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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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Dasatinib as a Potential Targeted Therapy for Chronic Pancreatitis: A Narrative Review of Macrophage-PSC Interactions Purnomo, Anton; Suyata
Biomedical Journal of Indonesia Vol. 11 No. 3 (2025): Vol 11, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i3.280

Abstract

Chronic pancreatitis is a long-term inflammatory condition affecting the pancreas, with progression worsening over time. One of the effects of this disease is the formation of scar tissue, which can permanently damage the pancreas and disrupt its functions, both exocrine and endocrine. Chronic pancreatitis can result in various serious complications and even be fatal. In the effort to treat chronic pancreatitis, therapies targeting macrophages have begun to attract attention as an innovative approach. One of the drugs in the spotlight is dasatinib, a tyrosine kinase inhibitor, which has shown the ability to alter the inflammatory response by affecting the macrophage population in the pancreatic microenvironment. This literature review aims to dig deeper into the role of dasatinib in the treatment of chronic pancreatitis and explain the pathophysiology of this disease, especially how macrophage activation contributes to the inflammatory process, as well as the therapeutic effects of dasatinib, we can find new insights to develop more effective treatment strategies.
Determinant Factors Influencing Malaria Incidence in an Endemic Area of Sumbawa, Indonesia Hasifah, Herni; Rinenggantyas, Nikodimus Margo
Biomedical Journal of Indonesia Vol. 11 No. 3 (2025): Vol 11, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i3.276

Abstract

Introduction. Indonesia still records the incidence of malaria every year, as several malaria cases still occur in the country. Contributing factors and community aspects have a noteworthy effect on any malaria elimination activities. Methods. This study is a correlational study with a cross-sectional time approach. The population in this study were 59 respondents in Ropang sub-district, Sumbawa. The sampling technique used was simple random sampling. Bivariate analysis of statistical tests used was logistic regression. Results. There are two variables that have a significant effect on the incidence of malaria, namely knowledge and preventive behavior. The knowledge variable had a significance value of 0.019 (p < 0.05), and an odds ratio value of 0.235. The preventive behavior variable also showed a significant influence on malaria incidence with a significance value of 0.008 (p < 0.05). Meanwhile, the perception variable did not show a significant effect on the incidence of malaria, with a significance value of 0.359 (p> 0.05). Conclusion. The results of this study showed that knowledge and preventive behavior had a significant effect on the incidence of malaria in respondents, while perception did not show a statistically significant relationship. These findings provide a new contribution to the understanding of the determinants of malaria prevention behavior in the study area.

Page 40 of 40 | Total Record : 392

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