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INDONESIA
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES
Published by Universitas Udayana
ISSN : 20854773     EISSN : 23022906     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesia Journal of Biomedical Science (IJBS), Print-ISSN 2085-4773; E-ISSN 2302-2906 is an international and peer-reviewed journal published twice per year in print and online by Indonesian of Biomedical Association in collaboration to Postgraduate School of Biomedicine Udayana University, Bali-Indonesia which was founded in 2007. The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of biomedical scholarship, and to encourage a vigorous dialogue between biomedical scholars and researches. The Journal welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and biomedical researchers all over the world.
Arjuna Subject : -
Articles 87 Documents
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NUTRITION STATUS CORRELATED TO THE FIRST PERMANENT MANDIBULAR MOLAR TEETH OF ELEMENTARY SCHOOL CHILDREN IN LINTAU BUO, TANAH DATAR REGENCY, WEST-SUMATRA A., Syukra
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 6 No 2 (2012): Indonesian Journal of Biomedical Sciences
Publisher : Udayana University

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Abstract

The first permanent mandibular molar teeth is the most important for child, especially to stimulate growth of jaw. The teeth has normally erupted at children age of 6-7 years old. However, it is frequently not happened at this stage. This study aims to determine the nutritional status relate to the first permanent mandibular molars teeth eruption in the elementary school children age of 6-7 years old at Lintau Buo, Tanah Datar Regency, West-Sumatra Indonesia. This is an analytical cross-sectional study, with anthropometric measurements of body mass index/BMI of elementary school children related to eruption of the first permanent mandibular teeth. The results showed that nutritional status of elementary school children age of  6-7 years old for the most were within normal category (51.2%). Grade-I (6-7 years old) suffered from emaciation is still quite high (45.4%), 20.3% of 187 students who suffer from emaciation first permanent mandibular molars have erupted, the first permanent mandibular molars in first grade children (6-7 years old) with normal nutritional status, risk of overweight and obese have erupted. Nutritional status affects children’s first permanent mandibular molar erupted lower jow. The better the nutritional status of a child then the erupstion of the  first mandibular molars  will get better and grow in time.   Key words: nutritional status, tooth eruption, the first permanent mandibular molars, dental and oral health
INTERLEUKIN -2 ( IL-2 ) AND GAMMA INTERFERON ( IFN ? ) OF LYMPHOCYTE CULTURE SUPERNATANT IN IRON DEFICIENCY ANEMIA PATIENTS WITH INFECTION Suega, Ketut; Bakta, I M; Sudewa D., AAG; Suata, Ketut
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 4, No. 1 Januari 2010
Publisher : Udayana University

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Abstract

Iron is an essential nutrient for every living cells because of it role as molecule fortransport of oxygen, as well as DNA synthesis through synthesis of ribonucleotidereductase. Iron deficiency anemia patients, especially pregnant women and children aremore susceptible to infection because of deterioration of their immune response. This wassupported by findings of decreased in phagocytic activities of white blood cells and Tcelllymphocyte proliferation impairment. Iron deficiency anemia (IDA) patients alsoaffect working capacities hence diminishing working outcomes. Although the underlyingmechanism of immune defect in iron deficiency anemia is not clearly understood,multifactor events considered play their contributing roles such as abnormality ofribonucleotide reductase enzym, impairment of T-cell proliferation and activities, alteredcytokine production of IL-2 and IFN?.The study was done to asses the relationship of IL-2 and gamma IFN withinfection in IDA patients on lymphocyte culture supernatant of IDA patients. Study wasconducted on cross-sectional analytic design. Sixty-four iron deficiency anemia patientstreated in Sanglah General Teaching Hospital were recruited, and 31 (48.4%) out of 64IDA patients were man and 33 (51.6%) women, have been selected for the study. Thisstudy found 17 (26.7%) IDA patients with infection, aged 38 ± 14.48 years and 47(73.3%) IDA patients without infection, with age average of 40.5 ± 14.4 years. Allvariables of data characteristics examined did not indicate any statistical significantdifference between group of IDA patients with infection and those without infection. Theaverage level of hemoglobin between the two groups did not differ statistically. Similarresult was obtained if samples were differentiated into severe (Hb< 7g/dl) and mildanemia. The study also revealed that there were no differences of cytokine level observedbetween older and younger age (upper and below 44.5 years) in IDA patients withinfection and without infection. Furthermore, no differences of cytokine level were foundbased on gender between IDA male 10.9 (8.60 – 12,65) (pg/l) patients and IDA femalepatients 10.6 (7.50 – 13.43) (pg/l) with Z -0.490, p =0.624. Nevertheless, significantdifferences were noted between supernatant of IL-2 and IFN? in IDA patients withinfection when compared to IDA patients without infection (Z= - 2.509, p= 0.012 forsupernatant IL-2; and Z= -2.569, p= 0.010 for supernatant IFN?).The study conclusion is that level of IL-2 and IFN? from lymphocyte culturesupernatant of patient suffered from IDA with infection is significantly lower whencompared to IDA patient without infection. It therefore summarized that lower level ofIL-2 and gamma IFN in patients suffered from iron deficiency impaired their immune response to certain infections therefore this findings support the theory that IDA patientsmore susceptible to get infected.
UNSAFE ACT AS THE RISK FACTORS OF ACCIDENTS IN USING MILL IN ROOF TILE INDUSTRY AT PEJATEN VILLAGE TABANAN REGENCY Sutjana, D.P.; Adiputra, N.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 2, No. 1 Maret 2008
Publisher : Udayana University

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Abstract

The use of mill and hand press machines had been increased the productivity ofroof tile home industry at Pejaten Village Tabanan Regency. But the increased ofproductivity followed by increased of working accidents. Many effort had been done toreduced the accident such as equipped the mill machine with machine’s cover, footprotective devices, and training to the new employees; but, the accident still happen.Although the incident of accident was lower but the disability was severed such as loss ofhand, loss oh finger, or other physical defects of the body part. Such physical defectscaused a serious effect on worker’s daily lives and social activities. To find out the unsafeacts as the risk factors of accident, a retrospective study was done using interview and onthe spot observation to the milling process. The results are found: there are three riskfactors contributed to the accidents, namely: the human factor, the tools and theenvironment. The human factor contributed highest one for the accident. From humanfactors it was found that there are many unsafe acts, such as: careless, going up to theupper inlet of mill to push mixing raw material with foot or hand, moving the millwithout turn off the machine, cleaning the mill without turn off the mill, taking out thestone which trapped the rollers using hand, operating the machine without guarding,working with tired condition, working without knowing the operation procedure, withouttraining, improver lighting, working without personal protective devices, etc. The highestincidents come from pushing the raw materials on inlet of mill in order to speed-up themilling process. To solve the problems some actions must be done such as providing themill with the appropriate equipments; by doing so, the operator can push the materialsafely to speed-up the mill process, turn off the machine before cleaning, appropriatetraining before operating of mill, using the personal protective devices, and doing goodhouse keeping and inspection, regularly.
RISKS FOR PERIPHERAL ARTERIAL DISEASE IN THE ELDERLY WITH TYPE 2 DIABETES MELLITUS : Their Correlation with High Sensitivity C-reactive Protein and Ankle-Brachial Index Ayu Tuty Kuswardhani, Raden; Wita, Wayan; Bakta, Made; Santosa, Anwar
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 3, No. 2 Juli 2009
Publisher : Udayana University

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Abstract

The Indonesian elderly population has been projected to increase up to about four-fold inthree decades (1990-2020). As a consequence of this population trend, the increased prevalence ofdegenerative diseases would be inevitable; this would include the prevalence of peripheral arterialdisease.This study aims to identify the correlation of diverse risk factors, either traditional or nontraditional,with the ankle-brachial index scores, and the correlation of novel non-traditional riskfactor, e.i. high sensitive C-reactive protein with the prevalence of perioheral arterial disease in theelderly, age 60-80 years old, with type 2 diabetes mellitus.Among the 146 elderly patients with type 2 diabetes mellitus, and based on measurement ofthe ABI score, approximately 30.9% of them had PAD. Some traditional and non-traditional riskfactors having a significant correlation with the ankle-brachial index score, were age (r = -0.396, p <0.001 for right ABI; r = -0.509, p < 0.001 for left ABI), supine systolic blood pressure (r= -0.268, p =0.012 for right ABI; r = -0.267, p = 0.013 for left ABI), 2-hour post-prandial blood glucose (r= -0.252, p = 0.018 for right ABI), and hsCRP (r = -0.280, p = 0.011 for right ABI; r = -0.402, p <0.001 for left ABI); whereas other risk factors like obesity based on waist circumference and BMI,non-supine systolic blood pressure, fasting blood glucose, HbA1C, duration of diabetes, plasma lipidsdid not show statistically significant different odd ratios. After linear regression test for risk factorshaving significant correlations with ABI, age and hsCRP were found to influence the ABI scores.Based on a case-control study, risk factors which, to some extent, had statistically significant valuesas risk factors, include older age (? 70 years old; OR = 7.737 [CI = 2.515-23.805]; p < 0.001),relatively high supine diastolic blood pressure (? 90 mmHg; OR = 6.882 [CI = 0.789-60.060]; p =0.048), and high concentration of hsCRP (> 3 mg/L; OR = 4.420 [CI = 1.287-15.181]; p = 0.013).Among these statistically significant risk factors, after logistic regression test analysis, only the age ofthe patient appeared to have significant influence on the prevalence of PAD.In conclusion, this study demonstrates a negative correlation between hsCRP and ABI score;and high levels of hsCRP appeared to be a risk factor for PAD. The age of the patient, however,appeared to be the strongest risk factor for PAD.
ROLE OF EXCLUSIVE BREASTFEEDING AND S-IGA ANTIBODIES ANTIROTAVIRUS BREAST MILK TOWARDS RISK OF ACUTE ROTAVIRUS DIARRHEA IN INFANTS AGE OF 1-6 MONTHS: DO THEY CORELATE TO BREASTFEEDING "DAILY DOSE" AND ANTIBODY TITERS? Lely, Oka; -, Soetjiningsih; Wibawa, I D. N.; Mantik Astawa, IN
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 6, No. 1 Januari 2012
Publisher : Udayana University

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Abstract

ABSTRACT Exclusive breastfeeding reduces the incidence of diarrhea, especially in children who live in densely populated neighborhood. This study aims to determine the relationship between exclusive breastfeeding and breast milk contains antirotavirus s-IgA antibodies towards risk of acute rotavirus diarrhea in infants aged of 1-6 months. Case-control study design is applied to determine the relationship between exclusive breastfeeding and breast milk contains s-IgA antibodies antirotavirus with risk of acute rotavirus diarrhea. Cases in this study were patients with acute rotavirus diarrhea and controls were patients without acute rotavirus diarrhea. Cases and controls were matched based on age. There were 23 cases and 69 controls. The proportion who received exclusive breastfeeding was 34.8% in cases and 34.4% in controls, with OR of 1.21 (95% CI: 0.45 to 3.28) and p = 0.28. Breast milk contains sIgA antibodies antirotavirus for case was 17.39% and controls was 23.2%, OR was 1.12 (95% CI: 0.29 to 4.29), p = 0.203. In conclusion, exclusive breastfeeding and breast milk contains sIgA antibodies antirotavirus were not associated with risk of acute rotavirus diarrhea in infants 1-6 months. This may be caused by differences in population and demographic studies as well as low of milk sIgA antibody antirotavirus titters. Further research of breastfeeding regardless of antirotavirus containing high antibody titters sIgA is needed.
PHOTOCHEMOPROTECTION OF CAULERA SPP ACTIVE COMPONENT ON RAT MODEL SKIN Wiraguna, A. A. G. P.; Pangkahila, W.; Mantik-Astawa, and N.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 7 No 2 (2013): IJBS Vol2 No2
Publisher : Udayana University

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Abstract

Caulerpa spp. including seaweed and macro-algae can be found in a large number at Coastal Serangan, Bali-Indonesia. Caulerpa spp was historically used for food and vegetable. However, in our today life, this plant was applied as material for skin care products, especially for UV protection. The aim of this study is to know the active component of caulerpa spp extract and its inhibition of premature skin aging induced by UV-B radiation through collagen expression. This was descriptive and experimental research applying a randomized posttest only control group design. Active component contained in the caulerpa spp extract are carotenoid, vitamin A, C, and E, polyphenols, minerals and amino acids. Topical application of caulerpa spp can suppress the UV-B radiation induced collagen damage. Increased of collagen expression in all groups of caulerpa spp. just as good as astaxanthin group in improving collagen expression and 0.2% of caulerpa spp. extract is the most effective dose in improving collagen expression.
EXERCISE REDUCE OXIDATIVE DAMAGE IN PREGNANCY Wagey, F. W; Pangkahila, A.; Surya, I.G.P; Bagiada, A
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 5, No. 2 Mei 2011
Publisher : Udayana University

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Abstract

Pregnancy is a vulnerable condition to all kinds of "stress", resulting in changes of physiological and metabolic functions. This research aims to determine effect of exercise during pregnancy in reducing oxidative demage marked by decrease of malondialdehyde and 8-hydroxy-diguanosine levels. Randomized pre and posttest control group design was employed in this study. A number of 66 pregnant women were recruited in this study and grouped to two groups, i.e 30 of them as control group and the rest as treatment group. Pregnancy exercise was performed to all 36 pregnant women from 20 weeks gestation on treatment group. The exercise was performed in the morning for about 30 minutes, twice a weeks. On the other hand, daily activities was sugested for control group. Student’s t-test was then applied to determine the mean different of treatment and control group with 5 % of significant value. This study reveals that there were significantly higher decrease of (MDA) and 8-OHdG about 0.15 nmol/ml and 0.08 ng/ml, respectively, amongs treatment and control groups (p < 0.05). Clinical outcomes, such as strengten of pelvic muscle and quality of life of treatment group were significantly better compared to control group (p < 0.05). This means that exercise during pregnancy ages of 20 weeks decrease MDA and 8-OHdG levels higher compare to control group without exercise.
PENDEKATAN ERGONOMI TOTAL MENINGKATKAN KUALITAS HIDUPPEKERJA WANITA PENGANGKUT KELAPA DI BANJAR SEMAJA ANTOSARI SELEMADEG TABANAN BALI Artayasa, I Nyoman
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 2, No. 2 Mei 2008
Publisher : Udayana University

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Abstract

Kelompok (sekeha) pemetik kelapa (ngalap nyuh) ini terdiri dari 3 bagian pekerja yaitu (a) pemetik kelapa (tukang ngalap) (b) pengumpul (tukang nuduk) kelapa, (c) pengangkut kelapa (tukang suwun). Pengangkut kelapa melaksanakan pekerjaannya dengan meletakkan keranjang di atas kepala yang memuat sebanyak ± 25 biji kelapa, berat ± 25 kg, jarak ± 500 m dan dilaksanakan di tegalan dengan sudut kemiringan 10º - 25º. Setelah selesai bekerja mereka merasakan sakit pinggang, pegal-pegal di seluruh tubuh terutama di bagian tungkai dan leher. Jika dilihat beban kerja yang dihitung berdasarkan frekuensi denyut nadi kerja ternyata besarnya adalah 126,24±14,10 denyut/menit dan digolongkan pada katagori pekerjaan berat. Demikian pula dengan skor kelelahan mencapai 64,10±15,29 dan skor gangguan muskuloskeletal 56,25±7,44. Ergonomi total dapat diterapkan pada sektor ini, sehingga beban kerja, kelelahan dan keluhan sistem muskuloskeletal dapat diminimalkan dan pada akhirnya produktivitas kerja dapat ditingkatkan. Penelitian eksperimental ini menggunakan rancangan sama subjek, dan melibatkan 20 sampel penelitian yang dipilih secara acak sederhana pada pekerja wanita pengangkut kelapa di Banjar Semaja Antosari Tabanan Bali. Data dianalisis dengan uji t-paired dan Wilcoxon Signed Rank Test pada taraf signifikansi 5%. Hasil penelitian menunjukkan penurunan beban kerja, kelelahan, keluhan muskuloskeletal, dan peningkatan produktivitas secara bermakna (p<0,05). Dapat disimpulkan, pendekatan ergonomi total menurunkan beban kerja dilihat dari penurunan denyut nadi kerja sebesar 10,61%. Penurunan kelelahan 53.97%, keluhan sistem muskuloskeletal 48,01%. Konsekuensinya, terjadi peningkatan produktivitas sebesar 48.84%. Dengan demikian dapat dikatakan pendekatan ergonomi total dapat meningkatkan kualitas hidup pekerja wanita pengangkut kelapa di Banjar Semaja Antosari Tabanan Bali.
Obstetric and Gynecologic Departments, Faculty of Medicine Udayana University, Bali-Indonesia Mahendra-Dewi, I G. A. S.; Suwiyoga, and I K.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 7 No 1 (2013): IJBS Vol.7 No.1 January-June 2013
Publisher : Udayana University

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Abstract

The high risk of human papillomavirus (HPV) have already known widely and accepted as a causative agent for cervical cancer. Epidemiologically, predominant high-risk is HPV-16 and squamous cell carcinomas (SCC) is the most common histological type. HPV genotype probably correlates to histologic type. This study aims to determine how many fold is the risk of SCC on HPV-16 infection. This is a case control with SCC HPV-16 positive as the cases and SCC HPV-16 negative as the controls. Tissues diagnosed as SCC and non SCC was paraffin-embedded. SPF-10 and specific E7-primer types by LiPA were employed for genotyping of HPV-16. c2 was applied to analyze the correlation. A number of 65 SCC consisted of 33 cases and 32 controls were observed in this study. The risk of SCC on HPV-16 infection was 3.40-fold (95% CI = 1.44-8.03; p = 0.004) compare with HPV-16 negative. Controls in this study consist of 18 (27.69%) of HPV-18, 9 (13.85%) of HPV-52, and 5 (7.69%) of other HPV types. The mean-age of case group and control group infected by HPV were 52.28 ± 12.43 and 47.70 ± 8.02 year, respectively (p = 0.02). HPV-16 infection caused SCC is 3.5 more than other high risk group.
HIGH PLASMA TNF-? LEVELS AND MONONUCLEAR CELLS iNOS AND TNF-? EXPRESSION AS RISK FACTORS FOR PAINFUL DIABETIC NEUROPATHY Eko Purwata, Thomas; Suastika, Ketut; Raka Sudewi, A. A.; Widjaja, Djoenaidi
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 4, No. 2 Juli 2010
Publisher : Udayana University

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Abstract

Painful Diabetic Neuropathy (PDN) is one of the most common and annoyingcomplications of diabetes mellitus. The pathogenesis of PDN is complex and still unclear.Recently it has become clear that nitric oxide (NO) and proinflammatory cytokines playan important role in the pathogenesis and maintenance of pain in PDN. Based on thisphenomenon, this study was conducted to investigate whether the cytokine tumornecrosis factor-alpha (TNF-?) and NO, in this case inducible Nitric Oxide Synthase(iNOS), play a role in PDN pathogenesis.The study was carried in two steps. The first step was a cross sectional and thesecond step was a case-control study. The study was performed in 110 type-2 diabeticpatients. The plasma TNF-? levels were determined by ELISA while the expression ofTNF-? and iNOS in mononuclear cells were analyzed immunohistochemically.Of 110 subjects, 59 patients suffered from Painful DN (case) and the remaining51 patients were Painless DN (control). Cross sectionally, plasma TNF-? levels andimmunoreactivity for iNOS and TNF-? were higher in patients with more severe pain inthe Visual Analog Scale (VAS). There were statistically significant differences (p <0.05) between mild and severe pain in regard to TNF-? level (15.24 pg/ml ± 5.42 vs.20.44 pg/ml ± 10.34 ); to iNOS immunoreactivity (9.72 % ± 8.61 vs. 15.6% ± 11.84); andto TNF-? immunoreactivity (13.0 % ± 9. 48 vs. 20.44% ± 11.75).The case control study showed that TNF-? had an odd ratio of 5.053 [CI 95%(2.241-11.392); p < 0.001]. TNF-? immunoreactivity of 4.125 [CI 95% (1.805-9.425); p< 0.001]; and iNOS immunoreactivity of 3.546 [CI 95% (1.613-7.795); p = 0.002]. There were correlations between TNF-? level, TNF-? and iNOS immunoreactivity andVAS with coefficient correlation: 0.330; 0.285 and 0.275 (p < 0.05) respectively.It is concluded that Diabetic Neuropathy patients with high TNF-? levels, iNOSand TNF-? immunoreactivity of mononuclear cells have higher risk for painful DN thanpainless DN. The higher TNF-? level, iNOS and TNF-? immunoreactivity the moresevere was the pain. This supports the hypothesis that TNF-? and iNOS have role inPDN pathogenesis. The results of this research could be applied as a basic for furtherresearch in pursuit of better management of PDN.

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