mataram, West Nusa Tenggara.
ASSOCIATION OF PHYSICIAN BURNOUT WITH HEADACHE AND LOW BACK PAIN DURING PANDEMIC COVID-19 Kharisma Ridho Husodo; Dea Hadfina Kartika Sari; Lintang Daru Jati; Airin Angelina
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.7

Abstract

Background: Physician burnout is a common problem seen in health workers, especially doctors and it is characterized by emotional exhaustion, depersonalization, and reduced personal accomplishment in daily work. The pandemic of Corona Virus Disease 2019 (COVID-19) causes an increase in the workload among doctors which will affect the incidence of Burnout. Burnout not only includes psychological problems, but also has a risk for physical disorders including pain disorders. Objective: To investigate the association of burnout level with headache and low back pain among physicians at Yogyakarta Islamic Hospital PDHI. Methods: This research design was a descriptive analytic study with a cross-sectional design. The subjects in this study were 46 doctors who worked at the Yogyakarta Islamic Hospital PDHI. Burnout levels were assessed using the Maslach Burnout Inventory (MBI) test. The incidence of headache and its impact on daily activities were assessed using the Headache Impact Test (HIT-6) questionnaire while Low Back Pain was assessed using Oswestry Disability Index (ODI). Results: Among burnout parameters, depersonalization was the most influential parameter which caused burnout. COVID-19 pandemic gave more impact to burnout level. The headache and low back pain incidence were 39,1% (18 subjects) and 43,4% (20 subjects) respectively. There were significant correlations between headache and every burnout parameter. Low back pain also had significant correlations to each burnout parameters. Conclusion: There was association of Burnout level with headache and low back pain incidence among physicians.
NEUROPROTECTANT OF 7,8-DIHYDROXYFLAVONE IN ISCHEMIC STROKE THROUGH MODULATION GLUTATHIONE S-TRANSFERASE AND TYROSINE RECEPTOR KINASE C: A BIOINFORMATICS STUDY Aldita Husna Violita; Safira Dita Arviana; Rislan Faiz Muhammad; Basyar Adnani; Titin Andri Wihastuti; Husnul Khotimah; Shahdevi Nandar Kurniawan; Yuyun Yueniwati
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.8

Abstract

Background: Times New Roman 9, single space, contains the brief description of the research. Stroke is the greatest cause of disability and mortality worldwide. Several biological mechanisms underlying this disease such as failure of glutamate reuptake and ATP synthesis, resulting in high levels of reactive oxygen species (ROS), neuroinflammatory responses, and apoptosis, resulted in cell death and brain tissue damage. Neurotherapeutics agents are given to affect the pathophysiological pathways and prevent expanding infarct area. Objective: This study aims to analyze the modulation of Gluthatione S-Transferase (GST) and Tyrosine kinase receptor C (TrkC) by 7,8-DHF as neuroprotective agent in ischemic in silico. Methods: This study used in silico simulation to predict 7,8-dihydroxyflavone (DHF) as neuroprotective agent by using PubChem, RCSB, Biovia Discovery Studio, PyRx, and PyMol. This study analyzes the pharmacodynamics, pharmacokinetics, and molecular interactions between 7,8-DHF as a ligand with GST (13GS) and TrkC (6KZC) as protein target, compared to their native ligand. Results: 7,8-DHF may increase intracellular endogenous antioxidants mainly GST and stimulate TrkC to activate further neuron survival signaling. 7,8 DHF has a much lower bond energy (-8.1 Kcal/mol) when it binds to GST compared to the native ligand (-5.9 Kcal/mol). Besides, binding affinity between 7,8-DHF-TrkC was -9 Kcal/mol, while native ligand-TrkC was -10.6 Kcal/mol. This study showed that there were the same amino acid residues between 7,8-DHF-GST and 7,8-DHF-TrkC, compared to their native ligand. Conclusion: As an adaptive response to hypoxia caused by ischemic stroke, these findings are likely to induce protective mechanism through indirectly TrkC activation which regulates neurogenesis and increasing intracellular endogenous antioxidants.
RADIOLOGICAL EVALUATION OF SINONASAL, INTRAORBITAL AND INTRACRANIAL EXTENSION OF MUCORMYCOSIS IN POSTCOVID PATIENTS Tushar Kalekar; Varsha Rangankar; Pooja Karanjule; Radhika Jaipuria; Sahil Kathuria; Neeraj Patil; Girish NK
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.1

Abstract

Background: Mucormycosis is a fatal and progressive condition that affects immunocompromised patients in the post-COVID state. Radiological assessment by computed tomography and magnetic resonance imaging is useful to determine the severity and extent of the disease. Objective: The objective of this research is to evaluate mucormycosis in post-COVID patients using radiological investigations like computed tomography and magnetic resonance imaging and also to study the extent of disease in patients with diabetes and with steroid/ immunosuppressant use. Methods: A prospective observational study was undertaken at Dr. D. Y. Patil Hospital and Medical College, Pimpri Pune from March-June 2021. All patients who presented with mucormycosis were either COVID-19 positive or recovered from COVID-19 infection. Computed tomography and magnetic resonance imaging were performed in these patients. Results: The association between the status of diabetes mellitus and extent of involvement, steroids/immunosuppressant use and extent of involvement was statistically significant with a p value of <0.001. Conclusion: Patients with post COVID-19 status and diabetic status with steroid therapy during the treatment of COVID-19 may increase the risk of developingopportunistic infections like mucormycosis. Post COVID-19 related mucormycosis on computed tomography and magnetic resonance imaging
ASSOCIATION BETWEEN SLEEP QUALITY AND GERIATRIC SYNDROMES IN NURSING HOME RESIDENTS Tuğba Turgut; Remzi Bahşi; Deniz Mut Sürmeli; Hande Selvi Öztorun; Çağlar Coşardereliğoğlu; Volkan Atmış; Ahmet Yalçın; Murat Varlı; Sevgi Aras
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.4

Abstract

Background: With aging, an increase is observed in some geriatric syndromes as well as sleep disorders. Objective: The aim of this study is to investigate the relationship between sleep quality and geriatric syndromes (dementia, depression, sarcopenia, malnutrition, and frailty) in nursing home residents. Methods: The participants’ demographic characteristics, comorbid diseases, number of drugs, cognitive performance, mood and nutritional states, sarcopenia and fraility screening tests and sleep quality test were evaluated by two geriatricians. The participants were divided into two groups as good sleep quality and poor sleep quality. Correlation analysis of sleep quality and geriatric and mental functionality tests was performed with Spearman correlation analysis. Results: A total of 104 nursing home residents (34 females, 74 males, aged 61-98) participated in the study. Sleep quality was found to be worse in the elderly between the ages of 75-84, with a higher number of children, using assistive devices, and taking selective serotonin reuptake inhibitors. In addition, in participants with poor sleep quality, SARC-f (strength, assistance with walking, rising from a chair, climbing stairs, and falls) and geriatric depression scale scores were significantly higher. The Pittsburgh Sleep Quality Index global score was negatively associated with total sleep time and positively associated with geriatric depression scale score and SARC-f score. Conclusion: Findings from the present study in relation between poor sleep quality and some geriatric evaluation parameters suggests that there may be a common pathophysiological alteration with aging.
SUSCEPTIBILITY WEIGHTED IMAGING TECHNIQUE UTILITY IN DIVERSE NEUROLOGICAL ENTITIES Vijetha Chanabasanavar; Sanjay Khaladkar; Darshana Dilip; Satvik Dhirawani; Vinay Kumar Parripati
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.2

Abstract

Background: Susceptibility Weighted Imaging (SWI) is a novel modality based upon GE (Gradient Echo) sequences that employ differences in susceptibility of various paramagnetic as well as diamagnetic substances that aid in the better diagnosis of various neurological entities such as intracranial tumors, vascular malformations, arterial stroke, venous hemorrhagic infarcts. Objective:To assess utility of SWI in various neurological diseases. Methods: The retrospective observational study was held in a tertiary care medical center in India in 2021. Multiple neurological diseases on SWI were analyzed in 100 patients with neurological complaints. The inclusion criteria included patient of all age group who presented with neurological signs and symptoms. The exclusion criteria included presence of post-operative non-compatible orthopedic hardware and patients with cardiac pacemakers, cochlear implants in situ. Results: The majority were males and > 60 years (23%) in age. Among 100 patients, most had tumors (18%), followed by trauma (16%), arterial stroke (15%), and hemorrhage (14%). Most of 14 patients with hemorrhage have intraparenchymal hemorrhage 9 (64.29%). There were10 patients with venous sinuses thrombosis and 15 cases with arterial stroke amongst whom most had middle cerebral artery thrombosis (46.66%). Most 13 patients with vascular pathologies had amyloid angiopathy 4 (30.77%). The majority of tumors were primary 15 (83.33%) with 10 (66.67%) newly diagnosed tumors, 11 (61.11%) tumors had a hemorrhage, 3 (16.67%) presented with calcification, and 4 (22.22%) had both hemorrhage and calcification. According to SWI grading of the tumor by intratumoral susceptibility score (ITSS), the majority were in grade III. On the correlation of SWI grading with MR Spectroscopy (MRS) and MR perfusion (MRP) study, 6 (100%) grade III patients showed hyperperfusion on MRP with raised choline/Creatinine ratio. SWI was better than CT (P<0.05) in detecting trauma, hemorrhage, cerebral venous sinus thrombosis, vascular pathologies, and tumors. Conclusion: SWI is a helpful imaging tool in neuroradiological practice and should be incorporated into standard procedures. It is beneficial in identifying hemorrhages, low-flow vascular abnormalities, diffuse axonal injury, and neurodegenerative illnesses. In addition, it is a supplementary sequence in the stroke by distinguishing calcium from hemorrhage in the brain and categorizing brain tumors.
EFFICACY OF INTRAVENOUS TIROFIBAN THERAPY IN LACUNAR STROKE PATIENTS Ahmet Yabalak; Petek Sarli; Murat Yilmaz; Hilmiye Tokmak; Muhammed Nur Ogun
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.3

Abstract

Background:  Lacunar ischemic infarcts are small-sized infarcts that develop as a result of occlusion of perforating arteries. Although its pathophysiology differs from other stroke types, there is no separate treatment option from non-cardioembolic strokes. Early neurological worsening in lacunar strokes is a common condition reported up to 41%. There is no effective treatment method to prevent or correct progression. Tirofiban is a reversible receptor antagonist of glycoprotein IIb/IIIa. There are cohort studies with small number of cases related to its use in ischemic stroke. We wanted to evaluate its effectiveness on the progression of lacunar stroke because it is a powerful antiplatelet agent. Objective: Tirofiban is a reversible receptor antagonist of glycoprotein IIb/IIIa. There are cohort studies with small number of cases related to its use in ischemic stroke. We wanted to evaluate its effectiveness on the progression of lacunar stroke because it is a powerful antiplatelet agent. Methods: The data of patients who were followed up in our clinic with the diagnosis of lacunar stroke between August 2020 and May 2022 and who received tirofiban treatment were evaluated retrospectively. Patients' ages, infarct localizations, NIHSS scores at admission, at the beginning and end of tirofiban treatment, and 3rd month mRS scores were recorded. Results: Fifteen patients, 11 male and 4 female, were included in the study. The mean age of the patients was 68.73±9.58 (range, 51-85). Tirofiban was started proactively in 2 patients, after progression in 13 patients. The NIHSS scores were 7.20±2.65 at the start of the infusion, and 4.80±3.93 after the infusion, and the decrease was statistically significant (P=0.010). Conclusion: These findings suggest that intravenous tirofiban therapy is a safe and effective treatment option to stop symptomatic fluctuations and shorten the duration of deficit in patients with progressive lacunar stroke.
PATTERN OF ANTICOAGULANT THERAPY IN CARDIOEMBOLIC STROKE Reihan Achmad Reza; Lisda Amalia; Nushrotul Lailiyya Dahlan; Cep Juli; Hanna Goenawan
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.11

Abstract

Background: Cardioembolic stroke is a category of ischemic stroke that manifests more severe, is prone to recurrence, and is related to a higher mortality rate than the other categories of ischemic stroke. Anticoagulant therapy is recommended in cardioembolic stroke, both for primary and secondary prevention. Objective: The objective of this study is to understand the pattern of anticoagulant therapy in cardioembolic stroke patients admitted at Hasan Sadikin General Hospital Bandung. Methods: The methodology of this study uses retrospective descriptive cross-sectional and use data from medical records collected during January 2015 to December 2020 at Neurology Department of Hasan Sadikin General Hospital with total sampling method. The inclusion criteria were cardioembolic stroke patients that received anticoagulant therapy. Anticoagulant therapy was stratified into Warfarin and New Oral Anticoagulants (NOACs) which consist of dabigatran, rivaroxaban, and edoxaban. To assess stroke severity outcome between warfarin and NOACs we use the National Institutes of Health Stroke Scale (NIHSS) Score. Results: From the 162 cardioembolic stroke patients, the most common oral anticoagulant used was warfarin (90.12%), followed by dabigatran (4.94%), rivaroxaban (3.70%), and edoxaban (1.23%). Only 1 (0.62%) patient who experienced complications from anticoagulant therapy, the complication was non-major bleeding and occurred in warfarin users. Both warfarin and NOACs mainly had NIHSS on discharge in a moderate category with the mean of NIHSS 7.615 and 7.276 for warfarin and NOACs respectively. Conclusion: Warfarin is the most common oral anticoagulant used for cardioembolic stroke based on this study. Both warfarin and NOACs groups have similar stroke severity outcomes measured by NIHSS on discharge and NOACs have lower incidence of bleeding compared to warfarin group.
SLEEP DISTURBANCE AFTER TRAUMATIC BRAIN INJURY: NEW INSIGHT Desak Ketut Indrasari Utami; Faldi Yaputra
MNJ (Malang Neurology Journal) Vol. 9 No. 2 (2023): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2023.009.02.13

Abstract

Disruptions in sleep-wake cycles are particularly prevalent after a Traumatic Brain Injury (TBI). Sleep disruptions may occur as a main impact of brain damage or as a result of other neuropsychiatric sequelae of TBI, such as anxiety disorder, depressive disorders, substance abuse, chronic pain, and/or medication consumption. Chronic discomfort (headache and broad pain, presumably of central origin) and/or sleep difficulties (insomnia, disturbed breathing, periodic limb movements) occur in about one in five people with TBI. Disruptions in sleep-wake cycles linked with TBI need therapy. Although data specific to individuals with TBI is currently limited, cognitive-behavioral treatment and medication may be beneficial in alleviating sleep-wake problems in people who have sustained a TBI. This article aims to raise awareness of sleep disturbance after TBI to enhance diagnosis, assessment, and therapy and disclose new research opportunities.

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