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Science and Technology Indonesia

JSTI
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Published by Universitas Sriwijaya

ISSN : 25804405 EISSN : 25804391 DOI : -

Core Subject : Science, Social, Engineering,

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Materials Science & Nanotechnology Physics

An international Peer-review journal in the field of science and technology published by The Indonesian Science and Technology Society. Science and Technology Indonesia is a member of Crossref with DOI prefix number: 10.26554/sti. Science and Technology Indonesia publishes quarterly (January, April, July, October). Science and Technology Indonesia is an international scholarly journal on the field of science and technology aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that covers a typical subject of natural science and technology such as: > Chemistry > Biology > Physics > Marine Science > Pharmacy > Chemical Engineering > Environmental Science and Engineering > Computational Engineering > Biotechnology Journal Commencement: October 2016

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Articles 17 Documents

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Search results for , issue "Vol. 7 No. 2 (2022): April" : 17 Documents clear

Preparation and Evaluation of Antihypercholesterolemic Activity of Atorvastatin Calcium-Maleic Acid Co-Amorphous Solids Yudi Wicaksono; Shofiatul Izzah Al Amaliyah; Finas Rahmayanti; Viddy Agustian Rosidi; Lina Winarti; Dwi Setyawan
Science and Technology Indonesia Vol. 7 No. 2 (2022): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Atorvastatin calcium is a statin drug used for antihypercholesterolemic. The oral bioavailability of atorvastatin calcium is relatively low because it is poorly soluble in water. The low oral bioavailability of the drug causes a decrease in its therapeutic effectiveness. This study aimed to increase the solubility of atorvastatin calcium through the formation of co-amorphous solids and evaluate its activity as antihypercholesterolemic. Atorvastatin calcium was prepared into co-amorphous solids with a maleic acid coformer using the spray drying method. Solids characterization was carried out using Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transforms Infra Red (FTIR), and Scanning Electronic Microscopy (SEM). The solubility test was carried out using the shaking method, while the evaluation of antihypercholesterolemic was carried out in vivo in experimental animals. The results of the analysis of diffractograms, thermograms, FTIR spectra, and micrograph images showed that the atorvastatin calcium-maleic acid solids prepared by spray drying were a co-amorphous solid. The atorvastatin calcium-maleic acid co-amorphous solids had a greater solubility in water (p<0.05) when compared to pure atorvastatin calcium. However, the in vivo antihypercholesterolemic activity results in experimental animals showed that the cholesterol-lowering activity of the atorvastatin calcium-maleic acid co-amorphous solidswas not significantly different (p>0.05) with pure atorvastatin calcium. This phenomenon is thought to be because atorvastatin calcium from co-amorphous solids in solution is more present as a charged fraction, affecting the permeability and absorption process.

Optimization of Liquid Smoke from Shorea pachyphylla using Response Surface Methodology and its Characterization Hasan Ashari Oramahi; Kustiati; Elvi Rusmiyanto Pancaning Wardoyo
Science and Technology Indonesia Vol. 7 No. 2 (2022): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

The present study aims to optimize the processing variables producing liquid smoke from mabang wood (Shorea pachyphylla) by using Response Surface Methodology (RSM). In this investigation, a design of experiment with different combinations of pyrolysis temperature and pyrolysis time on the liquid smoke yield from mabang wood was applied. The response of the optimal yield, temperature, and time of pyrolysis was predicted using a mathematical model. The optimal operating conditions for the process of yielding 31.31% liquid smoke were identified at the pyrolysis temperature of 440◦C and pyrolysis time of 124 minutes. The effect of pyrolysis temperature was more significant than the pyrolysis time (p<0.05). The liquid smoke samples were evaluated by a GC-MS. The main chemical compound of the liquid smoke were 1,2-ethanediol (19.26%), fluoromethane (6.69%), formic acid (4.96%), 2-propanone (4.17%), acetic acid (18.64%), acetol (4.80%), furfural (9.94%), 2,4-hexadecanoic acid (3.45%), and guaiacol (2.93%).

Dynamic Modeling and Forecasting Data Energy Used and Carbon Dioxide (CO2) Edwin Russel; Wamiliana; Nairobi Saibi; Warsono; Mustofa Usman; Jamal I. Daoud
Science and Technology Indonesia Vol. 7 No. 2 (2022): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

The model of Vector Autoregressive (VAR) with cointegration is able to be modified by Vector Error Correction Model (VECM). Because of its simpilicity and less restrictions the VECM is applied in many studies. The correlation among variables of multivariate time series also can be explained by VECM model, which can explain the effect of a variable or set of variables on others using Granger Causality, Impulse Response Function (IRF), and Forecasting. In this study, the relationship of Energy Used and CO2 will be discussed. The data used here were collected over the year 1971 to 2018. Based on the comparison of some criteria: Akaike Information Criterion Corrected (AICC), Hannan-Quin Information Criterion (HQC), Akaike Information Criterion (AIC) and Schwarz Bayesian Criterion (SBC) for some VAR(p) model with p= 1,2,3,4,5, the best model with smallest values of AICC, HQC, AIC and SBC is at lag 2 (p= 2). Then the best model found is VECM (2) and further analysis such as Granger Causality, IRF, and Forecasting will be based on this model.

Tritirachium oryzae and Other Endophytic Mediated Jambu Bol (Syzygium malaccense) are Potential as an Antioxidant Yustina Hapida; Elfita Elfita; Hary Widjajanti; Salni
Science and Technology Indonesia Vol. 7 No. 2 (2022): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Natural bioactive substances have been discovered produced of intracellular fungi. Intracellular fungi, as well as endophytic fungi, it can be found in organs are leaves, stems, roots, fruits, flowers, and seeds. This study aimed to specify for antioxidant activity of intracellular fungi Jambu Bol (Syzygium malaccense) mediated and identify secondary metabolites compounds. The liquid culture was partitioned with ethyl acetate solvent. Using chromatographic techniques, extracts were separated from their secondary metabolites with antioxidant activity apply the DPPH procedure. Its chemical structure was determined using NMR spectroscopic research, and endophytic fungi were recognized using phenotypic characteristics and molecular classification. The endophytic fungus isolation yielded four isolates: YF11, YF12, YF13, and YF14. YF12, with an IC50 of 53.03 g/mL, was the fungus that exhibited good antioxidant activity. Pure chemical secondary metabolites compounds were identified as 2-(4-hydroxyphenyl)-4-methoxytetrahydrofuran-3-ol. Tritirachium oryzae was identified as the endophytic fungus YF12 based on morphological studies and a phylogenetic tree. To boost its antioxidant activity, more study is needed to perform a semi-synthetic reaction on this pure molecule

Mg/Al-chitosan as a Selective Adsorbent in The Removal of Methylene Blue from Aqueous Solutions Patimah Mega Syah Bahar Nur Siregar; Aldes Lesbani; Risfidian Mohadi
Science and Technology Indonesia Vol. 7 No. 2 (2022): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

The use of dyes in the textile industry is detrimental to aquatic biota and humans. Pollution caused by dye waste can be overcome by adsorption methods using adsorbents such as LDH. LDH is known as an adsorbent that is often found in the process of removing dye waste, but repeated use is not effective. This can be overcome by the LDH modification process using a supporting material such as chitosan. Modification of LDH can be done using coprecipitation or precipitation simultaneously at pH 10. XRD analysis where the peaks that appear in Mg/Al-chitosan are similar to the typical peaks of the constituent materials, namely Mg/Al and chitosan. This is confirmed by FTIR analysis where the spectrum that appears in Mg/Al-chitosan is similar to the spectrum in Mg/Al and chitosan. As well as BET analysis where there is an increase in the surface area of Mg/Al after being modified to Mg/Al-chitosan from 5.845 m2/g to 24.556 m2/g. In this study, the selectivity process for the dye mixture was carried out first with the most selective dye for the Mg/Al-chitosan adsorbent was methylene blue. Methylene blue was continued for adsorption processes such as isotherm adsorption kinetics and adsorption thermodynamics as well as adsorbent regeneration studies. The results showed that at 90 minutes the adsorption reached equilibrium. The adsorption capacity of Mg/Al increased after modification using chitosan from 84.746 mg/g to 108.696 mg/g. The adsorption process follows the Langmuir isotherm type where adsorption occurs chemically (monolayer). Regeneration studies show that Mg/Al-chitosan is an adsorbent that can be used repeatedly with stable adsorption effectiveness until the fifth cycle.

The Enhancement Solubility and Stability of Erythromycin Formatted in Solid Lipid Nanoparticles by Utilizing PVA as Stabilizer Mardiyanto; Budi Untari; Najma Fithri Annuria; Ady Mara; Andre Agung Aprianto; Gustina Emilia Ningsih
Science and Technology Indonesia Vol. 7 No. 2 (2022): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Infectious diseases have changed the world order today where the infection is the main cause of illness and death in the world. Erythromycin is a macrolide antibiotic that can generally inhibit the growth of Staphylococcus aureus and resistant strains. The free molecule of erythromycin in the part of the body does not reach Staphylococcus aureus because it is degraded by the first-pass effect. Nanoparticles can minimize damage to active substances due to first-pass effects because the particles have been protected by biopolymers leading to the minimizing damage of active substances. Formulation of nanoparticles loading erythromycin was used with the following variations in the amount of erythromycin 25 to 100 mg. Erythromycin was formulated by the coated polymer to changes the physics of the erythromycin into a particle. Preparation of erythromycin into nanoparticles was utilized stearic acid polymer, PEG-400, and polyvinyl alcohol using hot homogenization and ultrasonication method. Results showed that the optimum formula was the second formula (F2) with a percentage of encapsulation efficiency of 80.89773±0.11364. The results of the characterization of submicron particle formation such as morphology, diameter (particle size) and distribution (PDI) of F2 were spherical 518.6 nm; 0.096 PDI; and a zeta potential value of -12 mV respectively. The particles loading erythromycin were successfully increasing the stability of erythromycin for up to 5 cycles in terms of the heating-cooling-cycles test and also the solubility in SIF.

Facility Location Problem of Dynamic Optimal Location of Hospital Emergency Department in Palembang Robinson Sitepu; Fitri Maya Puspita; Ide Lestari; Indrawati; Evi Yuliza; Sisca Octarina
Science and Technology Indonesia Vol. 7 No. 2 (2022): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

The Emergency Department (ED) is one part of a hospital that provides initial treatment for patients who suffer from illness and injury, which can threaten their survival. The importance of integrated care in the ED is one of the keys to successfully treating patients at an advanced level. This becomes complex because the ED works in a team consisting of various multi-disciplinary sciences and limited human resources, facilities, and infrastructure. In the City of Palembang, 23 hospitals have emergency room facilities from 18 Sub-Districts, by using the TOPSIS (Technique for Others Reference by Similarity to Ideal Solution) method to vary the distance (radius) the optimal location of the emergency department is obtained according to the number of hospitals that have emergency room facilities, namely Ilir Timur I District, Ilir Barat I District, Sukarami District, and Plaju District. Based on the formulation of the p-median model and the completion of the TOPSIS method, the order of Districts that have optimal locations from 18 Sub-Districts that have emergency department facilities in the City of Palembang is obtained.

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