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INDONESIA
Indonesia Chimica Acta
Published by Universitas Hasanuddin
ISSN : 2085014X     EISSN : 26556049     DOI : -
Core Subject : Engineering,
Chemical Engineering, Chemistry & Bioengineering
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of chemistry. The result of research and development in the fields of chemistry in both experimental and theory/ computation, chemical-based technological innovations, and chemical applications in industrial fields. The journal publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Volume 14, No 1: June 2021" : 5 Documents clear
Synthesis and Inhibitory Activity Evaluation of N-butyl-3(4-hydroxyphenyl)acrylamide Against Receptor Tyrosine Kinases (R.T.K.s) hmuddin, amiruddin
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 14, No 1: June 2021
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v14i1.12111

Abstract

Cinnamic acid amide derivatives play an essential role as anticancer agents because of their excellent inhibitory activity against tyrosine kinases. Tyrosine kinases are enzymes that are directly involved in the development of cancer cells. Therefore, to develop a new class of inhibitors, the amide derivative of cinnamic acid has been synthesized from p-coumaric acid to give N-butyl-3-(4-hydroxyphenyl)acrylamide (5). The synthesis stages include acetylation, chlorination, amidation, and deacetylation. The products were characterized by T.L.C. test, melting point determination, FT-IR, 13C-NMR, and 1H-NMR spectroscopy. The inhibitory activity of compound 5 was evaluated against the eight receptor tyrosine kinases (R.T.K.s) using the bioluminescent A.D.P. detection method. The results showed that compound 5 was obtained as a white crystalline solid with a melting point a 140-142°C and 95.45% yield. Of the eight R.T.K.s used, compound 5 only showed feeble inhibitory activity against the three R.T.K.s, namely c-MER, FLT1, and F.M.S., with inhibition percentages are lower than erlotinib. Thus, compound 5 has no potential as a tyrosine kinase enzyme inhibitor.
Antioxidant Activity from synthesis product of Hydoxycinamic Acid Derivative.: Antioxidant Activity from synthesis product of Hydoxycinamic Acid Derivative. Novia, Ni Kadek Ayu
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 14, No 1: June 2021
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v14i1.12271

Abstract

Hydroxycinamic acid derivatives have potential as antioxidants. The synthesis of hydroxycinamic acid derivatives from p-coumaric acid with hexylamine yielded 4-(3-hexylamine-3-oxopropenyl) phenyl acetate compounds. Synthesis is carried out through the acetylation, chlorination, and amidation reaction stages. Amidation products were characterized by TLC test, melting point determination, FT-IR spectroscopy. The antioxidant activity was tested using 1,1-diphenyl picrylhydrazyl (DPPH). The results showed that the compound obtained was a white crystalline solid (yield 15.59%, melting point 104 - 106 °C). Compound 4 only shows very weak antioxidant activity with an IC50 value of 11453.03 μg / mL%. Thus compound 4 has no potential as an antioxidant.
Esterification Reaction of Glycerol to The Derivatives Catalyzed by Amberlyst 36 Aisyah, Aisyah; Rezeki, Rezeki; Firnanelty, Firnanelty; Abubakar, A. Nur Fitriani; Zahra, Ummi; Patunrengi, Iswadi Ibrahim; Nur, Arfiani
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 14, No 1: June 2021
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v14i1.12837

Abstract

Several studies reported the use of acid catalysts of esterification of glycerol to acetin derivatives and amberlysts are no exception. However, among these strong sulfuric acid catalysts, amberlyst 36 is still rarely used and hence challenging to investigate. This study aimed to determine the yield and the selectivity of the esterification reaction of glycerol into acetine derivatives using a 5% of solid catalyst amberlyst 36 at a temperature of 90°C in a reflux system. The conversion value resulting from the reaction was 80.74%, with a selectivity value of 6.8% for triacetin. FTIR and GC-MS data support the monoacetin and triacetin structures. The findings indicate that the simple method and easily obtained catalyst can produce a high yield of acetin derivatives. This method is still possibly optimized to perform maximum yield with high selectivity.
Beta-carotent and Antioxidant Activity of Starfruit Extract Powder (Avverhoa blimbi L) Taufiq, Nuramaniyah; Mus, Rosdiana; Palimbong, Deske
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 14, No 1: June 2021
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v14i1.13214

Abstract

Wuluh starfruit is as a tropical plant that has sour taste but it has high nutritional value. One of wuluh starfruiut antioxidant contents is β-carotene. This research aimed to know β-carotene and test of antioxidant activity on Wuluh starfruit. Method of reseach was observational conducted at Chemistry Laboratory of Ujung Pandang Polytechnic with poject of quantitative test using spectrophotometry UV-Vis. The length of wave (nm) was 480 with 0,066 ABS (Absorban) value to analyze β-carotene level and antioxidant test (IC50) with wave length (nm) of 517. Concentration varian used were 0,1 %, 0,2 %, 04 % dan 0,8 % using spectrophotometry UV-Vis with DPPH solution reagent (1,1-dhipenyl-2-picryhirdazyl). This research indicated that quantitative test using spectrophotometry UV-Vis was obtained 24,99555 ppm β-carotene level and the result of antioxidant test (IC50) to reduce 50 % free radicals in DPPH solution required a dry powder sample contentration of 0,6 %.
Chemical Assessment of Crop Producing Soil: A Study in Tangail Sadar, Bangladesh Muliadi, Muliadi; Afrin, Rezuana; Gazi, Sydur Rahman; Md. Hossain Khan, Abu Abdulla Al-Mamun; Mamun, Shamim Al
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 14, No 1: June 2021
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v14i1.13654

Abstract

Soil is a heterogeneous body and varies in characteristics. Different soils have different requirements for fertilizers, liming, and irrigation and tillage practices depending on the physical and chemical characteristics of soils. The study was conducted to investigate the soil chemical properties of four agricultural areas (Sakrail, Santosh, Porabari and Charabari) of Tangail Sadar, Bangladesh. The values of pH, EC, TOC, total N, K, Ca, Mg and Zn ranged 6.40- 7.85, 0 dsm-1, 0.61- 1.47%, 0.05- 0.131%, 0.11- 0.18 meq/100g, 7.46- 11.26 meq/100g, 2.57- 2.78 meq/100g and 0.78- 1.30 µg/g, respectively. The highest pH level was found in Charabari area indicating almost neutral condition. The highest TOC, total N, Ca and Mg were found in Sakrail area indicating nutrient rich soil in this area. The value of K was highest in Santosh and Charabari areas and Zn level was highest in Santosh area. Significant positive correlations were found between TOC and total N in Santosh area, total N and TOC in Porabari area, Ca and TOC in Charabari area and significant negative correlations were found between Zn and Ca in Porabari area, pH and TOC, pH and Ca and pH and total N in Charabari area. Most of the nutrients were found higher in Santosh and Sakrail areas. So the crop production levels of Porabari and Charabari areas may be hampered due to lack of the essential nutrients.

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