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A Caffeic Acid Derivative Potential for Anticancer Drug: Synthesis of N-(piperidinyl)caffeamide and Its Activity against P388 Leukemia Murine Cells Firdaus Firdaus; Nunuk Hariani Soekamto; Syadza Firdausiah; Musrifah Tahar
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.10962

Some esters and amide derivatives of p-hydroxycinnamic acid have anticancer activity. However, the amide compound is more stable to metabolic reactions compared to its ester derivative. In this research, the synthesis of a new compound, namely N-(piperidinyl)caffeamide (M5) and its anticancer activity assay, has been conducted. The compound M5 was synthesized using p-hydroxycinnamic acid and piperidine as starting materials, and the activity assay was carried out against P388 Leukemia Murine Cells by the MTT method. By these methods, the compound M5 was obtained a yellowish crystalline with a melting point of 212-214°C, and it was very active as an anticancer with an IC50 value of 0.861 μg/mL. This compound was more active than the analog compounds previously synthesized.

Effect of Storange Time on the Quality of Shrimp Paste Isdaryanti Isdaryanti; Musrifah Tahar; Ayu Indayanti Ismail
Baselang Vol 2, No 2: OKTOBER 2022
Publisher : Fakultas Pertanian Universitas Muara Bungo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36355/bsl.v2i2.55

Shrimp paste is a product of fermentation that every time it will continue to be degradated by microorganisms. The degradation has a time limit to continue to produce the best quality shrimp paste based on the value of the Indonesian National Standard. The purpose of this study was to determine the quality of shrimp paste up to a storage period of 3 months 7 days. This study was used a randomized block design (RBD) method with different storage times of 7, 37 and 67 days. The quality parameters of shrimp paste used were physicochemical value by measuring pH and salt content and proximate analysis by measuring protein, fat, carbohydrate, ash content and air content. The results were showed that the pH of the shrimp paste was in the alkaline range from 7.72 to 7.33, the proportion of salt content was 5.09%. Proximate analysis were showed protein content (37.05%), fat (3.26%), carbohydrates (4.23%), ash content (19.45%), and air content (36%). Based on the results of this study, it was found that shrimp paste with a storage period of 3 months and 7 days met national standards except for the ash content.

Effect of Storange Time on the Quality of Shrimp Paste Isdaryanti Isdaryanti; Musrifah Tahar; Ayu Indayanti Ismail
Baselang Vol 2, No 2: OKTOBER 2022
Publisher : Fakultas Pertanian Universitas Muara Bungo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36355/bsl.v2i2.68

Shrimp paste is a product of fermentation that every time it will continue to be degradated by microorganisms. The degradation has a time limit to continue to produce the best quality shrimp paste based on the value of the Indonesian National Standard. The purpose of this study was to determine the quality of shrimp paste up to a storage period of 3 months 7 days. This study was used a randomized block design (RBD) method with different storage times of 7, 37 and 67 days. The quality parameters of shrimp paste used were physicochemical value by measuring pH and salt content and proximate analysis by measuring protein, fat, carbohydrate, ash content and air content. The results were showed that the pH of the shrimp paste was in the alkaline range from 7.72 to 7.33, the proportion of salt content was 5.09%. Proximate analysis were showed protein content (37.05%), fat (3.26%), carbohydrates (4.23%), ash content (19.45%), and air content (36%). Based on the results of this study, it was found that shrimp paste with a storage period of 3 months and 7 days met national standards except for the ash content.

Training and Assistance in Making Bokashi Fertilizer for Teachers in Polewali Mandar Regency, West Sulawesi Musrifah Tahar; Ariandi Ariandi; Mesra Damayanti; Ayu Indayanti Ismail; Sufyan Hakim
JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat) Vol 7 No 2 (2023): Jati Emas (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat)
Publisher : Dewan Pimpinan Daerah (DPD) Perkumpulan Dosen Indonesia Semesta (DIS) Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36339/je.v7i2.752

Dry leaves or grass in schools are generally thrown away or burned which has an impact on pollution and environmental pollution. Prevention of this pollution can be done by utilizing the dry leaves/grass into other products that are more useful. The Biology and Science Education Study Program Community Service implementation team in collaboration with the Polewali Mandar District Mobilizing Teacher Community provided training for teachers to be able to process dry leaves/grass in the surrounding environment into bokashi fertilizer. This community service aims to provide knowledge and skills to the community regarding the processing of dry leaves/grass into bokashi fertilizer. This activity was carried out by providing material and the practice of making bokashi fertilizer. Participants in the activity gave a positive response to the implementation of the activity. The results of the lesson indicate that the majority of the participants agreed that the lesson was in line with the topic and that the instructor was capable of providing materials and answering questions appropriately. In addition to that, participants agreed that the course increased the teacher's ability to transform dry leaves/grass in the schoolyard into bokashi fertilizer.

Edukasi Pemanfaatan Lingkungan Rumah melalui Program Tanaman Buah dalam Pot (Tabulampot) kepada Masyarakat desa Balombong Ayu Indayanti Ismail; Meili Yanti; M Irfan; Isdaryanti; Alexander Kurniawan Sariyanto Putera; Nursyamsi SY; Musrifah Tahar
KREATIF: Jurnal Pengabdian Masyarakat Nusantara Vol. 3 No. 2 (2023): Juni : Jurnal Pengabdian Masyarakat Nusantara
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/kreatif.v3i2.1728

An indicator of a good village is having a clean environment and local residents free from all diseases. In addition, local residents have commodities to be more independent in terms of economic development. This is of course not only the responsibility of village officials, but requires the support and cooperation of local residents as well. Therefore it is necessary to make use of the village environment which can realize the indicators previously mentioned. The first step that can be taken is to start with your own yard. Because based on observations, the service team found that in the partner village, namely Balombong village, it had not been used properly and there were empty lands in the residents' yards. So that the purpose of implementing this service is to provide education for residents to be able to take advantage of the yard by planting fruit in pots. This can make the environment more beautiful, healthy and the results can help the local economy

Synthesis of 3-(3,4-diacetoxyphenyl)acrylic acid and 4-(oxo-3-(piperidin-1-yl)pro-1-en-1-yl)-1,2-phenylendiacetate from 3-(3,4-dihydroxyphenyl)acrylic acid and their toxicity test by Brine Shrimp Lethality Test method Musrifah Tahar; Nunuk Hariani Soekamto
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 16, No 1: June 2023
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v16i1.26898

Derivatization 3-(3,4-dihydroxyphenyl)acrylic acid to 3-(3,4-diacetoxyphenyl)acrylic acid (1) and 4-(oxo-3-(piperidin-1-yl)pro-1-en-1-yl)-1,2-phenylendiacetate (3) and its toxicity test has been successfully carried out. Derivatization was carried out through acetylation, chlorination, and amidation reactions. The acetylation reaction was carried out using acetic anhydride in pyridine solvent at room temperature for 4 hours to produce compound 1 as a white amorphous solid with m.p. 181-183oC and yield of 85.68%. The chlorination reaction was carried out using thionyl chloride in toluene solvent at the reflux temperature of 79°C for 4 hours and continued with in situ amidation using piperidine in dichloromethane solvent at room temperature to produce compound 3 as a white crystal with m.p. 139-141oC and yield of 39.45%. The toxicity test of the two compounds against Artemia salina Leach shrimp larvae using probit analysis showed that compounds 1 and 3 were toxic with LC50 values of 8.919 μg/mL and 84.511 μg/mL, respectively. This data shows that the acetylation of 3-(3,4-dihydroxyphenyl)acrylic acid compound (LC50 = 46.50 μg/mL) increases the toxicity to larvae of Artemia salina Leach shrimp. Keywords: 3-(3,4-dihydroxyphenyl)acrylic acid, 3-(3,4-diacetoxyphenyl)acrylic acid, 4-(oxo-3-(piperidin-1-yl)pro-1-en-1-yl)-1,2-phenylendiacetate, Artemia salina Leach.

Etnobotani Tanaman Sebagai Bahan Obat, Bahan Kecantikan dan Kebugaran Di Kabupaten Mamuju Sulawesi Barat Musrifah Tahar; Nurzakinah Nurzakinah; Hairunnisa Ramadani; Nur Ainun
CELEBES BIODIVERSITAS : Jurnal Sains dan Pendidikan Biologi Vol 5, No 2 (2022): Science, Conservation, Biology Education
Publisher : Universitas Patompo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51336/cb.v5i2.433

Etnobotani merupakan ilmu yang mempelajari hubungan manusia dengan alam sekitarnya, dalam penelitian ini bertujuan untuk mengetahui jenis tanaman apa saja yang masyarakat gunakan sebagai obat dan bahan kecantikan. Sebanyak lima belas masyarakat yang berasal dari Kabupaten Mamuju yang berperan sebagai responden. Adapun metode yang digunakan yaiatu metode wawancara dan analisis deskriptif kualitiatif. Hasil yang diperoleh yaitu terdapat 28 jenis tanaman yang digunakan Masyarakat setempat sebagai bahan obat dan kecantikan dengan bagian dan teknik pengolahan yang berbeda-beda pada setiap tanaman.

Eksplorasi Tumbuhan Lokal Asal Budong-Budong Sebagai Obat Traditional, Bahan Kecantikan Dan Kebugaran Tahar, Musrifah; Isdaryanti, Isdaryanti; Wiyarzah, Ice; Mardewi, Mardewi; JA, Puspita Hadriani; Puspa, Rati; Khaerunnisa, Khaerunnisa
Jurnal Ilmu Pertanian dan Perkebunan Vol 5 No 2 (2023): Juli : Jurnal Ilmu Pertanian dan Perkebunan
Publisher : Universitas Gajah Putih

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55542/jipp.v5i2.681

The Budong-Budong community, Topoyo District, Central Mamuju Regency, West Sulawesi Province is known as a community that uses many plants for various functions in their activities. The purpose of this research was to eksplore the types of local plants that used in traditional medicine, beauty and fitness ingredients. This research used descriptive qualitative method with data collection method are carried out by interviewing, observing and literature studying. The results showed that there are 40 types of local plants that were used both as herbal medicines, beauty and fitness ingredients. The parts of the plant used are leaves, flowers, seeds, fruit, skin, rhizomes and tubers. The parts of plants that have the most functions are leaves and fruit.

Pemanfaatan Sabut Kelapa Sebagai Bahan Dasar Pembuatan Pupuk Organik Cair (POC) Ramah Lingkungan di Desa Balombong Tahar, Musrifah; Nur, Syamsiara; Firman, Firman
Sipakaraya : Jurnal Pengabdian Masyarakat Vol 3 No 1 (2024): Sipakaraya : Jurnal Pengabdian Masyarakat
Publisher : Universitas Sulawesi Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31605/sipakaraya.v3i1.4183

Banyaknya sabut kelapa di lingkungan masyarakat umumnya hanya dibuang, dibakar atau dibiarkan dilingkungan. Hal ini akan mengakibatkan terjadinya pencemaran dan kerusakan lingkungan. Permasalahan tersebut dapat dicegah melalui pemanfaatan dan pengolahan sabut kelapa menjadi produk yang lebih bermanfaat dan bernilai ekonomis. Salah satu desa yang mengalami permasalahan tersebut adalah Desa Balombong, Kecamatan Pamboang, Sulawesi Barat. Sehingga pada kegiatan ini akan diberikan pengetahuan dan keterampilan secara langsung kepada masyarakat Desa Balombong terkait pengolahan sabut kelapa menjadi Pupuk Organik Cair (POC). Adapun metode yang diberikan melalui sosialisasi, pemberian materi serta praktik dan pendampingan pembuatan POC secara langsung. Hasil yang didapatkan dari kegiatan ini adalah seluruh peserta merasa sangat setuju pada setiap indikator penilaian yang diberikan dengan capaian persentase masing-masing diatas 80%.

An Antioxidant and Toxicity Test as Anticancer of Jewawut Extract (Setaria italica L.) Local Varieties of West Sulawesi Tahar, Musrifah; Wahid, Masyitha; Hakim, Sufyan
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 17, No 2: December 2024
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v17i2.40506

Jewawut (Setaria italica L.) is a local plant that is widely found and consumed by the people of West Sulawesi. This cereal plant has various benefits, one of which is as an anticancer. So this study aims to determine the antioxidant and anticancer potential of methanol extract of Jewawut (Setaria italica L.). This research includes phytochemical test of secondary metabolites, antioxidant activity test with 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and identification of anticancer potential based on toxicity test with Brine Shrimp Lethality Test (BSLT) method. The results showed that the methanol extract of Jewawut (Setaria italica L.) contained secondary metabolite compounds including alkaloids, flavonoids, tannins, saponins, steroids and terpenoids. The extract has very weak antioxidant activity with an IC50 value of 4104.63 ppm and has potential as an anticancer with a toxicity value (LC50) of 41.65 μg/mL which means the toxicity is very strong.

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