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INDONESIA
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES
Published by Universitas Udayana
ISSN : 20854773     EISSN : 23022906     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesia Journal of Biomedical Science (IJBS), Print-ISSN 2085-4773; E-ISSN 2302-2906 is an international and peer-reviewed journal published twice per year in print and online by Indonesian of Biomedical Association in collaboration to Postgraduate School of Biomedicine Udayana University, Bali-Indonesia which was founded in 2007. The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of biomedical scholarship, and to encourage a vigorous dialogue between biomedical scholars and researches. The Journal welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and biomedical researchers all over the world.
Arjuna Subject : -
Articles 87 Documents
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REGULATION OF SHIFT WORK TO AVOID SHACK OUT OF EMPLOYEES IN HOTEL. Sutjana, D.P.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 2, No. 1 Maret 2008
Publisher : Udayana University

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Abstract

Since the tragedy of bomb blast at Legian Kuta and SARS epidemictogether with travel warning from foreign country resulting a stepdecreasng of tourist visit to Bali. The Decreasing number of touristvisit cause of tourism stake holders facing many problem such as: emtyroom of hotel, restaurant, travel bureau, small scakle industries. Manyof them close their activities and sack out their employees. But sometwo star hotel in Sanur treid to manage their own way inorder toregulate their employees jog to maintain hotel operational without sackout their employees. The study has been done to find out how to manageemployees shift work in those hotel. The result shown of those 4 hotelat Sanur: 1) one of them gave the employees for 15 days work and 15 daysoff with 50% salary, 2) the second hotel gave one week of and three weekwark with 30% salary off, 3) the third full work, salary as usual butemployees take over hotel renovation job, 4)the employees work as usualwith full salary but laundry work take over by employees themselves.With those management system the hotel operational cost can be minimizedso the dayly operation can be maintain with out shack out theiremployees.
HYPOALBUMINEMIA: a hospital based study P, Singh; S, Khan; A. H., Siddiqui
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 6 No 2 (2012): Indonesian Journal of Biomedical Sciences
Publisher : Udayana University

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Abstract

Hypoalbuminemia occurs in a variety of disease states and is associated with an increased rate of complications during hospitalization, resulting in an increased length of stay. The purpose of this study is to investigate the prevalence of hypoalbuminemia in IPD and OPD patients and to see which age group and sex have high prevalence of hypoalbuminemia.Nine hundred forty four patients, attending Nepalgunj medical college and Teaching Hospital, Banke, Nepal from March 2011 to February 2012 were included in this study. The normal reference range for serum albumin was 3.5 – 5.5gm/dL in males and females. Hypoalbuminemia is defined as serum albumin < 3.5 gm/dL. The outcome assessments in the hypoalbuminemia and normal albumin groups were compared. Serum albumin level estimation was done by using the diagnostic reagent kit manufactured by RFCL kit , India. A number of 944 studies were selected, the statistical information of which was collected for systematic analysis.The results showed that the high prevalence of hypoalbuminemia found in males (89.72%) as compare to females(88.12%). The prevalence of hypoalbuminemia is different as the period of age and it increases after 21-40 years and high prevalence seen in after the age of 60. Serum albumin level was low in male as compare to female.
CHARACTERISTICS OF PILI HEMAGLUTININ PROTEIN AND ITS ROLE IN THE PATHOGENESIS OF URINARY TRACT INFECTION WITH UROPATHOGENIC ESCHERICHIA COLI Sudhana, I Wayan; Suwitra, Ketut; -, Sumarno
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 3, No. 2 Juli 2009
Publisher : Udayana University

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Abstract

Urinary tract infection (UTI) is one of the most common infectious diseasesencountered in the community. The bacteria most frequently implicated as the causes ofUTI are the Gram-negative bacteria, especially Escherechia coli. Early phase of thepathogenesis of the infection constitutes adhesion of bacteria onto the epithelial cells ofurinary tract. SDS-PAGE examination was carried out to investigate molecule ofhemagglutinin protein and hemagglutination (HA) test continued by adhesion andinhibited adhesion tests.The observation of molecular weight of pili E. coli protein molecule byexplorative examination using SDS-PAGE showed on E. coli strip that the mostprominent molecular weights (MW) of the proteins were 61 kDa, 37 kDa, 30 kDa, and 20kDa. Purification by electro-elusion was done to proteins of the MW of 20 kDa, 37 kDaand 61 kDa. The HA test results indicated the 61 kDa, 37 kDa, and 20 kDa werehemagglutinin proteins and one which subsequently applied as sub unit proteins ofUropathogenic E. coli (UPEC) was the 37 kDa. Adhesion test of UPEC bacteria carriedout on urinary bladder epithelial cells of rabbit showed a significant correlation betweenadhesion index and various doses of subunit proteins of UPEC 37 kDa as coat of urinarybladder epithelial cells. Spearman rank correlation test and regression/non regressionanalysis confirmed an exponential decrease of UPEC adhesion to urinary tract epithelialcells as a response to the increasing doses of coating protein. This finding points out thatpili hemagglutinin protein subunit of UPEC 37 kDa was an adhesive molecule. Pilihemagglutinin protein subunit of UPEC 37 kDa is an adhesive molecule, which plays arole in adherence of UPEC to epithelial cells of urinary bladder at the early pathogenesisof urinary tract infection.
SISTEM KERJA DENGAN PENDEKATAN ERGONOMI TOTAL MENGURANGI KELUHAN MUSKULOSKELETAL, KELELAHAN DAN BEBAN KERJA SERTA MENINGKATKAN PRODUKTIVITAS PEKERJA INDUSTRI GERABAH DI KASONGAN, BANTUL Purnomo, Hari; Manuaba, Adnyana; Adiputra, Nyoman
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 1, No. 3 Desember 2007
Publisher : Udayana University

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Abstract

Era globalisisi saat ini, industri kecil dituntut untuk meningkatkan produktivitasagar dapat bersaing untuk kelangsungan hidup. Dalam upaya meningkatkan produktivitaskerja perlu adanya usaha yang kondusif untuk mengoptimalkan sistem kerja. Peningkatanproduktivitas akan tercapai jika semua komponen dalam sistem kerja dirancang secaraergonomis. Sistem kerja pada industri gerabah di Kasongan Bantul banyak melibatkanaktivitas fisik, sehingga perlu sistem kerja yang ergonomi untuk dapat meningkatkanproduktivitas. Pada penelitian ini dilakukan perbaikan sistem kerja pada industri gerabahdi Kasongan dengan pendekatan ergonomi total. Rancangan penelitian yang digunakanadalah rancangan eksperimental yang menggunakan randomized pre and post-test controlgroup design dengan jumlah sampel 14 orang untuk masing-masing kelompok. Hasilpenelitian menunjukkan bahwa sistem kerja dengan pendekatan ergonomi total dapat : (a)menurunkan keluhan muskuloskeletal pekerja sebesar 87,8% ; (b) menurunkan kelelahanpekerja sebesar 77,5% ; (c) menurunkan beban kerja pekerja sebesar 21,55 denyut/menitatau sebesar 21,69% ; (d) menurunkan risiko cedera di tempat kerja sebesar 10,65% ; (e)meningkatkan produktivitas pekerja sebesar 59,49% ; dan (f) meningkatkan pendapatanpekerja sebesar 23,81% dan meningkatkan pendapatan perusahaan sebesar 76,19%.
SENSITIVITY AND SPECIFICITY OF ELISA TEST USING 30 KDA RECOMBINANT ANTIGEN TO DETECT Toxoplasma gondii INFECTION IN PIG WITH MICE BIOASSAY AS A GOLD STANDARD Nyoman Adi Suratma1????, I Made Bakta2, I Made Damriyasa3 Adi Suratma, Nyoman; Bakta, I Made; Damriyasa, I Made
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 3, No. 1 Januari 2009
Publisher : Udayana University

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Abstract

Toxoplasmosis is a zoonotic disease caused by the protozoa Toxoplasma gondii.Primary infection in pregnant women can cause abortion, neonatal death or abnormalityof fetus. Accurate diagnosis is needed to prevent infection especially related to thepresence of cyst in the tissuesThe aim of this research was to study sensitivity and specificity of ELISAmethod with 30 kDa protein antigen to detect T.gondii infection in pig with micebioassay as gold standard.. Samples were 171 pigs slaughtered at pig slaughter house inDarmasaba BadungThe result showed that sensitivity of ELISA method was 100% and 90,7% inspecificity.Research about sensitivity using ELISA test to predict cysts presence in tissuewere needed in the future.
ASSOCIATION OF B-CELL LYMPHOMA PROTEIN-2 AND CASPASE-3 EXPRESSION IN OVARIAN CANCER Budiana, I N. G.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 7 No 2 (2013): IJBS Vol2 No2
Publisher : Udayana University

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Abstract

Ovarian cancer remains a major problem of women’s health in the world, including Indonesia, and is associated with high rates of incidence and mortality. There are many efforts in early diagnosis on ovarian cancer, but until now there have not been found any satisfactory method. On the other hand, knowledge and research in the field of molecular biology become more advance, one of them is a mechanism to control the growth of cells in ovarian cancer through a process of programmed cell death or apoptosis. B-cell lymphoma protein 2 (Bcl-2) and caspase-3 are proteins that play a role on the mechanism of apoptosis. The purpose of this study was to determine the expression of Bcl-2 and caspase-3 and their association with ovarian cancer. Materials and method: The design of this study was a cross-sectional study. Expression of Bcl-2 and caspase-3 examined by immunohistochemistry under light microscope with 400x light power field and expression as a negative when the protein expressed in 10% or less of cells and as a positive when the protein expressed in more than 10% of cells. A number of 45 subjects were recruited in this study. Thirthy one of 45 subjects showed the expression of Bcl-2 positive (68.9%), while the positive expression of caspase-3 present in 20 subjects (44.4%). There was a significant association between the expression of Bcl-2 with the expression of caspase-3 in ovarian cancer patients (p=0.002; lambda=0.4). There was also a significant association between stage of disease with expression of Bcl-2 (p=0.002; lambda=0.3) dan expression of caspase-3 (p=0.001; lambda=0.3). Conclusion: It concluded that there is a significant association between the expression of Bcl-2 and the expression of caspase-3 in ovarian cancer.
ORAL INTAKE OF SARDINELLA LONGICEPS OIL THE DECREASE OF TNF-? AND IL-6 LEVELS IN ATHEROSCLEROTIC WISTAR RAT Wahjuni, S.; Sudewa, A.A.G.; Wita, I Wayan; Astawa, I.N. Mantik
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 5, No. 2 Mei 2011
Publisher : Udayana University

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Abstract

Lifestyle changes to consumption of variegated instant food may be associated several heath hazards, such as obesity, dyslipidemia, and atheroschlerosis. This study was conducted to investigate the effects of orally administered Sardinella longiceps oil as an anti inflammatory agent on the serum levels of TNF-? and IL-6 considered as biomarkers for atherosclerosis.The study design is an true experimental with randomized pretest and posttest control group design, using 50 Wistar rat equaly divided into 5 groups, i.e. placebo control group 0% and 4 treatment groups each treated daily with 10%, 15 %, 20 % and 25 % fish oil respectively for 6 weeks. Before the treatment was started, all rats were orally fed daily with a high cholesterol diet for 13 weeks to induce atherosclerosis. Our study showed that the intake of 20% fish oil had resulted in the significantly greatest decrease of 45,63 % in the TNF-? serum levels,from 28.62 ± 1.25 to 15.56 ± 7.20 ?g/mL and similar significant decrease 15,42% in of IL-6 serum levels from 134.64 ± 1.98 to 113.87 ± 4.30 ?g/mL. The overall results of our study seemed to imply than in the Wistar rats, oral intake of Sardfinella longiceps oils signifacantly decreased serum levels of TNF-? and IL-6 probably through their anti-inflamatory effects. Futher research to determin the magnitude of effects sardinella longiceps oils on the serum levels TNF-? and IL-6 human.
MASSAGE STIMULATION REDUCES TUMOR NECROTIC FACTOR-ALPHA AND INTERLEUKIN-6 IN PRETERM, LOW BIRTH WEIGHT WITH APPROPRIATE GESTATIONAL AGE NEWBORNS Trisna Windiani, I G. A.; Sotjiningsih, S.; Mantik Astawa, N.; Kusnandi, and R.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 7 No 2 (2013): IJBS Vol2 No2
Publisher : Udayana University

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Abstract

Preterm newborn is susceptible from various stresses such as infections or non infections. During stress, immune response is activated by synthesizing and releasing of cytokines from activated immune cells into the circulation. One of the efforts to overcome the stress is massage stimulation. Several studies have been carried out to find out the benefit of massage stimulation. The objective of this study is to find out the effect of massage stimulation to reduce of TNF-? and IL-6 levels on preterm, low birth weight, appropriate to gestational age newborn. This was a randomized controlled trial. Subjects of the study were all preterm newborns with a stable medical condition, birth weight 1,500-2,499 gram, appropriate to gestational age. The study was carried out on October-December 2011, in neonatology ward, Sanglah General Hospital, Vali-Indonesia. The number of cases was 35 subjects and the number of controls was 36 subjects. The examination of TNF-?, IL-6 levels and birth weights before and after massage stimulation were performed on both groups. The level of TNF-? and IL-6 was examined by applying ELISA method. The level of confidence was ? = 0.05. All statistical analysis was performed by computer programme. There was different level of cytokine pro-inflammation TNF-? (p=0.025) and IL-6 (p=0,001) comparing before and after condition massage stimulation. Outcome of body weight were also different at before and after massage stimulation, with p value 0.042. The conclusion of this study is that massage stimulation can reduce the level of TNF-?,   IL-6 and increasing of birth weight on preterm, low birth weight appropriate gestational age newborn. Based on this study, in the future, massage stimulation can be done in newborn with stable medical conditions by parents or trained staffs.
“TEMPE” REDUCES DNA DAMAGE IN RATS IRRADIATED WITH ULTRAVIOLET RAY Maryam, Siti; Sudewa Djelantik, A. A. Gde; Agus Bagiada, I Nyoman; Mantik Astawa, Nyoman
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 5, No. 1 Januari 2011
Publisher : Udayana University

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Abstract

‘Tempe’ is a popular Javanese-Indonesian tradisional food made of fermentedsoyabean. This study aims to examine whether ‘tempe’, used as a strong anti-free,has the ability to decrease DNA damage induced by ultraviolet ray irirradiation inthe Wistar rats as indicated by the levels of urinary 8-hydroxy-2-deoxyguanosine.A Total of 24 Wistar rats, 2.5 to 3 mounths and 200 gr body weight, weredividing into 4 groups of equal size i.e. three treatment and one control groups.All rats were exposed to 5-hours daily UV ray sources of UV 15 watt Philip for 60days. Randomized post test only control group design was used in this study withindependent variables of 0, 1, 2 and 3 g ‘tempe’ per kilogram body weight per dayand independent variables of 8-hydroxy-2-deoxyguanosine urinary level as aDNA damage biomarker following an oxidative stress. Data were analyzed byusing one way ANOVA followed by Tukey HSD.The results of our study indicates that there is a decrease of DNA damageis manifested by progressive decrease of 8-hydroxy-2-deoxyguanosine level in thetreatment groups as compared to the control group. Statistically significantdecrease of 22.61 % and 25.62 % was shown with p > 0.05.From our analysed data is could be inferred that ‘tempe’ has the ability todecrease DNA damage caused by ultraviolet ray irradiation. Supplementation of2 g ‘tempe’ per kilogram body weight per day appeared to have the strongesteffect of decreasing DNA damage in Wistar rats.
FRACTIONS OF THE HEXANE EXTRACT OF YOUNG CARICA PAPAYA SEEDS CAN INHIBIT SPERMATOGENESIS IN MALE MICE MORE THAN FRACTION OF THE METHANOL EXTRACT OF YOUNG CARICA PAPAYA SEEDS Satriyasa, Bagus Komang
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 2, No. 1 Maret 2008
Publisher : Udayana University

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Abstract

Fraction of hexane extract contains glycosides and triterpenoids, which isassumed to have an anti fertility ingredient, so it can be used as a male contraceptive,although the mechanism of action is not yet clear.This study used the pre-test and post-test control group design, using 30 malemice of balb C strain, aged 12 weeks, weight 20-22 gram, subsequently grouped byrandom into 3 groups each consisting of 10 male mice. One control group (P0 = controlgroup) was given double distilled water, and two treatment groups (P1 = treatment group)was given fraction of the hexane extract of young Carica papaya seed 20 mg/20gram/day,P2 = treatment group) was given fraction of the methanol extract of young Carica papayaseed 20 mg/20 gram/day). After 36 days of treatment, evaluation of the testis and blood,of the male mice was conducted.Data were analysed by normality test of Kolmogorov Smirnov Goodness of Fit,homogeneity test, and Anova test. This study showed that cells of spermatogonia A,primary pakhiten spermatocyte, spermatid, and Sertoli cells, decreased significantly (p <0,05) but Leydig cells and testosterone were not decreased significantly (p > 0,05).It is concluded that fraction of hexane extract of carica papaya seeds can decreasethe mean number of cells spermatogonia A, spermatocyte of primary pakhiten, spermatid,Sertoli, and Leydig cells and the level of testosterone hormone better than fraction ofmethanol extract of young Carica papaya seeds.

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