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INDONESIA
Indonesia Chimica Acta
Published by Universitas Hasanuddin
ISSN : 2085014X     EISSN : 26556049     DOI : -
Core Subject : Engineering,
Chemical Engineering, Chemistry & Bioengineering
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of chemistry. The result of research and development in the fields of chemistry in both experimental and theory/ computation, chemical-based technological innovations, and chemical applications in industrial fields. The journal publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 6 Documents
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Search results for , issue "Volume 18, No 2: December 2025" : 6 Documents clear
Secondary Metabolites Compounds And Bioactivity Extract Of Telang Flowers Usman, Usman; Lita Yulianti, Lita Yulianti; Karisa , Apriyani R; Nur , Aliah; Meisya Adelia Salsabilah , Awaliyah
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 18, No 2: December 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i2.44580

Abstract

Indonesia has many medicinal plants that are good for health. Telang flower (Clitoria ternatea L.) is used by the community as a traditional medicine. The purpose of this study is to ascertain what secondary metabolite compounds, antioxidant activity, and toxicity of telang flower extract. Extraction of telang flower was carried out using the maceration method with n-hexane, ethyl acetate, ethanol, and methanol solvents. Antioxidant activity test used 2,2-diphenyl-1-picrylhydrazyl (DPPH), while toxicity to shrimp larvae (Artemia salina) was tested using the Brine Shrimp Lethality Test (BSLT) method. Based on the results of phytochemical tests, telang flowers are understood to include secondary metabolites, such as alkaloids, flavonoids, steroids, triterpenoids, saponins, and phenolics. The antioxidant activity of ethanol extract of telang flower was classified as very strong compared to methanol, ethyl acetate, and n-hexane extracts, with IC50 values of 49.442 ppm, 50.648 ppm, 54.950 ppm, and 59.935 ppm, respectively. Meanwhile, methanol extract showed higher toxicity to Artemia salina than ethanol, et hyl acetate, and n-hexane extracts, with LC50 values of 76.995 ppm, 97.073 ppm, 266.162 ppm, and 297.934 ppm, respectively. Based on these results, ethanol extract of telang flower has antioxidant activity with a very strong category, while methanol, ethyl acetate, and n-hexane extracts are included in the strong category. On the other hand, the toxicity of methanol extracts and n-hexane extracts was not significant. In contrast, the toxicity of methanol and ethanol extracts to Artemia salina was categorized as strong, while the toxicity of ethyl acetate and n-hexane extracts was classified as weak. Telang flowers have potential as an alternative anticancer drug, but further research is needed.
The Development of Bioplastic Research as an Alternative to Conventional Biodegradable Plastics: Bibliometric Analysis Natasha, Febiana; Pardi, Hilfi
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 18, No 2: December 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i2.44595

Abstract

Meningkatnya konsumerisme dan terbatasnya kesadaran masyarakat terhadap penggunaan plastik telah mengakibatkan penumpukan sampah plastik yang signifikan di wilayah pesisir Kepulauan Riau. Contoh nyata adalah tumpukan sampah setinggi 3,5 meter di Pantai Senggarang, dan produksi sampah harian Batam yang mencapai 1.200 ton, dengan kapasitas TPA yang terbatas. Penelitian ini melakukan analisis bibliometrik, yang bertujuan untuk mengidentifikasi tren publikasi dan pola kutipan dalam penelitian bioplastik dari tahun 2020 hingga 2025 untuk memahami dinamika pertumbuhan dan dampak ilmiah bidang ini. Analisis bibliometrik terhadap 990 publikasi bioplastik (2020–2025) dengan 49.801 kutipan dan h-indeks 105 menunjukkan evolusi penelitian dari karakterisasi bahan dasar seperti pati dan selulosa hingga eksplorasi bahan baku inovatif termasuk limbah makanan dan mikroalga. Analisis kepadatan mengungkap bahwa konsep "bioplastik" memiliki intensitas penelitian tertinggi, dengan kaitan signifikan dengan plastik, bio, PLA, dan biopolimer, serta aplikasi praktis seperti pengemasan makanan dan sifat mekanis. Pola temporal menunjukkan bahwa konsep produksi bioplastik, mikroalga, dan degradasi muncul sebagai area penelitian yang signifikan pada tahun 2022. Hal ini menandai pergeseran paradigma dalam penelitian menuju proses produksi berkelanjutan dan peningkatan biodegradabilitas sebagai solusi untuk krisis plastik konvensional.
New Synthesis Method of AuNPs Using Moringa oleifera Extract as Bioreductor and Potential Study as Colorimetric Microplastic Detection Thohir, Muhammad Bakhru; Setyaningrum, Dyah; Saputra, Arya Ananda; Nursaida, Marta Citra
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 18, No 2: December 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i2.44733

Abstract

Nanoparticles are multipurpose materials that have been utilized in the medical, energy, and environmental monitoring fields. The advantage of nanoparticles is that they have unique physicochemical properties such as surface area, optical activity, and surface modifiability. One of the important uses of nanoparticles is for environmental monitoring. This is because the surface of nanoparticles could be modified, and with their small size, they could reach analytes in difficult matrices. However, the synthesis of nanoparticles has been an unsustainable process. Therefore, the synthesis of AuNPs using bioreductors finds its urgency. The aim of this research is to determine the optimum conditions for the synthesis of AuNPs-MO, the character of the synthesized AuNPs-MO, and to study the application of AuNPs-MO for monitoring microplastic pollutants. This research was conducted through the stages of extraction, determination of optimum conditions, characterization, and literature study of the potential of AuNPs-MO as a detector. Determination of optimum conditions was carried out by applying variations in pH and precursor-reducing agent ratio. Characterization of AuNPs-MO was done with FTIR and PSA. In addition, microplastic detection models with AuNPs-MO have been obtained directly and indirectly. From this series of experiments, satisfactory results have been obtained.
Antioxidant and Cytotoxic Activities of Rhizome and Fruit Extracts of Susube (Meistera aculeata (Roxb.) Škorničk. & M.F. Newman) from Southeast Sulawesi. Megawati, Megawati; Alif, Alfiah; Sabandar, Carla Wulandari
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 18, No 2: December 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i2.45144

Abstract

Susube (Meistera aculeata (Roxb.) Škorničk. & M.F.Newman) is one of the species of the zingiberaceae family that grows in Southeast Sulawesi, especially in Konawe Regency. The fruit of this plant is often consumed and used as a cooking spice by the native. Meanwhile, the compounds content and bioactivity of the rhizome and fruit which is a characteristic of the Zingiberaceae family, has never been reported. Therefore, this study aimed to identify compounds contained in the rhizome along with their antioxidant and cytotoxic properties. The research method used is experimental research, starting with qualitative phytochemical screening in ethanol exctract and then continued with antioxidant (1,1-diphenyl-2-picrylhydrazyl or DPPH) and cytotoxicity assay (Brine Shrimp Lethality Test or BSLT). The results of the phytochemical screening indicate that the ethanol extract of the Susube rhizome and fruit contains alkaloids, flavonoids, tannins, terpenoids, and saponins. Antioxidant activity was determined based on the ability to reduce DPPH radicals and was calculated by determining the IC50 value, while toxicity was assessed based on shrimp larvae mortality and calculated by determining the LC50 value. The study results show that the IC50 values for the ethanol extract of Susube rhizome, fruit and the positive control ascorbic acid are 4.9 µg/mL, 4,5 µg/mL and 2.2 µg/mL, respectively. Meanwhile, the LC50 values for the ethanol extract of Susube rhizome, fruit, and the positive control potassium bichromate are 578 µg/mL, 958 µg/mL, and 2.8 µg/mL, respectively. Based on these results, it can be concluded that the ethanol extract of Susube rhizome and fruit (Meistera aculeata (Roxb.) Škorničk. & M.F.Newman) exhibits toxic effects on shrimp larvae (≤1,000 mg/L). Additionally, its ethanol extract shows very strong antioxidant effects in scavenging DPPH free radicals. Therefore, this study suggests that the Susube rhizome and fruit extract warrants further investigation as a promising candidate for treatment or prevention of diseases, supporting the potential of Southeast Sulawesi's local natural resources for phytopharmaceutical or herbal medicine
The Effect of Contact Time of Javabark Adsorbent (Lannea coromandelica ( houtt.)merr) on Cd (II) Adsorption Capacity Musrifah, Linda Ayu; Widwiastuti, Hanandayu; Asworo, Riska Yudhistia
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 18, No 2: December 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i2.46432

Abstract

According to Indonesian Minister of Health Regulation No. 2 of 2023, the maximum limit for cadmium in bottled water is 0.003 mg/L. In this study, tannin biosorbents were used from the extraction of Javanese bark. Javanese bark contains tannin compounds that have the potential to bind heavy metals. This study aims to determine the effect of varying contact times of Java wood bark biosorbent on the adsorption capacity of Cd (II). The method used is an experiment to study the effect of contact time of Java wood bark biosorbent on the adsorbate. The contact times used for the Java wood bark biosorbent were 20, 40, 60, 80, 100, 120, 140, and 160 minutes. The residual Cd (II) concentration in the solution was determined using a UV-Vis spectrophotometer. The adsorption capacity of Cd (II) at contact times of 20, 40, 60, 80, 100, 120, 140, and 160 minutes was 0.073; 0.075; 0.078; 0.079; 0.116; 0.060, 0.052; 0.035 mg/g. From the results of the study, it can be concluded that the longer the contact time of the biosorbent in the adsorption of Cd (II) metal, the adsorption capacity will increase until it reaches the optimal contact time. After reaching the optimal contact time, adsorption decreases due to the desorption process. In this study, the optimal contact time for Java wood bark biosorbent was obtained at 100 minutes with an adsorption capacity of 0.116 mg/g. Keywords:Tannin;Cadmium;Adsorption;Biosorbent;Javabark;
In Silico Investigation of 2-Anilino 4-Amino Substituted Quinazolines as Potential Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase Aurellyallodia Faiza Kusuma; Muhammad Farhan Shadiq; Rizarullah; Reza Aditama; Trina Tallei; Masduki, Fifi Fitriyah
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 18, No 2: December 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70561/ica.v18i2.48260

Abstract

Malaria continues to present significant global health challenges due to emerging resistance against conventional antimalarial drugs, necessitating novel therapeutic agents targeting Plasmodium falciparum. Dihydroorotate dehydrogenase (DHODH) is a crucial target in antimalarial drug development due to its essential role in pyrimidine biosynthesis within Plasmodium species. This study aimed to evaluate several candidate compounds from previous study - namely ligand 56, 65, 89 and 90 - as potential DHODH inhibitors using in silico methods, including molecular docking and molecular dynamics (MD) simulations. Molecular docking was performed using AutoDock Vina against the DHODH receptor structure (PDB ID: 4CQ8). The results indicated that ligand 89 exhibited the highest binding affinity (-9.575 kcal/mol), followed by ligands 90, 56, and 65, all demonstrating superior affinity compared to the control compound chloroquine (-7.462 kcal/mol). Interaction analyses revealed the formation of hydrogen bonds with key residues HIS185, GLY181, and ARG265, along with significant pi-sulfur interactions involving residue CYS184, thereby stabilizing the ligand interactions within the DHODH active site. Pharmacokinetic evaluations conducted using SwissADME revealed that all candidate ligands met Lipinski's rule and demonstrated high gastrointestinal absorption, despite their generally low solubility. MD simulations conducted over 100 ns at 300 K showed that all ligand-DHODH complexes, maintained stability, with Root Mean Square Deviation (RMSD) values ranging between 1.0 and 3.5 Å throughout the simulation. Overall, the findings suggest that ligand 89 and other evaluated ligands hold significant potential for further development as DHODH inhibitors in the pursuit of novel antimalarial drug candidates.

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