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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 422 Documents
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Comparative Effects of Monday–Thursday and Daud Fasting Regimens on Serum Testosterone Levels in Male Wistar Rats (Rattus norvegicus) Nanda Fadhilah Witris Salamy; Wiwik Winarningsih; Nur Intania Puteri Kusnandar; Zamirah Mabarroh El Haque
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.323

Abstract

Introduction. Intermittent fasting has attracted increasing attention because of its metabolic and endocrine benefits. However, evidence regarding the effects of non-daily fasting regimens, particularly Monday–Thursday fasting and Daud fasting, on male reproductive hormones remains limited. This study compared the effects of these regimens on serum testosterone levels in male Wistar rats. Methods. A true experimental study with a post-test-only control group design was conducted using 27 healthy male Wistar rats (Rattus norvegicus). Animals were randomly assigned to a control group, a Monday–Thursday fasting group, or a Daud fasting group (n = 9/group). The fasting groups underwent 12-hour daily feeding restriction (18:00–06:00) for 21 days, comprising six and ten fasting days, respectively. Serum testosterone levels were measured using ELISA and analyzed by one-way ANOVA followed by Tukey's post hoc test. Results. Mean serum testosterone concentrations were 15.003 ± 3.55 mg/dL in the control group, 11.682 ± 3.05 mg/dL in the Monday–Thursday fasting group, and 8.501 ± 1.31 mg/dL in the Daud fasting group. Significant differences were observed among groups (p < 0.001). Both fasting groups showed significantly lower testosterone levels than the control group (p = 0.049 and p < 0.001), whereas no significant difference was found between the two fasting regimens (p = 0.061). Conclusion. Both Monday–Thursday fasting and Daud fasting for 21 days were associated with reduced serum testosterone levels in male Wistar rats. Further studies should control energy intake and evaluate hormonal and metabolic biomarkers to clarify the underlying mechanisms.
Optimization of Vulvovaginal Candidiasis Induction in Rattus norvegicus using Estradiol Benzoate: A Preliminary Study Dariatul Janah; Andi Yasmon; Ibnu Agus Ariyanto
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.345

Abstract

Introduction. Approximately 75% of women of reproductive age have opportunistic vaginal infection with Candida albicans at least once in their lifetime, which is known as vulvovaginal candidiasis (VVC). The increasing global prevalence and emergence of antifungal agents underscore the importance of research into effective prevention and treatment. In vivo studies using rats are commonly conducted, as they provide valuable knowledge on reproductive diseases in humans such as VVC. Methods. Pseudoestrus was induced in wistar rats by subcutaneous injection of estradiol benzoate at doses of 0.1 and 0.2 mg/rat/week. Cytologic observation using vaginal smear staining is used to detect cornified epithelial cells and leukocytes. VVC was induced by intravaginal administration of Candida albicans ATCC10231 (0.5 and 1.0 McFarland) daily for 5 consecutive days. VVC confirmation by microscopic detection of Candida albicans pseudohyphae from vaginal swabs, supported by viability testing of vaginal lavage cultures. Results. Pseudoestrus induction was optimal at a dose of 0.2 mg/rat/week, as both animals were maintained in this phase for 3 consecutive days. Furthermore, an inoculum of 1.3×107 CFU/mL (McFarland standard 1.0) administered for 5 days successfully induced VVC in both animals. Microscopic confirmation revealed intracellular pseudohyphae, supported by the growth of viable Candida albicans from vaginal lavage cultures. Conclusion. The optimal estradiol benzoate protocol for pseudoestrus induction was 0.2 mg/rat/week, and pseudoestrus was maintained for 3 days without ovariectomy. The optimal VVC rat model was established using intravaginal Candida albicans at 1.3×107 CFU/mL for 5 days, with viability from lavage cultures of 1.3×102 CFU/mL and 0.3×102 CFU/mL.

Page 43 of 43 | Total Record : 422

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