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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 405 Documents
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Dasatinib as a Potential Targeted Therapy for Chronic Pancreatitis: A Narrative Review of Macrophage-PSC Interactions Purnomo, Anton; Suyata
Biomedical Journal of Indonesia Vol. 11 No. 3 (2025): Vol 11, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i3.280

Abstract

Chronic pancreatitis is a long-term inflammatory condition affecting the pancreas, with progression worsening over time. One of the effects of this disease is the formation of scar tissue, which can permanently damage the pancreas and disrupt its functions, both exocrine and endocrine. Chronic pancreatitis can result in various serious complications and even be fatal. In the effort to treat chronic pancreatitis, therapies targeting macrophages have begun to attract attention as an innovative approach. One of the drugs in the spotlight is dasatinib, a tyrosine kinase inhibitor, which has shown the ability to alter the inflammatory response by affecting the macrophage population in the pancreatic microenvironment. This literature review aims to dig deeper into the role of dasatinib in the treatment of chronic pancreatitis and explain the pathophysiology of this disease, especially how macrophage activation contributes to the inflammatory process, as well as the therapeutic effects of dasatinib, we can find new insights to develop more effective treatment strategies.
Determinant Factors Influencing Malaria Incidence in an Endemic Area of Sumbawa, Indonesia Hasifah, Herni; Rinenggantyas, Nikodimus Margo
Biomedical Journal of Indonesia Vol. 11 No. 3 (2025): Vol 11, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i3.276

Abstract

Introduction. Indonesia still records the incidence of malaria every year, as several malaria cases still occur in the country. Contributing factors and community aspects have a noteworthy effect on any malaria elimination activities. Methods. This study is a correlational study with a cross-sectional time approach. The population in this study were 59 respondents in Ropang sub-district, Sumbawa. The sampling technique used was simple random sampling. Bivariate analysis of statistical tests used was logistic regression. Results. There are two variables that have a significant effect on the incidence of malaria, namely knowledge and preventive behavior. The knowledge variable had a significance value of 0.019 (p < 0.05), and an odds ratio value of 0.235. The preventive behavior variable also showed a significant influence on malaria incidence with a significance value of 0.008 (p < 0.05). Meanwhile, the perception variable did not show a significant effect on the incidence of malaria, with a significance value of 0.359 (p> 0.05). Conclusion. The results of this study showed that knowledge and preventive behavior had a significant effect on the incidence of malaria in respondents, while perception did not show a statistically significant relationship. These findings provide a new contribution to the understanding of the determinants of malaria prevention behavior in the study area.
The Role of Immunity in The Epidemiology of Adolescent Syphilis Kwarta, Cityta Putri; Fathiyyah, Nurul; Ganisia, Ainun; Imeldawati, Rakhmalia
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026 (In Press)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.233

Abstract

Introduction. Syphilis is a sexually transmitted infection (STI) caused by the bacterium Treponema pallidum and remains a global health problem with a significant increase in prevalence. Adolescents are vulnerable to syphilis because they lack sufficient sexual health information and services. This study aims to explore the role of cellular immune response in the pathogenesis of syphilis in adolescents and the factors that influence it. Methods. This research study adopted a systematic literature review methodology, sourcing data from PubMed, Scopus, Web of Science, and Google Scholar databases. Results. The results demonstrate a crucial involvement of macrophages, dendritic cells, and T lymphocytes in the cellular immune response against Treponema pallidum causes Syphilis. The immune response is principally influenced by variables such as age, nutritional status, and the presence of HIV infection. High infection rates are also attributable to factors such as risky sexual behaviour and socioeconomic conditions. Enhanced interventions, including comprehensive sexual health education and improved access to healthcare services, are crucial for mitigating the adverse effects of syphilis in adolescents. Conclusion. In conclusion, this research underscores the necessity of a deeper understanding of the immunopathogenic mechanisms of syphilis in adolescents to facilitate the development of more effective preventive, diagnostic, and therapeutic strategies.
The Effect of Maternal Separation on Anxiety Behavior in of White Mice (Mus Musculus L.) Male Swiss Webster Strain Santoso, Budi; Putri, Siti Sarahdeaz Fazzaura; Zulissetiana, Eka Febri; Hasbi, Alfian; Luthfiyyah, Alvita Putri; Triastuti, Nada
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026 (In Press)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.241

Abstract

Introduction. Maternal separation (MS) is a commonly utilized model of early-life stress to explain the influence on brain development and psychological behavior. MS has been demonstrated to elevate the likelihood of developing anxiety disorders as a consequence of alterations in hypothalamic- pituitary-adrenal (HPA) functionality and neurotransmitter levels. This study aimed to evaluate the impact of maternal separation (MS) duration on anxiety behavior in male Swiss Webster strain white mice (Mus musculus L.). Methods. The study used a true experimental method with a posttest- only control group design.  A total of 28 male mice aged 2 days were randomly assigned to one of four groups: a control group that did not undergo maternal separation (MS) and three MS treatment groups with a duration of 2 hours, 4 hours, and 6 hours per day for 21 days. Anxiety behavior was evaluated using the Elevated Plus Maze (EPM), with the number and duration of entries into the closed and open arms serving as the primary analysis metrics. The data were analyzed using one-way ANOVA and post-hoc LSD statistical tests. The duration of MS significantly impacted the anxiety behavior of the mice. Results. The MS groups of 2, 4 and 6 hours demonstrated a notable increase in the number and duration of entries into the closed arm in comparison to the control group (p < 0.05), which is indicative of increased anxiety. In contrast, the number of entries into the open arm decreased in the 6 h MS group compared to the control. Conclusion. The results indicated that MS negatively affected the anxiety behavior of mice, with longer duration exacerbating the trend.
Physical Activity and Body Composition Profiles in Elderly Individuals: Insights from a Community-Based Study Sayisvir, Nadia Farah; Kurniati, Ardesy Melizah; Santoso, Budi; Husin, Syarif; Amalia, Ella; Izzulhaq, Muhammad Agung
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026 (In Press)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.251

Abstract

Introduction. Obesity and sarcopenia are two metabolic disorders that can result from an increase in body fat and a reduction in muscle mass that are not balanced by enough physical exercise.  The goal of this study was to examine whether there is a link between physical activity and body composition in the elderly.  Methods.  This cross-sectional study was carried out in the elderly community of RSUP Dr. Mohammad Hoesin Palembang from October to November 2019.  The study's sample consisted of older persons over the age of 60 who were able to speak clearly and carry out daily tasks independently.  Respondents who agreed to participate signed informed consent. Physical activity data were collected by PASE questionnaire interviews, and body composition was measured using the BIA Tanita.  Results.  The Chi-Square test was used in all analyses.  In this study, there were 94 old people: 12 men and 82 women.  Physical activity was found to have a significant link with muscle mass (p=0,001) as well as fat mass (p=0,001).  Conclusion.  There is a strong link between physical activity and body composition in the elderly. Physical activity data were obtained through interviews based on the PASE questionnaire and body composition measurements using the BIA Tanita.
Diagnosis and Management of Carcinoma of the Larynx Hedianto, Tri; Fadhlina, Afia Nuzila; Radiansyah, Riva Satya
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026 (In Press)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.286

Abstract

Introduction. Laryngeal carcinoma is a major malignancy of the head and neck, with a global incidence of 58.67%. This malignancy commonly affects men over the age of 50 with a significant history of smoking. The diagnosis is frequently delayed until advanced stages, especially in low-resource settings. The study aimed to present a case series of laryngeal carcinoma and evaluate the diagnosis and management. Method. A case series and literature review involving patients diagnosed with laryngeal carcinoma who underwent assessment through to definitive treatment. Results. We report four male patients aged 51–67 years who presented with longstanding hoarseness and respiratory distress. All underwent tracheotomy followed by micro-laryngoscopic biopsy, which confirmed squamous cell carcinoma. Tumor staging was determined via CT imaging ranging from T2N0M0 to T4aN2M0. Treatment for all patients consisted of total laryngectomy combined with either selective or modified radical neck dissection. Histopathology revealed well to moderately differentiated squamous cell carcinoma in each case. Postoperative outcomes were favourable, with no major early complications. Conclusion. The diagnosis and management of laryngeal carcinoma remain challenging, particularly in resource-limited settings. Early detection is crucial for improving treatment outcomes and overall prognosis. Enhancing public awareness, strengthening multidisciplinary approaches, and expanding diagnostic infrastructure are essential to optimize patient care and survival.
Serum Creatine Kinase-MB Levels in Elderly Patients After Hemorrhagic and Ischemic Stroke Without a History of Heart Disease Daba, Mariel; Ferdyastari, Nathasya
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026 (In Press)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.287

Abstract

Introduction. Elevations in cardiac biomarkers such as creatine kinase-MB (CK-MB) have been reported in stroke patients, even without clinical signs of heart disease. CK-MB, a cardiac-specific isoenzyme, indicates myocardial stress or injury. Exploring CK-MB dynamics in elderly post-stroke patients may provide insights into cardiovascular risk and prognosis. Methods. This comparative analytical cross-sectional study involved two groups of stroke patients admitted to Sentra Medika Hospital, Cikarang: hemorrhagic stroke (n=8) and ischemic stroke (n=8), totaling 16 participants. Inclusion criteria were age ≥60 years, stroke history within 3–6 months, and no cardiovascular disease based on medical records. Venous blood samples were collected to measure serum CK-MB levels using ELISA. Data were analyzed with an independent sample t-test. Results. A significant difference in mean CK-MB levels was observed (p=0.03). The hemorrhagic group had a mean CK-MB of 29 U/L, while the ischemic group had 26 U/L. Both values exceeded the reference level of <25 U/L, showing elevated CK-MB in both stroke types. Conclusion. Serum CK-MB levels were significantly elevated in elderly patients after hemorrhagic and ischemic stroke compared with normal values, suggesting CK-MB as a potential clinical marker in post-stroke patients.
Regenerative Roles of the Cyclooxygenase-2 Pathway in Neovascularization and Stem Cell Regulation: A Brief Perspective from In Vitro and In Vivo Studies Puspadewi, Melati; Dewi, Syarifah
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026 (In Press)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.288

Abstract

Cyclooxygenase-2 (COX-2) is a key enzyme in prostanoid production and is best known as a mediator of the inflammatory response. Beyond this well-established role, COX-2 also contributes to tissue regeneration by promoting neovascularization and supporting stem cell recruitment, proliferation, and differentiation. Despite this, research on harnessing the COX-2 pathway as a therapeutic tool, rather than solely as a target for inhibition, remains limited, presenting a promising avenue for future studies. In this review, we summarize current insights from both in vitro and in vivo models into COX-2 signaling in tissue regeneration, focusing on molecular mechanisms through which its downstream mediators, especially prostaglandin (PGE2), regulate vascular formation, tissue growth, and stem cell function. We also briefly outline the dual nature of these processes, which can either facilitate repair or drive pathological outcomes, and discuss emerging strategies for achieving controlled therapeutic applications.
Hypolipidemic Effect of Galoba Fruit (Hornstedtia sp.) Extract on LDL-Cholesterol in Hypercholesterolemic Mice Rahmah, Nadia Fathiyatur; Agustin, Rachmawati; Latief, Rahmi; Sanaky, Marliyati; Latuconsina, Vina Zakiah; Sulfiana
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026 (In Press)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.289

Abstract

Introduction. Elevated low-density lipoprotein cholesterol (LDL-C), particularly in its oxidized form, contributes to atherosclerosis and increases the risk of cardiovascular disease. Galoba fruit (Hornstedtia sp.) contains antioxidant phytochemicals that may support lipid regulation. This study evaluated the hypolipidemic effect of Hornstedtia sp. extract in hypercholesterolemic mice. Methods. Twenty-five male mice were randomly assigned to five groups: normal control (KN), negative control (K–, high-fat diet only), positive control (K+, simvastatin 10 mg/kg BW), and two treatment groups receiving Galoba fruit extract at doses of 200 mg/kg BW (P1) and 400 mg/kg BW (P2). Hypercholesterolemia was induced with a high-fat diet, and the extract was prepared by ethanol maceration. Because of limited serum volume, LDL-C levels were estimated indirectly using the Anandaraja equation based on total cholesterol and triglyceride concentrations. Results. LDL-C levels decreased in the extract-treated groups compared with the negative control. The Kruskal–Wallis test showed significant differences among groups (p < 0.05; overall p = 0.000). The greatest reduction was observed in P1 (11.90 mg/dL), followed by P2 (16.60 mg/dL), although neither exceeded the effect of K+ (7.90 mg/dL). Conclusion. Hornstedtia sp. extract demonstrated potential in lowering LDL-C in hypercholesterolemic mice, suggesting its role as a natural adjunct for lipid control. However, the use of indirect LDL-C estimation and the small sample size warrant cautious interpretation. Further studies with direct lipid profiling and mechanistic exploration are recommended before translational application.
Inflammatory Markers and Diabetic Foot: Their Role in Type 2 Diabetes Patients at H. Adam Malik Hospital Siregar, Syahrozad Fuadah; Zubir, Zuhrial; Syafril, Santi
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026 (In Press)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.292

Abstract

Introduction. Diabetic foot is a severe complication of type 2 diabetes mellitus, resulting from chronic hyperglycemia, vascular disorders, neuropathy, and infection. Inflammatory markers such as C-Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESR), fibrinogen, and D-dimer reflect inflammation and coagulation that worsen diabetic foot conditions. However, data from the local population in Medan remain limited. Methods. This cross-sectional study was conducted at H. Adam Malik General Hospital, Medan, from May to June 2025. Participants were hospitalized patients with type 2 diabetes mellitus, both with and without diabetic foot, recruited by consecutive sampling. Inclusion criteria were patients ≥18 years with type 2 diabetes, with or without diabetic foot (grade II–V). Exclusion criteria included chronic diseases (HIV, malignancy, autoimmune), concurrent infections, use of anticoagulants, NSAIDs, steroids, hormones, immunomodulators, pregnancy, or incomplete records. Data on demographics, HbA1c, CRP, ESR, fibrinogen, and D-dimer were analyzed with significance set at p<0.05. Results. A total of 63 patients were included. BMI showed a significant association with diabetic foot (p<0.05), while age, sex, and HbA1c did not. Levels of CRP, ESR, fibrinogen, and D-dimer were significantly higher in patients with diabetic foot than those without (p=0.001). CRP was also significantly associated with ulcer severity based on Wagner classification. Conclusion. CRP, ESR, fibrinogen, and D-dimer were elevated in diabetic foot patients, with CRP as the strongest predictor of ulcer severity. Monitoring these markers is essential for risk assessment and management of diabetic foot in type 2 diabetes.

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