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INDONESIA
Indonesia Chimica Acta
Published by Universitas Hasanuddin
ISSN : 2085014X     EISSN : 26556049     DOI : -
Core Subject : Engineering,
Chemical Engineering, Chemistry & Bioengineering
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of chemistry. The result of research and development in the fields of chemistry in both experimental and theory/ computation, chemical-based technological innovations, and chemical applications in industrial fields. The journal publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 13 Documents
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Search results for , issue "Volume 13, No 2: December 2020" : 13 Documents clear
Analysis of Metal Fe at Algae Eucheuma cottoni in Region of Baubau Coastal Muhammad Tasjiddin Teheni
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.8279

Abstract

Abstract. Eucheuma cottoni (called algae) is one of plant that usefull for human life as well as alternative energy, bioaccumulation of metal in waters, food, fertilizer and also in health. This study aims to determine the level of Fe ions in Eucheuma cottoni in the region of Baubau coastal. The concentration of Fe metal was determined by atomic absorption spectrophotometer (AAS) which destructing process was done by HNO3 concentrated. The results showed that the highest and lowest level of Fe available on Lowu-Lowu and Palabusa village which value of 0.4885 and 0.0498 ppm, respectivelly. The high concentration of Fe metal expecially in Lowu-lowu had been passed the specific threshold. The monitoring of heavy metal pollution in Baubau coastal necessary to be done in the aquatic environment so it can be maximize the quality and production of seaweed
Antifeedant Activity of Benzopyrans from Melicope latifolia Mulyadi Tanjung
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.10439

Abstract

Two benzopyrans, evodionol (1), and evodion (2) were isolated from the stem bark of Melicope latifolia. The structure of both compounds was identified based on 1D and 2D NMR, UV, and IR spectroscopy. Antifeedant activity of compounds 1-2, and ethyl acetate extract, showing inhibition value of 28.9; 31.3, and 46.8%, respectively, which were categorized as moderate.
Antibacterial Activity of Ethanol Extract of Dragon’s Blood (Daemonorops didymophylla) Against Salmonella typhi and Streptococcus mutants. Minarni - Minarni
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.10506

Abstract

Abstract. Dragon’s blood is essentially a red-colored resin secreted by the fruits of rattan species. Dragon’s blood originated from Indonesia which becomes widespread in the international market is indigenous from Daemonorops sp. Dragon’s blood has been popularly used as traditional medicines. The benefit of dragon’s blood as medicine certainly cannot be separated from the content of secondary metabolites. To confirm such dragon’s blood efficacy, an assessment was already conducted regarding the phytochemical screening and activity dragon’s blood produced by three rattan species, i.e. Daemonorops didymophylla. Ethanol extract of dragon’s blood contains secondary metabolites which are effective as an antibacterial against Salmonella typhi and Streptococcus mutants. This study aims to determine what are the classes of compounds contained in the ethanol extract of dragon’s blood Daemonorops didymophylla which is effective as an antibacterial against the bacteria Salmonella typhi and Streptococcus mutants. Results revealed that the separation of the active compound ethanol extract of dragon’s blood Daemonorops didymophylla, where the separation of compounds through liquid vacuum chromatography has 4 combined fractions. The class of compounds found in the ethanol extract of dragon’s blood Daemonorops didymophylla are flavonoids, triterpenoids and alkaloids. Antibacterial activity of Daemonorops didymophylla dragon’s blood ethanol extract against Salmonella typhi and Streptococcus mutans showed that the higher the concentration the higher the inhibitory power produced, for Salmonella typhi in the 1000 ppm extract obtained an inhibition zone of 13.63 mm with a strong category while Streptococcus mutans in the 1000 ppm extract obtained a inhibition zone of 11.86 mm with a strong category and fraction 1 is the fraction that has the largest inhibition zone than the other three fractions with a large inhibition zone of 14.6 mm in testing Salmonella typhi and 12.1 mm in testing Streptococcus mutants. 
Test the Activity of Vegetable Oils from Shorea Sumatrana SYM Against Bacteria Salmonella and Bacteria Eschericia Coli Minarni - Minarni
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.10526

Abstract

Abstract. Tengkawang oil obtained from shorea sumatrana Sym fruit contains vegetable oil, extracts of tengkawang oil using n-hexane organic solvents. Tengkawang oil from shorea sumatrana fruit is a genus of dipterocarpacea family shorea which produces high value vegetable oil, is used for food preservatives, canker sores and diarrhea and as cosmetics. This study aims to determine the activity of salmonella bacteria, and escheria coli from tengkawang oil. Tengkawang oil was obtained by shocletation and bacterial testing by diffusion method with various oil concentrations (12.5,25,50 b/v) tengkawang oil mixed with bacterial supposition in NA medium and incubated at 37 0C for 18-34 hours to determine the level minimum inhibition (LMI) of culutation liquid results incubated on SDA (Sabourraud Dextrose Agar) media. The phytochemical screening test was carried out to determine the class of compounds contained in tengkawang oil from shorea Sumatrana. The results of the bacterial activity testing study showed that the LMI of concentrated salmonella bacteria was 12.5% b/v. MIC of 21, concentration of 25% b/v. LMI of 16 and concentration of 50% b/v. The LMI is 15, the test of tengkawang oil activity from shorea sumatrana fruit to Eschericia Coli is at a concentration of 12.5% b/v. LMI of 8, concentration of 25% b/v. LMI of 19 and concentration of 50% b/v. LMI is equal to 17. by using the control as a comparison if compared with the positive control of 10 and control negative equal to 7. The extracts of the pitochemical srening test showed that tengkawang oil from shorea sumatrana fruit contained penicillin, coumarin and flavonoids. The highest activity of tengkawang oil on salmonella bacteria was LMI at 12.5% b/v. The level of LMI was 21 activities using the larger Eschericia Coli LMI bacteria at a concentration of 25% b/v. LMI 19, from the activity test both bacteria were categorized as inhibiting the growth of Salmonella bacteria and Eschericia Coli bacteria.
Seasonal Variations of Major Anions in Water at Baro Haor of Kishoreganj, Bangladesh and Revealing The Suitability for Aquatic Resource Management Shamim Al Mamun
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.10747

Abstract

Haors are areas with sweet water that inhabits a large variety of fishes and other aquatic animals. The quality of water in haors affects the lives in haors and the deterioration of the quality of water due to different anthropogenic reasons may affect the total ecosystem of haors. The study was conducted to investigate the physicochemical parameters and major anions of water of Baro haor area in Kishoreganj during the period from September 2016 to August 2017. The water samples were collected monthly during the pre-monsoon (Feb. to May), monsoon (Jun. to Sep.) and post-monsoon (Oct. to Jan.) seasons from five sampling stations as: (i) Bayershuil beel (St-1), (ii) Tegulia beel (St-2), (iii) Singpur beel (St-3), (iv) Neora beel (St-4) and (v) Bara beel (St-5). The physicochemical water quality was analyzed in the laboratory of the Department of Environmental Science and Resource Management (ESRM), Mawlana Bhashani Science and Technology University (MBSTU), whereas, anions were analyzed in Bangladesh Institute of Nuclear Agriculture (BINA), Mymensingh. Results of the study showed that the mean temperature, electrical conductivity (EC), total dissolved solid (TDS), dissolved oxygen (DO), biochemical oxygen demand (BOD), pH, alkalinity and hardness were found 28.03°C, 696.70 µS/cm, 484.35 mg/L, 6.62 mg/L, 2.36 mg/L, 7.40, 291.35 mg/L and 106.85 mg/L, respectively which revealed that the water was suitable for aquatic environment as well as fish production. Mean concentration of fluoride (F-), chloride (Cl-), bromide (Br-), nitrite (NO2-), nitrate (NO3-) and sulfate (SO42-) were 0.35, 121.35, 0.15, 5.63, 28.41 and 66.29 mg/L, respectively. The water quality was found suitable for aquatic environment and for fish production but the haor area is highly subjected to anthropogenic disturbances. To conserve the aquatic environment of the Baro haor regular monitoring and management should be taken to maintain the water quality.
Antibacterial Activity Test of Elephant ginger (Zingiber officinale Rosc.) Endophytic Fungi Variation of Elephants Against Bacteria That Cause Skin Infections seniwati seniwati; Laras Aprilia; Rusli Rusli; Tadjuddin Naid
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.10771

Abstract

Elephant ginger rhizome has the potential as an antibacterial, therefore the research was conducted to test the antibacterial activity of elephant ginger endophytic fungi against bacteria that cause skin infections, determine test bacteria that can be inhibited by elephant ginger endophytic fungi and bioautogram profile for its antibacterial activity. Isolation of endophytic ginger elephant fungi using the direct planting method. Screening of endophytic fungi isolates was placed on the surface of NA medium containing test bacteria Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acne. The screening results obtained were 2 isolates namely isolates which had the highest activity namely IFDRJG03 and IFDRJG04. For IFDRJG03 isolates can inhibit the antibacterial activity of Staphylococcus aureus 25.26 mm, Staphylococcus epidermidis 26.89 mm and Propionibacterium acne 27.12 mm, IFDRJG04 isolates can inhibit the antibacterial activity of Staphylococcus aureus 15.87 mm, Staphylococcus epidisidis 18 and 96 mm. 27.43 mm. Then the TLC-Bioautography test was carried out, the results of IFDRJG03 isolates were obtained using chloroform eluents: methanol (1: 1) had antibacterial activity against Staphylococcus aureus with Rf1 = 0.9 and Rf2 = 0.5, Staphylococcus epidermidis with Rf1 value = 0.8 and Rf2 = 0.5 and Propionibacterium acne with Rf1 value = 0.9 and Rf2 = 0.5 and isolation of IFDRJG04 isolates with ethyl acetate eluent: ethanol: water (8: 2: 1) has antibacterial activity against Staphylococcus aureus Rf1 values = 0.9 Rf2 = 0.7 Rf3 = 0.6, Staphylococcus epidermidis with Rf1 value = 0.7 Rf2 = 0.6, Rf3 = 0.5 and Propionibacterium acne with Rf1 value = 0.9 and Rf2 = 0.7.lephant ginger rhizome has the potential as an antibacterial, therefore the research was conducted to test the antibacterial activity of elephant ginger endophytic fungi against bacteria that cause skin infections, determine test bacteria that can be inhibited by elephant ginger endophytic fungi and bioautogram profile for its antibacterial activity. Isolation of endophytic ginger elephant fungi using the direct planting method. Screening of endophytic fungi isolates was placed on the surface of NA medium containing test bacteria Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acne. The screening results obtained were 2 isolates namely isolates which had the highest activity namely IFDRJG03 and IFDRJG04. For IFDRJG03 isolates can inhibit the antibacterial activity of Staphylococcus aureus 25.26 mm, Staphylococcus epidermidis 26.89 mm and Propionibacterium acne 27.12 mm, IFDRJG04 isolates can inhibit the antibacterial activity of Staphylococcus aureus 15.87 mm, Staphylococcus epidisidis 18 and 96 mm. 27.43 mm. Then the TLC-Bioautography test was carried out, the results of IFDRJG03 isolates were obtained using chloroform eluents: methanol (1: 1) had antibacterial activity against Staphylococcus aureus with Rf1 = 0.9 and Rf2 = 0.5, Staphylococcus epidermidis with Rf1 value = 0.8 and Rf2 = 0.5 and Propionibacterium acne with Rf1 value = 0.9 and Rf2 = 0.5 and isolation of IFDRJG04 isolates with ethyl acetate eluent: ethanol: water (8: 2: 1) has antibacterial activity against Staphylococcus aureus Rf1 values = 0.9 Rf2 = 0.7 Rf3 = 0.6, Staphylococcus epidermidis with Rf1 value = 0.7 Rf2 = 0.6, Rf3 = 0.5 and Propionibacterium acne with Rf1 value = 0.9 and Rf2 = 0.7.
A Caffeic Acid Derivative Potential for Anticancer Drug: Synthesis of N-(piperidinyl)caffeamide and Its Activity against P388 Leukemia Murine Cells Firdaus Firdaus; Nunuk Hariani Soekamto; Syadza Firdausiah; Musrifah Tahar
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.10962

Abstract

Some esters and amide derivatives of p-hydroxycinnamic acid have anticancer activity. However, the amide compound is more stable to metabolic reactions compared to its ester derivative. In this research, the synthesis of a new compound, namely N-(piperidinyl)caffeamide (M5) and its anticancer activity assay, has been conducted. The compound M5 was synthesized using p-hydroxycinnamic acid and piperidine as starting materials, and the activity assay was carried out against P388 Leukemia Murine Cells by the MTT method. By these methods, the compound M5 was obtained a yellowish crystalline with a melting point of 212-214°C, and it was very active as an anticancer with an IC50 value of 0.861 μg/mL. This compound was more active than the analog compounds previously synthesized.
Review: Phytochemical Screening, Secondary Metabolites and Biological Activities of Southeast Sulawesi Plants Megawati Megawati
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.11138

Abstract

Southeast Sulawesi is one of the provinces in Indonesia which has a variety of medicinal plants that have been used by its people in treating diseases. The results of research on phytochemical screening and isolation of secondary metabolites from local researchers indicated that the plants from Southeast Sulawesi have the potential to be studied further. Plants from Southeast Sulawesi show pharmacological potential activities that can be developed for the purpose of treating diseases caused by bacteria, fungi, cancer, and as an antioxidants. There are Southeast Sulawesi endemic plants from the Etlingera genus that are interesting to explore (phytochemical screening, isolation of pure compounds and pharmacological studies) considering that of the 14 species of Etlingera plants scattered in Southeast Sulawesi, 2 (two) of which have recently been reported, namely E. elatior and E. calophrys
Molecular Docking of Chemical Compounds from n-Hexane Extract of Moringa oleifera Seeds with E.coli and S.aureus ATP Synthase Subunit C Fredy Saudale; Apriono Sutiono; Luther Kadang; Early G. Boelan; Origenes B Kapitan
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.11536

Abstract

The development of new antibiotics is an urgent need amidst the reported increase in bacterial resistance. The n-hexane extracts of Moringa oleifera seeds have been known to have antibacterial effects against E.coli and S.aureus. However, the mechanism of inhibition and the protein from these bacteria targeted by the chemical compounds from n-hexane extracts of Moringa seeds remains elusive. ATP synthase subunit c (ATPase c) plays an important role in the synthesis and hydrolysis of ATP providing energy for bacterial growth. It is an attractive for the new antibiotic development. This study aims to computationally study the interaction between the chemical compound from n-hexane extract of Moringa seeds and ATPase c from E. coli and S. aureus that may shed the light on their inhibitory potentials using molecular docking method. The compound trans-9-octadecenoic acid shows the highest affinity energy with ATPase c from E. coli (-4.1 kcal/mol). Meanwhile, 9-cis-octadecanoic acid and glycerol-1,3-dioctadecanote show the highest interaction (-4.3 kcal/mol) with ATPase c from S.aureus. Nonetheless, these interaction energies are lower than a positive control Tomatidine on ATPase c E.coli (-6.9 kcal/mol) and S. aureus (-6.2 kcal/mol). Further in vitro assays are needed to validate their potential as novel antibacterial candidates.
Dengue Antiviral Activity of n-Hexane and Acetone Extract of X. testudinaria’s Rhizome from Spermonde Islands, South Sulawesi Nur Awaliah
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.11597

Abstract

DHF is a disease that continues to spread in Indonesia and often causes death to sufferers. DHF is caused by the dengue virus which is transmitted by A. aegypty and A. albopictus mosquitoes. Even though there is a vaccine available in Indonesia, its use is still very limited and requires a very large cost, so a solution is needed to find a drug that is effective in inhibiting the dengue virus. The research conducted was related to the assessment of dengue antiviral activity from the sponge extract X. testudinaria originating from the waters of the Spermonde Islands, South Sulawesi. The research stage included the extraction process with the maceration method using alternating n-hexane and acetone solvents, the extract phytochemical test, the extract's toxic activity test against vero cells and the dengue antiviral activity test (DENV2) from the extract. The results of the study obtained evidence that the extract contains steroid and flavonoid compounds. The extract of n-hexane and acetone X. testudinaria had toxic activity against vero cells where the acetone extract with a lower CC50 value of 2.1 μg/mL had stronger toxic properties to cells compared to n-hexane extract with a CC50 value of 21 μg/mL. While the n-hexane extract had very strong inhibitory activity against dengue virus with a low IC50 value of 3.11 μg / mL, and stronger than acetone extract with an IC50 value of 73.1 μg/mL. The SI values ​​of n-hexane and acetone extract respectively showed that the n-hexane extract was more selective with an SI greater than 3, namely 6.75 compared to acetone extract with SI 0.028. This means that the n-hexane extract has more potential to be used as an antiviral drug than the acetone extract

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