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Nusantara Medical Science Journal
Published by Universitas Hasanuddin
ISSN : 24609757     EISSN : 25977288     DOI : -
Core Subject : Science,
Materials Science & Nanotechnology Neuroscience
Nusantara Medical Science Journal (NMSJ) is an open access, peer-reviewed journal published by Faculty of Medicine, Hasanuddin University twice a year in June and December. NMSJ encompasses all basic and molecular aspects of medical sciences, with an emphasis on the molecular studies of biomedical problems and molecular mechanisms. Subjects suitable for publication include, but are not limited to the following fields of Cardiovascular; Allergy and immunology; Cancer and stem cells; Endocrinology; Gastroenterology; Tropical and Infectious Disease; and Internal medicine.
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Articles 6 Documents
 1 
Search results for , issue "Volume 9 Issue 2, July - December 2024" : 6 Documents clear
The Cure Rate of COVID-19 Patients with Comorbid Hypertension Giri, Made Widiantara; I Made Subhawa Harsa
Nusantara Medical Science Journal Volume 9 Issue 2, July - December 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.33144

Abstract

Introduction: Coronavirus Disease 2019 (COVID-19) is an outbreak that has resulted in a global pandemic. In 2020, 185 countries were affected, and more than 3,000,000 cases have been reported worldwide, with more than 210,000 deaths. COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2), an RNA virus that can cause respiratory system disorders. Hypertension, commonly called high blood pressure, is a health problem that often occurs in the community because its prevalence is relatively high throughout the world. Approximately 7.5 million deaths, or 12.8% of all annual deaths in the world, are caused by hypertension. Generally, the presence of comorbid hypertension in COVID-19 can worsen the patient's condition. Methods:  This literature review study aims to determine the recovery rate of COVID-19 patients with comorbid hypertension. Journals in this literature review used three databases, including Google Scholar, PubMed, and Science Direct, using the keywords COVID-19 with Hypertension and COVID-19 with Hypertension. The literature search was adjusted based on the inclusion and exclusion criteria. Results: The search results obtained 25 journals consisting of 4 national journals and 21 international journals. The results showed that the average recovery rate for COVID-19 patients with comorbid hypertension was 75.40%. Factors influencing the recovery rate of COVID-19 patients with comorbid hypertension include ACE-2, ACEI/ARBs, age, male, and cytokines. Conclusions:  It can be concluded that the presence of comorbid hypertension affects the recovery rate of COVID-19 patients.
Potential of Cat’s Whisker (Orthosiphon stamineus B) As Antidiabetic in Traditional Medicine of The Dayak Tribe in West Kalimantan : A Literature Review Hartono Putra, Galih Abisatya; Andayani, Sari; Qisthi, Dianelita Asyifa; Aurelion, Candra; Mochammad, Taufiq; Zakiah, Mistika; Assegaf, Syarifah Nurul Yanti Rizki Syahab
Nusantara Medical Science Journal Volume 9 Issue 2, July - December 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.37072

Abstract

Introduction: Diabetes mellitus or better known as diabetes is a disease characterized by the body's inability to produce insulin or the inability to use insulin (insulin resistance). The high prevalence of diabetes sufferers in Indonesia requires attention and treatment, especially through medication. One of Indonesia's advantages compared to other countries is the biodiversity and cultural diversity sector in Indonesia, namely medicinal plants. The cat's whisker plant (Orthosiphon stamineus B) can be an alternative treatment for treating complications of diabetes mellitus. Cat's whisker leaves contain orthosiphon glucose, saponins, essential oils, flavonoids, polyphenols, potassium salts and myoinositol, several substances contained in this plant have the potential to lower blood sugar levels. Methods: This writing is a literature review by collecting literature from English and Indonesian language articles from 2014-2024, most of which are research articles. Results: The search using the keywords, resulting in a final total of 5 articles to be included in the literature review. Conclusion:  This research reveals that cat's whiskers (Orthosiphon stamineus B) show potential as an effective antidiabetic agent. Treatment with Orthosiphon stamineus B extract significantly reduced blood glucose levels, increased insulin secretion, and increased ghrelin and GLP-1 levels, all of which contribute to glucose regulation
Twin Reversed Arterial Perfusion Sequence (TRAPS): A Case Report Astari, Prilly; Efendi Lukas
Nusantara Medical Science Journal Volume 9 Issue 2, July - December 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.42368

Abstract

Introduction and importance: Acardiac twins are a complication of monozygotic twin pregnancies. Twin Reversed Arterial Perfusion Sequence (TRAPS) is reported to occur in approximately 1% of monochorionic twin pregnancies and 1 in 35,000 pregnancies. The objective is to provide a brief description of acardiac twins. Presentation of case: A 25-year-old multigravida, 35/36 weeks of twin pregnancy. On ultrasound examination of acardiac twins, no heart structure, head bones, and sternum were found, and the shape of the fetus was unclear. Vaginal delivery was carried out; the first live female baby was born, followed by the acardiac baby. The acardiac baby is seen to have imperfect development of the head and upper extremities, Spina bifida, deformity of the lower extremities, Phocomelia of the lower limb, and Split foot. After 9 days, the baby's condition improved, and she was allowed to go home. Discussion: TRAPS's etiology and pathophysiological mechanisms are still poorly understood. Ultrasound findings show an absent or non-functioning heart in one twin, malformation with cystic hygroma, and generalized edema. The first baby (donor twin) was born prematurely, weighing 2200 grams, and there were no signs of heart failure, while the second baby (acardiac) was born weighing 1050 grams. Current therapy for acardiac twins aims to prevent congestive heart failure in the donor twin and stop blood flow to the acardiac twin. Conclusions: Early diagnosis of abnormalities in monochorionic pregnancy using ultrasound in the first trimester plays a role in assessing the prognosis for the viability of the pregnancy.
Perioperative Pediatric Transfusion Strategy Ahmad Nur Islam; Elizeus Hanindito; Muhammad Ramli Ahmad; Maman Surya Permana; Hanna Aulia Namirah
Nusantara Medical Science Journal Volume 9 Issue 2, July - December 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.42398

Abstract

Introduction: In the modern healthcare system, blood transfusion is an essential treatment that plays a significant role in the clinical improvement of adult and pediatric patients. Given the physiological and hematological differences between children and adults, careful planning and an individualized approach are essential to maximize its effectiveness and avoid serious side effects. Method:  A thorough review of the literature was performed, utilizing PubMed, Embase, and the Cochrane Library, to gather evidence on pediatric perioperative transfusion practices. The search encompassed studies published between 2013 and 2024, employing a combination of terms and free-text keywords, as well as Boolean operators, to refine the results. Conclusion: Intraoperative blood loss in pediatric patients requires special attention with an approach that includes pre to postoperative management. This approach must be adapted to the anatomical and physiological differences of children compared to adults. Research, development of universal transfusion strategies, and education and training for medical personnel are essential to improve blood management and prevention of complications.      
Surgical Treatment Of Pendred Syndrome With Thyroid Nodule: A Case Report Ferianto, Djonny; Syamsu, Salman Ardi; Sapan, Vannes Caesar Palebangan; Indra; Sampepajung, Elridho; Pieter Jr, John
Nusantara Medical Science Journal Volume 9 Issue 2, July - December 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.42770

Abstract

Introduction and importance: Pendred syndrome (PS) is a genetic disease inherited in an autosomal recessive pattern. In PS patients, the ability of thyroid gland to accumulate iodide in the follicle lumen is disrupted, causing insufficient thyroid hormone synthesis and goiter to occur as compensation. However, this symptom does not often appear, as goiter is only detected in 30–75% of PS patients. Presentation of case: A 33-year-old Buginese man complained of a painless mass in the neck. In the past 3 months, the mass has shown rapid growth, followed by symptoms of agitation, irritability, and hyperhidrosis. The patient was previously diagnosed with nodular goiter and was taking Levothyroxine. Furthermore, there was a history of the same disease in the patient’s grandmother and younger sibling. Physical examination showed grade III goiter (WHO criteria) with hard consistency and no palpable nodules. Laboratory tests showed routine blood tests, kidney and liver function in normal limits, 1.14 ng/dL FT4, free triiodothyronine level of 6.07 pg/dL, and 2,401 mIU/L TSH level. Chest X-ray results showed tracheal narrowing at the level of the superior thoracic aperture. Similarly, thyroid USG showed that the size of the right lobe was enlarged and anechoic. CT (Computerized Tomography) scan of the cervix showed diffuse enlargement in each lobe and the patient was diagnosed with PS. Right isthmolobectomy and thyroid biopsy were carried out and pathological anatomical examination results showed thyroid follicular nodular disease with cystic degeneration. After surgery, thyroxine hormone replacement therapy was continued. Discussion: Surgical intervention strategies may be employed to inhibit the advancement of disease and mitigate thyroid enlargement, consequently decreasing the likelihood of obstruction and malignancy. Conclusions: In cases of PS with large thyroid nodules pressing on the trachea, isthmolobectomy was carried out to obtain good results and no recurrence.
The Immunoreactivity of recombinant protein MPT63 Mycobacterium tuberculosis as serodiagnostic tuberculosis Fidhatami, Ian Imanuel; R Agus; M N Massi
Nusantara Medical Science Journal Volume 9 Issue 2, July - December 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.42583

Abstract

Introduction: Mycobacterium tuberculosis protein-63 (MPT63) is an extracellular protein encoded by the Rv1926c gene with a size of 16 kDa. MPT63 can specifically induce macrophage activation, stimulate cytokine production (TNF-α and IL-6), and stimulate Th1 cells. The immunogenic properties of MPT63 can be concluded from the presence of a high density of T cell epitopes in the N-terminal immunodominant. This research aims to emphasize and determine the antibody response from the administration of the MPT63 antigen as a candidate in active TB serodiagnostic testing. Methods:  This type of research is quantitative and is a diagnostic study. Serum samples were taken from Hasanuddin University Hospital stored biological material with 10 for healthy serum and 36 for sick serum. The determination of optical density values ​​is based on the results of the ELISA reader.  The determination of optical density values ​​is based on the results of the ELISA reader. Sensitivity and specificity were tested using the Mc Nemar formula and then they calculated the sensitivity and specificity values ​​manually. Results:  Based on the interpretation of the ELISA test from the MPT63 antigen, the antibody reaction response was obtained for a sensitivity of 50% and a specificity of 58.33%. Conclusions: Antibody responses to an antigen that is used indicate that all samples successfully respond well to the serum antigen in the serum of healthy and active tuberculosis but have a sensitivity that is still lacking.

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